Hong Wang's research while affiliated with Wenzhou Medical University and other places

Publications (73)

Article
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RNA structure plays a crucial role in gene regulation, in RNA stability and the essential biological processes. RNA secondary structure (RSS) motifs are the basic building blocks for investigating the biological mechanisms of structure. Here, we present a strategy for structural motif-based dynamic alignment, namely, RNA secondary-structural motif-...
Article
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Introduction Enterocytozoon bieneusi ( E. bieneusi ) Microsporidia can cause opportunistic infections in immunocompromised patients and is also an emerging disease in these individuals. Its clinical manifestations are chronic diarrhea and severe wasting syndrome, these can be extremely debilitating and carry a significant risk of death for immunoco...
Article
FLQY2 is a camptothecin derivative modified by FL118 and proved to be good antitumor activity in vitro. However, its poor solubility leads to the low therapeutic efficacy in vivo. Here, the injectable FLQY2 lyophilized powder was prepared with Kolliphor® HS 15 (HS 15), which was called HS 15-FLQY2. The preparation process of HS 15-FLQY2 was optimiz...
Preprint
High myopia (HM) is one of the leading causes of visual impairment and blindness worldwide. Here, we report a whole-exome sequencing (WES) study in 9,613 HM cases and 9,606 controls of Han Chinese ancestry to pinpoint HM-associated risk variants. Single-variant association analysis identified three novel genetic loci associated with HM, including a...
Article
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Background 7-p-trifluoromethylphenyl-FL118 (FLQY2) is a camptothecin analog with excellent antitumor efficacy against various solid tumors. However, its poor solubility and low bioavailability limited the development of the drug. Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus ® ), an emerging carrier for prepa...
Article
A visible‐light‐promoted radical tandem reaction of N‐arylsulfonyl‐acrylamides with α‐oxocarboxylic acids is described. It undergoes decarboxylation, Smiles rearrangement, and intramolecular cyclization under mild reaction conditions, providing a series of arylacylated oxindoles with potential pharmacological activities. Various arylacylated oxindo...
Article
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Chromatin regulators (CRs) regulate the gene transcription process through combinatorial patterns, which currently remain obscure for pan-cancer. This study identified the interaction of CRs and constructed CR-CR interaction networks across five tumor cell lines. The global interaction analysis revealed that CRs tend to function in synergistic. In...
Article
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The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic activity is one of the important inducements for bacteria to develop drug resistance. Bacteria gain drug resistance through spontaneous mutation so as to achieve the goals of survival and reproduction. Quorum sensing (QS) is an intercellular communication...
Article
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Chrysomycin A, a compound derived from marine microorganisms, proved to have a specific great in vitro inhibitory effect on methicillin-resistant Staphylococcus aureus (MRSA). It exhibits high safety for the skin, as well as a better therapeutic effect than the current clinical drug, vancomycin. Nevertheless, its poor water solubility highly limits...
Article
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Background: N6-methyladenosine (m6 A) plays an essential role in tumorigenesis and cancer progression. Long noncoding RNAs (lncRNAs) are discovered to be important targets of m6 A modification, and they play fundamental roles in diverse biological processes. However, there is still a lack of knowledge with regards to the association between m6 A a...
Article
A metal‐free and mild cascade reaction of acryloylbenzamides with carboxylic acids and α‐imino oxy acid is developed. It undergoes decarboxylation, radical addition, and intramolecular cyclization in the presence of visible light, providing 4‐substituted‐isoquinoline‐1,3(2H,4H)‐diones in moderate to good yields. A visible light‐promoted cascade rea...
Article
Fourteen 20(S)-substituted FL118 hybrids coupled with non-steroidal anti-inflammatory drugs (NSAIDs) or amino acids (AA) were synthesized and characterized. Most of them exhibited excellent antitumor activity against the four types of human cancer cell lines (A549, HepG2, HeLa and HCT116) . FL118-NSAID derivatives(6a-6d) showed insoluble and lacton...
Article
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Micromonospora, one of the most important actinomycetes genera, is well-known as the treasure trove of bioactive secondary metabolites (SMs). Herein, together with an in-depth genomic analysis of the reported Micromonospora strains, all SMs from this genus are comprehensively summarized, containing structural features, bioactive properties, and mod...
Article
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Remote sensing image scene classification (RSISC) plays a vital role in remote sensing applications. Recent methods based on convolutional neural networks (CNNs) have driven the development of RSISC. However, these approaches are not adequate considering the contributions of different features to the global decision. In this paper, triplet-metric-g...
Article
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Irinotecan and Topotecan are two Camptothecin derivatives (CPTs) whose resistance is associated with the high expression of breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp). To reverse this resistance, two novel CPTs, FL77-28 (7-(3-Fluoro-4-methylphenyl)-10,11-methylenedioxy-20(S)-CPT) and FL77-29 (7-(4-Fluoro-3-methylphenyl)-10,11...
Article
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To investigate the Th1/Th2 cytokine profile in patients with lymphoma during the myelosuppression stage of infection. 52 patients with gram-negative bacterial infection (G- group), 49 patients with gram-positive bacterial infection (G+ group), 51 uninfected patients with lymphoma (uninfected group) and 20 healthy controls (healthy group) were enrol...
Article
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Background: Myopia is the most common visual impairment among Chinese children and adolescents. The purpose of this study is to explore key interventions for myopia prevalence, especially for early-onset myopia and high myopia. Methods: Univariate and multivariate analyses were conducted to evaluate potential associations between risk factor exposu...
Article
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An accumulating body of research indicates that long-noncoding RNAs (lncRNAs) regulate the target genes and act as competitive endogenous RNAs (ceRNAs) playing an indispensable role in lung adenocarcinoma (LUAD). LUAD is frequently accompanied by the feature of chromosomal instability (CIN); however, CIN-related ceRNAs have not been investigated ye...
Article
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Human papillomavirus (HPV) is a common virus, and about 5% of all cancers worldwide is caused by persistent high-risk HPV infections. Here, we reported a comprehensive analysis of the molecular features for HPV-related cancer types using TCGA (The Cancer Genome Atlas) data with HPV status. We found that the HPV-positive cancer patients had a unique...
Article
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Target detection in hyperspectral images (HSIs) aims to distinguish target pixels from the background using knowledge gleaned from prior spectra. Most traditional methods are based on certain assumptions and utilize handcrafted classifiers. These simple models and assumptions’ failure restrict the detection performance under complicated background...
Article
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Convolutional neural networks (CNNs) have been widely used in remote sensing (RS) scene classification tasks due to their remarkable feature representation and inference capability. The complexity of RS images not only brings the challenges of high inter-class similarity and large intra-class diversity, but also introduces the problem that category...
Article
Modern object detection for aerial images requires numerous annotated data. However, the data annotation process inevitably introduces noise due to the bird's eye view perspective of aerial images and the professional requirements of annotations. While recent noise-robust object detection methods achieved great success, the noise side effect during...
Article
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Endophytic fungi are one of prolific sources of bioactive natural products with potential application in biomedicine and agriculture. In our continuous search for antimicrobial secondary metabolites from Fusarium oxysporum R1 associated with traditional Chinese medicinal plant Rumex madaio Makino using one strain many compounds (OSMAC) strategy, tw...
Article
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Background Myopia is the most common visual impairment in children and adolescents worldwide. This study described an economical and effective population-based screening pipeline and performed the project of a million scale children and adolescents myopia survey (CAMS), which will shed light on the further study of myopia from the level of epidemio...
Article
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Cystatin E/M (CST6), a representative cysteine protease inhibitor, plays both tumor-promoting and tumor-suppressing functions and is pursued as an epigenetically therapeutic target in special cancer types. However, a comprehensive and systematic analysis for CST6 in pan-cancer level is still lacking. In the present study, we explored the expression...
Article
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This real-world, observational study aimed to assess and compare the clinical efficacy and safety of eltrombopag with recombinant human thrombopoietin (rhTPO) in the treatment of chemotherapy induced thrombocytopenia (CIT) in patients with lymphoma. One hundred and fifty-three patients who experienced grade 3 or 4 thrombocytopenia after chemotherap...
Article
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Image dehazing algorithms based on dark channel prior principle have achieved good results for most scenes. However, the popular dark channel prior tends to underestimate transmissions of bright areas or objects, such as the skies, white areas and self-luminous bodies, which may cause color distortions during dehazing. A complementary prior called...
Article
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Numerous studies have demonstrated that lncRNAs could compete with other RNAs to bind miRNAs, as competing endogenous RNAs (ceRNAs), to regulate each other. On the other hand, ceRNAs were found to be recurrently dysregulated in cancer status. However, limited studies considered the upstream epigenetic regulatory factors that disrupted the normal co...
Article
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Background Chrysomycin A (CA) has been reported as numerous excellent biological activities, such as antineoplastic and antibacterial. Though, poor solubility of CA limited its application in medical field. Due to good amphiphilicity and potential anticancer effect of disodium glycyrrhizin (Na2GA) as an excipient, an amorphous solid dispersion (Na2...
Article
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COVID-19 quarantine provides the largest intervention data of myopia progression in schoolchildren. We found grade is an important risk factor, and COVID-19-induced modifications of student's online time and outdoor activity time sufficiently change myopia progression.
Article
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Polarization modulation imaging technology plays an important role in microscopic super-resolution imaging. However, the specimen medium contains retardancy, while charge-coupled devices may provide discrete under-sampling, and the coupled wavefronts consisting of the polarization state of the light and the anisotropic distribution of the specimen...
Article
Transcriptional regulation is associated with complicated mechanisms including multiple molecular interactions and collaborative drive. Long noncoding RNAs (lncRNAs) have highly structured characteristics and play vital roles in the regulation of transcription in organisms. However, the specific contributions of conformation feature and underlying...
Preprint
Full-text available
Background: Chrysomycin A (CA) has been reported as numerous excellent biological activities, such as antineoplastic and antibacterial. Though, poor solubility of CA limited its application in medical field. Due to good amphiphilicity and potential anticancer effect of disodium glycyrrhizin (Na2GA) as an excipient, an amorphous solid dispersion (Na...
Article
Full-text available
Chrysomycin A is one of the valuable drug leads used to treat infectious diseases such as tuberculosis and methicillin-resistant Staphylococcus aureus. In order to increase its yield, this work firstly focuses on optimization of fermentation conditions and medium compositions of a wild-type chrysomycin A-producing strain Streptomyces sp. 891 from m...
Preprint
Full-text available
Background High prevalence of myopia of adolescent has been a global public health concern. Their risk factors and effective prevention methods for myopia across schoolchildren developmental stages are critically needed but remain uncertain due to the difficulty in implementing intervention measurements under normal life situation. We aimed to stud...
Article
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PurposeCase reports suggest that ruxolitinib-containing treatment could increase the clinical response rate of patients with hemophagocytic syndrome (HPS). This study aimed to explore the effect of ruxolitinib-containing treatment for patients with lymphoma-associated hemophagocytic syndrome (LAHS).Methods This was a retrospective study of patients...
Article
Background: Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to significant mortality. Cyclocarya paliurus is a tree, the leaves of which are often utilized to prevent and treat diabetes mellitus. Whether C. paliurus leaves can prevent or treat DCM, however, it remains to be formally assessed. The present study was...
Article
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Recent studies have shown that structuralized long non-coding RNAs (lncRNAs) play important roles in genetic and epigenetic processes. The spatial structures of most lncRNAs can be altered by distinct in vivo and in vitro cellular environments, as well as by DNA structural variations, such as single-nucleotide polymorphisms (SNPs) and variants (SNV...
Article
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Noncoding RNAs (ncRNAs), especially microRNA (miRNA) and long noncoding RNA (lncRNA), have an impact on a variety of important biological processes during colon adenocarcinoma (COAD) progression. This includes chromatin organization, transcriptional and posttranscriptional regulation, and cell-cell signaling. The aim of this study is to identify th...
Article
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Autophagy is a self-degradation process that maintains homeostasis against stress in cells. Autophagy dysfunction plays a central role in the development of tumors, such as colorectal cancer (CRC). In this study, autophagy-related differentially expressed genes, their downstream functions, and upstream regulatory factors including RNA-binding prote...
Article
Background: IMpower 133 trial first confirmed the efficacy and safety of adding atezolizumab or placebo to first-line treatment with chemotherapy in patients with extensive-stage small-cell lung cancer (SCLC). While, overprice limited its broad use in clinical. The aim of this study was to evaluate the cost-effectiveness of atezolizumab plus chemo...
Article
Purpose: To determine the changes of the microvasculature and microstructure in the inner intra-retinal layers in systemic lupus erythematosus (SLE) patients without lupus retinopathy (LR). Methods: Thirty-two SLE patients (58 eyes) without LR (NLR), 14 patients (22 eyes) with LR and 50 healthy subjects (50 eyes) were enrolled. Spectral domain o...
Article
Glioblastoma multiforme (GBM) is a refractory tumor with poor prognosis and requires more effective treatment regimens. It has been confirmed that long noncoding RNAs (lncRNAs) substantially regulate various human disease including GBM. However, the biological roles and its underlying molecular mechanisms still need to be further investigated. In t...
Article
The recent extensive application of next-generation sequencing has led to the rapid accumulation of multiple types of data for functional DNA elements. With the advent of precision medicine, the fine-mapping of risk loci based on these elements has become of paramount importance. In this study, we obtained the human reference genome (GRCh38) and th...
Article
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Blind deconvolution is a highly ill-posed problem for the restoration of degraded images and requires prior knowledge or regularization. Recently, various priors have been proposed and the models based on these priors have achieved state-of-the-art performances. In this paper, we present a blind image deblurring method based on a computationally ef...
Article
GF-(Gaofen- means high resolution in Chinese) satellite launched in 2015 is the first geosynchronous orbit remote sensing satellite in China. To evaluate the on-orbit modulation transfer function (MTF) of the space-borne panchromatic camera in GF-4, a modified pulse target is proposed. This new type target is laid in the uniform low-reflection back...
Article
Two new compounds, including a diterpenoid glycoside (1) and a triterpenoid glycoside (6), along with six known compounds were isolated from Clinopodium chinense. The structures of the new compounds were determined on basis of extensive spectral analysis and chemical method. Compounds 1–8 were evaluated for their insulin resistance effect and cytot...
Article
The spatial position and interaction of drugs and their targets is the most important characteristics for understanding a drug's pharmacological effect, and it could help both in finding new and more precise treatment targets for diseases and in exploring the targeting effects of the new drugs. In this work, we develop a computational pipeline to c...
Article
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We aimed to characterize the clinical significance of epigenetic loss of death-associated protein kinase (DAPK) gene function through promoter methylation in the development and prognosis of lymphoma. PubMed, Web of Science and ProQuest databases were searched for relevant studies. Twelve studies involving 709 patients with lymphoma were identified...
Chapter
In this paper, we focus on the feature pooling methods for scene character recognition. We research three kinds of pooling methods: the average (sum) pooling, max pooling and weighted-based pooling methods. Specifically, various feature pooling methods are introduced, their merits and demerits are studied, and existing problems are discussed. Final...
Article
An increasing number of functional studies shows that long noncoding RNAs (lncRNAs) are involved in many aspects of cellular physiology and fulfills a wide variety of regulatory roles at almost every stage of gene expression. A major feature of lncRNAs is the highly folded modular domains in transcripts. With improved modeling and definition, it is...
Conference Paper
In this paper, we focus on the feature representation methods under the framework of bag-of-words model (BoW) for scene character recognition. We investigate three kinds of methods: the original BoW methods, the stroke-based methods, and the context-based methods. Specifically, various feature representation methods are introduced, their merits and...
Article
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Image fusion technology involves the use of complementary information from multiple sensors to generate a composite image that can highlight details in the region of interest. Some recent methods have tackled the problem of characterization of different source image features that are lacking in conventional methods. However, during fusion processin...
Article
Colorectal cancer (CRC) is a common malignant tumor of the digestive tract occurring in the colon, which mainly divided into adenocarcinoma, mucinous adenocarcinoma, and undifferentiated carcinoma. However, autophagy is related to the occurrence and development of various kinds of human diseases such as cancer. There is little research on the relat...
Article
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Recent evidence has suggested that competitive endogenous RNAs (ceRNAs) are important regulatory molecules in clear cell kidney carcinoma (KIRC) and their dysregulation may contribute to cancer pathogenesis. However, the critical roles of dysregulated ceRNAs in KIRC remain unknown. In the present study, a KIRC dysregulated ceRNA‑ceRNA network (KDCC...
Article
Driven by the rapid growth of communication technologies and the wide applications of intelligent mobile terminals, the scene character recognition has become a significant yet very challenging task in people’s lives. In this paper, we design a novel feature representation scheme termed consecutive convolutional activations (CCA) for character reco...
Article
A rich and robust representation for scene characters plays a significant role in automatically understanding the text in images. In this letter, we focus on the issue of feature representation, and propose a novel encoding method named bilateral convolutional activations encoded with Fisher vectors (BCA-FV) for scene character recognition. Concret...
Article
Two new flavonoid-triterpene saponin meroterpenoids, clinoposides G (1) and H (2) were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. Their structures were elucidated through spectroscopic and electronic circular dichroism (ECD) analyses. Compounds 1 and 2 were evaluated for their protective effects against anoxia/reoxyg...
Article
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Driven by the rapid development of digital imaging and network technologies, the opinion-unaware blind image quality assessment (BIQA) method has become an important yet very challenging task. In this paper, we design an effective novel scheme for opinion-unaware BIQA. We first utilize the convolutional maps to select high-contrast patches, and the...
Article
Characters, as a kind of symbols carrying rich semantic information, are composed of strokes arranged in a certain structure and are of great significance in our daily life. In this paper, we are concerned with the problem of scene character recognition, and study the problem from the perspective of feature representation. We propose a novel poolin...
Article
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The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. RNA-sequencing studies in mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (lncRNA). LncRNAs now have been s...
Article
Feature representation, as a key component of scene character recognition, has been widely studied and a number of effective methods have been proposed. In this letter, we propose the novel method named coupled spatial learning (CSL) for scene character representation. Different from the existing methods, the proposed CSL method simultaneously disc...
Article
LncRNAs fulfill a wide range of regulatory functions at almost every process of gene expression. While derived from secondary structural features, lncRNAs may function as landing pads for transcription factors (TFs). In this paper, we detected the global structural landscape of 20,338 lncRNAs by utilizing a thermodynamic model, and identified the l...
Article
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As a regulator of coagulation, abnormal Protein Z (PZ) expression may lead to the formation of blood clots in humans. While previous studies have shown that PZ protein is altered in several types of cancer, however, additional observations are needed to understand the complex biology involved. Herein, we investigated local alterations in PZ express...
Article
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Inflammation contributing to the underlying progression of diverse human cancers has been generally appreciated, however, explorations into the molecular links between inflammation and cancer in esophagus are still at its early stage. In our study, we presented a functional module-based approach, in combination with multiple data resource (gene exp...
Article
NK/T cell lymphoma (NKTCL) is a rare type of non-Hodgkin's lymphoma, occurs more frequently in Asia and Latin America. In China, NKTCL accounts for 30.1% in T-NHL and is highly related with EBV (Epstein-Barr virus) infection. This disease is highly aggressive, not sensitive to chemotherapy, with poor prognosis. The mean survival time is about 12-38...
Article
Promoted by diethyl azodicarboxylate, a novel and highly stereoselective synthesis of cis-β-enaminones via oxidative dehydrogenation and hydration of the substituted propargylamines was realized. The possible mechanism was also proposed.

Citations

... Among the QS mentioned above, the las system is at the top of the QS hierarchy and is required for optimal activation of the rhl and pqs systems QS. The las system includes two proteins, LasI (synthase) and LasR, while the rhl system includes the proteins RhlI (synthase) and RhlR [59]. Another example is the phytopathogenic soil bacterium Agrobacterium tumefaciens, which uses the determinants of the QS system belonging to the LuxR/LuxI class. ...