Hongxiang Zhang's research while affiliated with Tianjin University and other places

Publications (54)

Article
Full-text available
At the single-cell level, cellular parameters, gene expression and cellular function are assayed on an individual but not population-average basis. Essential to observing and analyzing the heterogeneity and behavior of these cells/clusters is the ability to prepare and manipulate individuals. Here, we demonstrate a versatile microsystem, a stereo a...
Article
Contactless acoustic manipulation of micro/nanoscale particles has attracted considerable attention owing to its near independence of the physical and chemical properties of the targets, making it universally applicable to almost all biological systems. Thin-film bulk acoustic wave (BAW) resonators operating at gigahertz (GHz) frequencies have been...
Preprint
Full-text available
At the single-cell level, cellular parameters, gene expression and function are assayed on an individual but not population-average basis. Essential to observing and analyzing the heterogeneity and behavior of these cells/clusters is the ability to prepare and manipulate individual. Here, we demonstrate a versatile microsystem, a stereo acoustic st...
Article
This paper investigates the mechanism of a new acoustic micro-ejector using a Lamb wave transducer array, which can stably generate picoliter (pL) droplet jetting without nozzles. With eight transducers arranged as an octagon array, droplets are ejected based on the mechanism of combined acoustic pressure waves and acoustic streaming. The acoustic...
Article
Full-text available
Background Controllable and multiple DNA release is critical in modern gene-based therapies. Current approaches require complex assistant molecules for combined release. To overcome the restrictions on the materials and environment, a novel and versatile DNA release method using a nano-electromechanical (NEMS) hypersonic resonator of gigahertz (GHz...
Article
Due to their easy, fast, and noninvasive natures, acoustic wave methods have been widely used in the physical property measurements of liquids, such as shear waves for viscosity and ultrasound for density. We investigate the physical interaction between approximately GHz longitudinal acoustic waves and simple Newtonian fluids in micro- and nanoscal...
Article
Full-text available
Rapid and reliable micromixing requires continuous improvement to renovate more powerful microfluidics chip for chemosynthesis, biological assay, and drug purification. In this work, we realized rapid in-situ mixing in droplets on a closed electro-microfluidic chip. Electrowetting and 2.5 GHz acoustic wave streaming were coupled into a monolithic c...
Article
As bendable, conformal electronic components, flexible gigahertz resonators are in demand as important building blocks (e.g., oscillators, filters, and signal processors) in future flexible radio‐frequency electronics for efficient wireless communication. Here, a 2.7 GHz piezoelectric thin‐film resonator (i.e., film bulk acoustic wave resonator) is...
Article
In article number 1800068, Xuexin Duan, Wei Pang and co‐workers develop hypersonic‐induced hydrodynamic tweezers (HSHTs) and demonstrate the capability for multifunctional manipulations of micro/nanoparticles including online trapping, on‐situ rotation, queuing, and continuous sorting. Benefitting from the advantages of the hydrodynamic approach, t...
Article
Full-text available
On-demand droplet dispensing systems are indispensable tools in bioanalytical fields, such as microarray fabrication. Biomaterial solutions can be very limited and expensive, so minimizing the use of solution per spot produced is highly desirable. Here, we proposed a novel droplet dispensing method which utilizes a gigahertz (GHz) acoustic resonato...
Article
Full-text available
In designing bioassay systems for low-abundance biomolecule detection, most research focuses on improving transduction mechanisms while ignoring the intrinsically fundamental limitations in solution: mass transfer and binding affinity. We demonstrate enhanced biomolecular surface binding using an acoustic nano-electromechanical system (NEMS) resona...
Article
We report the nonlinear acoustic streaming effect and the fast manipulation of microparticles by microelectromechanical Lamb-wave resonators in a microliter droplet. The device, consisting of four Lamb-wave resonators on a silicon die, generates cylindrical traveling waves in a liquid and efficiently drives nine horizontal vortices within a 1−μl dr...
Article
Full-text available
Developing microrobots for precisely manipulating micro/nanoscale objects has triggered tremendous research interest for various applications in biology, chemistry, physics, and engineering. Here, a novel hypersonic‐induced hydrodynamic tweezers (HSHTs), which use gigahertz nano‐electromechanical resonator to create localized 3D vortex streaming ar...
Article
This paper introduces an on-chip acoustic graphene transistor based on lithium niobate thin film. The graphene transistor is embedded in a microelectromechanical systems (MEMS) acoustic wave device, and surface acoustic waves generated by the resonator induce a macroscopic current in the graphene due to the acousto-electric (AE) effect. The acousti...
Article
Full-text available
This paper reports an on-chip acoustic sensor comprising a piston-mode film bulk acoustic resonator and a monolithically integrated nanochannel. The resonator with the channel exhibits a resonance frequency (f) of 2.5 GHz and a quality (Q) factor of 436 in deionized water. The f × Q product is as high as 1.1 × 10¹², which is the highest among all t...
Article
Full-text available
This work reported a wireless controlled micro-actuator system for rapid heating and mixing of multiple droplets using integrated arrays of micro-fabricated 2.5 GHz solid-mounted thin-film piezoelectric resonators (SMRs) and a millimeter-scale omnidirectional antenna. An equivalent circuit is proposed to analyze the mechanism of the heating, mixing...
Article
Nonspecific binding (NSB) is a general issue for surface based biosensors. Various approaches have been developed to prevent or remove the NSBs. However, these approaches either increased the background signals of the sensors or limited to specific transducers interface. In this work, we developed a hydrodynamic approach to selectively remove the N...
Article
Full-text available
This paper reports an uncooled infrared (IR) detector based on a micromachined piezoelectric resonator operating in resonant and resistive dual-modes. The two sensing modes achieved IR responsivities of 2.5 Hz/nW and 900 μdB/nW, respectively. Compared with the single mode operation, the dual-mode measurement improves the limit of detection by two o...
Conference Paper
acoustofluidics. This paper reports a minimized bio-particles manipulation tool utilizing localized ultrahigh frequency acoustic resonators (UHF-AR). The resonator works at frequency of 1540 MHz, which is high enough to break through scale effect and trigger localized acoustofluidic streaming (in formation of 3-D vortices) within microfluidic syste...
Article
In article number 1602962, Xuexin Duan and co-workers, explore a novel chemical-free cell poration method – “hypersonic poration”, which is developed to improve the cellular uptake, especially nucleus uptake, using a designed piezoelectric nanoelectromechanical resonator. The hypersound has a typical frequency larger than GHz, which can directly in...
Article
Efficient delivery of genes and therapeutic agents to the interior of the cell is critical for modern biotechnology. Herein, a new type of chemical-free cell poration method— hypersonic poration—is developed to improve the cellular uptake, especially the nucleus uptake. The hypersound (≈GHz) is generated by a designed piezoelectric nano-electromech...
Article
We developed a wireless and passive piezoelectric resonant sensor for contimuous volatile organic compound detection. An equivalent circuit is proposed to model the sensing system, and Lamb wave resonators are adopted to demonstrate the wireless interrogation achieved by near-field inductive coupling. The wireless sensing system is employed to moni...
Article
Full-text available
We present an acoustic microfluidic mixing approach via acousto-mechanically induced micro-vortices sustained by localized ultrahigh frequency (UHF) acoustic fields. A micro-fabricated solid-mounted thin-film piezoelectric resonator (SMR) with a frequency of 1.54 GHz has been integrated into microfluidic systems. Experimental and simulation results...
Article
Full-text available
Controlled drug release has a high priority for the development of modern medicine and biochemistry. To develop a versatile method for controlled release, a miniaturized acoustic gigahertz (GHz) resonator is designed and fabricated which can transfer electric supply to mechanical vibrations. By contacting with liquid, the GHz resonator directly exc...
Conference Paper
Coupling of acoustic disturbance into microfluidics has been widely investigated for micro-mixing, fluid heating, bioparticle manipulations including trapping, sorting, focusing, and cell lysis etc. Here, we demonstrated a microfluidic system which integrated with micro-fabricated bulk acoustic wave resonator (BAW) working at frequency of 1.54 GHz....
Article
Full-text available
We demonstrate a dual-mode gas sensor for simultaneous and independent acquisition of electrical and mechanical signals from the same gas adsorption event. The device integrates a graphene field-effect transistor (FET) with a piezoelectric resonator in a seamless manner by leveraging multiple structural and functional synergies. Dual signals result...
Article
We report on the excitation of acousto-eletric (AE) charge transport in monolayer graphene by acoustic transducers based on aluminum nitride thin films. The acoustic waves induced macroscopic current flow that linearly scaled with input power. The AE current exhibited unique frequency dependence due to special configuration and piezoelectric proper...
Article
Full-text available
In this letter, we demonstrate a technique to eliminate the spurious modes in aluminum nitride Lamb wave resonators (LWRs). The transverse acoustic wave characteristics are examined, and a resonance modulation theory on the regulation of mechanical boundary conditions is deducted. As examples of embodiments, vertical and lateral protrusion structur...
Article
Full-text available
This paper presents a transverse mode suppression theory and its experimental verification through aluminum nitride Lamb wave resonators (LWRs) operating at 142 MHz. An effective 2-D approximation model of the LWR is proposed, based on which the origin of transverse modes in LWR is investigated. The displacement distribution, resonant frequencies,...
Article
Full-text available
This paper reports on the implementation of an ultraminiature 140 MHz narrowband filter based on aluminum nitride Lamb wave resonators. Monolithically integrated with a pair of on-chip capacitors and cascaded with a pair of inductors, the filter is well matched to 50 ohm, showing a remarkably high performance. A low pass-band insertion loss of 2.78...
Article
Full-text available
A design guideline for one-port aluminum nitride (AlN) Lamb wave resonators (LWRs) working at S0 mode with high performance is reported. A fabricated 252 MHz LWR, with an aperture of 200 μm, 12 fingers, and 1.5 μm thick AlN, is found to have a remarkably high figure of merit (FOM), which exhibits a high ratio of the resistance at parallel resonance...
Conference Paper
Full-text available
In this paper, we report experimental results on band-pass aluminum nitride (AlN) MEMS filters that are based on Lamb wave resonators (LWRs) which exhibit a high ratio of the resistance at parallel resonance (Rp) to the resistance at series resonance (Rs). One-port LWRs working at S0 mode with various geometry dimensions are analyzed and the design...

Citations

... Particle trapping is an extraordinary method actively used in biomedical applications by creating physical tweezers depending on the acoustic field, electric field, magnetic field, optical field, or thermal field as a driving force in every particle manipulation method. Standing waves created by two identical interdigitated transducers are critical in acoustic method for creating a high-pressure point known as a tweezer that can trap different-sized particle, which could be micron-or sub-micron size particles [15,129,130]. Without standing waves, it is possible to confine silica nanoparticles, exosomes, and drugs inside a fluid chamber as rotating droplets for biomedical applications with the help of acoustic radiation force, acoustic microstreaming, and shear stresses [131]. ...
... Gentle acoustic fields with the ability to maintain cells in their native state in their original culture without harm shows the potential to generate and print the droplet containing single cells [45,46,[100][101][102][103][104][105]. In 2007, Demirci et al. applied a gentle acoustic field to generate picolitre droplets containing cells from a microfluidic chip and increased the reliability of cell encapsulation efficiency by as high as 98.4% (Figure 2a) [45]. ...
... A similar behavior was also reported in our recent work on solutions of the mixture of DNA and synthetic polyelectrolytes [38]. Indeed, while previous works have addressed the conformation of DNA with synthetic polyelectrolytes at the solution-solid interface [39,40], far fewer studies have addressed such interactions at the solution-air interface. Our recent work on the interactions of DNA with synthetic polyelectrolytes revealed that fibrous aggregates formed at the solution surface depend both on the hydrophobicity of the synthetic polyelectrolyte and the bulk molar mixing ratio [38]. ...
... Body fluids such as blood or urine are an attractive source of information for disease detection [1][2][3][4], and one of the techniques for track their condition is by monitoring their mechanical properties [5][6][7], among which are its compressional properties. Compressional information is an interesting parameter in analysis since, at microscales, it is closely related to the chemical bond strength between atoms, ions, or molecules, and therefore can be used in analyzing human physiological fluids [8,9]. For instance a change in the mechanical properties of blood can be potentially related with cardiovascular dysfunctions, providing a fast and simple method for rapid and early test of a possible disease as it is already explained in reference [5]. ...
... In the literature, µ-impactors have a planar physical design similar to that proposed by Paprotny et al., as seen in Figure 4a [84]. These devices can be manufactured through a variety of microfabrication processes [85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101], precise micromachining technologies [84,[102][103][104][105], and more recently, 3D printing manufacturing technologies [106][107][108][109][110]. ...
... To enhance the mixing, different types of active and passive methods are designed. Active methods need to exert an external field, such as magnetic (Kang et al. 2007), electronic (Mugele et al. 2006), and acoustic (Lu et al. 2018) for operation, and a more complicated device design is required. While passive methods, such as, altering the straight channel into a serpentine channel (Liu et al. 2000) and using asymmetric design of channels (Belousov et al. 2021), are all supposed to geometrically induce advection inside the droplet to enhance the mixing. ...
... At present, some progress has been made in the research of various functional flexible RF MEMS, mainly in flexible RF MEMS switches , phase shifters [76][77][78], reconfigurable antennas [78][79][80][81][82][83][84][85][86] and phased array antennas [87][88][89][90] based on them, in MEMS resonators [91][92][93][94][95][96][97][98][99][100][101][102][103], frequency selective hyper surfaces [104], etc. ...
... He et al. proposed a drop-on-demand droplet preparation technique based on a gigahertz acoustic resonator. The liquid was pushed upward, and produced droplets which were further transported onto the hydrophobic substrate under the highly strong force induced by the acoustic field at the center of piezoelectric device (Fig. 2a) [22]. Foresti et al. achieved the precise control of droplets in microliter-to-nanoliter by utilizing the highly localized acoustic field generated by a subwavelength Fabry-Perot resonator [23]. ...
... Microfluidic chips and acoustic streaming can now be combined thanks to the rapid advancement of MEMS technology. Combining streaming with microfluidic chips can achieve advantages including low consumption, high efficiency, integrated platforms, good biocompatibility, easy manipulation, and contactless [3][4][5][6][7]. Thus, acoustic streaming has become an important tool for particle manipulation [8][9][10][11][12], cell capture [13], micromixing [14], micropump [15], material concentration [16], and chemical reactions [17]. ...
... A 3D model of the UHF device was built in COMSOL Multiphysics 5.5. (COMSOL Inc., USA) 81 . More details are provided in the SI. ...