Heike E. Daldrup-Link's research while affiliated with Stanford University and other places
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Publications (23)
Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and...
Cells respond to a myriad of stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a senescence-associated-secretory-phenotype (SASP). The heterogeneity of senescent cells (SnCs) and their SASP is vast, yet poorly characterized. SnCs have diverse roles in health and disease and are therapeutically targetable...
Cells respond to a myriad of stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a senescence-associated-secretory-phenotype (SASP). The heterogeneity of senescent cells (SnCs) and their SASP is vast, yet poorly characterized. SnCs have diverse roles in health and disease and are therapeutically targetable...
Significance
Chimeric antigen receptor (CAR) T-cell therapy is approved by the US Food and Drug Administration (FDA) for the treatment of B-cell acute lymphoblastic leukemia. Efforts are now underway to evaluate the efficacy of CAR T-cell therapy in solid tumors. However, a key limitation in the advancement of T-cell therapy is the lack of informat...
One important metric of a radiologist’s visibility and influence is their ability to participate in discussion within their community. The goal of our study was to compare the participation level of men and women in scientific discussions at the annual meeting of the Radiological Society of North America (RSNA). Eleven volunteers collected particip...
PurposeTo generate diagnostic 18F-FDG PET images of pediatric cancer patients from ultra-low-dose 18F-FDG PET input images, using a novel artificial intelligence (AI) algorithm.Methods
We used whole-body 18F-FDG-PET/MRI scans of 33 children and young adults with lymphoma (3–30 years) to develop a convolutional neural network (CNN), which combines i...
Oligometastatic colorectal cancer (CRC) is potentially curable and demands individualised strategies.
This single-centre retrospective study investigated if positron emission tomography (PET)/magnetic resonance imaging (MR) had a clinical impact on oligometastatic CRC relative to the standard of care imaging (SCI). Adult patients with oligometastat...
Gadolinium chelates have been used as standard contrast agents for clinical MRI for several decades. However, several investigators recently reported that rare Earth metals such as gadolinium are deposited in the brain for months or years. This is particularly concerning for children, whose developing brain is more vulnerable to exogenous toxins co...
Males and females have physiological, hormonal, and genetic differences that can cause different responses to medicinal treatments. The role of sex in the pharmacokinetics and pharmacodynamics of drugs is well established in the literature. However, researchers have yet to robustly and consistently consider the impact of sex differences on the phar...
Accurate staging and re-staging of cancer in children is crucial for patient management. Currently, children with a newly diagnosed cancer must undergo a series of imaging tests, which are stressful, time-consuming, partially redundant, expensive, and can require repetitive anesthesia. New approaches for pediatric cancer staging can evaluate the pr...
Background
The transplantation of mesenchymal stem cells (MSCs) into cartilage defects has led to variable cartilage repair outcomes. Previous in vitro studies have shown that ascorbic acid and reduced iron independently can improve the chondrogenic differentiation of MSCs. However, the combined effect of ascorbic acid and iron supplementation on M...
A diverse biomedical workforce is essential to achieve excellence in patient care, clinical translational, and basic research. Diversity, equity, and inclusion challenges in cancer molecular represent a combination of the challenges facing the science, technology, engineering, and mathematics (STEM) field, and challenges in Radiology and Nuclear Me...
This paper summarizes the 2020 Diversity in Radiology and Molecular Imaging: What We Need to Know Conference, a three-day virtual conference held September 9–11, 2020. The World Molecular Imaging Society (WMIS) and Stanford University jointly organized this event to provide a forum for WMIS members and affiliates worldwide to openly discuss issues...
The disialoganglioside GD2 is consistently overexpressed in neuroblastoma and osteosarcoma, and is variably expressed in other sarcomas, gliomas, neuroendocrine tumors, and epithelial cancers. Anti-GD2 antibodies have improved the survival rates of patients with neuroblastoma only when administered as part of intense chemotherapy-based cytotoxic re...
Background
MR is an important imaging modality for evaluating musculoskeletal malignancies owing to its high soft tissue contrast and its ability to acquire multiparametric information. PET provides quantitative molecular and physiologic information and is a critical tool in the diagnosis and staging of several malignancies. PET/MR, which can take...
Ferumoxytol nanoparticles are being used clinically for the treatment of anemia and molecular imaging in patients. It is well documented that while most patients tolerate ferumoxytol well, a small percentage of patients (i.e., 0.01%) develop severe allergic reactions. The purpose of our proof-of-concept study was to determine whether patients with...
Recent evidence of gadolinium deposition in the brain has raised safety concerns. Iron oxide nanoparticles are re-emerging as promising alternative MR contrast agents, because the iron core can be metabolized. However, long-term follow up studies of the brain after intravenous iron oxide administration have not been reported thus far. In this study...
Autologous therapeutic cells are typically harvested and transplanted in one single surgery. This makes it impossible to label them with imaging biomarkers through classical transfection techniques in a laboratory. To solve this problem, we developed a novel microfluidic device, which provides highly efficient labeling of therapeutic cells with ima...
Background Whole-body diffusion-weighted (DW) MRI can help detect cancer with high sensitivity. However, the assessment of therapy response often requires information about tumor metabolism, which is measured with fluorine 18 fluorodeoxyglucose (FDG) PET. Purpose To compare tumor therapy response with whole-body DW MRI and FDG PET/MRI in children a...
Objectives
We compared the value of ferumoxytol (FMX)- and gadolinium (Gd)-enhanced MRI for assessment of sarcomas in paediatric/adolescent patients and hypothesised that tumour size and morphological features can be equally well assessed with both protocols.
Methods
We conducted a retrospective study of paediatric/adolescent patients with newly d...
Citations
... For example, the team at the University of Florida was successful in labeling T cells specific to the PMEL marker on brain tumor cells using SPIOs and tracking them toward aggressive tumors of glioma in a murine model [36]. In another approach, researchers at Stanford labeled CAR-T cells specific to the cancer checkpoint marker B7-H3 using a mechanoporation approach and successfully tracked the labeled cells to a tumor xenograft using a multimodal imaging approach encompassing MPI, MRI, and photoacoustic imaging [151]. ...
... Previous studies have focused on a single year of a conference 31,45 , or focused on subgroups of conference presenters 45 or presenters only without assessing the gender balance of conference organising committees 19,31,32,40,45 . In contrast, our study makes use of eight years of data from the RCRASM, using information on presenters in all roles, and on the gender balance of the conference committees to give as complete a picture as possible of the patterns of involvement of women and men at all levels of the RCRASM, and to assess for changes in these patterns over recent years. ...
... Laboratory examinations such as conventional CEA can facilitate patient screening to some extent (32). Computed tomography, ultrasonography, and magnetic resonance imaging are all helpful for early diagnosis (33)(34)(35). However, these methods and the diagnostic gold standard, tissue biopsy, have certain limitations. ...
... The potential risks of gadolinium contrast administration may be offset by improved diagnostic accuracy [92][93][94], in particular in pediatric stroke when time-to-diagnosis is vital for the prevention of neurological injury and death, and by improved prognostication [95][96][97]. Alternative contrast agents, including liposomes, micelles, and inorganic nanoparticles (e.g., ferumoxytol), remain an active area of study [98,99]. ...
... While some studies have suggested that male sex is associated with worse NAS, others have not (Jansson et al., 2010;Unger et al., 2011;Charles et al., 2017). Sex is an important biological variable that contributes to the fundamental differences seen in many diseases and pharmacologic responses (Bartz et al., 2020;Kantarci et al., 2020;Zucker and Prendergast, 2020;Sharifi et al., 2021). An urgent need exists to incorporate sex in the evaluation and management of NAS. ...
... Diffusion-weighted imaging (DWI) is routine in central nervous system (CNS) diagnostics [1], whole-body imaging (WBI) [2], in oncological questions [3] and suspected inflammatory processes [4]. In abdominal magnetic resonance imaging (MRI), diffusion-weighted sequences can reliably detect lesions and provide functional information on tumor tissue, like cellular density [5][6][7]. Frequently, a DWI with evaluation of the corresponding apparent diffusion coefficient (ADC) is included in most abdominal MRI protocols [8]. However, the use of DWI in abdominal imaging can be problematic due to respiratory motion artefacts, and due to greatly prolonged acquisition times in combination with respiratory gating [9], which is intensified in cystic fibrosis (CF) patients who suffer from irregular breathing patterns in the supine position during abdominal MR examinations [10,11]. ...
... These same students have a high dropout rate, lack mentors, and lack knowledge about the variety of careers available to them [17]. Lack of mentorship has been cited as a major contributing factor for the underrepresentation of Black trainees within the field of radiology [18]. ...
... For this reason, the pig is an attractive potential model for the study of certain pathologies [11]. In particular, mini pigs are widely used in medical research as a source of organs for xenotransplantation [12,13], as a model of cartilage repair [14,15], and in the field of embryonic stem cells and induced pluripotent stem cells research [16]. In recent years, many researchers have actively sought for techniques to create lines of porcine MSCs from various tissues. ...
... At the same time, two stated explicitly that COVID-19 and its consequences led to or could lead to a decrease in engagement with EDI [273] and DEI [274]. Four abstracts stated that the COVID-19 pandemic highlighted existing diversity, equity, and inclusion challenges such in the STEM field [275], the U.S. healthcare delivery system [276], the role of nurses [277], and gender pay equity, diversity, and inclusion [278]. One stated that "the COVID-19 pandemic has posed major challenges for diversity, equity, and inclusion (DEI) efforts in research and academia" [279] (p. ...
... Immunoglobulin-coated and fibrinogencoated nanosheets generated much stronger inflammatory effects (cytokine release) than the other two blood proteins. The question of whether the biomolecular corona induces an allergic reaction was addressed by Muehe et al. (2021). They sought a correlation between hypersensitivity reactions in patients and specific protein corona profiles around ferumoxytol NPs used clinically for the treatment of anemia and in molecular imaging. ...