Hong-Mei Ma's research while affiliated with First Affiliated Hospital of China Medical University and other places

Publications (5)

Article
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Hepatocyte nuclear factor 4 alpha (HNF4A) is a transcriptional factor which plays an important role in the development of the liver, kidney, and intestines. Nevertheless, its role in cervical cancer and the underlying mechanism remain unknown. In this study, both immunohistochemistry and western blotting revealed that the expression of HNF4A was do...
Article
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The leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is considered to be a stem cell marker in many normal tissues and promotes tissue development, regeneration, and repair. LGR6 is also related to the initiation and progression of some malignant tumors. However, the role of LGR6 in cervical cancer has not been reported. Here, imm...
Article
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Hexokinase 2 (HK2) is a member of the hexokinases (HK) that has been reported to be a key regulator during glucose metabolism linked to malignant growth in many types of cancers. In this study, stimulation of HK2 expression was observed in squamous cervical cancer (SCC) tissues, and HK2 expression promoted the proliferation of cervical cancer cells...
Article
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NF-YA is considered as a crucial regulator for the maintenance of cancer stem cell (CSC) and involved in various types of malignant tumours. However, the exact function and molecular mechanisms of NF-YA in the progression of cervical cancer remains poorly understood. Here, the expression of NF-YA detected by immunohistochemistry was gradually incre...
Article
Full-text available
HOXA5 is considered a regulator involved in embryonic development and cellular differentiation and a tumor suppressor. Nevertheless, its biological role in cervical carcinoma is still unclear. In the present study, immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions deepened. Ectopic expression of...

Citations

... Moreover, HK2 was reported to be facilitate for cell proliferation and tumor formation, such as cervical cancer [23,24], gallbladder cancer [25], diffuse large B-cell lymphoma [26], gastric cancer [27], hepatocarcinoma [28] and so on. Consistently, in this study, exogenously expressed of HK2 also promoted cell growth in human ovarian cancer cells by accelerating cell cycle progression (up-regulated the expression of cell cycle-related factors, like cyclin A1, cyclin D1 and cyclin E1). ...
... Khan M.A et al. revealed that TP53 has an association with cervical cancer pathogenesis [53]. NFYA promoted cell proliferation and tumorigenic properties by transcriptional activation of SOX2 in cervical cancer [54]. The E2F1 protein is considered as a potential biomarker for CC [55]. ...
... Consistent with our findings, the overexpression of Hoxa5 in cervical cancer markedly inhibited cell proliferation through protein p27 and kinase B [40]. In cervical cancer, Hoxa5 inhibited the proliferation and tumor formation through repression the activity of Wnt/β-catenin pathway [41]. However, other studies have reported that knockdown of Hoxa5 suppressed the esophageal squamous cell carcinoma (ESCC) cell proliferation, which might be partly mediated via interfering with Wnt/β-catenin signaling pathway [42]. ...