Hiroyuki Sagesaka's research while affiliated with Aizawa Hospital and other places
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Publications (3)
Background/objectives:
It has been unknown if attenuated insulin sensitivity (Si) in non-alcoholic fatty liver disease (NAFLD) is a cause or a result. We examined the impact of attenuated Si on NAFLD evolution.
Subjects/methods:
We observed 4856 NAFLD- and diabetes-free participants for a mean 2.9 years. Si was indexed by single point insulin se...
Aims
To compare impact of elevated HbA1c and fasting plasma glucose (FPG) on incident chronic kidney disease (CKD) in a non-diabetic cohort.
Methods
Data from diabetes- and CKD-free 25,109 health examinees were retrospectively analysed with a mean observation period of 5.3 years. Prediabetes was diagnosed by the ADA and WHO criteria, and CKD by es...
Purpose
We aimed to clarify the onset of diabetes.
Methods
Data from 27,392 non-diabetic health examinees was retrospectively analyzed for a mean of 5.3 years. Trajectories of fasting plasma glucose (FPG), body mass index (BMI) and the single point insulin sensitivity estimator (SPISE), an index of insulin sensitivity (Si), 10 years prior to diagn...
Citations
... Tomomichi Koshi showed that elevated HbA1c, but not FBG, could identify CKD risk in non-diabetic individuals. 34 Huang also suggested that HbA1c, not FBG or PBG, was independently associated with an increased risk of low-grade albuminuria in middle-aged and elderly Chinese individuals. 35 The above studies both used eGFR as a measure of CKD, while our study focused on UACR and people without CKD, which can be more precise in terms of responding to early renal impairment. ...
... Among these, the SPISE was developed as an easy and affordable tool for the evaluation of whole-body insulin sensitivity, which is comparable to clamp-derived M-value in sensitivity as well as specificity (19). Several studies have evaluated the SPISE in adult as well as juvenile populations (20,(41)(42)(43)(44)(45)(46). Correa-Burrows et al. assessed SPISE for its validity in diagnosing cardiometabolic risks, namely IR and metabolic syndrome, in post-pubertal Hispanic adolescents. ...
... Moreover, it has been reported that higher fasting plasma glucose levels can be observed at least 10 years before the diagnosis of T2DM. 191 Although migraine has been associated with some factors implicated in diabetes, such as obesity and insulin resistance, to date little is known about the relationship between migraine and T2DM. Interestingly, Fagherazzi et al. recently reported 59 a linear decrease in the prevalence of migraine during the 24 years prior to T2DM diagnosis. ...
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