Hun-Sung Kim's research while affiliated with Catholic University of Korea and other places

Publications (59)

Article
Artificial intelligence (AI)-based diagnostic technology using medical images can be used to increase examination accessibility and support clinical decision-making for screening and diagnosis. To determine a machine learning algorithm for diabetes complications, a literature review of studies using medical image-based AI technology was conducted u...
Article
Aims: Glucagon-like peptide-1 receptor agonist (GLP-1 RA) is used to treat obesity or type 2 diabetes mellitus (DM). We compared weight loss and side-effects between patients with and without DM using GLP-1 RA. Methods: This was a retrospective cohort study based on electronic medical records. Patients were categorized into three groups: liraglu...
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Background: The relationship between metformin intake and prostate cancer incidence remains unclear. Therefore, we examined the correlation between prostate cancer and metformin use.Methods: The subjects were diabetes patients aged ≥50 years who had been diagnosed with prostate cancer and had undergone surgery at Seoul St. Mary's Hospital. Groups t...
Article
Obesity is a disease requiring treatment. The prevalence of obesity is steadily increasing both in Korea and worldwide. Individuals with obesity are at elevated risks of diabetes, cerebrovascular disease, and solid cancer; therefore, obesity is now considered to be a disease requiring treatment, rather than merely a cosmetic problem. Nutrition and...
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Background: Few studies have investigated the cancer-preventive effects of statins, which are known to protect against cardio-cerebrovascular diseases. In this study, we analyzed the degree to which pravastatin, a low-potency statin, could prevent cancer.Methods: This retrospective cohort study used data from the Korean National Health Insurance Se...
Preprint
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The relationship between prediabetes and dementia remains controversial. We aimed to examine the association between cumulative exposure to impaired fasting glucose (IFG) and the risk of dementia in the general population. 1,463,066 middle-aged and elderly subjects who had had health examinations for four consecutive years were identified from a Ko...
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Objectives: The goal achievement rate of patients' low-density lipoprotein cholesterol (LDL-C) levels and prescribing pattern of statin potency should be continuously monitored in a real-world clinical setting. This study aimed to describe the comprehensive status of LDL-C management. Materials and methods: Patients first diagnosed with cardiova...
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Purpose: Liraglutide is known to have much lower weight loss effects in real clinical fields than in randomized clinical trials because of its side effects (SE) and discomfort associated with injections. This study is aimed at determining whether the side effects of liraglutide affect weight reduction and its maintenance in real-world practice. M...
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The early prediction of diabetes can facilitate interventions to prevent or delay it. This study proposes a diabetes prediction model based on machine learning (ML) to encourage individuals at risk of diabetes to employ healthy interventions. A total of 38,379 subjects were included. We trained the model on 80% of the subjects and verified its pred...
Article
The incidence of obesity is increasing throughout the world, including Korea. Liraglutide, the main purpose of which is glucose control, has recently gained significant attention due to its additional effect on weight loss. Liraglutide injections have been widely used as an important treatment for obese patients in Korea. In addition to weight loss...
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Backgruound: The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence of YOD increases, it is necessary to determine the characteristics of YOD and the factors that influence its development and associated complications. Methods: In this retrospective study, we recruited patients who were diagnosed with type 2...
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The prevalence of cancer, diabetes mellitus (DM), and hypertension is increasing in ageing populations. We analyzed the association of DM with cancer and its effects on cancer mortality. The data of 2009–2018 from the Korea National Hospital Discharge In-depth Injury Survey were used; 169,959 adults with cancer as the main diagnosis were identified...
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Almost every Korean (97%) is enrolled in the National Health Insurance program, and most receive medical treatment at least once a year. Data are collected by the Health Insurance Review and Assessment Service (HIRA), and the results of the review are sent to the National Health Insurance Service (NHIS). The data handled by NHIS and HIRA cover almo...
Article
Background: Liraglutide, a drug used for the management of obesity, has many known side effects. In this study, we developed a predictive model for the occurrence of liraglutide-related side effects using data from electronic medical records (EMRs).Methods: This study included 237 patients from Seoul St. Mary's Hospital and Eunpyeong St. Mary's Hos...
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Background: There are many models for predicting diabetes mellitus (DM), but their clinical implication remains vague. Therefore, we aimed to create various DM prediction models using easily accessible health screening test parameters. Methods: Two sets of variables were used to develop eight DM prediction models. One set comprised 62 easily acc...
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Background: The most important aspect of a retrospective cohort study is the operational definition (OP) of the disease. We developed a detailed OP for the detection of sodium-glucose cotransporter-2 inhibitors (SGLT2i) related to diabetic ketoacidosis (DKA). The OP was systemically verified and analyzed. Methods: All patients prescribed SGLT2i...
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Smart healthcare systems are being designed to provide medical services to and improve the daily lives of older adults. However, most research has been focused on technical issues, despite a need to conduct in-depth studies on related ethical issues. Therefore, this study aimed to examine ethical issues in smart healthcare for older adults. We revi...
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With the introduction of electronic medical records (EMRs), it has become possible to accumulate massive amounts of qualitative medical data. As such, EMRs have become increasingly used in clinical decision support systems (CDSSs). While CDSSs aim to reduce medical errors normally occurring in the process of treating patients by physicians, technic...
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Personal medical information is an essential resource for research; however, there are laws that regulate its use, and it typically has to be pseudonymized or anonymized. When data are anonymized, the quantity and quality of extractable information decrease significantly. From the perspective of a clinical researcher, a method of achieving pseudony...
Article
Background: Statin-associated muscle symptoms are one of the side effects that physicians should consider when prescribing statins. In this study, creatine kinase (CK) levels were measured following statin prescription, and various factors affecting the CK levels were determined using machine learning.Methods: Changes in the CK were observed every...
Article
Background: Glycated hemoglobin (HbA1c), which reflects the patient's blood sugar level, can only be measured in a hospital setting. Therefore, we developed a model predicting HbA1c using personal information and self-monitoring of blood glucose (SMBG) data solely obtained by a patient.Methods: Leave-one-out cross-validation (LOOCV) was performed a...
Article
Knowledge based systems have accomplished remarkable achievements in assisting evidence based decision making for complex problems. However, machine learning-driven, intelligent systems of today are dependent on the underlying knowledge model, which is acquired from domain experts, or the available datasets in a structured or unstructured format. M...
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Various digital healthcare devices and apps, such as blood glucose meters, blood pressure monitors, and step-trackers are commonly used by patients; however, digital healthcare devices have not been widely accepted in the medical market as of yet. Despite the various legal and privacy issues involved in their use, the main reason for its poor accep...
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With the advent of the big data era, the interest of the international community is focusing on increasing the utilization of medical big data. Many hospitals are attempting to increase the efficiency of their operations and patient management by adopting artificial intelligence (AI) technology that enables the use of electronic medical record (EMR...
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Due to the coronavirus disease 2019 (COVID-19) outbreak, consultation and prescription via telemedicine were temporarily allowed in the Korean population. However, at this point, it is difficult to determine whether telemedicine fulfills its role as a health care strategy. Arguably, if we had enough previous experience with telemedicine or sufficie...
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Objectives: Digital healthcare is expected to play a pivotal role in patient-centered healthcare. It empowers patients by informing, communicating, and motivating them. However, a pragmatic evaluation of the present status of digital healthcare has not been presented; therefore, we aimed to examine the status of digital healthcare in Korea. Metho...
Article
What is known and objectives: In Korea, the side effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have not been clearly reported, aside from voluntary reporting. We aimed to develop detection algorithms for SGLT2i-related genital tract infections (GTIs) and urinary tract infections (UTIs) via a common data model (CDM), an electronic m...
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Background: This study aimed to investigate the recent prevalence, management, and comorbidities of diabetes among Korean adults aged ≥30 years by analyzing nationally representative data. Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2016 to 2018, and the percentage and total number of people...
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Background: Concomitant papillary thyroid cancer (PTC) and hyperparathyroidism (HPT) have been reported in several studies. Our study aimed to investigate the incidence of concomitant PTC in HPT patients upon preoperative diagnosis and present a clinical opinion on detecting thyroid malignancy in case of parathyroidectomy. Methods: Patients who...
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Digital therapeutics (DTx), like drugs or medical devices, 1) must prove their effectiveness and safety through clinical trials; 2) are provided to patients through prescriptions from doctors; and 3) may require the approval of regulatory agencies, though this might not be mandatory. Although DTx will play an important role in the medical field in...
Article
What is known and objective There is much controversy over how angiotensin II receptor blockers (ARB) or angiotensin‐converting enzyme inhibitors (ACEI) affect blood uric acid levels. Though ARB is not used to lorcwer the uric acid concentration in the blood, losartan, one of the ARB series, is known to reduce the uric acid concentration in the blo...
Article
Objectives: The purpose of this study was to investigate the effect of sulfonylureas (SUs) and antimicrobial co-administration on hypoglycemia in patients with type 2 diabetes mellitus (T2DM). Methods: We conducted a case-crossover study using the Korean Health Insurance Review and Assessment Service-National Inpatient Sample database, using dat...
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Physical activity can have both positive and negative effects on sleep depending on how it is practiced. Regular exercise and vigorous physical activity aid in maintaining a healthy life and preventing chronic diseases. Rather than looking for a specific exercise type to help fall asleep, it is better to encourage patients to find exercises that th...
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Hypoglycemia is one of the severe complications of diabetes. To prevent hypoglycemia, an emphasis is placed on maintaining an appropriate balance between nutrition, activity, and treatment, which can be achieved by the repetition of self-trials based on self-monitoring. Clinicians routinely focus on patients' contribution, including timely intake o...
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Most people are now familiar with the concepts of big data, deep learning, machine learning, and artificial intelligence (AI) and have a vague expectation that AI using medical big data can be used to improve the quality of medical care. However, the expectation that big data could change the field of medicine is inconsistent with the current reali...
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Background: Bisphosphonate-induced osteonecrosis of the jaw (BRONJ) presents with a typical pattern of jaw necrosis in patients who have been prescribed bisphosphonates (BPs) and other antiangiogenetic drugs to treat osteoporosis or bone-related complications of cancer. Methods: This study divided 38 patients with BRONJ into two groups according...
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Background: Recent evidence of the effectiveness of mobile phone-based diabetes management systems is generally based on studies conducted in tertiary hospitals or professional diabetes clinics. Objective: This study aimed to evaluate the clinical efficacy and applicability of a mobile phone-based glucose-monitoring and feedback system for the m...
Preprint
BACKGROUND Recent evidence of the effectiveness of smartphone-based diabetes management systems is generally based in tertiary hospitals or professional diabetes clinics. OBJECTIVE To evaluate the clinical efficacy and applicability of a smartphone-based glucose monitoring and feedback system for the management of type 2 diabetes mellitus (T2DM) i...
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Background: The objective of this study was to investigate the prevalence, management, and comorbidities of diabetes among Korean adults aged 30 years and older. Methods: This study used 2013 to 2016 data from the Korea National Health and Nutrition Examination Survey, a nationally-representative survey of the Korean population. Diabetes was def...
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Clinical studies can be conducted to gather real world evidence (RWE) not available from randomized controlled trials, providing new information and knowledge. Although the concept of RWE emerged relatively recently, numerous clinical studies are utilizing it. However, many researchers are engaging in trial and error that may not overcome the vario...
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Background and aims: Visit-to-visit variability in biological measures has been suggested as an independent predictor of cardiovascular disease (CVD). Although low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) are important risk factors of CVD, there are few studies investigating the effect of variability...
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Real-world evidence (RWE) and randomized control trial (RCT) data are considered mutually complementary. However, compared with RCT, the outcomes of RWE continue to be assigned lower credibility. It must be emphasized that RWE research is a real-world practice that does not need to be executed as RCT research for it to be reliable. The advantages a...
Article
Previously, we have shown the long-term efficacy and biocompatibility of chitosan-coated alginate capsule in allogeneic islet transplantation with canine models of diabetes. In this study, we compared the efficacy and immune response of chitosan-coated alginate capsule in xenogeneic islet transplantation with non-human primates (NHPs). Porcine isle...
Article
A few patients who are administered sodium-glucose co-transporter 2 inhibitors (SGLT2i) for the first time often show an increase in their body weight and/or blood glucose levels. In this study, we used an electronic medical record database to identify the factors that affect blood glucose levels and body weight after the administration of SGLT2i....
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Objective: To investigate behavioral factors that contribute to the development of obesity among overweight children. Methods: Among a community sample of 884 children aged 9-13 years, 833 children completed a baseline and 1-year follow-up examination that included anthropometrics, physical fitness, and behavioral factors. Results: During the...
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Objectives: To enable early detection of adverse drug reactions (ADRs) in patients using HMG-CoA reductase inhibitors (statins), we developed an algorithm that automatically detects liver injury caused by statins from Electronic Medical Record (EMR) data. We verified the performance of our algorithm through manual ADR assessment and a direct chart...

Citations

... We found an overall achievement rate for the risk-based LDL-C goals of only 31.1%, despite all patients being on high-intensity statins, even with 62% of them on combination therapy of high-intensity statins plus ezetimibe. Regardless of differences in the recommended LDL-C targets, baseline CV risk of patients, or LLT used for CVD prevention, our findings are consistent with several international and Spanish studies that have consistently reported low rates of LDL-C goal a ainment in high-or very high-risk patients, ranging from 4% to 57% [6,[10][11][12][13][14][17][18][19][20][21][22][23][24][25][26]. It must be highlighted that most patients included in the TERESA study were categorized as very high CVD risk as they were recruited in cardiology and internal medicine units. ...
... For the linear models, we adjusted a range of hyperparameters and penalty functions that can be utilized in constructing different models, including logistic regression, lasso regression, ridge regression, and ElasticNet. For the tree-based models, we selected Extreme Gradient Boosting (XGBoost), which is widely recognized as one of the best-in-class algorithms for decision-tree-based models and has shown remarkable prediction performance in a wide range of studies [52][53][54][55][56][57] . Following ML best practices, the study data set was split into a modeling set that contains T2D patients diagnosed from 2015 to 2020, and an independent testing set that covers T2D patients diagnosed in 2021. ...
... patients. Also, UA, length of diabetes, and SBP were independent risk factors for EOD-associated nephropathy (20)(21)(22)(23). In young patients, the average duration to develop atherosclerotic cardiovascular disease (ASCVD) and arrhythmogenic cardiomyopathy (ACM) was 9.1 years in high-risk patients and 10.0 years in low-risk patients (23). ...
... The Korean National Health Insurance Service (NHIS) was established under the Ministry of Health and Welfare to provide mandatory health insurance services to about 97% of the Korean population [8]. This study used a customized database derived from the nationwide Korean NHIS. ...
... AI technology is used in various applications in the medical field, including early detection of complications, patient condition monitoring, clinical decision-making, and treatment. [12][13][14][15] In particular, AI-based medical image analysis technology is used for the diagnosis and prediction of various diabetes complications, and its accuracy is increasing through various machine learning and deep learning. 16,17 Despite the rapid development of AI models based on medical images in the field of diabetes, there are also problems with their clinical implementation in the real world. ...
... The ageing of the body becomes more pronounced as age increases, and the overall health and physical condition tend to deteriorate. The elderly are more likely to develop various diseases gradually, such as hypertension, diabetes, various cancers, and the resulting complications [1,2]. Population ageing is a global issue, and healthy ageing is one of the major directions for the research in gerontology in the world today. ...
... Computerised decision support systems (CDSS) are digital health technologies designed to analyse patient's clinical data to assist in clinical decision-making at the point of care [1]. CDSS can be knowledge based which involves predetermined rules based on literature, clinical practice or patients, or non-knowledge based which utilises advanced statistical pattern recognition, including artificial intelligence and machine learning, to produce an action or output from the data [2]. ...
... Furthermore, data quality is often unreliable, and in most cases, preprocessing is required [87,88], ultimately implying a critical privacy issue. To compensate for this, all information that can identify individuals should be removed from the accumulated data, and the extracted information should be stored in an encrypted file and made accessible only to designated persons [83,89]. ...
... They provide a structured approach to decision-making and knowledge representation [82], offering a systematic framework for integrating information from various modalities. By employing a set of predefined rules, these systems can effectively process and integrate data from multiple sources, enabling informed decisions and providing valuable recommendations [79]. The utilization of rule-based systems in multimodal medical data fusion enhances the overall knowledge generation process, aiding in accurate diagnoses, personalized treatment plans, and improved healthcare outcomes. ...
... For example, NLPs can write code that could be used to create research models or to collect data from the electronic medical records to create databases that can be updated periodically. 20 ML models are being used broadly in research, including in prediction models, improving pathology, and radiology reports, as mentioned earlier. ...