Hongxia Li's research while affiliated with 307 Hospital of the Chinese People's Liberation Army and other places

Publications (17)

Article
Full-text available
Background The difficulty of early diagnosis of bloodstream infection in the elderly patients leads to high mortality. Therefore, it is essential to determine some new methods of early warning of bloodstream infection in the elderly patients for timely adjustment of treatment and improvement of prognosis. Methods Patients aged over 65 years with s...
Article
Full-text available
Background Microparticles (MPs) are extracellular vesicles that are associated with cancer development and progression. Advanced non-small cell lung cancer (NSCLC) still shows disease progression after multiple lines of treatment. Therefore, the objective of this study was to explore the correlation between circulating MPs and disease progression i...
Article
Full-text available
Background There are limited methods to predict the therapeutic effect of immune checkpoint inhibitors (ICIs). The purpose of this study was to explore the value of circulating microparticles (MPs) in predicting thetherapeutic effects of immunotherapy. Methods A prospective study was conducted at the cancer center of PLA general hospital, includin...
Article
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Background: Serum lactic acid is considered a prognostic indicator in critically ill patients. However, studies on linezolid-induced lactic acidosis (LILA) are still limited. Individuals older than 85 years old (very elderly) have limited capacity for organ compensation, and LILA data from these patients are lacking. In this study, we evaluated the...
Preprint
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Background Optimal fluid management in patients with COVID-19 has not been reported. This retrospective, multicenter study investigated the impact of intravenous infusion volume in the early stage of COVID-19 on clinical outcomes. Methods 127 patients from two tertiary hospitals were separated into the “conservative” and “liberal” groups based on...
Article
Objective: To investigate the level and changing trend of microparticles (MPs) in super-elderly infected patients, and explore its early warning effect on infection. Methods: The infected patients ≥ 85 years old admitted to the Second Medical Center of Chinese PLA General Hospital from December 2018 to March 2019 were selected as the observation...
Article
Pirfenidone has been widely used in the treatment of idiopathic pulmonary fibrosis (IPF). However, the role of pirfenidone in LPS-induced acute lung injury (ALI) remains unclear. This study aims to investigate the protective effects of pirfenidone in ALI and to explore its underlying mechanism. Pirfenidone clearly reduces LPS-triggered ALI as indic...
Preprint
Full-text available
Background Lactate is considered a prognostic indicator in critically ill patients; however, studies on linezolid-induced lactic acidosis (LILA) are limited, and data from patients older than 85 are even more scarce, therefore we evaluated the risk factors for LILA in patients older than 85 years and established a risk prediction model. Methods I...
Article
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We used 335 Mycobacterium tuberculosis strains from 2010 National Epidemiologic Survey for TB in China and performed comparative sequence analysis of 38 kDa gene after amplification. From the results, we found that there were 5.07% M.tuberculosis strains that demonstrated genetic diversity of 38 kDa in China, and 2.99% strains showed polymorphism o...
Article
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Many studies have reported the association between the matrix metalloproteinase (MMP) polymorphisms and lung cancer susceptibility, but the results were inconclusive. We conducted a meta-analysis, using a comprehensive strategy based on the logistic regression and a model-free approach, to derive a more precise estimation of the relationship betwee...
Article
This study was conducted to investigate the effect of intratracheal and intravenous administration of microparticles (MPs) on developing acute respiratory distress syndrome (ARDS). The blood MPs from lipopolysaccharide-treated rats were collected and examined by transmission electron microscopy (TEM). Cellular source of the MPs was identified by fl...
Article
To investigate the alterations of microparticles in acute respiratory distress syndrome (ARDS) in rats. 18 Wistar male rats were randomly divided into three groups: no intervention, sham (saline control) group and ARDS group (LPS induced). Blood was collected from abdominal aorta and microparticles were extracted through multiple rounds of centrifu...
Article
Full-text available
A carbapenem-nonsusceptible Enterobacter aerogenes strain named 3-SP was isolated from a human case of pneumonia in a Chinese teaching hospital. NDM-1 carbapenemase is produced by a pNDM-BJ01-like conjugative plasmid designated p3SP-NDM to account for carbapenem resistance of 3-SP. p3SP-NDM was fully sequenced and compared with all publically avail...
Article
The aim of this study was to explore the population structure of multidrug-resistant (MDR) tuberculosis strains and distribution of resistance-associated nucleotide alteration among the different genotype MDR strains in China. The genotypes of 376 MDR strain were analyzed by 15-loci MIRU-VNTR and RD105 deletion-targeted multiplex PCR (DTM-PCR) meth...
Article
Full-text available
The aim of this study was to evaluate the effect and underlying mechanism of Yangyinqingfei decoction on radiation-induced lung injury in rats. Wistar rats (n=75) were randomly divided into five experimental groups (A-E). Rats in two of the groups were administered saline solution, whereas rats in the remaining three groups were administered differ...
Article
Full-text available
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary arterial pressure and vascular resistance. Despite advances in therapy for PAH, its treatment and prognosis remain poor. We aimed to investigate whether the transplantation of bone marrow mesenchymal stem cells (MSCs) overexpressing hepatocyte growth facto...

Citations

... High levels of MMP-9 during hospitalization are associated with subsequent pulmonary fibrosis as shown by chest computed tomography [112] (Table 2). Activated neutrophils release microvesicles to an extent correlated with the severity of several infectious, inflammatory and thrombotic conditions, and therefore PMN-MPs have been proposed as a marker of disease severity [113][114][115][116][117]. PMN-MPs induce myeloperoxidase-mediated endothelial cell injury [118] and express tissue factor [119], and are significantly increased in COVID-19 patients compared to healthy controls [64,67] correlating with NLR, a negative prognostic marker [64]. ...
... In particular, physicians may not know that linezolid can induce lactic acidosis, even though the incidence rate of linezolidassociated lactic acidosis in linezolid-treated patients is estimated at 6.8% (Im et al., 2015). Linezolid-associated lactic acidosis leads to inhibition of mitochondrial oxidative phosphorylation in the absence of obvious tissue hypoxia (Liu et al., 2021). Human mitochondrial DNA polymorphisms (A2706G) have been associated with linezolid-associated lactic acidosis (Del Pozo et al., 2014). ...
... EMPs can carry a wide range of transcripts and have angiogenic activity mainly in quiescent endothelial cells by promoting endothelial cell proliferation, organising capillary-like structures, and preventing apoptosis. Elevated levels of circulating lymphocyte-derived MPs (LMPs) are associated with disease progression in advanced NSCLC [90]. The total MPs, PMPs, and LMPs increased significantly with disease progression in patients with advanced NSCLC who were treated with immune checkpoint inhibitors. ...
... Total DNA was extracted from HK-2 cells using a mammalian genomic DNA extraction kit (Beyotime Biotechnology). NADH dehydrogenase subunit 1 (ND1) gene encoded by mtDNA and GAPDH encoded by nuclear DNA (nDNA) were determined by RT-qPCR analysis as described previously (Du et al., 2020). The mtDNA/nDNA ratio was used to assess the relative mtDNA copy number. ...
... Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A has been studied in various cancers including breast [47][48][49][50][51][52][53][54][55][56][57], lung [47,[58][59][60][61][62][63][64] and colon cancer [44,47,[65][66][67][68][69][70][71][72][73][74][75], but results were ambiguous. The results of metaanalyses suggest that polymorphisms in MMP-1, MMP-2, and MMP-7 may be associated with cancer risk in Asian or Latin-American populations, but not in European or Caucasian populations [63,[76][77][78][79][80]. The MMPs and MTs are strongly associated with Zn homeostasis, so it is highly probable that the influence of SNPs in these genes on cancer risk may be dependent on Zn status. ...
... The information is presented as the mean ± SD (n = 3), *P < 0.05, **P < 0.01. from LPS-treated rats into naive rats generates ARDS 44 . To our knowledge, the detailed mechanisms of exosomal APN-induced LEPC necroptosis have not been previously documented. ...
... Alveolar endothelial cells release EVs in response to various inflammatory stimuli such as LPS, plasminogen-activated inhibitor-1, and mechanical stretch [57,58]. Alveolar EEVs can contribute to the inflammatory response in an autocrine fashion; these EVs reduced endothelial nitric oxide (NO) production which was followed by arteriolar vasodilation and pulmonary edema in vivo [59,60]. ...
... Transconjugants that possessed the bla NDM−6 -carrying plasmid were detected on Mueller-Hinton agar plates (Oxoid, Hampshire, United Kingdom) containing 1 mg/L imipenem plus 100 mg/L sodium azide. The number and sizes of plasmid-located bla NDM−6 were estimated by S1 nuclease-pulsed field gel electrophoresis (S1-PFGE) followed by southern blot (Chen et al., 2015). Briefly, the linearised plasmids digested by S1 nuclease (Takara, Shiga, Japan) were separated via the CHEF Mapper XA system (Bio-Rad, Hercules, CA, United States). ...
... In addition, the deletion-targeted multiplex polymerase chain reaction (DTM-PCR), which is also faster and easier to perform, has been considered as a good alternative method to Spoligotyping to identify Mycobacterium tuberculosis Beijing strains. The Beijing genotype is predominant among MDR-TB strain in China [6,7]. ...
... [15] Yangyin Qingfei Decoction has a protective effect on RILI in rats, possibly by down-regulating the expression of MMP-12 and TIMP-1, which leads to the balance of extracellular matrix synthesis and degradation, and alleviates the occurrence of pulmonary fibrosis. [16] Intervention of BABL/C mice with flavonoids extracted from astragalus after exposure to 10 Gy thoracic radiation showed up-regulation of mouse SOD levels, while down-regulation of TGF-β1 and IL-6. The expression of TGF-β1 and TNF-α was significantly increased in alveolar epithelial cells and alveolar septal macrophages, suggesting that flavonoids may act as protective agents against RILI. ...