Henry H. Scofield’s research while affiliated with Medical University of South Carolina and other places

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Publications (8)


Malignant mixed tumor of salivary gland origin
  • Article

October 1969

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30 Reads

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60 Citations

Cancer

Ronald M. Gerughty

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Henry H. Scofield

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Francis M. Brown

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Gordon R. Hennigar

One hundred and thirty-four salivary gland tumors originally diagnosed as malignant mixed tumor at the Armed Forces Institute of Pathology and the Medical College of South Carolina were analyzed. These were reclassified and only 25 were found to possess specific histopathologic criteria necessary for the diagnosis of malignant mixed tumor. Where possible, the clinical behavior, therapy, and prognosis were correlated with the histopathology. The malignant mixed tumor was found primarily in the parotid gland and was observed more frequently in men. The median age of patients with this tumor was 38 years (60% occurred prior to age 40). Pain and fixation of the tumor could not be correlated with malignancy. Sixty-four percent of these tumors presented as primary malignant mixed tumors. Histologically proven metastases were observed in 71% of the cases, with lung, lymph node, central nervous system, and bone the most frequent sites. Certain histopathologic features of the malignant mixed tumor can be correlated with eventual metastases. Although the pathogenesis of the malignant mixed tumor remains undetermined, the results of this study indicate that this neoplasm is malignant from the onset and does not develop from malignant transformation of a preexisting “benign” mixed tumor.



Benign fibro-osseous jaw lesions of periodontal membrane origin. An analysis of 249 cases

November 1968

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61 Reads

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167 Citations

Cancer

An analysis of the clinical, radiographic, histologic and follow-up data on 249 cases of lesions of periodontal membrane origin is presented. Such lesions may be cementoid, osteoid, mixed (cemento-osteoid) or fibrous. These tumors may be single or multiple and usually behave in a benign fashion. Occasionally they may act in an aggressive manner and attain giant size, although none metastasize. The benign fibro-osseous lesions of periodontal membrane origin are more prevalent in the jaws than fibro-osseous lesions of medullary bone origin. The use of polarized light was most helpful in distinguishing mature cementoid lesions from tumors with mature lamellar bone; the former have finer lines of parallel birefringence. Fibrous dysplasia has often been misused as a diagnostic term and was found not to be prevalent as a fibro-osseous jaw lesion. Fibrous dysplasia has its own particular histologic features, and the immature "woven" bone within the lesion polarizes in a random birefringent pattern.






Acinic cell adenocarcinoma of the major salivary glands. A clinicopathologic study of 77 cases

October 1965

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33 Reads

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166 Citations

Citations (8)


... The differential diagnosis of jaw FD and HPT-JT should be made comparing findings of benign fibro-osseous lesions of periodontal origin [34], osteofibrous dysplasia (ossifying fibroma), central giant cell reparative granuloma (cGCRG) [35], giant cell tumor [36], osteitis fibrosa cystic resulting from hyperparathyroidism, desmoplastic fibroma, aneurismal bone cyst, and in cases showing hyper-cellular pattern with low-grade aggressive mesenchymal tumors such as desmoid-type fibromatosis, aggressive fibromatosis and low-grade fibrosarcoma [37]. ...

Reference:

Expression of Beta-Catenin, Cadherins and P-Runx2 in Fibro-Osseous Lesions of the Jaw: Tissue Microarray Study
Benign Fibro-osseus Jaw Lesions of Periodontal Membrane Origin
  • Citing Article
  • January 1968

... JOF behaves in a more aggressive fashion than ossifying fibroma, and it may require extensive surgery. [5,8] The presence of more mature lamellar bone is believed to be characteristic of ossifying fibroma. [9] Cemento‑ossifying fibroma is lesions with round or spherical bony islands along with calcified material. ...

Benign Fibro-Osseous Jaw Lesions of Periodontal Membrane Origin
  • Citing Article
  • April 1969

Plastic & Reconstructive Surgery

... Moreover, an analysis of recurrent PAs indicated that 7.1% underwent malignant transformation and that the risk of malignancy increased with disease progression [43]. In general, carcinoma arising in a PA is difficult to diagnose because the mixed tumor component is often small and easily overlooked and the malignant component may be difficult to classify [44]. From this viewpoint, it can be deduced that the diagnostic accuracy of incisional biopsy is not high. ...

Malignant mixed tumor of salivary gland origin
  • Citing Article
  • October 1969

Cancer

... 4 It is frequently seen in the third as well as fourth decades of life. In 1968, Hamner et al. 5 studied and categorised 249 cases of fibro-osseous jaw lesions which had periodontal membrane origin. In 1973, Waldron and Giansanti described 65 cases and established that this group of lesions was best considered as a range of processes that arises from cells in the periodontal ligament. ...

Benign fibro-osseous jaw lesions of periodontal membrane origin. An analysis of 249 cases
  • Citing Article
  • November 1968

Cancer

... Si riporta la gestione clinica di un caso di CGCG del mascellare, associato a ipersensibilità agli stimoli freddo/caldo e rias- Queste ultime caratteristiche radiografiche possono essere osservate, per esempio, nel caso di osteosarcoma dei mascellari [11] , che si associa a sintomatologia dolorosa urente e tumefazione gengivale. Patognomonico all'esame radiografico è il segno di Garrington, un ispessimento dello spazio del legamento parodontale degli elementi dentari coinvolti [12] . ...

Osteosarcoma of the Jaws. Analysis of 56 cases
  • Citing Article
  • April 1967

Cancer

... Previous literature indicated that the parotid gland can be affected by sarcoidosis (6-30%) (17)(18)(19). Brantley et al (20) reported approximately 11 positive parotid gland biopsy results (58%) in 19 patients with proven generalized sarcoidosis. We found a Hočevar score above the control range in approximately 19% of our sample, and in 37% when using a cutoff score of 15, as suggested in some studies (14). ...

Cervical lymphadenopathy and parotid gland swelling in sarcoidosis: a study of 31 cases
  • Citing Article
  • June 1967

The Journal of the American Dental Association

... Journal of Pigmentary Disorders Yasumizu et al., Pigmentary Disorders 2015, 2:10 http://dx.doi.org/10.4172/2376-0427.1000218 Research Hybrid open access Pigmentary Disorders ISSN:2376-0427 JPD, hybrid open access journal Volume 2 • Issue 10 • 1000218 Author(s) Year No. of Cases Ethnicity Ref. No. Bhende 1952 1 Indian 47 Young 1957 1 NR 48 Leonardi 1958 1 NR 49 Higginson 1960 1 African 41 Kennedy 1963 1 NR 5 Oettle 1963 1 African 50 Duron 1965 1 NR 59 Garrington 1967 1 Caucasian 51 Oluwasanmi 1969 1 NR 53 Halama 1974 1 NR 6 Alpert 1978 1 Caucasian 7 Stoll 1981 1 African 54 Scott 1982 1 NR 8 Wood 1982 1 NR 52 Pehamberger 1984 1 Caucasian 55 Luande 1985 1 NR 9 Kinnear 1985 1 NR 56 Levine 1992 1 Caucasian 10 Ihn 1993 1 Asian 11 Casswell 1989 1 Caucasian 57 Schulze 1989 1 1 Caucasian Hispanic 58 Perry 2001 1 NR 12 Asuquo 2009 1 African 44 Mabula 2012 1 African 46 ...

Intraoral malignant melanoma in a human albino
  • Citing Article
  • September 1967

Oral Surgery Oral Medicine Oral Pathology

... The histologic hallmark of these tumors is the presence of serous acinar differentiation which can be either focal or diffuse. In addition to this integral feature, AciCC also may have various mixtures of intercalated, vacuolated, clear and non-specific glandular components arrayed in a mixture of solid, microcystic, papillary-cystic and follicular patterns [5]. ...

Acinic cell adenocarcinoma of the major salivary glands. A clinicopathologic study of 77 cases
  • Citing Article
  • October 1965