Huanfeng Jiang’s research while affiliated with China University of Mining and Technology and other places

... This kinetic disparity rationalizes the experimentally o isolability of α-hydroxyphosphonates exclusively in aldehyde reactions, while ex the inherent predisposition of ketone substrates toward facile [1,2]-phospha-Bro rangement to directly yield α-phosphoryloxy esters. Recently, Wu's group [9] reported a palladium-catalyzed cyclization reactio aging [1,2]-phospha-Brook rearrangement to achieve base-modulated chemod synthesis of 2H-isoindole-1-carboxamide 4 and 2H-isoindole-1-carbonitrile 5 der ( Figure 4A). This methodology exhibits three hallmark characteristics: (i) dual iso incorporation, (ii) concurrent C-C/C-N bond formation, and (iii) ambient-tempera erability. ...

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Recent Developments in the [1,2]-Phospha-Brook Rearrangement Reaction

... This approach was later extended by the research group in 2024 to produce isochromeno[4,3-c]quinolines 26 b from diarylalkynes 24 b and isocyanides 25 b by palladium-catalyzed tandem cyclization (Scheme 8c). [31] Optimal reaction conditions were 0.10 equivalent of Pd(PPh 3 ) 4 as the catalyst, 2.0 equivalents of Cu(OAc) 2 as the oxidant and 2.0 equivalent of HOAc as the additive in toluene at 90°C for 12 h. Monosubstituents that exerted different electronic effects at the C-5 or C-4 position on the substrates 24 b could proceed well, giving the corresponding products in moderate to good yields (30-74 %). ...

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Exploring Synthetic Approaches for 2‐Aminoquinolines: Progress and Future Directions

... TYK2, a member of the Janus kinase (JAK) family, plays a crucial role in immune and hematopoietic cell functions, including cell growth, survival, differentiation, and immune response regulation [1]. Unlike JAK1, JAK2, and JAK3, TYK2 uniquely mediates intracellular signaling for key pro-inflammatory cytokines such as interleukin (IL)-12, IL-23, and type I interferons [2], which are central to the pathogenesis of psoriasis and other immune-mediated disorders. ...

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The Expanding Therapeutic Potential of Deucravacitinib Beyond Psoriasis: A Narrative Review

... The isoxazole ring is one of the heterocyclic rings known for good therapeutic responses [8], and because of its pharmacological relevance, the biological profile of isoxazole derivatives has received a lot of research over the years. They have shown diverse biological profiles, including anticancer [9,10], antidiabetic [11], antioxidant [12], anti-Alzheimer's agents [13], anti-inflammatory [14], anticonvulsant [15], antihyperlipidemic [16], anti-tubulin [17], antimycobacterial [18], and other biological activities. Isoxazole consists of a five-membered ring comprising nitrogen and oxygen atoms. ...

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Synthesis, Characterization, Molecular Docking and Pharmacological Evaluation of Isoxazole Derivatives as Potent Anti-Inflammatory Agents

... to the CDCl 3 solvent used in the 13 C NMR spectra [23]. The signals at 36 and 31 ppm may be attributed to the methyl groups present in the coordinated DMF solvent. ...

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Synthesis, Characterization and in Vitro Drug Delivery Applications of a Tin-Based Metal‒Organic Framework

... [9] Heterogeneous catalysts have also been explored, though very limitedly studied regarding transition metal catalyzed isocyanide insertions. [10,11] In this respect, atomically dispersed metal catalysts, known as single-atom catalysts (SACs), [12][13][14] have attracted attention. However, the transition metals of these SACs can aggregate, which necessitates suitable support materials to stabilize them for effective catalytic use. ...

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Unveiling the Potential of a Cobalt‐Based Metal‐Organic Framework in Carbodiimide Synthesis

... [1,2] These heterocycles are part of the core of numerous natural products, pharmaceuticals, and agrochemicals, contributing to their pharmacological, chemical and physicalchemistry properties. [3][4][5] The presence of an oxygen atom in the ring system significantly influences the compound's reactivity, stability, and interaction with biological targets, making them indispensable in medicinal chemistry. [6][7][8] Within this context, isochromenes, an oxygencontaining bicyclic moiety (highlighted in blue in Figure 1), emerge as a particularly promising building block due to their versatile reactivity and potential for diverse functionalization. ...

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Recent Developments in Synthetic Methodologies for Isochromenes

... 2-(Alkynylaryl)acetonitriles are a class of readily available, structurally diverse and bifunctional compounds with both cyano and alkyne groups used in the construction of important cyclic scaffolds such as naphthalenes, [15] azafluorenes, [16] benzocycloheptenes, [17] isoquinolines, [18] naphthyridines [19] and pyrroles. [20] Since the cyano group is a strong electron-withdrawing group, it can have an activating effect on the benzylic carbon. ...

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Copper‐Catalyzed Tandem Cyclization of 2‐(Alkynylaryl)Acetonitriles and Amines: Access to 3‐Hydroxyisoindolinones

... Recently, Qi, Jiang and their team developed a straightforward method for synthesizing a variety of structurally intriguing and valuable 14-membered macrocyclic lactones [31]. This is achieved through a carboxylative macrocyclization of 3-triflyloxybenzynes with CO 2 and THF, while the novel [2 + 2 + 5 + 5] coupling reaction proceeds under transition metal-free conditions, forming one new C-C bond and three new C-O bonds in a single step ( Figure 11). ...

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Recent Progress on Multi-Component Reactions Involving Nucleophile, Arynes and CO2

... Analytical samples were obtained by chromatography on silica gel using an EtOAc/petroleum ether or DCM/MeOH mixture as the eluent. 1 H NMR and 13 C NMR spectra were recorded on a Bruker Avance 400 MHz NMR spectrometer (400 MHz for 1 H, 100 MHz for 13 C), Bruker Avance 500 MHz NMR spectrometer (500 MHz for 1 H, 125 MHz for 13 C). The chemical shifts were referenced using residual undeuterated solvent (CDCl 3 : δ 7.26, 77.0 ppm; DMSO-d 6 : δ 2.50, 39.52 ppm unless otherwise stated). ...

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Concise Asymmetric Total Synthesis of (+)-Arbornamine