Hiroshi Kikuchi’s research while affiliated with Nagasaki University and other places

... In total, 60 clinical samples from 29 individuals were used, including 9 cross-sectional samples [27], 4 longitudinal samples, and 47 longitudinal samples described in [20] and [42], respectively. All clinical materials were collected by the Joint Study on Predisposing Factors of ATL Development (JSPFAD) [46,47]. HTLV-1-infected individuals were diagnosed based on the Shimoyama criteria [48]. ...

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Inferring clonal structure in HTLV-1-infected individuals: towards bridging the gap between analysis and visualization

... Human T cell leukemia is the deadliest form of cancer with few treatment options to patients with advanced metastatic disease. It has a very poor prediction [1][2][3] as the patients are usually highly immunocompromised and suffer from systematic painful disorders. Evidence have been provided that a correlation between chemokine receptor expression and prognosis has been found in cancers [4] . ...

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CCL19, not CCL21 induces CCR7-mediated stimulation of leukemia apoptosis by targeting endosomal signaling signaling

... 7.1.6. Trisomy 8 BD has increasingly been recognised in association with constitutional trisomy 8 mosaicism and acquired trisomy 8 secondary to myelodysplastic syndromes in adults [110,111]. Activation of the NF-κB pathway might be the underlying pathology for the BD-like phenotype in these patients [112]. ...

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Paediatric Behcet's Disease: A Comprehensive Review with an Emphasis on Monogenic Mimics

... Gastric adenocarcinoma is not consid- ered a HIV-related malignancy, being an unusual presentation of tumors in these patients. 24 In summary, we have demonstrated that gastroduodenal ero- sions and ulcers were not frequent in HIV-infected patients under HAART with dyspeptic symptoms. We have also shown a reversed association between H. pylori infection and immune deterioration. ...

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Dyspepsia in HIV-infected patients under highly active antiretroviral therapy

... # All patients who developed aGVHD developed within 100 days after transplant. CD4 + T-cell function caused by human T-cell leukemia virus type 1 infection [17,18]. A higher post-transplant incidence of CMV infection among transplant recipients with ATLL has been reported [19,20], and the results of our present analyses demonstrated a higher susceptibility to late CMV disease in patients with ATLL, indicating that immunodeficiency in ATLL patients could not recover even late after transplant. ...

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Clinical significance of late CMV disease in adult patients who underwent allogeneic stem cell transplant

... The cause of death was non-ATL malignancy in 20 and 4.9 % of patients with smoldering-and chronic-types ATL, respectively, which was the second most common cause of death in smoldering [15]. The trigger for ATL diagnosis was unknown in these studies; however, HTLV-1 carrier-only analysis conducted in a previous study indicated a situation wherein the examination of the anti-HTLV-1 antibody was noted during the treatment for other diseases [52]. It is unknown whether the treatment of non-hematological malignancies was preceded by the diagnosis of indolent ATL in the 11th Nation-wide Survey Study; however, follow-up care, including workup to assess the complications of non-hematological malignancies and cancer screening, might be considered in the management of indolent ATL. ...

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Treatment strategy for indolent adult T-cell leukemia-lymphoma

... DISCUSSION: Due to its distinct biological and clinicopathological features, PEL has been recognised as an independent lymphoproliferative malignancy-with a large cell morphology, B-cell genotype and tendency to infiltrate serous mucosa causing effusions without any tumoural mass or LAP. [1][2][3][4][5][6][7][8] More specifically, it is defined as a lymphoma of the post-germinal centre, pre-terminally differentiated Bcells. 2 PEL became salient around 1995, after which there has been much effort to clarify its, yet uncertain, obscure pathogenesis. By and large, HHV-8 and EBV are the leading suspective aetiological factors. ...

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Jebmh.com Case Report PRIMARY EFFUSION LYMPHOMA OF PLASMABLASTIC TYPE: A RARE PRESENTATION IN AN IMMUNOCOMPETENT MALE ADULT

... del (6) identification. [54][55][56][57][58] However, because CD56 expression has been identified in approximately 20% of patients with acute myeloid leukemia (AML), 59 the features of immature cytologic appearance and the presence of myeloid antigen without light-microscopic MPO reactivity in this type of leukemia overlap with those in AML with minimal differentiation (French-American-British classification, AML-M0). ...

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Natural Killer cell neoplasms

... Homing of neoplastic NK cells to body cavities has been outlined recently in NK cell neoplasms, including ANKL, creating a differential diagnosis with primary effusion lymphoma [37][38][39][40]. This differential diagnosis can be addressed successfully by using flow cytometry immunophenotyping when morphologic examination is impeded or is of limited value [36]. ...

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Aggressive NK Cell Leukemia: Current State of the Art

... nPCR utilizes two amplification rounds to significantly increase specificity and sensitivity. However, which is more suitable for HCMV infection monitoring is still under debate given that the results of many appropriate reports are contraindicatory ( Ikewaki et al., 2003;Botero et al., 2008). Zhang et al. (2010) compared two PCR techniques, qPCR and nPCR, for detecting HCMV DNA in 106 blood samples from 66 patients with potential HCMV infections. ...

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Methodology considerations for the molecular detection of TORCH organisms using PCR approaches