Henry W. Lim’s research while affiliated with Michigan State University and other places

... These ROS critically damage cell membranes, mitochondria, and other vital cell organelles, ultimately triggering apoptosis and/or necrosis of the affected cells. PDT may also involve an immunological mechanism, activating innate and adaptive immune cells through antigen presentation of the destroyed premalignant cell [35][36][37]. However, its role remains unclear, as a clinical immunohistochemical study on PDT for basal cell carcinoma found increased neutrophil infiltration and E-selectin expression post-treatment, but also a significant loss of Langerhans cells (specialized skin antigen-presenting cells), suggesting that PDT-induced immunosuppression may weaken antitumor immunity [38]. ...

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Daylight Photodynamic Therapy for Actinic Keratosis and Field Cancerization: A Narrative Review

... There is a lack of consensus on managing these co-occurring conditions, which is common in clinical practice. In the current issue, Lane and colleagues have published a systematic review of literature on managing patients with concurrent vitiligo and disorders of hyperpigmentation like melasma and post-inflammatory hyperpigmentation (PIH) [5]. Oral tranexamic acid (melasma and PIH), topical tretinoin (melasma and PIH), micro-needling (vitiligo and melasma), platelet-rich plasma injections (vitiligo and melasma), and oral Polypodium leucotomos extract (vitiligo and melasma) seem promising in such situation [5]. ...

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Advancing the Understanding and Management of Segmental Vitiligo and Co-Existing Pigmentary Disorders

... Accordingly, inhibition of JAK/STAT3 and activation of the SOCS3 signaling pathway could be effective in treating AD. However, long-term use of JAK/STAT3 inhibitors is associated with the development of serious adverse effects such as malignancy, thromboembolism, and severe infections compared to immunomodulatory agents (Atzeni et al. 2018;Lamberg et al. 2024). Furthermore, the JAK inhibitor tofacitinib is associated with the risk of gastrointestinal perforation (Hoisnard et al. 2022). ...

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Targeting the JAK/STAT3/SOCS signaling pathway in Alzheimer’s disease

... Black individuals with HS seem to be susceptible as they showed a higher rate of DM with chronic complications compared to White patients, with an OR of 1.73, which is supported by the results of a retrospective cross-sectional analysis by Young et al. [32] on a cohort of 13,130 patients with HS. ...

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Glucose metabolism disorders in hidradenitis suppurativa: Current evidence and future directions

... This At-home phototherapy has proven to be an effective method to combat the geographic and financial barriers that many patients face. The LITE study, which included multi-racial participants, provided compelling evidence that home phototherapy is non-inferior to office phototherapy and is effective across all skin types [47]. Home phototherapy has the potential to address the convenience and access challenges that many patients face, and it is cost-effective compared to standard biologics. ...

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Racial Disparities in Psoriasis Treatment: A Review of Prescription Patterns and Outcomes Across White and Skin of Color Populations

... A exposição solar excessiva e o uso de dispositivos de bronzeamento artificial têm sido associados a mutações no DNA celular, promovendo instabilidade genômica e proliferação descontrolada dos melanócitos (MULLENDERS LHF, 2018). A exposição cumulativa à RUV está diretamente relacionada à incidência de melanoma, sendo a queimadura solar um dos fatores predisponentes mais relevantes (KWA M, et al., 2024). Estudos apontam que a exposição a camas de bronzeamento artificial não apenas aumenta o risco de um primeiro melanoma, mas também está associada ao desenvolvimento de múltiplos melanomas primários (KARAPETYAN L, et al., 2021). ...

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Exposição à radiação ultravioleta artificial e risco de melanoma

... Women, the survey reported, were affected more frequently than men. 1 While hypopigmentation refers to lightened areas of skin, hyperpigmentation describes darkened patches or lesions caused by the excess production, distribution, or transport of melanin. 2 "Hyperpigmentation is one of the most common causes of dermatology visits, particularly in patients with skin of colour," said Dlova. ...

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Clinical Practice Insights for Hyperpigmentation Treatment

... Sin embargo, existen brechas en el conocimiento y en la adherencia a medidas de protección, motivadas por factores como el nivel educativo, la edad, el género y la percepción de riesgo. La utilización de protectores solares con un factor de protección solar (FPS) adecuado, la aplicación regular y correcta, además del uso complementario de medidas físicas, son recomendaciones ampliamente aceptadas por organizaciones internacionales como la AFD, AAD y OMS (4) Asimismo, cada vez hay mayor preocupación por el impacto ambiental de los bloqueadores solares tradicionales, además de la relación con posibles disruptores endocrinos (5,6). Esto motiva el interés en la búsqueda de formulaciones más seguras y ecológicas, además de la necesidad de educar a la población en prácticas sostenibles. ...

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Actitudes, conocimientos y prácticas de fotoprotección en alumnos de la facultad de ciencias medicas de UNICIT del periodo comprendido en el mes de Mayo del año 2025.

... Novel therapeutic approaches aimed at remodeling dysregulated microbiota and restoring compromised probiotics have been proven to be safe and effective in human dermatological diseases, such as acne vulgaris, diabetic infectious wounds, atopic dermatitis, psoriasis, and so on [74][75][76][77]. However, in the field of radiation-induced skin toxicity, researchers interested in host-microbiota interactions have focused almost exclusively on the interplay between human-associated microbiome and constant solar ultraviolet-induced injuries, which are usually attributed to the common type of nonionizing radiation [78][79][80]. The biological effect and underlying mechanisms of skin microbial communities in the pathogenesis of radiodermatitis resulting from the therapeutic ionizing radiation in clinical practice are yet to be systematically studied. ...

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Bidirectional Mendelian Randomization Analysis to Study the Relationship Between Human Skin Microbiota and Radiation-Induced Skin Toxicity

... This may be related to that females take more protective measures when exposed to extreme temperature, such as sun protection. 40 On the other hand, males work more hours outdoors, leading to more exposure to extreme temperature. 41 In terms of age, the decrease of temperature-related excess injury risk was the most pronounced for the elderly, with a reduction of nearly 50%. ...

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The temporal shift of temperature-related injury incidence risk and its driving factors in China: a nationwide case-crossover study from 2006 to 2021