Huayi Suo’s research while affiliated with Southwest University and other places

... Notwithstanding, some studies have explored strategies to enhance postbiotic delivery to targeted sites in combination with prebiotics for a synergistic result upon interfacing with the intestinal microbiota [193]. Alternatively, there is a continuous evaluation of incorporating these combinations into food products to develop fermented and/or functional foods [194]. ...

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Probiotic, Postbiotic, and Paraprobiotic Effects of Lactobacillus rhamnosus as a Modulator of Obesity-Associated Factors

... Postbiotics have emerged as a promising therapeutic option for the prevention and treatment of IBD, given their stability and safety in comparison to live probiotics. Researchers have demonstrated that the administration of postbiotics obtained from Lacticaseibacillus rhamnosus notably mitigates the symptoms of UC by enhancing intestinal barrier integrity and lowering levels of inflammatory cytokines [78]. ...

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Recent Advances in Gut Microbiome Modulation: Effect of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Inflammatory Bowel Disease Prevention and Treatment

... Beneficial effects of FMT include preserved intestinal barrier function, improved intestinal motility, production of SCFA or a reduced number of pro-inflammatory bacterial strains in the gut [181][182][183]. The potential benefit of FMT was reported, e.g., in obesity, cardiovascular disorders, epilepsy and cognitive impairment [184][185][186][187]. In the animal MPTP model of PD, FMT was shown to improve the composition of the gut microbiota, decrease α-synuclein expression, inhibit microglial activation in SN, block pro-inflammatory signaling pathways and reduce behavioral changes [188,189]. ...

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Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson’s Disease—A Narrative Review

... While some animal and plant proteins show better uric-acid-lowering effects. Previous studies have found that dietary peptides mainly play a role in reducing UA by inhibiting XOD activity, regulating the expression level of UA transporters, and regulating intestinal microbiota [33]. Animal and plant protein hydrolysates also play a significant role in reducing UA, such as walnut protein hydrolysate [34], tuna protein hydrolysate [35], and whey protein hydrolysate [36]. ...

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Research Progress on New Functions of Animal and Plant Proteins

... For example, fermented soybeans at 37 • C enhance soybean flavor compared to those at 45 • C and 53 • C, while fermented soybeans at 45 • C and 53 • C enhance soy sauce-like flavor compared to those at 37 • C [5]. Although traditional soybean flavor products such as Douchi and Chi-flavor-type Baijiu are popular and accepted worldwide due to their prominent soybean flavor [6,7], there are only a few reports on the study of soybean flavor. It is speculated that the synergistic effects of multiple metabolic pathways and multiple genes may produce soybean flavor [5]. ...

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Characterization of the Key Aroma Compounds of Soybean Flavor in Fermented Soybeans with Bacillus subtilis BJ3-2 by Gene Knockout, Gas Chromatography–Olfactometry–Mass Spectrometry, and Aroma Addition Experiments

... It exhibits remarkable abilities for selfrenewal and self-organization, faithfully reproducing the functionality of its original tissue [109]. In contrast to the complexity of animal models and the simplicity of 2D cell culture models, organoids provide a more relevant and sophisticated platform for studying human-specific disease modeling, tissue developmental biology, and personalized medicine [110][111][112]. Additionally, organoid transplantation is gaining attention as a promising method for tissue or organ replacement and regeneration [108]. ...

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Current advances in understanding endometrial epithelial cell biology and therapeutic applications for intrauterine adhesion

... Fábrega et al. reported that the ratio of Firmicutes to Bacteroides in patients with colitis had decreased [28]. Wang et al. proposed that, after DSS treatment, the abundance of Verrucomicobiota had decreased, and the abundance of Proteobacteria had increased, but this phenomenon could be reversed after drug treatment [29]. These results are consistent with our findings. ...

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Didymin Ameliorates Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis by Regulating Gut Microbiota and Amino Acid Metabolism in Mice

... Oral microorganisms are closely associated with various oral diseases such as dental caries, periodontal disease, and oral cancer [42]. Traditional antibiotic therapy has demonstrated limited efficacy in the clinical management of S. mutans infections, underscoring the urgent need for innovative antimicrobial and antibiofilm strategies [43]. Therefore, the effect of the T. bufonium extract against S. mutans, a key player in oral disease development, is of great significance. ...

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Determination of Biological Activity and Biochemical Content of Ethanol Extract from Fruiting Body of Tricholoma bufonium (Pers.) Gillet

... Furthermore, microbial metabolites like short-chain fatty acids have demonstrated inhibitory effects on the invasion, adhesion and metastasis of colorectal tumour cells (Ref. 147). Notably, butyric acid has shown efficacy in mitigating tumour cell apoptosis, diminishing cancer cell metastasis and counteracting carcinogens by upregulating detoxification enzyme expression (Ref. ...

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Molecular symphonies and signalling pathways orchestrated by the gut microbiome in metastatic colorectal cancer (mCRC); a state-of-the-art review

... It is an indispensable process for the human body, occupying one-third of human life [2] and playing a crucial role in maintaining physical and mental health. However, sleep disorders are becoming increasingly prevalent in society, affecting 37-58% of adults [3] and causing significant harm to cognition and physical performance [4,5]. Research indicates a close association between sleep and various diseases, including cardiovascular disease [6], diabetes [7], mental disorders [8], and even mortality [9]. ...

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Causality Investigation between Gut Microbiome and Sleep-Related Traits: A Bidirectional Two-Sample Mendelian Randomization Study