Huiqing Zhang’s research while affiliated with Xi’an Jiaotong-Liverpool University and other places

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Publications (5)


Fig. 5 Miniaturized sensor technologies for long-term monitoring of orthodontics. a Monitoring the compliance of wearing dental braces based on the degree of pigment diffusion from polymer pores and force required for orthodontics 33,36 . b Wearable devices to monitor pH and temperature of saliva 38 . c Judging the movement of teeth based on photos taken by smartphones 95 . d Wearable patch attached onto teeth to detect oral microbiomes 37 . Figure used with permission from Schott, T. C. et al. 33 Copyright © Allen Press Inc, 2011. Kyriacou, P. A. et al. 36 Copyright © Springer Berlin Heidelberg, 1997. Igarashi, K. et al. 38 Copyright © Elsevier, 1981. Hansa, I. et al. 95 Copyright © W.B. Saunders Ltd, 2018. Mannoor, M. S. et al. 37 Copyright © Springer Nature, 2012.
Fig. 6 Miniaturized sensor technologies for long-term monitoring of diabetes. Research advances in glucose sensors for one-point detection 42,96 , and continuous monitoring for minutes to days 44-46 . Commercially available glucose sensing devices for one-point detection and continuous monitoring for days to months 37,38 . Figure used with permission from Yetisen, A. K. et al. 42 Copyright © John Wiley and Sons, 2019. Xiao, J. et al. 96 Copyright © American Chemical Society, 2019. Kim, K. B. et al. 44 Copyright © Elsevier, 2019. Lee, H. et al. 45 Copyright © Springer Nature, 2016. Martin, A. et al. 46 Copyright © American Chemical Society, 2017. Mannoor, M. S. et al. 37 Copyright © Springer Nature, 2012. Igarashi, K. et al. 38 Copyright © Elsevier, 1981.
Miniaturized sensor technologies.
Flexible Miniaturized Sensor Technologies for Long-Term Physiological Monitoring
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December 2022

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580 Reads

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67 Citations

npj Flexible Electronics

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Hao Liu

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Physiological monitoring can provide detailed information about health conditions, and therefore presents great potentials for personalized healthcare. Flexible miniaturized sensors (FMS) for physiological monitoring have garnered significant attention because of their wide applications in collecting health-related information, evaluating and managing the state of human wellness in long term. In this review, we focus on the time scale of human physiological monitoring, the needs and advances in miniaturized technologies for long-term monitoring in typical applications. We also discuss the rational sample sources of FMS to select proper strategies for specific monitoring cases. Further, existing challenges and promising prospects are also presented.

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Fig. 3 Stretching test of the 3D graphene-based spiral sensor. It shows that the 3D graphene-based spiral sensor prepared by stretching the 2D graphene-based spiral sensor fabricated by laser kirigami. The resistance changes with the time of a continuous stretching test in a stretching cycle. The maximum stretching height reaches 21 cm. Laser speed 1%, power 0.3%, PPI 400.
Fig. 4 Performance and mechanism of the grip strength monitoring. a Resistance changes versus different forces of the smart ball sensor. b Cyclic performance (1 Hz, 17.7 N) and c stability under various levels of force. Under a contact area of 490.87 mm 2 , d the 2D loading model and e FEA results of the strains of the spiral sensor versus different compressing forces. Under a compressing force of 18 N, f the 3D loading model and g FEA results of the strains of the spiral sensor versus different 3D contact areas. The spiral sensor (diameter 45 mm × width 2 mm × thickness 0.075 mm, 4 circles, 1% laser speed, 0.3% power, 400 PPI), the egg-shaped ball model (width 3.8 cm × height 5.8 cm), and the indenter (diameter 25 mm × height 3 mm) were used here.
Fig. 5 Accuracy comparison of the grip strength under considering the 3D contact area or not. When considering the 3D contact area, F mon (Eq. (8)), the accuracy of the grip strength calculated from Eq. (8), is higher than that of not considering the 3D contact area from Eq. (1), namely F mon (Eq. (1)). Accuracy improves 11.18% after considering 3D contact area. Details in Fig. S12 in supporting information.
A smart ball sensor fabricated by laser kirigami of graphene for personalized long-term grip strength monitoring

May 2022

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115 Reads

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12 Citations

npj Flexible Electronics

Grip strength is an important indicator of health conditions and needs to be monitored for health management. However, different populations (e.g., babies and rehabilitation patients) have different hand sizes and different levels of grip strengths, requiring a personalized sensor to monitor grip strength. In this paper, we developed a smart ball sensor by laser kirigami of graphene for personalized grip strength monitoring. To realize the rational utilization of space, a transparent pill shell embedding all electronic accessories is installed in the center of the ball sensor with a spiral-sensing unit fabricated by laser kirigami of graphene on the surface. Furthermore, we assessed the influence of contact area between hand and ball on grip strength using finite-element analysis (FEA), which was then considered in our results readout. The grip strength can be continuously read by a mobile phone in a wireless manner. The smart ball sensor demonstrated a high performance in vitro against gold-standard method in diseased and healthy subjects. It would be a powerful tool for personalized long-term monitoring of grip strength, especially suitable for specific populations such as babies and sensitive enough for samll grip strength.


A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers

November 2021

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808 Reads

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109 Citations

Detection of biomarkers associated with body conditions provides in‐depth healthcare information and benefits to disease management, where the key challenge is to develop a minimally invasive platform with the ability to directly detect multiple biomarkers in body fluid. Dermal tattoo biosensor holds the potential to simultaneously detect multiple health‐related biomarkers in skin interstitial fluid because of the features of minimal invasion, easy operation, and equipment‐free result reading. Herein, a colorimetric dermal tattoo biosensor fabricated by a four‐area segmented microneedle patch is developed for multiplexed detection of health‐related biomarkers. The biosensor exhibits color changes in response to the change of biomarker concentration (i.e., pH, glucose, uric acid, and temperature), which can be directly read by naked eyes or captured by a camera for semi‐quantitative measurement. It is demonstrated that the colorimetric dermal tattoo biosensor can simultaneously detect multiple biomarkers in vitro, ex vivo, and in vivo, and monitor the changes of the biomarker concentration for at least 4 days, showing its great potential for long‐term health monitoring. Simultaneous detection of multiple biomarkers provides in‐depth healthcare information, where the key challenge is to develop a minimally invasive platform. To this end, a colorimetric dermal tattoo biosensor fabricated by a four‐area segmented microneedle patch is developed. The biosensor exhibits color changes in response to biomarker concentration variations, showing its great potential for health monitoring.


Graphene-enabled wearable sensors for healthcare monitoring

November 2021

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128 Reads

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121 Citations

Biosensors and Bioelectronics

Wearable sensors in healthcare monitoring have recently found widespread applications in biomedical fields for their non- or minimal-invasive, user-friendly and easy-accessible features. Sensing materials is one of the major challenges to achieve these superiorities of wearable sensors for healthcare monitoring, while graphene-based materials with many favorable properties have shown great efficiency in sensing various biochemical and biophysical signals. In this paper, we review state-of-the-art advances in the development and modification of graphene-based materials (i.e., graphene, graphene oxide and reduced graphene oxide) for fabricating advanced wearable sensors with 1D (fibers), 2D (films) and 3D (foams/aerogels/hydrogels) macroscopic structures. We summarize the structural design guidelines, sensing mechanisms, applications and evolution of the graphene-based materials as wearable sensors for healthcare monitoring of biophysical signals (e.g., mechanical, thermal and electrophysiological signals) and biochemical signals from various body fluids and exhaled gases. Finally, existing challenges and future prospects are presented in this area.


A Fully Integrated Wearable Electronic Device with Breathable and Washable Properties for Long-term Health Monitoring

February 2021

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66 Reads

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35 Citations

Sensors and Actuators A Physical

The fully integrated wearable electronics have recently found widespread applications in long-term health monitoring, where one major challenge is to develop substrate materials with excellent breathability and washability. In this work, we developed a fully integrated wearable electronic device with breathable and washable properties through a facile and scalable paradigm. We directly mixed hydrophilic graphene oxide with hydrophilic cellulose fibers to ensure that graphene nanosheets uniformly spread all over the paper matrix. Then laser reduction was applied to fabricate a graphene-cellulose temperature sensor (LRG-TS), and thermal reduction to make a graphene-cellulose pressure sensor (TRG-PS), both of which were then connected with a flexible printed circuit board (FPCB) to form a fully integrated wearable electronic device with results readable by a mobile phone through Bluetooth. The excellent breathability, attributed to the unique 3D hierarchical porous structure of the e-paper, lays a solid foundation for long-term monitoring as demonstrated in rabbit skin in vitro. Besides, it can endure long-term soaking in water and multiple washing-drying cycles without compromising structural integrity and functional performance, as shown by sensing of body temperature and human motion. The developed device with these two unparalleled properties holds great promise for versatile wearable electronics applications in personal healthcare monitoring.

Citations (5)


... In some special wet environment, such as bathing and swimming conditions, waterproof performance is necessary. Therefore, most paper-based sensors tend to use non-paper packaging to protect, such as PDMS 43,47,48 , PI 49 , PTFE 50 , and other polymers 31 , However, these polymers are difficult to degrade in nature 50 . In addition, good breathability is also extremely important for comfortable, noninflammatory wearable electronics 51,52 . ...

Reference:

Fully paper-integrated hydrophobic and air permeable piezoresistive sensors for high-humidity and underwater wearable motion monitoring
A smart ball sensor fabricated by laser kirigami of graphene for personalized long-term grip strength monitoring

npj Flexible Electronics

... Several innovative approaches for monitoring physiological parameters have emerged, particularly for small animal models. 14,15 These include smart wearable textiles, stretchable electronics, and battery-free implants. [16][17][18] In clinics, approaches based on piezoelectric devices that detect human body vibrations 19,20 and pulse oximeters that record blood oxygen saturation are used to monitor heart rate and breathing rate. ...

Flexible Miniaturized Sensor Technologies for Long-Term Physiological Monitoring

npj Flexible Electronics

... Until now, not only publications on optical fibre sensors based on graphene materials are limited, but the increase in the number of publications observed in the last few years is a clear indication of this fact. [26][27][28][29]. Industries such as sugar mills, oil refineries, power, chemical, and many other industries require a boiler for a specific operation. ...

Graphene-enabled wearable sensors for healthcare monitoring
  • Citing Article
  • November 2021

Biosensors and Bioelectronics

... In contrast, wearable sensing systems for glucose detection in sweat, interstitial fluid, and other bodily fluids offer non-invasive, portable, and highly sensitive alternatives with minimal skin irritation. 86,87 Since glucose detection relies on a two-step cascade reaction, research has focused on finding alternatives to GOx. Numerous nanomaterials, such as metallic nanoparticles, 88,89 carbon nanomaterials, 90 and metal oxides, 91 have demonstrated GOx-mimetic activity. ...

A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers

... We conducted a scoping review to systematically map evidence on the user experiences of mobile-linked POC diagnostics in community-based healthcare settings. Although there is much research on POC diagnostics [35][36][37][38][39][40][41][42][43] in this digital age, few studies have incorporated user experiences that would inform developers and ensure sustainable implementation of such diagnostic tools. This scoping review identified a lack of contextdriven development and implementation [28], thus hampering the upscaling of the developed diagnostic tools. ...

A Fully Integrated Wearable Electronic Device with Breathable and Washable Properties for Long-term Health Monitoring
  • Citing Article
  • February 2021

Sensors and Actuators A Physical