Hunter L. Little’s research while affiliated with Stanford University and other places

... Indocyanine green (ICG) angiography reveals hyperfluorescent areas that correspond to leaking points, and the choroid appears partly hypofluorescent owing to RPE atrophy and partly hyperfluorescent owing to the choriocapillary hyperpermeability. [2][3][4] Optical coherence tomographic (OCT) examinations reveal subretinal fluid and an irregular profile of the internal margin of the neurosensory retinal detachment secondary to a thickening and elongation of photoreceptor outer segments. A double-layer sign may appear with an undulating RPE profile, a hyporeflective middle layer, and an intact or slightly thickened Bruch membrane. ...

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Chronic Central Serous Chorioretinopathy Imaged by Optical Coherence Tomographic Angiography

... [20][21][22] CSR currently has no effective treatment available, but there is one case report of the use of topical nonsteroidal anti-inflammatory ointment that may have been useful in management, but as a single case, no definitive recommendations can be made. 23 ...

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Central serous retinopathy and hand–foot–mouth disease: coincidence or causation?

... These conditions cause leakage in the retinal vessels and neovascularization, leading to proliferative retinopathy. Panretinal laser photocoagulation (PRP) is the gold standard treatment for severe retinal ischemic diseases, including PDR [7][8][9][10] and rubeosis iridis, which arise from ischemic CRVO [11,12]. There is strong evidence that PRP prevents the development of NVG in PDR [7]. ...

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Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation

... In recent years, various treatment approaches have been reported for chronic CSC. Conventional laser treatments can induce thermal injuries in the retina, they have also side effects such as visual field defects, focal scar enlargement, CNV, and the development of new leak sites [17]. PDT, another alternative therapy, has achieved successful anatomical outcomes in the treatment of chronic CSC, but has various side effects such as choroidal ischemia, rupture or RPE atrophy, and CNV [6,[18][19][20][21]. ...

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Evaluation of the choroidal vascularity index after subthreshold yellow laser treatment in the patients with chronic central serous chorioretinopathy

... B Qiang Wu qiang.wu@shsmu.edu.cn 1 Department of Ophthalmology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China the clinical practice for diagnosing and monitoring NV [11]. However, ophthalmologists or specially qualified technicians and graders may need to manually analyze a few crosssectional OCT B-scan pictures from the volumetric scan slice by slice to identify NVD from OCTA images and determine blood flow information. ...

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A deep learning system for the detection of optic disc neovascularization in diabetic retinopathy using optical coherence tomography angiography images

... The argon green laser trial of extrafoveal CNV (200–2500 lm from the center of the foveal avascular zone) showed 25% and 60% severe visual loss in treated and untreated patients, respectively [14]. However, 59% of treated patients developed recurrent neovascularization, often soon after treatment (24% at 6 months, 43% by 1 year) [15]. The krypton red laser study treated juxtafoveal CNV lesions with a posterior border 1 to 199 lm from the center of the foveal avascular zone. ...

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Context for Protons as Adjunctive Therapy in Neovascular Age-Related Macular Degeneration: A Review

... In the current study, all patients who developed early postoperative VH were phakic, showed active fibrovascular membranes and none experienced ocular hypotony. Preoperative panretinal photocoagulation was not performed due to the risk of contraction of preretinal membranes [22][23][24], instead it was performed at end of surgery. To reduce the risk of intraoperative bleeding, IVB was injected 3-5 days prior to surgery in this series, but no more than 5 days to avoid causing fibrovascular contraction and subsequent worsening of the retinal detachment [25][26][27]. ...

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Twenty-seven-gauge vitrectomy for combined tractional and rhegmatogenous retinal detachment involving the macula associated with proliferative diabetic retinopathy

... Способ доставки -ключевой аспект лазерной фототерапии. В то время как рубиновый лазер был адаптирован к монокулярному прямому офтальмоскопу, последующие поколения лазеров стали адаптировать к непрямому офтальмоскопу [4], щелевой лампе [5] и операционному микроскопу [6]. Сочетание лазеров со щелевой лампой улучшило доставку лазерного излучения, особенно для его применения в области заднего полюса глаза, что позволило проводить лечение широкого спектра заболеваний сетчатки и хориоидеи в амбулаторных условиях. ...

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Possibilities of Using Laser Radiation in Vitreoretinal Surgery

... It is apocryphal that early in the experience of the rapidly growing post-insulin DR epidemic it was noted that eyes with large chorioretinal scars, such as from trauma or congenital toxoplasmosis, appeared to be protected from DR compared to otherwise normal fellow eyes (L'Esperance 1966). This observation gave rise to the idea of creating chorioretinal scarring as a therapeutic measure to treat or prevent DR (L' Esperance 1966, Zweng et al 1971, Townsend et al 1978. It was recognized that laser (or xenon arc) could produce photocoagulation (PC) scars that could mimic the traumatic and infectious lesions that appeared to confer protection. ...

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Modern Retinal Laser Therapy. Principles and Application

... Retinal photocoagulation (RPC) for complications of diabetic retinopathy (DR) and retinal vein occlusion (RVO) became major indications for retinal laser, principally as focal and grid RPC, while treatment of choroidal neovascular membranes (CNV), particularly associated with age-related macular degeneration (AMD), was the unique indication for suprathreshold ablative RPC in the macula [15,16] Despite steady progress in most other areas of ophthalmology, prototypical LIRD, i.e., photocoagulation, was believed to be the absolute prerequisite for therapeutic efficacy and remained so for over 50 years. This belief was universally accepted and questioned by no one of record during that time [17]. ...

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Lasers in medicine. The changing role of laser-induced retinal damage - from de riguer to Nevermore