Hung Tuck Chan's research while affiliated with University of the Ryukyus and other places

Publications (36)

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In this review, the botany, uses, bioactive metabolites, and health-promoting benefits of Undaria pinnatifida (wakame) and Saccharina japonica (kombu) are highlighted. Their clinical evidence is focused on clinical studies conducted in Japan and in other countries. These two species are brown seaweeds (Phaeophyta). In Japan, wakame and kombu seawee...
Article
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Alpinia zerumbet or shell ginger is a ginger plant with diverse chemical constituents and medicinal and non-medicinal uses. Dihydro-5,6-dehydrokawain (DDK) and Dehydrokawain (DK) are two kavalactones (also known as kava pyrones or styrylpyrones) from A. zerumbet. Both DDK and DK have a carbonyl group at C2, a methoxy group at C4, and a double bond...
Article
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This overview on Volkameria inermis (Lamiaceae) is the first in updating information on the chemical constituents and pharmacological properties of the species, notably on its unique ability in ameliorating motor tics. The information was procured from Google, Google Scholar, PubMed, PubMed Central, Science Direct, J-Stage, and PubChem. Previously...
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Globally, there are eight species of Avicennia with five species (A. alba, A. integra, A. marina, A. officinalis and A. rumphiana) in East Africa and Indo-Pacific, and three species (A. bicolor, A. germinans and A. schaueriana) in the New World and West Africa (Duke, 1991; Spalding et al., 2010). Avicennia species occur in tropical, subtropical inc...
Chapter
This chapter on Mangroves of Malaysia begins with a brief introduction on the geography of Malaysia, consisting of Peninsular Malaysia, Sabah, and Sarawak separated by the South China Sea. Information on the population, land area, and area of mangroves in Malaysia is presented. The largest area of mangroves is in Sabah, followed by Sarawak and Peni...
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In this article, the botany, uses, bioactive compounds and pharmacological properties of leaves and roots of Pluchea indica are reviewed for the first time. The coastal species occurs in open sites at the landward side of mangroves. Main botanical characters for the identification of P. indica are bushy shrub life-form, and leaves are short-stalked...
Article
Rosemary (Rosmarinus officinalis L.), a culinary herb of the family Lamiaceae, has promising anticancer activity. This overview has updated the current knowledge on the chemistry and anticancer properties of rosemary extract, carnosic acid, carnosol, and rosmanol, focusing on colon and prostate cancer cells since they are the most susceptible. The...
Article
Tetrandrine (TET) and fangchinoline (FAN) are dominant bisbenzylisoquinoline (BBIQ) alkaloids from the roots of Stephania tetrandra of the family Menispermaceae. BBIQ alkaloids comprise two benzylisoquinoline units linked by oxygen bridges. The molecular structures of TET and FAN are exactly the same, except that TET has a methoxy (−OCH3) group, wh...
Data
Mangroves dominate natural shorelines of Sabah and occupied approximately 60% of the total mangroves of Malaysia, yet their utilization by fishes, shrimps and other marine fauna is poorly understood. The focus of this notes is to identify the importance of mangrove habitats in relation to assemblage-level patterns of fish use, with very few studies...
Article
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Flavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves (MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins (benzofurans), caffeoylqu...
Article
Background and aims: The tidal flats on which mangrove plants grow tend to have low soil nitrogen contents because nitrogen-containing litter is repeatedly washed offshore by ebb tides. Under such circumstances, it is unclear how mangrove plants acquire the nitrogen required to support their vigorous growth. In the present work, chemical and biolo...
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Flavones are the most dominant type of flavonoids isolated from the roots of Scutellaria baicalensis (Radix Scutellariae), which is a traditional medicinal plant in East Asian countries, including China, Japan and Korea. Most of the flavones are derivatives with methoxyl and hydroxyl groups, and they include baicalein, baicalin, chrysin, norwogonin...
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The root bark of Morus alba L. or white mulberry is widely used as traditional medicine in China, Japan and Korea. Major classes and types of phenolic compounds isolated from the root bark are flavonoids (kuwanons, morusin, cyclomorusin and sanggenons), benzofurans (moracins and mulberrofurans), and stilbenoids (mulberrosides). Some of the flavonoi...
Article
This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leave...
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In this review, the botany and uses of Alpinia zerumbet (yan shan jiang) are described, and the current knowledge of its phytochemistry, pharmacological properties, and clinical trials is summarized. An important ginger crop in East Asia, A. zerumbet has many uses, both medicinal and non-medicinal. Leaves are used to produce essential oils and herb...
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From different plant parts of Calotropis species (C. gigantea and C. procera), various classes of compounds such as oxypregnanes, terpenoids, sterols, cardenolides and flavonoids have been isolated. Of these compounds, the cardenolides stand out as many of them have anticancer properties. Cardenolides are C23 steroids with a five-membered unsaturat...
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Mangifera pajang Kostermans of the mango family (Anacardiaceae) is endemic to the lowland rain forests of Borneo. Although growing wild in the forest, trees of are planted in orchards and home gardens due to increasing demand for the fruits which are among the largest of the genus. Fruits are oval in shape, and have a characteristic rough and brown...
Article
In Southeast Asia, the young leaves of ulam herbs are consumed raw as condiment. The regular intake of ulam is believed to assist in preventing degenerative diseases, delaying aging and improving overall health. In this review, the current knowledge on the phytochemistry and pharmacology of two ulam herbs of Anacardium occidentale (cashew) and Barr...
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The phytochemistry and pharmacology of two common tree species of sandy shores, namely, Calophyllum inophyllum and Thespesia populnea have been selected for review. There was global interest in C. inophyllum after its leaves were reported to possess anti-human immunodeficiency virus (HIV) properties. Since then, extensive research has been conducte...
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In Southeast Asia, ulam herbs are consumed raw as a condiment. It is believed that these herbs have medicinal benefits and their regular intake can prevent degenerative diseases, delay aging and improve overall health. In this review, the current knowledge on the phytochemistry and pharmacology of Oenanthe javanica (water dropwort) and Cosmos cauda...
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Apocynaceae is a large family of tropical trees, shrubs and vines with most species producing white latex. Major metabolites of species are triterpenoids, iridoids, alkaloids and cardenolides, which are known for a wide range of biological and pharmacological activities such as cardioprotective, hepatoprotective, neuroprotective, anti-inflammatory,...
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Among the Hibiscus species, H. tiliaceus and H. mutabilis display spectacular flower colour change. In this short review, the current knowledge on their phytochemistry and pharmacology is updated, and their botany and uses described. With phytosterols, triterpenes, triterpenoids, coumarins, amides, phenolic acids, and anthocyanins as chemical const...
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Artocarpus altilis (breadfruit) and Pandanus tectorius (screw pine) are two cultural icons of Oceania. Fruits of both species are rich in carbohydrates, and contain proteins, vitamins and minerals. Endowed with triterpenes, flavonoids, stilbenes, arylbenzofurans and sterols as chemical constituents, fruits of A. altilis possess antioxidant, antimic...
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Xylocarpus of the family Meliaceae is a small genus comprising tree species of X. granatum, X. moluccensis and X. rumphii (Giesen et al., 2007). Considered as true mangroves, X. granatum and X. moluccensis are found at the landward side of mangrove forests and in associated brackish-water habitats while X. rumphii occurs along rocky shores and prom...
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Metabolites and bioactivities of Rhizophoraceae including Rhizophora stylosa have only been reviewed by Nebula et al. (2013). In a review of natural products from mangrove flora by Wu et al. (2008), information on R. apiculata and R. mucronata was presented but not on R. stylosa. In this note, the chemistry and bioactivities of R. stylosa, which ar...
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Members of the mangrove genus Rhizophora represent the most commonly occurring and highly valued species in the Indo-West Pacific region. However, to date, few studies have been directed towards the understanding of their genetic variation. The levels and patterns of genetic variation at chloroplast and nuclear gene regions were studied in R. apicu...
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Natural hybridization is common in plants. Very often, the identity of a putative hybrid is inferred based on the observation of morphological features intermediate between two possible parental species occurring in a specific location. However, due to plasticity of morphological features and the co-occurrence of more than two possible parental spe...
Article
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The objective of this trial is to test the feasibility of cluster planting technique and to identify suitable species for rehabilitation.

Citations

... Malaysia's mangrove forests are the sixth largest in the world. In Malaysia, mangrove forests are categorized as permanent forest reserves (PFR), which include protected forest reserves, domestic forest reserves, mangrove forest reserves (MFR), virgin forest reserves (VJR), and wildlife reserves (Tangah et al., 2022). In Kuala Sepetang, the largest mangrove forest reserve in Malaysia, with an area of about 40,000 ha, is Matang Mangrove Forest Reserve (MMFR) (Romañach et al., 2018). ...
... The anticancer activity of rosemary extracts and their major bioactive constituents were widely studied in the last decades [101][102][103][104][105][106]. Numerous studies employing in vitro assays regarding different types of cancer, such as leukemia, breast, lung, liver, brain, prostate and colon cancer were conducted. ...
... P. indica is traditionally utilized by the Sundanese and the people of the Minahasa region in Indonesia to recover postnatal women (Zumsteg and Weckerle 2007;Roosita et al. 2008). Aerial parts and roots of P. indica have been reported to be pharmacologically useful for treating various diseases and a promising source of natural medicinal compounds (Chan et al. 2022). ...
... Tet is a bisbenzylisoquinoline alkaloid extracted from the roots of Stephamia tetrandra S. Moore [22]. It is commonly used to treat arthritis, hypertension, tumors, silicosis, liver fibrosis prevention and treatment, liver cell protection, and other conditions in clinical practice [23][24][25]. ...
... Although the types and contents of TPC vary among the species, maturation, processing, and cultivation environment, the TPC level is in the range of 10-18 mg/g (dry weight) [17]. According to Chan et al. [28], 81 out of 140 phenolic compounds detected in mulberry leaves are flavonoids. However, major constituents of phytochemicals Fatty acid derivative (9 S,11E,13 S,15Z)-9,13-dihydroxy-10-oxo-octadeca-11,15-dienoic acid p < 0.01). ...
... [77-78] Tree species and age of mangrove Mature mangrove forest Nitrogen fixation was promoted. [26,78] Different mangrove species Microbes involved in nitrogen cycling were selected. [79] Temperature High temperature (35 °C) Fixed rate of nitrogen was low. ...
... Baicalein reduced levels of the anti-apoptotic proteins Bcl-2 and Mcl-1 while increasing concentrations of the pro-apoptotic agent Bax by inactivating 12-LOX. This produced apoptosis by causing the ransom of cytochrome c from mitochondria into the cytoplasmic environment, stimulation of caspase-9, caspase-7, and caspase-3, and eruption of the caspase-3 precursor poly ADPribose polymerase (PARP) [93]. ...
... Phenological studies on the natural A. cucullata population in Ranong will be useful in determining the season for collecting mature fruits and seeds for raising in the nursery prior to outplanting in the field. Although A. cucullata was one of the species chosen for the mangrove rehabilitation project in Sabah (Baba et al., 2019), and planted in clusters along Sungai Garama (Tangah et al., 2012), its silviculture needs to be studied including nursery and planting techniques, growth and yield, and pests and diseases. ...
... Fish soup Flavonoids, benzofurans, stilbenoids, triterpenes, phenolic acids, and coumarin [22] Synergistic with other herbs in soups to relieve cough [22] T5758, T5759 ...
... Casticin Casticin ( Figure 5) is a methoxylated flavonol derived from Vites trifolia, Vites agnuscastus, and Vites negundo. Casticin has been demonstrated to possess antiproliferative and proapoptotic effects in numerous types of cancer, including breast, colon, liver, and others [332]. These anticancer effects have been validated in the setting of lung cancer using A549 cells. ...