Hélène Boisjoly's research while affiliated with Université de Montréal and other places

Publications (61)

Article
Purpose: To determine whether people with age-related eye disease have lower cognitive scores than people with normal vision. Methods: A hospital-based cross-sectional study was performed in which 420 people ages 65 and older from the ophthalmology clinics at Maisonneuve-Rosemont Hospital (Montreal, Canada) were recruited who had either age-related...
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Background The objective was to evaluate the eye care services offered to older residents living in long-term care facilities (LTCFs). Methods A questionnaire targeting residents aged ≥65 years was sent to all LTCFs in Quebec. Questions related to the institution’s characteristics, demographic data related to residents, oculovisual health of resid...
Article
Purpose: To examine whether patients with age-related macular degeneration (AMD), glaucoma, or Fuchs corneal dystrophy report limiting their activity due to a fear of falling as compared with a control group of older adults with good vision. Methods: We recruited 345 patients (93 with AMD, 57 with Fuchs, 98 with glaucoma, and 97 controls) from t...
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The purpose of this study is to examine whether patients with age-related eye diseases, like age-related macular degeneration (AMD), glaucoma, or Fuchs corneal dystrophy, are more likely to show signs of depression compared to a control group of older adults with good vision, and to determine whether reduced mobility mediates these relationships. W...
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To describe different methods of inter-eye asymmetry of rim area (RA) to disc area (DA) asymmetry ratio (RADAAR) analysis. This was an observational, descriptive, and cross-sectional study. Both the eyes of all participants underwent confocal scanning laser ophthalmoscopy (Heidelberg retina tomograph (HRT 3)), frequency-doubling technology perimetr...
Article
To examine the extent of mobility limitations in patients with age-related macular degeneration (AMD), glaucoma, or Fuchs' corneal dystrophy compared with that in a control group of older adults with good vision. Two hundred seventy-two patients (68 with AMD, 49 with Fuchs' dystrophy, 82 with glaucoma, and 73 controls) from the ophthalmology clinic...
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To determine the utility of combining rim area to disc area asymmetry ratio (RADAAR) and Moorfields regression analysis (MRA) to detect primary open-angle glaucoma (POAG) using confocal scanning laser ophthalmoscopy (CSLO) (Heidelberg retina tomograph 3 (HRT3)) in high-risk populations. Cross-sectional study. Subjects with high risk for developing...
Article
According to our clinical observation, patients with quiescent herpes simplex virus (HSV) stromal keratitis often seem to present with signs of dry eye in the contralateral eye. Our goal was to compare dry eye signs and symptoms in both eyes of patients with quiescent HSV stromal keratitis with those of age- and sex-matched control subjects with he...
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To assess the cost-utility of posterior lamellar keratoplasty (PLK) techniques, including deep lamellar endothelial keratoplasty, Descemet stripping endothelial keratoplasty, and Descemet stripping automated endothelial keratoplasty, in the treatment of corneal endothelial diseases. Cost-utility analysis based on a Markov model. Cohort of 100 patie...
Article
The goal of this study was to prospectively assess the deep lamellar endothelial keratoplasty (DLEK) wound anatomy and its evolution during the 12 months after surgery, using optical coherence tomography (OCT). The eyes of 8 patients (1 eye per patient) who consecutively underwent DLEK for Fuchs dystrophy or pseudophakic bullous keratopathy were pr...
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A cataract efficiency program was implemented in Montreal in 2003 to decrease surgery wait time. Our goal was to determine whether health, adverse events during wait time, and outcome of patients presenting for cataract surgery differed from 1999 to 2006 in Montreal. Prospective preoperative and postoperative observational study performed at 2 time...
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To estimate the annual incidence of endophthalmitis after cataract surgery from January 1, 1996, through December 31, 2005, in Quebec, Canada. Deidentified data were obtained from an outpatient physician billing database (Quebec State Control for Health Insurance [RAMQ]) with regard to all cataract surgical procedures performed from January 1, 1996...
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As provinces consider what an acceptable cataract surgery wait time should be, research is needed on the risk of adverse events, such as depression, while waiting for care. We sought to determine whether worse visual acuity is related to depressive symptoms in patients waiting to have cataract surgery. Cohort study. Six hundred seventy-two patients...
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To improve the admissions process for the Université de Montréal (UdeM) ophthalmology residency program, the interview structure was modified to encompass the seven CanMEDS roles introduced by the Royal College of Physicians and Surgeons of Canada (RCPSC). These roles include an applicant's abilities as a communicator, collaborator, manager, health...
Article
The amniotic membrane, the most internal placental membrane, has various properties useful in ophthalmology. Collected on delivery by elective Caesarean section, the amnion is prepared under sterile conditions, and, usually, cryopreserved until its use as a biological bandage or as a substrate for epithelial growth in the management of various ocul...
Article
To summarize the known uses of available medical tissue adhesives in the management of diseases of the anterior segment, highlighting recent developments in the field. Human fibrin glues may be used in place of cyanoacrylate tissue adhesives in the treatment of progressive corneal thinning and small perforations, potentially resulting in less corne...
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To estimate the misclassification rate of self-reported visual disabilities in a hospital-based population with known visual impairment. Subjects (N=570) were recruited among patients aged 50 years and more and classified to three categories of visual impairment level. The questionnaire was administered to consenting patients through a telephone in...
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To report one case of a bilateral ring-shaped opacity in the mid-peripheral corneal stroma of unknown origin. Case report. The authors describe the clinical history and ocular examination of an asymptomatic 82-year-old woman with a bilateral ring-shaped opacity located in the corneal stroma. This rare corneal anomaly was discovered by chance, and t...
Article
To assess visual functioning and other health-related quality of life outcomes after corneal grafting. A cohort study of corneal graft recipients observed for a minimum of 2 years after transplantation. Repeated measurements were obtained by telephone interviews preoperatively and later at 1 and 2 years post-corneal transplantation in 217 patients...
Article
The aim of this study was to develop a valid, reliable, and easy-to-administer instrument to assess patient satisfaction and perceived outcome after bilateral excimer laser photorefractive keratectomy. Development and validation of a psychometric questionnaire. Consecutive patients who underwent bilateral excimer laser photorefractive keratectomy f...
Article
Objective The aim of this study was to develop a valid, reliable, and easy-to-administer instrument to assess patient satisfaction and perceived outcome after bilateral excimer laser photorefractive keratectomy.
Article
Purpose. To determine whether visual acuity (VA) measurements performed at low levels of contrast and glare are a better diagnostic tool for determining whether corneal clouding warrants surgery. Methods. Fifty-nine subjects were recruited from among the candidates for corneal graft. Monocular VA was measured with three Regan contrast VA charts: 96...
Article
To validate the Visual Function-14 (VF-14) index of functional visual impairment in candidates for a corneal graft. One hundred thirty-four patients who were candidates for a corneal graft participated in this study between August 1996 and February 1997. Demographic, ocular history, best-corrected visual acuity, and detailed ocular examination data...
Article
The aim of the present study was to produce a reconstructed human cornea in vitro by tissue engineering and to characterize the expression of integrins and basement membrane proteins in this reconstructed cornea. Epithelial cells and fibroblasts were isolated from human corneas (limbus or centre) and cultured on plastic substrates in vitro. Reconst...
Article
A positive donor-recipient crossmatch (CM) due to preexisting recipient lymphocytotoxic antibodies is known to be an important factor in allograft failure in the majority of organ transplantations. However, the effect of positive CM on corneal graft outcome is less known. Between 1982 and 1994, CM was performed by the microlymphocytotoxicity method...
Article
To study the effect of patching on the speed of reepithelialization, slit-lamp signs of epithelial wound healing, and patient discomfort following a corneal abrasion. Forty-eight eyes of 46 patients with corneal erosion sparing Bowman membrane were randomized into 2 groups: with or without patching. Slit-lamp examination and photographs of the fluo...
Article
There are conflicting results regarding the role of human leukocyte antigen (HLA) matching and ABO compatibility in corneal graft rejection for low- and high-risk patients. Lewis blood group antigens could be an important histocompatibility system. Beneficial effects of Lewis antigens matching have been reported in renal transplantation, but its ef...
Article
To produce and validate French-language versions of the Visual Functioning Index (VF-14), the Cataract Symptom Score (CSS) and two global measures of trouble and satisfaction with vision. Survey by means of telephone interviews conducted 2 weeks apart. Ophthalmology clinic of a teaching hospital in Montreal. Subjects were recruited among patients w...
Article
Purpose. To assess the efficacy of visual acuity measurements in conditions of glare and reduced contrast in patients with severe corneal opacities and recipients of a corneal graft. Methods. Visual acuity was measured in four groups of subjects: pre-grafi (n=28), 12 months post-graft (n=29 , 24 months post-graft (n=20) and controls (n=23). The fou...
Article
Purpose. Document thé association between subjective visual function and perceived health status with clinical measurements of visual impairment in canditates to corneal transplantation. Methods. A group of patients waiting for a corneal transplant were submitted to a measure of VA and contrast ser sitivity with Reagan's 96, 25 and 11 % contrast ch...
Article
To evaluate the therapeutic effects of anterior stromal punctures (ASP) in patients with bullous keratopathy (BK). Twenty-seven patients awaiting penetrating keratoplasty with a diagnosis of BK were examined. They were seen before treatment with ASP and 1, 4, and 12 weeks after treatment. The examination included slit-lamp examination, photography...
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Objective: Validate a French adaptation of the Visual Functioning Index® (VF-14), the Cataract Symptom Score® (CSS), and a measure of the overall amount of trouble and the overall amount of satisfaction with vision. Methods: Reliability of the VF-14 French version was verified in a group of bilingual subjects with ocular media opacities and the tes...
Article
Purpose. To demonstrate decreased corneal endothelial cell counts in glaucoma suspects with ocular hypertension. Methods. 21 patients with ocular hypertension were compared to 21 age-matched controls. Hypertensive patients were recruited from the Glaucoma clinic and nonhypertensive patients from the cataract surgery waiting list of a teaching hospi...
Article
Purpose: To compare corneal endothelial cell loss after intermediate follow-up of phacoemulsification, trabeculectomy and combined procedures. Methods: We investigated 25 eyes from 25 patients, 10 undergoing phacoemulsification, 8 trabeculectomy and 7 combined phaco-trabeculectomy. Specular microscopy was performed before, at 12 and 36 months after...
Article
Purpose: To study the association between glaucoma and corneal endothelial cell vitality indicators. Methods: One hundred-two glaucomatous or ocular hypertensive patients were compared to fifty-two nonglaucomatous patients of the same age group. Exclusion criteria included past history of either ocular inflammation, trauma or surgery other than per...
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To measure the association between potential risk factors and corneal graft failure. Two failure outcomes are compared: those with and those without a prior immune allograft reaction. Based on a single-center observational study design, 539 adult recipients of a corneal graft were followed for a median time of 30 months. Survival analysis was carri...
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We investigated the effects of EGF, IL-1 and their combination on closure of wounds inflicted on rabbit corneal epithelial cell cultures and on migration of these cells in microchemotaxis chambers. In vitro corneal epithelial wound closure depended on the applied concentrations of EGF or IL-1. Twenty-four hours after wounding, the smallest wounds w...
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The purpose of this study was to measure the association between antibody formation and endothelial corneal allograft reactions in 533 consecutive corneal graft recipients. The median follow-up time of these recipients was 732 days. Pretransplant panel-reactive antibodies were not found to be associated with endothelial corneal allograft reactions....
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We evaluated the effect of fibronectin (an adhesive protein) and aprotinin (a protease inhibitor) as single or combined topical therapies for primary healing and prevention of recurrent corneal epithelial defects in the rabbit keratectomy wound model. The biological activity of the prepared solutions of rabbit plasma fibronectin (0.6 g/L) was sugge...
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Human limbal explants obtained from 44 eyebank donors were cultured in medium 199 supplemented with 20% fetal bovine serum, vascular endothelial cell growth supplement and heparin. Cells grew abundantly out of the explants. They initially formed a 'cobblestone' patterned monolayer but later exhibited an elongated morphology with growth in parallel...
Article
The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. Most of the recipients under obs...
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Three cases of Wilms' tumour and sporadic aniridia were followed up for periods ranging from 32 months to seven years. All had a deletion of the short arm of the eleventh chromosome 11p13, including one case with mosaicism, a cytogenetic feature that has not been previously described in the Wilms' tumour and sporadic aniridia association. Unusual n...
Article
Preoperative topical nonsteroidal anti-inflammatory drugs such as flurbiprofen and indomethacin have been found to maintain mydriasis during cataract surgery. Steroidal anti-inflammatory drugs are commonly used to treat postoperative inflammation, but their effect on the maintenance of intraoperative mydriasis is unknown. Forty-six patients admitte...
Article
One hundred and fifty-two consecutive corneal transplants were performed with recipients selected on the basis of the best HLA-A, B, and DR match, and observed for corneal transplant rejection episodes. Following a descriptive analysis of data, the transplants were subdivided into well matched transplants (109 cases) and poorly matched transplants...
Article
We examined 348 consecutive adult recipients of a corneal transplant for clinical signs of an endothelial rejection episode in a single-center follow-up study. The variables studied included primary diagnosis, number of previous corneal transplants, previous transplant failures from rejection episodes, transplant size, recipient corneal vasculariza...
Article
Symptoms of uveitis developed in the left eye of a 61-year-old woman 2 weeks after bronchoscopy to investigate hemoptysis. The true diagnosis of metastatic endophthalmitis was unsuspected for 1 month. Both sputum and vitreous samples yielded Pseudomonas aeruginosa when cultured. Despite aggressive medical treatment, subtotal vitrectomy and intraocu...
Article
One hundred eighty-five consecutive corneal transplants were performed in recipients selected on the basis of the best available HLA-A,B and DR match. Endothelial rejection-free transplant survival in this group was compared to a retrospective historical control group of 199 consecutive transplants performed in recipients selected on the basis of a...

Citations

... In the late 1990s, wait time for cataract surgery was a problem in many countries, including Canada. 4 We conducted a prospective study in 1999-2000 to evaluate patient health and distress during their wait. 5 Canadian provincial health ministries later mandated local health agencies to improve efficiency to provide higher cataract surgery volumes at lower costs per case. Performing surgery in ambulatory care centres is an avenue of efficiency taken by many centres. ...
... 20 The VF-14 has a format which makes it easy to administer and has a high rate of patient compliance. Although it has been validated in several languages other than English, 21,22 its applicability in a German population has yet to be determined. ...
... A study done among glaucoma suspects with ocular hypertension, also showed lower corneal endothelial cell counts. 5 The RNFL thinning seen on spectral domain OCT is a known risk factor in the progression of glaucoma but its association with the corneal changes needs further detailed evaluation. Hence, visualisation and study of HCEC is paramount in the complete assessment of a glaucoma suspect patient, as endothelial cell loss may be a significant risk factor [3] . ...
... Three participants in one study had keratitis, hypersensitivity reactions, and conjunctival hyperemia, [17] while other studies have not reported any adverse effects with the use of CMC. [10,20] Besides being highly viscous and mucoadhesive, CMC may have some additional properties which could be responsible for the observed higher efficacy of CMC when compared with HPMC. CMC has been demonstrated to have a prolonged ocular residence time and good shear thinning properties in a small-angle neutron scattering and rheology study by Lopez et al. [18] An experimental study demonstrated that CMC may have a modulatory effect on corneal epithelial wound healing. ...
... A significant sensory change can deprive people of many simple pleasures while also making routine daily activities more challenging. Sensory changes might result in decreased mobility, increased dependence on others, a lack of environmental awareness, inadequate communication and interpersonal abilities, and a loss of self-esteem [10,11]. For instance, because 'deafness' involves 'social experiences' , it is likely the most significant sensory disorder. ...
... The deregulation was attributed to the false claim of the government that the public was wellinformed about eye care. 26 The need for understanding the perceptions of eyes and eye care among the Canadian public is heightened by the limited number of Canadian-based studies, 10,13,[27][28][29] underutilised eye care by Canadians in certain regions and age groups, 30,31 and the reported finding of the Canadian Association of Optometrists that 'the majority of Canadians think eye exams are for people with vision problems'. 32 Canadian focus groups reveal knowledge gaps regarding eye conditions, sight risks, test procedures, and eye practitioner roles, 13 impactful perceptions about online purchasing of eyewear, 29 and motivators and deterrents to seeking eye care. ...
... Amniotic membrane (AM) is the inner layer of the fetal membranes that is in contact with the fetus. An avascular stroma and single epithelial cells constitute the amniotic membrane [21] It has been documented in various clinical trials that transplantation of amniotic mem‐ brane is therapeutically useful in different superficial ocular pathologies [22, 23, 24, 25] Its beneficial effects for transplantation are due to the following characteristics: amniotic mem‐ brane promotes epithelialization, [26] inhibits angiogenesis [27] and has been used as a car‐ rier for ex-vivo expansion of corneal epithelial [28] and endothelial cells [29] Recently, we demonstrated that AM is able to induce apoptosis, inhibit cell proliferation of human PBMC, and abolish the synthesis and the secretion of pro-inflammatory cytokines even when they are LPS stimulated in vitro. [30] Similarly to us, Bauer et. ...
... Among older people, about one in three without a fall history and two in three with a falls history report some FoF [67]. Impaired vision [68], the presence of psychological disorders like depression and anxiety [67], balance and gait impairment [69], and cognitive dysfunction [70] were some of the risk factors for FoF. FoF can have some bad consequences like falls, increase dependency, a decrease in social activity, decrease quality of life, depression, and the person avoiding doing daily activities [67,71]. ...
... BAT has been used to identify patients who might benefit from keratoplasty. 29 Hence, we felt that BAT could represent an important functional visual assessment in post-DSAEK patients. Visual dysfunction associated with glare was worse in post-DSAEK patients than previously reported in normals. ...
... There are not many reports on the use of vision corridor in the literature however studies on self-reported visual status in an adult population [14,21] have also found a good correlation with supervised visual acuity. ...