Hiroyuki Kumamoto’s research while affiliated with Tohoku University and other places

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Publications (143)


Effects of antigen-induced arthritis and compressive mechanical stress on condylar head of mandible
  • Article

March 2025

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8 Reads

Journal of Oral Biosciences

Shinnosuke Nogami

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Kensuke Yamauchi




Intraoral view showing redness and swelling in the lingual site of the left mandibular molar area
PET/CT imaging showing increased FDG uptake in the lingual side of left mandibular molar area (arrowhead)
Histopathological finding from hematoxylin–eosin staining. A The figure containing NEC on the left, and SCC on the right, confirming oral cavity as the primary site (×40). B NEC showing proliferation of large-sized undifferentiated cells with eosinophilic cytoplasm and large nuclei (×400). C Comedonecrosis-like appearance (×400x). D SCC showing proliferation of atypical cells with squamous differentiation (×400)
Immunohistochemical reactivity of epithelial and squamous cell markers in NEC (A, C, E) and SCC (B, D, F) (×400). (A and B: cytokeratin (AE1/3), C and D: cytokeratin 20, E and F: p40)
Immunohistochemical reactivity of neuroendocrine markers in NEC (A, C, E, G) and SCC (B, D, F, H) (×400). (A and B: chromogranin A, C and D: synaptophysin, E and F: CD56, G and H: INSM1)

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Primary Oral Mixed Neuroendocrine–Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature
  • Article
  • Full-text available

February 2024

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58 Reads

Head and Neck Pathology

Mixed neuroendocrine–non-neuroendocrine neoplasms (MiNENs) are rare tumors recently characterized by the presence of both neuroendocrine and non-neuroendocrine components within the same tumor tissue. Although MiNEN found their place in the WHO classification for various organs, this composite tumor in the head and neck region remains exceptionally rare. We present a case of primary oral MiNEN in a 64-year-old male located on the left side of lower gingiva. Biopsy raised suspicion of neuroendocrine carcinoma (NEC) and the patient underwent partial mandibulectomy. The resected specimen showed two distinct components of NEC and squamous cell carcinoma (SCC) with the confirmation of immunohistochemical markers. There has been no sign of recurrence nor metastasis 6 years after the surgery. In addition, we have conducted a review of published cases with potential relevance to this entity, resulting in five cases. The diverse terminology reinforces the need for a standardized classification system of oral/head and neck MiNENs.

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Primary oral mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN): a rare case report and review of the literature

November 2023

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30 Reads

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare tumors recently characterized by the presence of both neuroendocrine and non-neuroendocrine components within the same tumor tissue. Although MiNEN found their place in the WHO classification for various organs, this composite tumor in the head and neck region remains uncharted. We present a case of primary oral MiNEN in a 64-year-old male located on the left side of lower gingiva. Biopsy raised suspicion of neuroendocrine carcinoma (NEC) and the patient underwent partial mandibulectomy. The resected specimen showed two distinct components of NEC and squamous cell carcinoma (SCC) with the confirmation of immunohistochemical markers. There has been no sign of recurrence nor metastasis 6 years after the surgery. In addition, we have conducted a review of published cases with potential relevance to this entity, resulting in 5 cases. The diverse terminology reinforces the need for a standardized classification system of oral/head and neck MiNENs.



A case of localized tenosynovial giant cell tumor in the temporomandibular joint顎関節に生じた限局型腱滑膜巨細胞腫の1例

May 2023

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2 Reads

Japanese Journal of Oral & Maxillofacial Surgery

Tenosynovial giant cell tumor (TSGCT) is a benign tumor that mainly affects the joints of the fingers and knees, and is considered to be extremely rare in the temporomandibular joint. In this report, we describe a case of localized TSGCT in the temporomandibular joint. The patient, a 48-year-old male, had been suffering from pain in the right temporomandibular joint and right ear for several years, and had been treated by a general practitioner based on a diagnosis of temporomandibular joint arthrosis. CT images showed a soft tissue shadow in the posterior portion of the right mandibular head, but there was no evidence of destruction of the surrounding tissue or mandibular head resorption. MR images showed a nodular lesion between the right-side mandibular head and external auditory canal with low-signal area on T1-weighted and T2-weighted images. Two years after the first admission, the patient underwent enucleation of the tumor, and a diagnosis of TSGCT was obtained by histopathological examination. Two years have passed since the surgery. The aperture has remained at 40 mm, with no evidence of recurrence.


Immunoexpression of SIRT1, 6, and 7 in oral leukoplakia and oral squamous cell carcinoma

May 2023

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20 Reads

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1 Citation

Odontology

Sirtuins (SIRTs) are a family of proteins involved in the metabolic process responsible for extending the lifespan. The role of SIRT1, 6, and 7 in oral squamous cell carcinoma (OSCC) and oral leukoplakia (OLP), one of its precursors, is still elusive. In this study, 82 OLP and 77 OSCC were immunohistochemically examined for SIRT1, 6, and 7. Stained sections were thoroughly scanned and evaluated using a digital image analysis program. The SIRT1, 6, and 7 expressions were detected in the nuclei of epithelial and carcinoma cells in various degrees. Afterward, any correlations among SIRTs, including associations with clinicopathological features and the Kaplan-Meier curves were analyzed. OSCC demonstrated significantly higher SIRT1 expression than OLP, while non-dysplastic lesions showed significantly higher SIRT6 expression than other lesions. A strong correlation was observed between SIRT6 and 7 in OLP, SIRT1 and 6 in in OSCC and in SIRT6 and 7 when all lesion types were considered. There were no significant differences between SIRTs reactivity and the clinical features in OLP. For OSCC, SIRT1 and 6 was found to be directly associated with site of the lesion, while SIRT7 showed a direct relationship between gender, stromal lymphocytic infiltration, and depth of the invasion. OSCC with high SIRT7 expression revealed a slightly lower survival probability, although not statistically significant (p = 0.1019). Our findings suggest that SIRT1, 6, and 7 may play correlated and diverse roles in the development and advancement of OSCC.



Citations (57)


... Genetic expression profiling of 34 HNSCC patients and TCGA database both revealed a significant upregulation of SIRT6 in the cancer group [107]. Furthermore, the mRNA and protein expression levels of SIRT6 were also found to be higher in OSCC tissues compared to noncancerous tissues [108]. As the direct target of miR-34a, down-regulation of SIRT6 replicated the pro-differentiation effects of miR-34a [109], thus playing a pivotal role in SCCs. ...

Reference:

Targeting histone deacetylases in head and neck squamous cell carcinoma: molecular mechanisms and therapeutic targets
Immunoexpression of SIRT1, 6, and 7 in oral leukoplakia and oral squamous cell carcinoma
  • Citing Article
  • May 2023

Odontology

... Joss and Vassalli (2009) found that patients with a low mandibular plane angle have increased vertical relapse, whereas patients with a high mandibular plane angle have more horizontal relapse; advancements in the range of 6-7 mm or more predispose to horizontal relapse. This could be explained by compressive mechanical stress on the anterior surface of the condyle head following mandible advancement, resulting in bone resorption in that region (Nogami et al., 2022). These advancements are usually associated with counterclockwise rotation of the OP in class II patients, with a high incidence of relapse, because the muscles of mastication are lengthened in the ramus area. ...

Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases
  • Citing Article
  • September 2022

... Stable isotope analysis showed that HM2-HA-3 had a similar diet to other individuals from the Hamanaka 2 site and other individuals from Hamanaka 2 site displayed little or no calculus deposition (Fig. 2). Abnormally high amounts of calculus deposition could occasionally be seen in modern patients, but the underlying cause is unidentifiable in most cases 55,56 . At least, this individual would not have a routine tooth cleaning habit during the period of calculus deposition. ...

A case of giant dental calculus in a patient with centronuclear myopathy
  • Citing Article
  • August 2022

Special Care in Dentistry

... The anatomical regions most affected by MOR are the posterior mandible and, when it is in soft tissue, the gingiva (1)(2)(3)(4)(5)(6). The clinical symptoms of MOR include pain, swelling, local bleeding due to ulceration and mass formation (4)(5)(6)(7). The predominant primary sites of MOR are the lung, breast and kidney (1,(4)(5)(6)(8)(9)(10)(11). ...

Pulmonary pleomorphic carcinoma metastasizing to the anterior mandibular gingiva: A case report and literature review

International Journal of Surgery Case Reports

... Ultrasonography is useful to detect cervical lymph nodes (LNs) and guide fine needle aspiration [6]. Due to the high spatial resolution and tissue contrast, contrast-enhanced computed tomography (ceCT) and magnetic resonance imaging (MRI) are the techniques of choice for primary tumor evaluation and loco-regional staging, with preferential indications for each of them (for example, MRI is preferred over CT to assess skull-base invasion and perineural spread) [2,7]. However, their role in detecting lymph nodes and distant metastases is suboptimal, except for lung metastases that are better detected by chest CT [2,8,9]. ...

Comparison of different diagnostic imaging techniques for the detection of bone invasion in oral cancers
  • Citing Article
  • September 2021

Oral Oncology

... Scale bars, 80, 40 and 20 μm at 10x, 20x and 40x magnification, respectively. (C) The IHC analysis of changes in Ki-67 expression showed a higher positive rate in the F. nucleatum intervention group a prevalent oncogene overexpressed in OSCC [33,34], has strong associations with clinical indicators such as tumor-node-metastasis (TNM) stage, high histological grade, and poor prognosis. The Myc family exhibits amplified expression in various solid malignancies, contributing to tumor growth and drug resistance [35,36]. ...

Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma
  • Citing Article
  • April 2021

International Journal of Oral and Maxillofacial Surgery

... The final review included 48 articles (46 studies included patients with OSCC [9,13,[19][20][21][22][28][29][30][31][32][33][34]16,1 study included both patients with OSCC and OPMD [67,68] (Fig. 1.). Of these, 23 reported enough data to be included in the meta-analysis [13,[19][20][21][22]28,31,33,16,36,44,46,47,49,51,55,[59][60][61][62][64][65][66].(See Fig. 2). ...

The accuracy of ultrasound and magnetic resonance imaging for estimating thickness of oral tongue squamous cell carcinoma and influence of biopsy on those findings
  • Citing Article
  • March 2021

Oral Science International

... Upon implantation into bone defects, HAP does not form a fibrous tissue interface with the surrounding bone tissue; instead, it develops a carbonate apatite layer on its surface within the body. Consequently, HAP holds immense potential as a hopeful biomaterial for bone repair applications [25]. In the field of biomedical engineering, HAP finds extensive utilization in bone defect repair, including HAP-based bioactive glass composites, HAP-graphene composites, and HAP-polymer composites [26]. ...

In vivo behaviors of highly flexible paper consisting of ultralong hydroxyapatite nanowires

Journal of Biomedical Materials Research Part B Applied Biomaterials

... 50 Although existent research has predominantly focused on the distribution of Mg and alloying elements near the implant, with some studies reporting an increased Mg concentration in periimplant tissues, 13,51 there has been few investigations into the systemic accumulation of REE in organs distant from the implant site. 52 Therefore, although we are far from being able to apply biodegradable WE43 implants in significant human long bones, such as the femur, the prospect of employing multiple smaller WE43 implants for fracture repair emphasizes the urgency of comprehensively examining the long-term systemic consequences of REE. ...

Osteogenic response under the periosteum by magnesium implantation in rat tibia
  • Citing Article
  • February 2021

Dental Materials Journal