Hui-Ren Chen's research while affiliated with Chinese PLA General Hospital (301 Hospital) and other places

Publications (20)

Article
B-cell acute lymphoblastic leukemia (B-ALL) with MLL-rearrangements (MLL-r) is rare in pediatric patients (aged >1 year), and optimal treatment strategies remain unclear. This study aimed to retrospectively evaluate the clinical characteristics, outcomes, and effects of allogeneic hematopoietic stem cell transplantation (allo-HSCT) of 37 non-infant...
Article
Background: B-acute lymphoblastic leukemia (B-ALL) with t(v;11q23)/MLL-rearrangement (MLL-r) in children (1 year or older) is rare, and its outcome and optimal treatment options remain controversial. This study aimed to analyze the clinical characteristics and outcomes of these patients, and to explore the role of allogeneic hematopoietic stem cell...
Article
Full-text available
Angiogenesis is important in pathophysiological processes, including the pathogenesis of acute monocytic leukemia (AML). MicroRNA‑21 (miR‑21) is overexpressed and exhibits oncogenic activity in cancer. However, the biological mechanism underlying the effect of miR‑21 in AML remains to be fully elucidated. In the present study, the expression levels...
Article
Full-text available
Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (VEGF) and vitamin D receptor (VDR) gene polymorphisms and additional gene- gene and gene- smoking interaction with multiple myeloma (MM) risk in Chinese population. Methods: Generalized multifactor dimensionality redu...
Article
Objective: To investigate the efficacy and safety of haploidentical allo-HSCT in combination of reduced intensity preconditioning combined with cyclophosphamid (CTX)-induced immune tolerance after transplanitation for treatment of severe aplastic anemia (SAA). Methods: A total of 15 patients with SAA received the haploidentical allo-HSCT of redu...
Article
The aim of the present study was to construct a chimeric adenovirus (Ad)5/F35 co-expressing human CD4O ligand (CD4OL) and interleukin (IL)-2 (Ad5/F35 CD40L-IL-2). The infection efficiency to human monocyte-derived dendritic cells (Mo-DCs), expression of genes, phenotype changes and IL-12 production of Mo-DC by Ad5/F35 CD40L-IL-2 were investigated....
Article
The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Region General Hospital. All were...
Article
This study aimed to compare the efficacy and safety between haploidentical hematopoietic stem cell transplantation (HHCT) and immunosuppressive therapy (IST) for the treatment of pediatric acquired severe aplastic anemia (SAA). The clinical data of 28 children with SAA treated from June 2010 to October 2014 at our hospital were retrospectively revi...
Article
This study was purposed to investigate the therapeutic efficacy of haploidentical allogeneic hemopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA), and evaluate the safety of this treatment by retrospective analysis. A total of 21 patients with SAA (13 cases of SAA-I, 8 cases of SAA-II) were treated with haploidentical...
Article
Full-text available
This study was purposed to evaluate the curative efficacy of second allogeneic hematopoietic stem cell transplantation (allo-HSCT) after failure of the first allo-HSCT in aplastic anemia patients, the cause of implant failure after allo-HSCT and clinical data of 10 severe aplastic anemia (SAA) patients in the second allo-HSCT were retrospectively a...
Article
This study was aimed to explore the effect and feasibility of reduced conditioning intensity allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of relapsed ETO positive acute myeloid leukemia (AML) patients. Fifteen cases of relapsed AML received the reducing conditioning intensity allo-HSCT from January 2011 to January...
Article
This study was purposed to explore the efficacy and feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of multiple myeloma (MM). Three patients with MM from January 2011 to January 2012 in General Hospital of Beijing Military Area were treated by reduced-intensity allo-HSCT. All donors a...
Article
Objective of this study was to evaluate the efficacy and safety of haploidentical or unrelated donor hematopoietic stem cell transplantation (HSCT) for patients with severe aplastic anemia (SAA). Twenty patients with SAA received allogeneic HSCT from haploidentical or unrelated donors (14 from haploidentical donors and 6 from unrelated donors) from...
Article
The objective of this study was to explore the incidence and therapeutic efficacy of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 140 patients undergoing allo-HSCT in our department of hematology from 2010-01 to 2012-01 were retrospectively analyzed. The results showed th...
Article
To explore the preventative effect of donor peripheral blood stem cell (PBSC) infusion mobilized by granulocyte colony-stimulating factor (G-CSF) for the relapsing patients with leukemia after haplotype hematopoietic stem cell transplantation (HSCT), as well as its therapeutic effect and safety. G-CSF was given at 5 - 10 µg×kg(-1)×d(-1) to donor an...
Article
To report the efficacy and safety of imatinib plus Hyper-CVAD chemotherapy regimen in the treatment of patients with ph chromosome positive acute lymphocytic leukemia (Ph(+)ALL). A sequential 2-year and 8-cycle treatment of imatinib plus Hyper-CVAD (A/B program) was administrated in 18 Ph(+)ALL patients treated at our hospital since January 2005 to...
Article
Cytokine-induced killer (CIK) cell therapy, an adoptive T-cell immunotherapy, has been reported to be a safe and effective mode of treatment for patients with metastatic diseases, lymphoma and acute leukaemia. To investigate the clinical efficacy of cytokine-induced killer cells for the treatment of refractory lymphoma, the present clinical study w...
Article
To study the feasibility of CD25 monoclonal antibody (basiliximab) in the treatment of severe III-IV intestinal acute graft-versus-host disease (GVHD) following haploidentical hematopoietic stem cell transplantation (HSCT). Twenty patients, 13 males and 7 females, who developed III-IV intestinal acute GVHD after haplotypic HSCT between October 2004...
Article
To explore the feasibility and safety of conditioning regimen containing fludarabine (Flud) for haploidentical hematopoietic stem cell transplantation (HSCT). Preparative regimen containing Flud 40 mgxm(-2)xd(-1) on day -7 to -3 in place of cyclophosphamide (CTX) for haploidentical HSCT was given to 35 patients with hematologic malignancies (4 stan...

Citations

... In addition to 4 patients (receiving a matched sibling donor transplant [MSDT]), 17 children underwent haploid hematopoietic stem cell transplantation (haplo-HSCT). The preconditioning protocol was performed in accordance with previous reports [14][15][16]. The conditioning regimen for haplo-HSCT included cytarabine (4 g/m 2 /d) from days−10 to−9; busulfan (3.2-4.8 mg/kg/d) from days−8 to−6; cyclophosphamide (1.8 g/m 2 /d) from days−5 to −4; methyl chloride hexamethylene urea nitrate (Me-CCNU) (250 mg/kg/d) on day−3; anti-thymocyte globulin (ATG) (2.5 mg/kg/ d; Genzyme Polyclonals S.A.S) from days −5 to −2. ...
... Besides, we also Previous studies showed many miRNAs are abnormally expressed in the occurrence and development of AML. Zhu found miR-9 decreased in AML patients with adverse prognosis [44]. In addition, miR-21 is up-regulated in subjects with acute myeloid leukemia and is associated with a low-risk state [45]. ...
... Additionally, IL-2, as a classical Th1 type cytokine, plays a dominant role in promoting the expansion and survival of Treg cells [70], which play a major role in the preservation of host tissue integrity during T. gondii infection [71]. A recent study showed that adenovirus coexpressing CD40 ligand and IL-2 can stimulate the maturation of DCs and high levels of IL-12 production [72]. However, IL-12 production can be inhibited by enhancing the production of Th2 type cytokines such as IL-4 and IL-10 [62]. ...
... VRD polymorphisms have been reported in MM cell lines with an increased risk stage. Specifically, single-nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (VEGF) and VDR (Fok1) have been reported in several studies [121][122][123][124]. These reports were confirmed by a different group of researchers, who studied plasmablastic lymphoma and myeloma cells more broadly [120]. ...
... For nosocomial infection of Gram-negative pathogens, hydrolysis of carbapenems by β-lactamase is an important mechanism of antimicrobial resistance. [24][25][26] Expert recommendation 1) Before HSCT is carried out, the use of chemotherapeutic drugs (pre-treatment regimen) should be discussed in detail by the HSCT MDT, which includes clinicians, nursing team, clinical pharmacists, dieticians, psychologists, to develop a complete pre-treatment chemotherapy prescription and gastrointestinal complication prevention protocol with regular reviews and updates. (Level I recommendation) 2) Oral mucositis is a common complication after transplantation, which usually causes severe pain and affects nutrition intake. ...
... Haplo-HSCT is usually considered as a salvage treatment option for SAA patients after failed IST. In recent years, some studies have evaluated haplo-HSCT as an upfront therapy for newly diagnosed SAA patients [6,20,21]. The currently available data reflect a favorable survival outcome of haplo-HSCT in China. ...
... Guo ve ark. (5) 'nın Çin'de yapmış olduğu çalışmada allojenik kök hücre nakli yapılan 140 hasta retrospektif olarak incelenmiş; ikisi interstisyel pnömoni olmak üzere toplam 48 olguda (% 4.3) CMV infeksiyonu, 65 olguda GVHD saptanmış; GVHD gözlenen hastaların da yaklaşık yarısında (% 49.2) CMV infeksiyonu gelişmiştir. GVHD gelişen hastalarda CMV infeksiyonu takip ettiğimiz olguda olduğu gibi sık olarak karşımıza çıkmaktadır. ...
... Penurunan modal sel imun ini dapat diikuti dengan melemahnya sistem pertahanan tubuh seseorang sehingga kanker semakin ganas. Penelitian sebelumnya juga telah melaporkan bahwa adanya korelasi penurunan sel imun terhadap tingkat ganasnya kanker terutama pada stadium akhir (Rocca et al., 2013;Kawaguchi et al., 2017 (Zhang et al., 2021;Guo et al., 2011). Penelitian yang dilakukan di Korea menunjukkan bahwa pasien kanker yang diberikan terapi CIK memiliki 1,5 kali lebih tinggi keberlangsungan hidup dan sebanyak 30% meningkat efek pengendalian pada kanker glioblastoma, Kong et al., (2017). ...
... 8 Thus far, studies enrolled more than 400 patients had proved the efficacy of IL-2R blockades treatment (ie, basiliximab, daclizumab, and inolimomab) in patients with SR-aGVHD. [8][9][10][11][12][13][14][15][16][17][18][19][20][21] However, the samples for these studies were relatively small, which limited the further researches about the prognostic factors for therapeutic response to IL-2R blockades. In addition, the follow-ups for most of these studies were relatively short, and the long-term clinical outcomes of SR-aGVHD patients receiving IL-2R blockades were unclear either. ...