Hui Li's research while affiliated with China Geological Survey and other places

Publications (83)

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A traffic accident severity prediction study is an estimation of the expected future traffic accidents in combination with available data. One of the core objectives of this study is to predict the number and severity of possible traffic accidents so that optimal solutions can be taken in case of accidents. In this study, we propose a research meth...
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Osteoarthritis (OA) is a debilitating joint disease affecting nearly 400 million people with no efficient etiological therapies. OA is primarily identified by cartilage destruction, and gradual degeneration of the whole joint would happen when the OA progresses. Hence, cartilage has been identified as the primary therapeutic target of OA. Unfortuna...
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Pest monitoring of forest areas is essential to pest control. The existing remote sensing satellite image methods have been widely used in detecting pine wilt disease due to their low cost and large detection range. However, most existing methods for pine wilt disease detection are based on multi-phase remote sensing satellite imagery and use manua...
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Various metal oxide nanomaterials have been widely used as carriers to prepare pH-sensitive nanomedicines to respond to the acidic tumor microenvironment promoting antitumor efficiency. Herein, we used zinc oxide nanoparticles (ZnO NPs) as metal oxide nanomaterial coated with low-molecular-weight heparin (LMHP) and doxorubicin (DOX) complex (LMHP-D...
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Introduction Due to the actual limitation of training conditions, the freestyle skiing aerials winter training term is short. Training tasks such as adaptability training and developing new skills are needed in summer training. When facing different training environments, freestyle skiing aerial athletes’ executive control over their abilities coul...
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Hepatic carcinoma (HC) is the sixth most frequently occurring malignancies and the third leading cause of cancer death worldwide. Sepantronium bromide (YM155) is a small molecule inhibitor of survivin, which has broad-spectrum anticancer therapeutic effects in various xenograft models. However, several-day continuous infusion is required to achieve...
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Thermally rearranged(TR) polymers are usually prepared at an insert atmosphere and display high gas permeability, but their low gas selectivity results in high energy consumption. Thermal oxidation is an effective method to enhance the gas selectivity of microporous polymers. In this work, thermal-oxidative membranes were prepared to enhance gas se...
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We demonstrated a compact cavity-dumped Q-switched Yb:YAG laser based on a 72-pass pump module. A highly stable nanosecond pulse laser with a duration of 18.38 ns was achieved at a repetition rate of 100 kHz, which is pumped by multimode laser diode stacks at 969 nm. The average output power of more than 150 W is delivered in a good output beam cha...
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Tumor microenvironment (TME)‐responsive intelligent photodynamic therapy (PDT) systems have attracted increasing interest in anticancer therapy, due to their potential to address significant and unsatisfactory therapeutic issues, such as limited tissue penetration, inevitable normal tissue damage, and excessive impaired vessels. Here, an H2O2‐trigg...
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In view of the inaccuracy of rock movement observation data and the inaccuracy of mining subsidence prediction parameters, a prediction model of mining subsidence parameters based on fuzzy clustering is proposed. Through the analysis of the main geological and mineral characteristics of mining subsidence, the geological and mineral characteristics...
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In order to improve the accuracy of cloud detection in multispectral remote sensing images, this paper first proposes a deep learning framework to solve the problem of cloud detection accuracy in remote sensing images. This framework benefits from the Full Convolutional Neural Network (FCN), Cloud regions in Landsat 8 images are pixel-level labeled...
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Glioma is among the deadliest types of brain cancer, for which there currently is no effective treatment. Chemotherapy is mainstay in the treatment of glioma. However, drug tolerance, non-targeting, and poor blood–brain barrier penetrance severely inhibits the efficacy of chemotherapeutics. An improved treatment method is thus urgently needed. Here...
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Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD) inducers, stimulating an antitumor response which results in synergistic antitumor activity by...
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Small molecule-chemotherapeutic drug conjugate nanoparticles (SMCDC NPs) has a great advantage in improving drug loading. However, the factors which influence these conjugates forming stable nanoparticles (NPs) are currently unclear. In our previous studies, we synthesized a series of fatty acid-paclitaxel conjugates and suggested that the changes...
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Purpose: Small molecule modified antitumor drug conjugate nanoparticles have the advantages of high drug loading, simple synthesis and preparation, and better biocompatibility. Due to the large demand for exogenous α-linolenic acid (ALA) by tumor cells, we synthesized α-linolenic acid-paclitaxel conjugate (ALA-PTX) and prepared α-linolenic acid-pa...
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The antitumor immune response involves a cascade of cancer-immunity cycles. Developing a combination therapy aimed at the cancer-immunity cycle is of great importance. In this research, we designed and tested a combined therapeutic—Au nanorod (AuNR)/doxorubicin (DOX) gel (AuNR/DOX gel)—in which the sustained release of DOX was controlled by Pluroni...
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Background: The prevalence of metabolic syndrome (MetS) has increased along with rapid socio-economic development in China in recent decades, aggravating the burden of the health care system. Both plasma levels of fatty acids (FAs) and aberrant DNA methylation profiles are associated with MetS risk. However, studies exploring the role of DNA methyl...
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Osteoporosis poses an immense burden to the society in terms of morbidity, mortality, and financial cost. Accurately and early diagnosis of the onset of osteoporosis and fracture risk is the key to reduce this burden and deliver effective therapy. Current screening and monitoring approaches for osteoporosis mainly include computed tomography (CT),...
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Osteoporosis is one of the most common bone disorders, characterized by low bone mass and deterioration of the bone tissue, and seriously affects the health and quality of life of elderly individuals and postmenopausal women. Small microRNAs (miRNAs) are emerging as epigenetic regulators of gene expression which abnormal expression is closely relat...
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Purpose: Nanomaterial-based drug-delivery systems allowing for effective targeted delivery of smallmolecule chemodrugs to tumors have revolutionized cancer therapy. Recently, as novel nanomaterials with outstanding physicochemical properties, boron nitride nanospheres (BNs) have emerged as a promising candidate for drug delivery. However, poor dis...
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Block polymers with thermal annealing are attractive routes to produce 6FDA-based polyimide membranes with enhanced gas separation performance. However, some 6FDA-based polyimide membranes exhibit different gas separation behavior trends under the thermal annealing process. In this work, Two 6FDA-DETDA/DMMDA block polyimide membranes with different...
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To provide insight into the formation process of carbon molecular sieve (CMS) hollow fiber membranes (HFMs), P84 co-polyimide HFMs were thermally treated at 200, 250, 300, 350, 400, 550, 650, and 800 °C. TG-MS was used to study the weight loss and released gases at all temperatures. In situ SEM, HIM (helium ion microscope) and in situ XRD were used...
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Poly(ether-block-amide) (Pebax)/tricaproin (TCP) gel membranes were prepared for the first time with TCP content varying from 0 to 80 wt.%. And the effect of structure change from Pebax polymeric membrane to Pebax/TCP gel membrane on CO2 separation was studied. Membrane morphology and crystallinity was characterized by scanning electron microscope...
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Propofol is known as an intravenous anesthetic drug utilized for stimulation and prolongation of general anesthesia. However, the side effects of propofol are still elusive in the blood system. Therefore, in this study the interaction of propofol with immunoglobulin G (IgG) and peripheral blood mononuclear cells (PBMCs) as a model of blood system w...
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Potassium 1,1,3,3-tetranitropropane-1,3-diide (K2TNP) was found to react readily with various (hetero)aryl amines (12 examples) to give corresponding N-(hetero)aryl-3,5-dinitropyrazoles in moderate to excellent yields. The reactions were performed at mild temperature, and most of the reactions completed in less than 4 h. Four potential energetic co...
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Pd composite membranes show great potential in several important fields, such as H2 production for fuel cell or pre-combustion applications. This study presents a facile and effective approach to develop high performance stainless-steel supported Pd composite membranes with a finger-like and gap structure by coating the finger-like porous stainless...
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Boron nitride nanospheres (BNNS) have attracted increasing attention in many fields due to their unique physicochemical properties. Biomedical application of BNNS has also been explored recently. However, limited by the hydrophobicity and poor dispersity of BNNS, their biocompatible performance especially the in vivo biosafety has rarely been repor...
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Introduction: Because tumor-associated inflammation is a hallmark of cancer treatment, in the present study, sorafenib mesoporous silica nanomatrix (MSNM@SFN) co-administrated with flufenamic acid (FFA, a non-steroidal anti-inflammatory drug (NSAID)) was investigated to enhance the anti-tumor activity of MSNM@SFN. Methods: Metastatic breast tumo...
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Angiogenesis is a crucial event during cancer progression that regulates tumor growth and metastasis. Activin receptor-like kinase 1 (ALK1), predominantly expressed in endothelial cells, plays a key role in the organization of neo-angiogenic vessels. Therapeutic targeting of ALK1 has been proposed as a promising strategy for cancer treatment, and m...
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A novel synthesis methodology for the construction of functionalized dihydropyrones has been developed with amines, glyoxylic acid and 4-substituted-1,2-oxaborol-2(5H)-ols from Petasis reaction. Mechanistic investigation indicated that the intermolecular SN2 cyclization to provide 3,6-dihydro-2H-pyran-2-ones (3,6-DHP) and 5,6-dihydro-2H-pyran-2-one...
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State-to-state rotational relaxation processes play a critical role in predicting rotational nonequilibrium, which can significantly affect total laser power and spectral distribution. In this paper, the state-to-state rotational relaxation rate coefficients for the pumping reaction of F + H2, the rotational energy transfer processes of HF(υ, j = 0...
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Cell‐material interactions and compatibility are important aspects of bioactive materials for bone tissue engineering. Phosphate glass fiber (PGF) is an attractive inorganic filler with fibrous structure and tunable composition, which has been widely investigated as a bioactive filler for bone repair applications. However, the interaction of osteob...
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In this paper, BTDA-TDI/MDI (P84) co-polyimide hollow fiber membranes (HFMs) were prepared by dry-jet wet spinning technique. The P84 HFMs were thermally annealed below and above P84 Tg (321.5 °C) to investigate their mechanical properties and gas separation properties. Thermally annealing at different temperature below and above Tg influenced the...
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In this paper, we report the performance of supported Pd[sbnd]Ru membranes for possible applications to hydrogen purification and/or production. For this purpose, we fabricated three ultra-thin α-alumina-supported membranes by combined plating techniques: a Pd[sbnd]Ag membrane (3 μm-thick ca.) and two Pd[sbnd]Ru (1.8 μm-thick ca.). The former is se...
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Polyether‐block‐amide (Pebax)/glycerol triacetate (GTA) blend membranes with various compositions were prepared with a solution‐casting method. The gas‐separation performance, thermal stability, and storage stability of the prepared membranes were investigated at different pressures and temperatures. The Arrhenius equation was used to describe the...
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The kinetic processes of Xe (6p[1/2]0, 6p[3/2]2, and 6p[5/2]2) atoms under the focused condition were investigated. The atomic density of the laser prepared state significantly increases. Therefore, the probability of the energy-pooling between two high-lying atoms increases. There are three major types of the energy-pooling collisions. The first t...
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Nucleus-targeting drug delivery systems (NTDDs) deliver chemotherapeutic agents to nuclei in order to improve the efficacy of anti-tumour therapy. Histone H1 (H1) plays a key role in establishing and maintaining higher order chromatin structures and could bind to cell membranes. In the present study, we selected H1 as a target to prepare a novel H1...
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Background: 3-(2-Nitrophenyl) propionic acid-paclitaxel (NPPA-PTX) is a paclitaxel (PTX) bioreductive prodrug synthesized by our lab. We hypothesize that NPPA-PTX can self-assemble to form nanoparticles (NPs). Materials and methods: In the present research, the theoretical partition coefficient (XlogP) and Hansen solubility parameters of NPPA-PT...
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In this paper, Pebax and Pebax-Tripropionin (TPP) blend multilayer composite membranes were firstly prepared with the aids of low-temperature plasma treatment, and the CO2/N2 separation properties of the prepared composite membranes were studied. For multilayer composite membranes, PDMS gutter layer was modified with low-temperature plasma of air....
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The chemical kinetics of supersonic hydrogen fluoride (HF) chemical lasers determines combustion characteristics and output power. However, the inherent complexity of chemical reactions and complex structure still challenge the numerical simulations involving a comprehensive chemical mechanism. Therefore, a high fidelity and low computational consu...
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The incidences of nodular goiter (NG), thyroid adenoma (TA), and thyroid cancer (TC) are increasing rapidly; however, the etiologies of these diseases remain unclear. The present study aimed to evaluate the differences in plasma fatty acids among these three thyroid diseases to facilitate etiological research. Four ω-3 and seven ω-6 polyunsaturated...
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Background: Arachidonic acid (AA) is the major polyunsaturated fatty acid (PUFA) substrate for potent eicosanoid signaling to modulate inflammation and thrombosis and is controlled in part by tissue abundance. Fatty acid desaturase 1 (FADS1) catalyzes synthesis of omega-6 (n-3) AA and n-3 eicosapentaenoic acid (EPA). The rs66698963 polymorphism, a...
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Background In the present study, the tumor-specific, pH-responsive peptide H7K(R2)2-modified, theranostic liposome-containing paclitaxel (PTX) and superparamagnetic iron oxide nanoparticles (SPIO NPs), PTX/SPIO-SSL-H7K(R2)2, was prepared by using H7K(R2)2 as the targeting ligand, SPIO NPs as the magnetic resonance imaging (MRI) agent, PTX as antitu...
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Small molecule modified anti-cancer drug conjugates (SMMDCs) can self-assemble into nanoparticles (NPs) as therapeutic NP platforms for cancer treatment. Here we demonstrate that the XlogP and Hansen solubility parameters of paclitaxel (PTX) SMMDCs is essential for SMMDCs self-assembling into NPs. The amorphous state of PTX SMMDCs will also affect...
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Membranes from block copolymer poly (amide-12-b-ethylene oxide) (Pebax1074) and its blends with different molecular weight poly (ethylene glycol) (PEG) (200, 400, 600, 1500, 4600 and 8000) were prepared. The thermal properties and structures of Pebax1074/PEG blend membranes were characterized by DSC and SEM, and the gas permeation properties of CO2...
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To determine whether treatment with ginseng oligopeptides (GOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in rats induced by high-fat diet and low doses of alloxan, type 2 diabetes was induced in male Sprague-Dawley (SD) rats by injecting them once with 105 mg/kg alloxan and feeding them high-carbohydrate/high-fat die...
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Studies have showed that lead was associated with human health. However, the effects of lead on thyroid functions are inconsistent, and studies based on Chinese population are fragmentary. To evaluate the correlation between lead and thyroid functions of Chinese with different thyroid diseases, we conducted a hospital-based study. Ninety-six papill...
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The work functions of the (110) and (100) surfaces of LaB are determined from ambient pressure to 39.1 GPa. The work function of the (110) surface slowly decreases but that of the (100) surface remains at a relatively constant value. To determine the reason for this difference, the electron density distribution (EDD) is determined from high-pressur...
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Information on the structural evolution of materials under high pressure is of great importance for understanding the properties of materials exhibited under high pressure. High-pressure powder diffraction is widely used to investigate the structure evolution of materials at such pressure. Unfortunately, powder diffraction data are usually insuffic...
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1-ethyl-3-methylimidazolium hexafluorophosphate ([Emim][PF6]) was incorporated into poly(amide-6-b-ethylene oxide) (Pebax1657) to prepare blend membranes. The physical properties of Pebax1657/[Emim][PF6] blend membranes were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and scanning electro...
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Pebax®/CNTs (MWNTs, MWNTs-OH and MWNTs-NH2) and Pebax®/MWNTs-NH2/GTA mixed matrix membranes (MMMs) were prepared with solution-casting method. First, the effect of CNTs functionalization on the properties of Pebax®/CNTs MMMs was studied. The functionalization of CNTs promoted their dispersion in Pebax® matrix. The gas permeabilities of Pebax®/CNTs...
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We have observed unusual blue-shifted radiations in water pumped by a strong 532-nm nanosecond laser. Properties including divergence, polarizations, and pulse shapes of the unusual radiations are measured and compared with those of the regular stimulated Raman scattering (SRS) in water. The unusual radiations are attributed to the parametric anti-...
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Infection of schistosomiasis japonica may eventually lead to liver fibrosis, and no effective antifibrotic therapies are available but liver transplantation. Hedgehog (HH) signaling pathway has been involved in the process and is a promising target for treating liver fibrosis. This study aimed to explore the effects of pentoxifylline (PTX) on liver...
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Poly(amide-6-b-ethylene oxide) (Pebax1657)/1-butyl-3-methylimidazo-lium bis[trifluoromethyl)sulfonyl]-imide ([Bmim][Tf2N]) blend membranes with different [Bmim][Tf2N] contents were prepared via solution casting and solvent evaporation method. The permeation properties of the blend membranes for CO2, N2, CH4 and H2 were studied, and the physical pro...
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Polyether-block-amide (Pebax)/graphene oxide (GO) mixed-matrix membranes (MMMs) were prepared with a solution casting method, and their gas-separation performance and mechanical properties were investigated. Compared with the pristine Pebax membrane, the crystallinity of the Pebax/GO MMMs showed a little increase. The incorporation of GO induced an...
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Stimulated Raman Scattering (SRS) is an effective means of laser wavelength conversion. Hydrogen is an excellent Raman medium for its high stimulated Raman gain coefficient and good flowability which can rapidly dissipate the heat generated by SRS process. In this paper we reported the H2 SRS in multiple-pass cell pumped by the fundamental frequenc...
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Oxygen molecules existed in pairs under liquid condition, the radiation from vibrational ground state of 1 Δ state to the first vibrational excited state of 3 ∑ state was electronic dipole moment transition allowed, and a photon with wavelength of 1580 nm was emitted. In our experiment, dye laser with wavelength of 581 nm, 634 nm, 764 nm was used t...
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Achieving population inversion through multi-photon cascade pumping is almost always difficult, and most laser medium work under 1-photon excitation mechanism. But for alkali atoms such as cesium, relatively large absorption cross sections of several low, cascading energy levels enable them properties such as up conversion. Here we carried out rese...
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The experimental study of the amplification of stimulated Raman scattering (SRS) in high purity H2gas was demonstrated employing a Q-switched Nd:YAG laser at 1064 nm as the pump source. A part of the 1064 nm pump light (20% in energy) was focused into the first H2 gas cell to generate the backward first Raman Stokes light (BS1), which is taken as t...
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Sodium based excimer-pump alkali laser (Na-XPAL) is expected to be an efficient method to generate sodium beacon light, but the information about the spectroscopic characters of Na-XPAL remains sparse so far. In this work, we utilized the relative fluorescence intensity to study the absorption spectrum of blue satellites of complexes of sodium with...
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Amino modified multi-walled carbon nanotubes (MWNTs-NH2) were incorporated into poly(amide-6-b-ethylene oxide) (Pebax 1657) to prepare mixed matrix membranes (MMMs). The permeation properties of CO2, N-2, CH4 and H-2 were studied and the physical properties of Pebax/MWNTs-NH2 MMMs were characterized by X-ray diffractometer (XRD), Fourier transform...
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In this paper, poly(amide-6-b-ethylene oxide) (Pebax1657)/SAPO-34 mixed matrix membranes (MMMs) were prepared by solvent-evaporation method with acetic acid as a novel solvent. CO2, N-2, CH4 and H-2 permeation properties were investigated, and the physical properties of Pebax/SAPO-34 MMMs were characterized by XRD and SEM. At low SAPO-34 content, i...
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The polypropylene/polydimethylsiloxane/graphite fluoride (PP/PDMS/GF) composites are prepared with dynamic curing technology by simple blending of polypropylene, graphite fluoride and polydimethylsiloxane, and then their superhydrophobic properties are investigated. The results indicates that the static WCA reaches 148° with a sliding angle 6° for...
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Nitric oxide (NO) is cooled to 1 K in a seeded Ar supersonic molecular beam. NO molecules are ionized by one-color two-photon resonant enhanced multiphoton ionization (REMPI) process to form an ultracold plasma. The density of the ionized molecules in the illuminated volume approaches to 1.5 x 10(13) cm(-3). Prompt electrons, plasma electrons and i...
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A series of functionalized 2,5-dihydrofurans were efficiently synthesized via an amine-promoted Petasis borono-Mannich reaction of 4-substituted 1,2-oxaborol-2(5H)-ols with salicylaldehydes in high yields. The process, which combines a boronic acid-based Mannich reaction and a highly efficient intramolecular SN2 cyclization, provides a one-step and...
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In this paper, blend membranes from polyvinyl acetate (PVAc) and block copolymer poly(amide-12-b-ethylene oxide) (Pebax1074) are prepared by solution casting and solvent evaporation method. Although they are homogeneous on a macro-scale, the observations from DSC and SEM indicate micro-phase separation for PVAc/Pebax1074 blend membranes. With the i...
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In this paper, CO2-philic membranes are prepared with poly(amide-12-b-ethylene oxide) (Pebax1074) and glycerol triacetate (GTA) by polymer blending, which show excellent compatibility for different GTA compositions. The additive GTA into Pebax1074 matrix can improve the chain mobility, induce high CO2-philicity and decrease membrane crystallinity....
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In this paper, block copolymer poly(amide-12-b-ethylene oxide) (Pebax1074)/poly(ethylene glycol) (PEG1500) blend membranes are prepared by solution casting and solvent evaporation method. According to DSC experiments, the melting temperature for PEO phase in Pebax1074/PEG1500 blend membranes increases with the increase of PEG1500 content, which wil...
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In this paper, poly(amide-6-beta-ethylene oxide) (PEBA1657) copolymer was used to prepare multilayer polyetherimide (PEI)/polydimethylsiloxane (PDMS)/PEBA1657/PDMS composite membranes by dip-coating method. Permeation behaviors of ethylene, ethane, propylene, propane, n-butane, methane and nitrogen through the multilayer composite membranes were in...
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Petasis reaction is a powerful method for the synthesis of a-amino acids, β-amino alcohols and their derivatives. Chiral Petasis reaction has been applied in synthesis of nature products and drugs. This review describes the mechanism, reaction components and reaction conditions of Petasis reaction, and the applications of Petasis reaction are also...
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In this paper, block copolymer poly (amide-6-b-ethylene oxide) Pebax® MH 1657 (PEBA1657) is used to prepare multilayer polyetherimide (PEI)/polydimethylsilicone (PDMS)/PEBA1657/PDMS composite membranes according to dip-coating method. The PDMS gutter layer is mainly used for preventing the pore penetration of PEBA1657 solution and the PDMS protecti...
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The chlorination reaction of 4-substituted-1,2-oxaborol-2(5H)-ols with jV-chlorosuccinimide (NCS) afford (Z)-2-substituted-3-chloroallyl alcohol in moderate to good yields under the optimized condition. The structures of the products were identified by 1 H NMR, 13 C NMR, FT-IR and MS techniques. This method is simple, mild, high yield and the confi...
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A novel polysulfone/polyethylene oxide/silicone rubber (PSf/PEO/SR) multilayer composite membrane was fabricated by double coating polysulfone substrate membrane with polyethylene oxide and silicone rubber. Gas permeation experiments were performed at 30 °C for hydrogen and nitrogen. PSf/PEO/SR membrane displayed high and steady performance for H2/...

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