Honghai Hong's research while affiliated with Guangzhou Medical University and other places

... While the identification of molecular alterations, such as isocitrate dehydrogenase IDH1/2 mutations, 1p/19q codeletion, and MGMT promoter methylation, has improved the accuracy of diagnostics, prognostication, and prediction of treatment response for glioma patients, there has been no tangible improvement in clinical management and patient outcomes. Epitranscriptomics of known glioma sub-entities may yield further advances in tumour stratification and help guide treatment selection for precision medicine, as was shown in preliminary studies of colon cancer [152] Several studies explored m 6 A RNA methylation regulators in public primary brain cancer sequencing datasets, and these key findings are summarised in Table 3. Many of these studies are not based on integrated brain tumour diagnostic definitions (WHO 2021 classification), and tumours are often referred to in broad terms (GBM, glioma, astrocytoma, or low-grade glioma, LGG). ...

... Weight loss and behavioral abnormalities are common symptoms of PD. The neuropathological hallmark of PD includes abnormal deposition of a protein called α-synuclein and dopamine deficiency [107]. The native form of α-synuclein is intrinsically disordered, and it undergoes a transition of the structure due to PD [108]. ...

... In fact, the existing studies on the relationship between these two lipid indexes and the prognoses of CRC is not sufficient, and the results are inconsistent. progression of CRC by enhancing lipid mobilization or lipolysis (40), which also reflects that high serum TG level are related to the improvement of prognosis. Other studies showed that increased TG or decreased HDL-C are associated with poor prognosis in CRC (11,41), or not (13,42). ...

... Natural products can regulate the immune response or reshape the tumor inflammatory microenvironment to combat the side effects of oncology drug resistance. A study on traditional Chinese medicine anti-tumor found that three typical natural products of Huangqin, oroxylin A, wogonin and baicalin, may overcome anti-cancer drug resistance by modulating the tumor immunosuppressive microenvironment (233). Natural products modulate immune checkpoint-related signaling molecules via multiple signaling cascades in the tumor microenvironment combined with immune checkpoint inhibitors (ICIs), which not only enhance the effectiveness of immunotherapy but also reduce the adverse effects of resistance (234). ...

... In turn, it acts as a regulator of c-Myc associated cellular processes including proliferation, cell cycle progression, apoptosis, transcription, translation, and RNA splicing (58). Aberrantly expressed FUBP1 was associated with an increased proliferation, anti-apoptotic rates, and poor prognosis in different cancer types (57,(59)(60)(61). Knockdown of FUBP1, in contrast, reversed the effects on cell growth via arresting cells in the G1 phase and inhibiting transition through S and G2 phases (57,59,62). ...

... Oxaliplatin is one of the main chemotherapy drugs used as the first-line therapy for CRC, and previous research has indicated that oxaliplatin-related autophagy induction could lead to chemotherapy resistance [59]. The antitumor effect of oxaliplatin is closely related to ROS accumulation [60]. As we expected, our results indicated that LINC01615 knockdown enhanced oxaliplatin efficacy in PDO and PDX models (Fig. 7). ...

... Adult wild-type zebrafish (Danio rerio) were raised under a 14 h light/10 h dark cycle to maturity, at which time male and female zebrafish were combined at a 1:2 ratio in a 1 L tank the night before breeding, separated by a mesh screen. Fertilized embryos were collected during the following light cycle, and all subsequent analyses were conducted at 28.5 • C using E3 medium [23]. Sprague-Dawley rats (male rats, 6-8 weeks) and C57BL/6 mice (male mice, 8 weeks) were obtained from the Experimental Animal Center of Guangzhou University of Chinese Medicine (Guangzhou, China), and were housed in a climate-controlled facility with free food and water access. ...

... The mean and standard deviation of the reference distribution were used to calculate a z-score by normalizing the observed (non-Euclidean) distance. More information on the network proximity measure is presented in earlier studies (Fang et al., 2022;Wu et al., 2020). ...

... Further correlation analysis indicated that there is a high degree of correlation between the above three lncRNAs and these 17 pathways. Interestingly, two well-known pathways were detected, including the P53 signaling pathway that was associated with the tumorgenesis and immune formation of CRC and the ECM-receptor interaction pathway that was significantly associated with the formation of the tumor microenvironment (Cho et al., 2020;Yin et al., 2020;Zou et al., 2019). The correlation plots between lncRNAs and two vital pathways are shown in Figures 6A-F. ...

... The S2 subunit tethers the S protein to the virion membrane and includes the machinery required for virus-cell fusion (5,6). S2 is more conserved than S1 (90% similarity with SARS-CoV-2, and 35-43% similarity with the other coronavirus S2s). ...