Hossein Sadeghi-Nejad's research while affiliated with Rutgers New Jersey Medical School and other places

Publications (23)

Article
Introduction Sexual health problems affect approximately 60% of male cancer survivors in the U.S. Erectile dysfunction (ED) is the most common sexual health condition men seek professional help for after cancer treatment with some studies reporting ED rates as high as 85% in these men. Inflatable penile prosthesis (IPP) implantation is a safe and h...
Article
Introduction Penile Prosthesis (IPP) is an effective treatment for men with ED that significantly improves quality of life but is likely being underutilized in men who were treated for prostate cancer (Pca). Objective To better characterize the utilization of IPP treatment after Pca therapy, we explored the relationship between timing of ED diagno...
Article
Objective To evaluate the number of PubMed-indexed research projects of medical students matching at top-ranked urology programs as compared to the average publications reported in the Electronic Residency Applicant Service (ERAS). Methods Doximity Residency Navigator was used to generate the top 50 residency programs when sorted by reputation. Re...
Article
Full-text available
Collagenase clostridium histolyticum (CCH, Xiaflex, Xiapex) is the only FDA-approved medication for treatment of Peyronie’s disease. It is unclear how practitioners actually use CCH in their own practices. The objectives of the study were: (1) to identify variability in practice patterns for CCH among practitioners, (2) to assess adherence to the p...
Article
Xiaflex or collagenase Clostridium histolyticum intralesional injections are safe and effective as first-line treatment for Peyronie's disease.
Article
Introduction: Over the last several decades, the opioid epidemic has become a national crisis, largely spurred by the spike in the use of prescription painkillers. With the epidemic came a concomitant rise in the incidence of opioid-induced androgen deficiency (OPIAD). Although OPIAD can significantly impact male sexual function and quality of lif...
Chapter
Robust evidence exists supporting the effectiveness of Botulinum toxin A (BoNTA) in the treatment of lower urinary tract disorders including neurogenic detrusor overactivity and non-neurogenic overactive bladder. Following several randomized controlled trials with promising outcomes, the US Food and Drug Administration approved application of BoNTA...
Article
Full-text available
Prostate cancer most commonly metastasizes to bone, lung and liver. Omental metastasis of prostate cancer is extremely rare, with only a few cases reported in the literature, many of which have associated ascites. We present a case of non-ascitic omental metastasis of prostate cancer without any bone metastases. Furthermore, this patient has had tw...
Article
The incidence of hypogonadism has been steadily increasing over the last few years. Exogenous testosterone has been the standard treatment for hypogonadal men, but is associated with suppression of spermatogenesis as well as other possible adverse effects. There are other medications, currently considered "off label" for androgen replenishment, tha...
Chapter
Peyronie’s disease (PD) is characterized by scarring and alteration of the intricate architecture of the tunica albuguinea of the penis. This anatomic deformity may cause an abnormal penile curvature toward the site of scarring, cosmetic displease, painful erections during the active phase, and erectile dysfunction (ED) that in some may preclude se...
Conference Paper
Full-text available
Background: Fatigue is a major problem for men on androgen deprivation for prostate cancer (PC). DeLorme developed a short muscle length (SL) progressive resistance exercise (PRE) program for WWII veterans 1. Resistance exercise for PC with 60% SL exercises have reduced fatigue 40% 2, compared to only 10% reduction in fatigue with 12% short exercis...
Article
Objective To examine the safety of intralesional injection of CCH for the treatment of PD, using a pooled safety analysis of subjects who received at least 1 dose of CCH in any of 6 clinical studies.Materials and Methods Subjects from 6 clinical studies, including 3 randomized, double-blind, placebo-controlled studies and 3 open-label safety and ef...

Citations

... Additionally, a 2018 study found that 99% of all ophthalmology applicants had at least one publication [4]. Urology had a similar average number of publications among successfully matched residents in the top 50 residency programs at 2.38 ± 4.19 in 2020 [5]. Urology also demonstrates higher interview rates among applicants with more research experiences [6]. ...
... Though not all videos performed well; the video "Movember & why you should support men's health" was part of an educational campaign and did not receive as many lifetime views as the other 5 videos. A recent study by Warren and colleagues showed that YouTube videos featuring physicians were of significantly higher quality and less biased, but had lower viewership compared to videos not featuring a physician (9). Despite prior evidence suggesting content disseminated by physicians has its challenges in reaching successful viewership, our data demonstrate that streaming videos created by an academic health system can have prodigious reach, though not all content may be equivalently successful in achieving high viewership numbers. ...
... As use of CCh becomes more widespread, standardization of the language used to describe complications will prove critical, particularly with expanded indications or modified treatment protocols. Indeed, a recent survey of members of the International Society of Sexual Medicine found that only 10.7% of respondents adhered to all practices recommended in the CCh package insert [15]. Overall, this study demonstrated a 5.3% rate of hematoma formation, 54.6% rate of bruising, 27.0% ...
... Peyronie's disease is a penile condition characterized by pain, curvature, and/or shortening of the penis and is often associated with erectile dysfunction and difficulty engaging in sexual intercourse [1]. Disorganized and excessive deposition of collagen likely results in the formation of a fibrous penile plaque within the tunica albuginea [2], most commonly observed in the dorsal midline [3]. ...
... med kort halveringstid, som i nogle studier viser lavere grad af seksuelle bivirkninger. Ved nødvendigt kronisk påvirket hormonproduktion kan hormonsubstitution overvejes (11). ...
... AZ has been used in men with TD in an effort to reduce the conversion to E2 to T while maintaining fertility. 6 We employed a cut-off for the use of AZ, but the literature does not support a clear cut-off or indication for the initiation of estradiol-lowering therapy. 7 Similar to our series, in a national sample, 3.5% (1,200/34,016) of men were placed on an AI. 7 Men in our series receiving AZ, and therefore with higher E2, had greater rates, although not statically significant, of OSA. ...
... The majority of cases were treated with ADT ± docetaxel with, in some patients, biological and radiological response. Only four patients have been treated with new generation hormonal agents (three with abiraterone acetate and one with enzalutamide) with description of response without any precision in outcome [26,[31][32][33]. In our patient, due to the prior sensitivity to ADT (biological response lasting more than 1 year), we started abiraterone acetate that resulted in rapid decrease of PSA and long lasting complete radiological response for more than 4 years. ...
... Currently, drugs for the local injection are mainly CCH, verapamil, and interferon-α2b, of which CCH is the most widely used (9,12,13). Previous clinical trials focused on the effectiveness of CCH (14)(15)(16), but most of them were reviews or case reports, lacking evidencebased medical evidence, and there are still some clinicians who are concerned about its safety and efficacy. Therefore, we are the first to use meta-analysis to explore the efficacy and safety of CCH in the treatment of PD all over the world. ...