Hui Li’s research while affiliated with Linyi People's Hospital and other places

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Publications (41)


Detection of dithiocarbamate pesticide residues in tea by colorimetric and fluorescent double-mode probe regulated by tyrosinase
  • Article

November 2024

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1 Read

Sensors and Actuators B Chemical

Yingying Feng

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Wanqi Jiang

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Hui Li

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[...]

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Yingnan Liu


Clinical Findings of Toxic epidermal necrolysis.
PRISMA flowchart for selecting phenobarbital-induced SJS/TEN case reports for analysis.
Toxic epidermal necrolysis caused by phenobarbital: a case report and literature review
  • Article
  • Full-text available

August 2024

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17 Reads

Background Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare, life-threatening immunologic reactions. Previous relevant literature has provided limited information regarding this disease’s genetic susceptibility and management principles. Objectives This study aimed to describe a phenobarbital-induced TEN case report with HLA-B*15:02 and HLA-B*58:01 negative, CYP2C19*1/*2. In addition, we revised the existing literature on phenobarbital-induced SJS/TEN to explore its clinical characteristics. Methods We describe a woman undergoing treatment with Phenobarbital for status epilepticus who developed classic cutaneous findings of TEN. A systematic search was conducted in the PubMed, Medline, WanFang, and CNKI databases from 1995 to 2023. The search terms used were “Stevens-Johnson Syndrome,” “Toxic Epidermal Necrolysis,” and “Phenobarbital.” Results We report a case of TEN resulting from phenobarbital; it tested negative for the HLA-B*15:02 and HLA-B*58:01 allele and CYP2C19*1/*2 intermediate metabolism. Supportive treatment with steroids and antihistamines resulted in complete resolution of the skin lesions and improvement in clinical symptoms after 14 days. Physicians and clinical pharmacists should be aware of these potential phenobarbital-related adverse events and closely monitor patients with first-time use of phenobarbital. Among 19 cases were identified in the literature, with 11 (57.9%) cases of SJS, 6 (31.6%) cases of TEN, and 2 (7.2%) cases of SJS-TEN/DRESS overlap. A total of 5 (26.3%) did not survive, of which 4 (21.1%) were under 12 years old and 1 (5.3%) was over 12 years old. Conclusion Phenobarbital-induced SJS/TEN may still occur in patients who test negative for HLA-B*15:02 and HLA-B*58:01, CYP2C19*1/*2. Most cutaneous adverse events occur early in the course of Phenobarbital therapy and should be closely monitored early in the course of treatment. In addition, Phenobarbital should be used with caution in patients with a history of asthma and allergy to antipyretics and analgesics.

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Figure 3. Optimization of dcELISA: (A) pH; (B) Na + concentration; (C) Methanol concentration; (D) Acetonitrile concentration.
Figure 6. Optimization of MLFIA: (A) EDC/NHS ratio; (B) pH value; (C) Antibody amount; (D) Enrichment volume; (E) Enrichment time.
Cross reactivity of mAb 1A91H11 with HM and other sulfonylureas.
Comparison between dcELISA and LC-MS/MS for halosulfuron recovery in tomato and maize.
Comparison between MLFIA and LC-MS/MS analysis for halosulfuron recovery in paddy water.
Development of Magnetic Lateral Flow and Direct Competitive Immunoassays for Sensitive and Specific Detection of Halosulfuron-Methyl Using a Novel Hapten and Monoclonal Antibody

July 2023

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27 Reads

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3 Citations

Foods

Halosulfuron-methyl (HM) is widely used for the removal of noxious weeds in corn, sugarcane, wheat, rice, and tomato fields. Despite its high efficiency and low toxicity, drift to nontarget crops and leaching of its metabolites to groundwater pose potential risks. Considering the instability of HM, the pyrazole sulfonamide of HM was used to generate a hapten and antigen to raise a high-quality monoclonal antibody (Mab, designated 1A91H11) against HM. A direct competitive immunoassay (dcELISA) using Mab 1A91H11 achieved a half-maximal inhibitory concentration (IC50) of 1.5 × 10−3 mg/kg and a linear range of 0.7 × 10−3 mg/kg–10.7 × 10−3 mg/kg, which was 10 times more sensitive than a comparable indirect competitive ELISA (icELISA) and more simple to operate. A spiking recovery experiment performed in tomato and maize matrices with 0.01, 0.05, and 0.1 mg/kg HM had average recoveries within 78.9–87.9% and 103.0–107.4% and coefficients of variation from 1.1–6.8% and 2.7–6.4% in tomato and maize, respectively. In addition, a magnetic lateral flow immunoassay (MLFIA) was developed for quantitative detection of low concentrations of HM in paddy water. Compared with dcELISA, the MLFIA exhibited 3.3- to 50-fold higher sensitivity (IC50 0.21 × 10−3 mg/kg). The average recovery and RSD of the developed MLFIA ranged from 81.5 to 92.5% and 5.4 to 9.7%. The results of this study demonstrated that the developed dcELISA and MLFIA are suitable for rapid detection of HM residues in tomato and maize matrices and paddy water, respectively, with acceptable accuracy and precision.


Citations (26)


... Within the first 11 mL, dichlorvos was quantitatively converted into the non-toxic product dichlorvos, and after the 13th mL, the conversion rate of dichlorvos slightly decreased to 94% [70]. Zhang et al. [71] created defect structures in MOF materials to increase active sites. They doped L-cysteine (L-Cys) into the cobalt-based zeolitic imidazolate framework (ZIF-Co) to synthesize ZIF-Co-Cys nanozymes with high oxidase-like activity. ...

Reference:

A Comprehensive Review of Multifunctional Nanozymes for Degradation and Detection of Organophosphorus Pesticides in the Environment
A novel fluorescent and photothermal probe based on nanozyme-mediated cascade reaction for detecting organophosphorus pesticide residues
  • Citing Article
  • July 2024

Talanta

... [18] The uncontrolled aggregated tendency of nanomaterial can weaken the catalysis activity and lead to a significant increase in the cost of use. [19,20] To gain outstanding mimic enzyme activity, the mixed transition metal oxides with the benefits of low cost, environment-friendly, and multiple valences have been widely investigated. [13,21] Bimetallic oxides are particularly desirable due to their mixed valence and structural properties. ...

Platinum-nickel nanoparticle-based oxidase-like nanozyme for colorimetric/photothermal dual-mode detection of organophosphorus pesticides
  • Citing Article
  • April 2024

Sensors and Actuators B Chemical

... Comparing with aptamers, antibodies exhibit advantages in terms of chemical stability, binding specificity and affinity for serving as the recognition element [22,23]. Benefiting from these merits, immunochromatography assay (ICA) using antibodies as the recognition element has been in developed and widely applied for rapid and on-site testing of various contaminants in agricultural products, such as pesticide residues, mycotoxins, veterinary drugs and foodborne pathogens [24][25][26][27][28][29]. In China, commercially available test strips have been developed for rapid screening of phorate. ...

Development of Magnetic Lateral Flow and Direct Competitive Immunoassays for Sensitive and Specific Detection of Halosulfuron-Methyl Using a Novel Hapten and Monoclonal Antibody

Foods

... Disulfoton has been extensively used across a wide range of crops to manage sap-feeding insects, including aphids, mites, and thrips [76]. Its mode of action involves inhibiting the enzyme acetylcholinesterase (AChE) [77,79], which leads to the accumulation of acetylcholine in nerve endings in both the peripheral and central nervous systems. Consequently, disulfoton poses a high level of toxicity to humans [80][81][82]. ...

Development and Validation for Simultaneous Determination of Disulfoton and Its Five Metabolites in Seven Agro-Products Using Liquid Chromatography-Tandem Mass Spectrometry Combined with QuEChERS Extraction Method

Chromatographia

... Due to their high efficiency and low toxicity [1][2][3], sulfonylurea-based herbicides are widely used to remove noxious weeds in maize, cereal, sugarcane, and tomato fields. HM (a sulfonylurea) is the active ingredient in many registered products in China. ...

An optimized LC–MS/MS workflow for evaluating storage stability of fluroxypyr and halosulfuron-methyl in maize samples
  • Citing Article
  • November 2020

Journal of Environmental Science and Health Part B Pesticides Food Contaminants and Agricultural Wastes

... More recently, Shimojo et al. (1997) reported IAA concentrations of 514-2226 pmol/g fwt in healthy human cells, and concentrations ranging between 7992 and 26,829 pmol/g fwt in squamous cell carcinomas in patients with esophageal cancer. Sadik et al. (2020) and Zhang et al. (2020) show that in humans and other vertebrates, in general, that the gene IL4I1 (interleukin induced 1) is a flavin-containing amine oxidase that as a downstream metabolite of indole-3-pyruvic acid also leads to the synthesis of IAA. ...

An endogenous indole pyruvate pathway for tryptophan metabolism mediated by IL4I1
  • Citing Article
  • August 2020

Journal of Agricultural and Food Chemistry

... Recently, the use of superficially porous particles (sub-3 μm particle size) has received considerable attention. The distinctive feature of this column is that the particles consist of solid cores surrounded by a porous silica shell measuring about 0.5 μm, allowing for high peak efficiency (even at higher flow rates), low solvent consumption, and short handling time, thereby rendering this method economical and less environmentally hazardous [31,32]. ...

A “half” core-shell magnetic nanohybrid composed of zeolitic imidazolate framework and graphitic carbon nitride for magnetic solid-phase extraction of sulfonylurea herbicides from water samples followed by LC-MS/MS detection

Microchimica Acta

... Even so, the lowest fortification levels for disulfoton and its five metabolites in all matrices added up to 10 µg/kg. The LODs and LOQs of the method were evaluated according to the method described by Jiang [27]. Specifically, the LOD was calculated for the lowest point used in the matrix-matched calibration standards on the basis of signal-to-noise (S/N) ratios of 3, while the lowest validated fortification level with acceptable precision and accuracy was considered as the LOQ. ...

Fast determination of alkylphenol ethoxylates in leafy vegetables using a modified quick, easy, cheap, effective, rugged, and safe method and ultra-high performance supercritical fluid chromatography-tandem mass spectrometry
  • Citing Article
  • January 2017

... The LODs of MOF-5-SPE-HPLC-UV method [34] are comparable to the developed method for water sample, but the SPE method is time-consuming and consumes large toxic solvents. The LODs of the developed method are better than the Fe 3 O 4 @MIL-100, Fe 3 O 4 @SiO 2 @polythiophene-MSPE-GC-MS method [35], and comparable to Fe 3 O 4 @GC-MSPE-HPLC-UV [36] method. The results further indicate that the developed method is simple, easy to perform, sensitive, efficient, and environmentally friendly for the analysis of phthalate esters in water and juice sample. ...

Magnetic solid-phase extraction using a mixture of two types of nanoparticles followed by gas chromatography-mass spectrometry for the determination of six phthalic acid esters in various water samples †
  • Citing Article
  • March 2020

... Compared to the SPE with unsatisfied selectivity, mt-MIPs-based SPE (mt-MIPs-SPE) demonstrated enhanced efficiency and simplified processes in the simultaneous cleanup of multiple targets in plant component [36], clinical drug [37], toxins [38], and organic pollutants [39]. As depicted in Fig. 2A, Wang et al. [40] synthesized a dual-templates MIPs as SPE sorbent using atrazine and prometryn as dual templates. ...

The determination of patulin from food samples using dual-dummy molecularly imprinted solid-phase extraction coupled with LC-MS/MS
  • Citing Article
  • March 2020