Homayoun Sheikholeslami’s research while affiliated with Qazvin University of Medical Sciences and other places

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Publications (12)


Trace elements and bone mineral density in pre- and postmenopausal women
  • Conference Paper

May 2011

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11 Reads

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1 Citation

Homayoun Sheikholeslami

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Mahmood Gharbavi

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Kamilia Kani

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Trace elements and bone mineral density in pre- and postmenopausal women

April 2011

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26 Reads

Introduction: In postmenopausal women the rate of bone remodeling increases. Trace elements are known to influence bone metabolism. The aim of the study was to assess serum concentrations of some elements in pre- and postmenopausal women with and without osteopenia. Methods: Serum concentrations of magnesium, copper, cadmium and vanadium were measured by inductively coupled plasma atomic emission spectroscopy in 51 postmenopausal women (19 women with osteopenia and 32 with normal bone mineral density) and 29 age- and BMI-matched premenopausal women (12 women with osteopenia and 17 with normal bone mineral density). The diagnosis of osteopenia was based on assessment of bone mineral density (BMD) at the spine and proximal femur by dual-emission X-ray absorptiometry. Results: Mean concentration of vanadium was significantly higher in postmenopausal than in premenopausal women. In addition, magnesium, copper and cadmium concentrations in postmenopausal women were lower than in premenopausal women, but with no significant differences. There were no statistically significant differences observed between the osteopenic and normal pre- and postmenopausal women with respect to magnesium, copper, cadmium and vanadium levels. In premenopausal women the serum level of copper was positively correlated with the T-score at the femoral neck and with the BMI. Conclusion: The consequences of changes in bone turnover can be detected by increased levels of bone biomedical markers. Vanadium accumulates in bone, though its role on bone quality is not clear. Serum vanadium level might be a marker of bone turnover and its serum level may reflect processes related to bone resorption. Copper plays an important role in bone development in part due to its role as cofactor for various enzymes (lysyl oxidase and superoxide dismutase) required for the synthesis or modification of bone matrix. The results of study provide more evidence of a correlation between copper status and osteopenia.



P0620 THYROID FUNCTION ABNORMALITIES IN PATIENTS WITH DIFFERENT SEVERITY OF LIVER CIRRHOSIS ACCORDING TO THE CHILD-PUGH CLASSIFICATION SYSTEM
  • Article
  • Full-text available

May 2009

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27 Reads

European Journal of Internal Medicine

Homayoun Sheikholeslami

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Farzaneh Minou

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[...]

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Repetition of Suicide-Related Behavior: A Study of the Characteristics, Psychopathology, Suicidality and Negative Life Events in Iran

February 2009

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70 Reads

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9 Citations

The International Journal of Psychiatry in Medicine

Repetition of suicide-related behavior (SRB) is a risk factor for further suicidal behavior and death. The purpose of this study was to compare characteristics of patients with and without repeated episodes of SRB to determine whether characteristics of suicide attempt, psychopathology, and psychiatric comorbidity differ between groups, and if specific aspects of core suicidality may help guide screening of individuals at risk of further suicidal behaviors. Thirty-five patient with repeated episodes of SRB and 49 with a single episode who came to the emergency room of two Qazvin referral hospitals after an episode of SRB were compared on demographic and background characteristics, the circumstances of the suicide attempts, levels of suicidality (i.e., ideation), and psychological characteristics. Patients with repeated episodes were more depressed, hopeless, and impulsive, had higher scores on factors associated with expected outcome and planning activities of the Suicide Intent Scale. They displayed greater suicidality, psychiatric comorbidity, and reported more negative life events, dissatisfaction with life, and poorer perceive social support. Some of the characteristics of patients with repeated suicide-related behavior propose major clinical challenges that should be addressed in an endeavor to reduce suicide risk.


Attempted Suicide Among Iranian Population

September 2008

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44 Reads

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29 Citations

Suicide and Life-Threatening Behavior

Predictors of suicide attempts in Iran, to distinguish any similarities and differences of these predictors between suicide attempts in Iran and other developed and developing countries and to investigate the relation between general psychiatric symptoms and repetition of suicidal attempts were assessed. The validated Farsi version of the General Health Questionnaire-28 (GHQ-28) was used to assess multiple dimensions of quality of life of suicide attempters as depression, anxiety, social dysfunction, and somatic symptoms. Pivotal differences emerged in the clinical profiles of suicide attempters living in a developing country versus developed countries. In developing countries, those who attempt suicides are more likely to have no psychiatric disorder and are less likely to have used alcohol as part of the suicide attempt, but are more likely to have been assaulted physically or verbally. The results on the GHQ-28 indicate that the process through which individuals move from suicidal thought to action may decrease multiple dimensions of quality of life.


Insulin resistance in patients with polycystic ovary syndrome and idiopathic hirsutism

May 2008

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15 Reads

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3 Citations

Objectives: Hirsutism is a common clinical condition in women during reproductive age and characterized by excessive growth of terminal hair in the androgen-sensitive skin regions. Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) account for most of the cases of hirsutism. Insulin resistance and hyperinsulinemia have been demonstrated in women with PCOS and IH. We intended to investigate the degree of insulin resistance in women with PCOS compared to weight-matched women with IH. Methods: Thirty women with PCOS (mean age, 31.2±3.7 years; body mass index (BMI), 23.3±2.1 kg/m2) and 38 women with IH (mean age, 25.0±5.1 years; BMI, 24.9±3.4 kg/m2) were included in the study. The presence of insulin resistance was investigated by using basal insulin levels, the oral glucose tolerance test, and the homeostasis model assessment (HOMA) score in both groups. Written informed consent was obtained after the procedure had been fully explained. Results: Patients with PCOS had significantly (P<0.05) higher basal insulin levels (26.9±6.1 vs 10.8±6.5 mU/l), HOMA scores (6.3±1.3 vs 2.3±1.7) and FBS (95.4±8.2 vs 82.4±8.9 mg/dl) than patients with IH. Twenty-seven normal-weighted patients (90%) with PCOS and 10 (26.3%) normal-weighted women with IH had HOMA scores of greater than 2.5. Six patients (20%) with PCOS and 2 women with IH (5.3%) had impaired glucose tolerance. Conclusion: PCOS and IH are associated with insulin resistance independent of total body mass. In women with PCOS, insulin resistance appears more common in both obese and non-obese women compared to women with IH. Hyperinsulinemia appears to play a key pathogenic role in the ovarian androgen overproduction, because of the stimulatory effect of insulin on ovarian steroid production.


Autoantibodies to thyroid peroxidase and hypothyroidism in patients with type 1 diabetes

May 2008

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22 Reads

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1 Citation

Objective: Genetic susceptibility to autoantibody formation in association with autoimmune thyroid disease and type 1 diabetes mellitus has been described with varying frequencies. We have, therefore, investigated the prevalence of anti-thyroid peroxidase (anti-TPO), overt and subclinical hypothyroidism in type 1 diabetic patients. Methods: Sixty-five subjects with type 1 diabetes mellitus and 65 unrelated normal controls were recruited for the detection of anti-TPO and Thyroid-stimulating hormone (TSH). Written informed consent was obtained after the procedure had been fully explained. Results: Among 65 type 1 diabetic patients, 18 (27.7%) were positive for anti-TPO and 18 (27.7%) had abnormal serum TSH level. Among these patients 11 (16.0%) had overt hypothyroidism and 7 (10.8%) had subclinical hypothyroidism. Compared with those without thyroid autoimmunity, there was a female preponderance for the type 1 diabetic patients with thyroid autoimmunity (female:male, 24:23 vs 11:7 respectively). Patients with thyroid antibodies were older, had a longer duration of diabetes (17.6±9.3 vs 10.8±7.8 years), and developed diabetes later in life than those without antibodies. The mean anti-TPO levels were higher in patients with overt hypothyroidism (238.18±223.69 U/ml) than in patients with subclinical hypothyroidism (36.38±22.46 U/ml). Among 11 patients with overt hypothyroidism 9 (81.1%) had abnormal anti-TPO levels, whereas positive anti-TPO were detected in 57% of patients (4:7) with subclinical hypothyroidism. Conclusion: The presence of anti-TPO in 27.7% of our type 1 diabetic patients confirmed the strong association of autoimmune thyroid disease and type 1 diabetes mellitus. For early detection of autoimmune thyroid disease in patients with type 1 diabetes mellitus, measurement of anti-TPO and TSH preferably at type 1 diabetes mellitus onset is recommended.


Celiac disease in patients with type 1 diabetes mellitus.

Objective: This study has been conducted to evaluate the prevalence of Celiac Disease in type1 diabetic patients and to prefer an efficient strategy for diagnosing Celiac Disease using IgA-class tissue transglutaminase in this population. Methods: sixty consecutive adult patients with type1 diabetes were screened for celiac disease. The mean age of patients was 28±6.8 years old. There were 38 females and 22 males. For the screening of celiac disease, we used IgA-class antigliadin antibodies (IgA-AGA) and IgA-class tissue transglutaminase antibodies (IgA-tTG). Those were found to be tTG-positive and/or AGA-positive investigated further with distal duodenal or proximal jejunal biopsy. Results: Among 60 patients with type 1 diabetes, 3.3% (2/60) were found to be tTG-positive and 23.3% (14/60) had AGA levels above the normal. Intestinal biopsy was performed in 10 patients, (2 tTG /AGA-positive, 1 tTG-negative/AGA- positive and 7 tTG -negative/AGA-negative). Of the biopsies, 1 revealed villous atrophy (Type IIIc). The mean duration of diabetes in patients with the positive versus the negative tTG-IgA was 6±2.4 year versus 11.6±4.7 year respectively. The sensitivity and specificity of tTG-IgA test was 100% and 89%, respectively. Prevalence of biopsy-proven celiac disease was 1.6% (95% CI, 1.2-2). Conclusion: Serological screening for celiac disease in type 1 diabetes is important because many patients are asymptomatic and most are detected by the screening. A combination of AGA-IgA and tTG-IgA tests for Celiac Disease screening can not improve the sensitivity and specificity as compared to tTG-IgA test alone. Thus, tTG-IgA test alone may be considered as a valuable diagnostic tool for Celiac Disease screening.


Polycystic Ovary Syndrome (PCOS): Insulin resistance and Hyperandrogenism

November 2007

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28 Reads

Objective: It has been estimated that 20-40% of PCOS women have insulin resistance (IR), impaired glucose tolerance and increases in fasting insulin levels. The aim of the study was to compare insulin resistance and hyperandrogenism between the patients with PCOS and age and the body mass index (BMI) matched healthy controls. Methods: Thirty consecutive patients with PCOS and thirty, age and BMI matched healthy control women were included in the study. Blood samples were obtained for luteinizing hormone, dehydroepiandrosterone-sulfate, free testosterone, prolactin, insulin, and fasting glucose levels. Insulin resistance was estimated by fasting insulin level and fasting glucose/insulin ratio. Results: Free testosterone, dehydroepiandrosterone-sulfate and luteinizing hormone levels were significantly higher in patients with PCOS compared to the control women (P=0.004, P=0.005 and P<0.001, respectively). Fasting glucose/insulin ratio was significantly lower in the PCOS group compared to the controls (P=0.002). In the cases with PCOS compared to the controls the mean free testosterone (P=0.063 and P=0.029), dehydroepiandrosterone-sulfate, fasting glucose and insulin were higher than controls (3.7±1.0 vs 1.3±0.7, P<0.001, 95% CI=1.9-2.8), (5.4±0.7 vs 4.1±2.0, P=0.003, 95% CI=0.5-2.1), (95.4±8.3 vs 86.9±10.5, P= 0.001, 95% CI=3.6-13.4) and (26.9±6.0 vs 19.5±3.1, P<0.001, 95% CI=4.9-9.9) respectively. Cases with PCOS also had higher infertility rate (P=0.01), hirsutism (P<0.001) and oligo-anovulation (P<0.001) than controls. Conclusions: The high insulin levels associated with IR increase ovarian androgens and increase LH secretion, that all disrupt ovulation. Therefore IR can provide an explanation for hyperandrogenic chronic anovulation for women with PCOS.


Citations (4)


... The results of current study showed that FPG was positively correlated with anti-TPO, which in agreement with Homayoun et al. (2008). T1DM is an autoimmune disorder that results from immune destruction of pancreatic beta cells (Voltarelli et al.,2007) . ...

Reference:

Early detection of type 1 diabetes mellitus using Anti-Glutamic Acid Decarboxylase and Anti-Thyroid Peroxidase
Autoantibodies to thyroid peroxidase and hypothyroidism in patients with type 1 diabetes
  • Citing Conference Paper
  • May 2008

... Patients who had repeated attempts in their history are not only more likely to suffer from depression instead of another psychiatric disorder, but seem to have higher depression scores than patients who had a single attempt (Mendez-Bustos et al., 2013). In this study, females but not males with multiple attempts in their history were found to be more depressed compared to females with a single attempt in agreement with other studies which showed that increased depression scores associate with repetition of suicide attempts (Andover et al., 2007;da Silva Cais et al., 2009;Groholt et al., 2006;Scoliers et al., 2009;Sheikholeslami et al., 2009). Our results are in accordance with the study of Monnin et al. (2012), who showed that more severe depressive symptoms constitute a significant risk factor for reattempt in women but not in men. ...

Repetition of Suicide-Related Behavior: A Study of the Characteristics, Psychopathology, Suicidality and Negative Life Events in Iran
  • Citing Article
  • February 2009

The International Journal of Psychiatry in Medicine

... This stands in stark contrast to observations made in advanced countries, where around 90% of individuals dead by suicide have been diagnosed with a psychiatric disorder [15]. Conversely, AUD represents a significant and escalating issue in developing regions, seemingly unrelated to suicidal behavior [16][17][18]. ...

Attempted Suicide Among Iranian Population
  • Citing Article
  • September 2008

Suicide and Life-Threatening Behavior