Hong Yu's research while affiliated with Government of the People's Republic of China and other places

Publications (20)

Article
Full-text available
By reason of surgical demand, the majority of cardiovascular procedures still depend on the use of cardiopulmonary bypass (CPB). Due to the nonphysiological state of CPB, it can cause complex and unpredictable inflammatory response, which may lead to significant morbidity and mortality. Unfortunately, the pharmacological and mechanical strategies t...
Article
Full-text available
Background Intralipid is a necessary fatty acid carrier that has been safely used as an energy supplier in the clinic. It has played an important role in rescuing the cardiac arrest caused by local anesthetic toxicity. In recent years, experimental studies have shown that intralipid postconditioning (ILPC) could reduce myocardial ischemic/reperfusi...
Preprint
Full-text available
Background Intralipid is a necessary fatty acid carrier that has been safely used as an energy supplier in the clinic. It has played an important role in rescuing the cardiac arrest caused by local anesthetic toxicity. In recent years, experimental studies have shown that intralipid postconditioning (ILPC) could reduce myocardial ischemic/reperfusi...
Preprint
Full-text available
Background: Intralipid is a necessary fatty acid carrier that has been safely used as an energy supplier in the clinic. It has played an important role in rescuing the cardiac arrest caused by local anesthetic toxicity. In recent years, experimental studies have shown that intralipid postconditioning (ILPC) could reduce myocardial ischemic/reperfus...
Preprint
Full-text available
Background: Intralipid is a necessary fatty acid carrier that has been safely used as an energy supplier in the clinic. It has played an important role in rescuing the cardiac arrest caused by local anesthetic toxicity. In recent years, experimental studies have shown that intralipid postconditioning (ILPC) could reduce myocardial ischemic/reperfus...
Article
Full-text available
Background: Since postoperative pulmonary complications are one of the main causes of morbidity and mortality in patients undergoing lung resection surgery, we performed a meta-analysis to compare the incidence of postoperative pulmonary complications and hospital death, and the length of hospital stay in patients who received nonintubated or intu...
Article
Full-text available
Background: This study aimed to evaluate the effect of intralipid postconditioning (ILPC) on myocardial damage in patients undergoing valve replacement surgery with concomitant radiofrequency ablation (RFA) for atrial fibrillation (AF). Methods: Randomized patient and assessor-blind controlled trial conducted in adult patients undergoing valve r...
Article
Full-text available
Background Acute renal injury (AKI) is a common renal complication after cardiac surgery. The aim of this study was to determine the effect of perioperative statin therapy (PST) on postoperative renal outcome in patients undergoing cardiac procedures. Methods We searched for the reports that evaluating the effect of PST on renal outcomes after car...
Article
Objective This study was conducted to determine whether the administration of intralipid just before aortic cross-unclamping would reduce myocardial injury in patients undergoing valve replacement surgery. Methods Seventy-three adult patients, scheduled for elective aortic or mitral valve surgery without significant coronary stenosis (>70%), were...
Article
Full-text available
Remote ischemic preconditioning (RIPC) may attenuate acute kidney injury (AKI). However, results of studies evaluating the effect of RIPC on AKI after cardiac surgery have been controversial and contradictory. The aim of this meta-analysis is to examine the association between RIPC and AKI after on-pump cardiac surgery. The authors searched relevan...
Article
Endoscopic radiofrequency ablation (RFA) is a novel palliation therapy for malignant biliary stricture; however, its feasibility and safety has not yet been clearly defined. The aim of the present study was to evaluate the feasibility and safety of endoscopic RFA for the treatment of malignant biliary strictures. A total of 12 patients treated by e...
Article
Full-text available
Objective To determine whether patients with severe sepsis or septic shock could benefit from a strict and early goal-directed therapy (EGDT) protocol recommended by Surviving Sepsis Campaign (SSC) Guidelines. Methods MEDLINE/PubMed, EMBASE/OVID and Cochrane Central Register of Controlled Trials (CENTRAL) were searched between March 1983 and March...
Article
To evaluate the technique of transpancreatic septotomy (TS) for cannulating inaccessible common bile ducts in endoscopic retrograde cholangiopancreatography (ERCP). Between May 2012 and April 2013, 1074 patients were referred to our department for ERCP. We excluded 15 patients with previous Billroth II gastrectomy, Roux-en-Y anastomosis, duodenal s...
Article
A 67-year-old man had a sev-ere cough and pulmonary infection for 1 wk before seeking evaluation at our hospital. He had undergone esophagectomy with gastric pull-up and radiotherapy for esophageal cancer 3 years previously. After admission to our hospital, gastroscopy and bronchoscopy revealed a fistulous communication between the posterior trache...
Article
The aim of the present study was to investigate the role of NK4, an antagonist for hepatocyte growth factor (HGF) and the Met receptor, in regulating the response of cholangiocarcinoma (CCA) cells to 5-fluorouracil (5-FU). We established the CCA cell line, HuCC-T1, to produce abundant NK4 (Hu-NK4). Cell proliferation, cell cycle distribution, apopt...
Article
Background and objective: NK4, a competitive antagonist for hepatocyte growth factor (HGF) and the Met receptor, is a bifunctional molecule that acts as an HGF antagonist and an angiogenesis inhibitor. The objective of this study was to investigate the anti-tumor effects of NK4 on the cholangiocarcinoma (CCA) cell line HuCC-T1. Methods: We asses...

Citations

... Several studies and case series supported the use of Polyvalent intravenous Immunoglobulins and blood purification based on pleiotropic effects on the inflammatory and immune mechanisms and the beneficial effects on hemodynamic and survival [17][18][19][20][21][22][23][24]. ...
... The premise of the molecular mechanism responsible for MIRI is complex and involves multiple cellular components [4,7]. Oxidative stress, calcium overload, inflammatory response, and energy metabolism disorders have been shown to promote MIRI in various animal models. ...
... Surgical factors that may necessitate conversion to GETA include poor maneuverability of instruments due to excessive respiratory movement of the lung and mediastinum, patient movement, pleural adhesions preventing lung collapse, and bleeding. Anesthesia-related factors that require conversion to GETA include intractable hypoxia, hypercarbia, and hemodynamic instability [43]. This is why the anesthesia team has to be vigilant in monitoring these patients. ...
... Based on the above background, our research group has innovatively conducted a pilot randomized controlled trial (RCT) to investigate whether ILPC would display the same cardioprotective effects in patients of cardiac surgeries, who were inevitably subject to I/R during cardiopulmonary bypass (CPB) [18,19]. The results showed that ILPC could reduce the release of myocardial damage biomarkers of serum cardiac troponin T (cTnT) and creatine kinase-MB (CK-MB) after cardiac valve replacement surgery, and the total 72-h postoperative area under the curve (AUC) of cTnT and CK-MB were significantly reduced by 32.3% and 26.4% compared with control, respectively [19]. ...
... and other meta-analyses, with 1 suggesting that although the class, on the whole, may not provide benefit, rosuvastatin may increase risk. 77 80,81 A large, retrospective, observational study provided further contention with preoperative use associated with a lower incidence of all-stage CSA-AKI compared with control (31% v 36%, p < 0.001). 82 Currently, there is no renal indication for use, but continuation until surgery is appropriate and further evidence is required. ...
... In addition, intralipid has been used in the treatment of cardiotoxicity caused by overdose of local anesthetics such as bupivacaine [36]. Recent animal studies have shown that postischemic administration of lipid emulsion protects the heart against I/R injury[14, 37,38]. Meanwhile, clinical studies have also demonstrated that intralipid postconditioning reduces the release of markers of myocardial injury after heart valve replacement and has a cardioprotective effect [39]. ...
... but no impact on RRT requirement. 201 However, a similar-sized meta-analysis (21 trials, n = 5,262) found no reduced CSA-AKI incidence (a co-primary outcome), and a Cochrane Database Systematic Review (primary outcome, 28 studies, n = 6,851) found similar, reporting a minimal impact for one AKI criteria alone (Acute Kidney Injury Network: risk ratio 0.76 [0.57-1.0]). 202,203 In contrast, another RCT (the RenalRIPC study) reported reductions in CSA-AKI and major adverse kidney events with RIPC compared with a sham intervention (AKI: 38% v 53%, p = 0.02; major adverse kidney events: 14% v 25%, p = 0.03). ...
... The draw backs of using RFA described in the literature are as follows: iatrogenic thermal injury that can lead to biliary remodeling or strictures if no biliary stents are inserted, perforation, vessel injury with secondary liver ischemia especially for proximal cholangiocarcinomas (early after the procedure), and/or hemobilia (usually with a 4-week delay) [26]. ...
... Hence, a crystalloid bolus of 40% of the circulating blood volume (or 66% of the circulating plasma volume) within 1 hour of presentation to the ED should be reconsidered. [6][7][8] Deeper understanding of the underlying complex pathology (like primary and secondary organ dysfunction, the often-impaired cardiac function and the pronounced venous vasoplegia) has raised concerns about the validity of evidence base of the mandatory 30 mL/kg crystalloid resuscitation. [9][10][11][12][13] To the best of our knowledge, no systematic review has been published in either emergency or prehospital settings investigating the optimal rate/ volume of fluid resuscitation for adult patients screened positive for sepsis. ...
... Only few studies have evaluated the long-term complication risks of TPBS [22,23] or pancreatic sphincterotomy (PS) when PS was performed to gain the access to PD [24,25]. As stated in a recent meta-analysis, long-term follow-up studies in TPBS are lacking [13]. ...