January 1995
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13 Reads
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39 Citations
Planta Medica
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Publications (4)
November 1994
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45 Reads
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21 Citations
Planta Medica
June 1994
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66 Reads
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179 Citations
Phytomedicine
The term adaptogen has not yet been accepted in medicine. This is probably due to the difficulties in discriminating adaptogenic drugs from immunostimulators, anabolic drugs, nootropic drugs, and tonics. There can be not doubt, however, that, at least in animal experiments, there are plant drugs capable of modulating distinct phases of the adaptation syndrome as defined by Seyle. These drugs either reduce stress reactions in the alarm phase or retard / prevent the exhaustion phase and thus provide a certain degree of protection against long-term stress. The small number of drugs the antistress activity of which has been proven or reported includes, among others, the plant drugs Ginseng, Eleutherococcus, Withania, Ocimum, Rhodiola, and Codonopsis. This review summarizes the major findings of pharmacological tests and human studies carried out with these drugs. Currently used assay systems allowing detection of antistress activities are also reported. At present the most likely candidates responsible for the putative antistress activity of plant drugs are special steroids, phenylprogane compounds and lignanes, respectively. Apart from influencing activities of the pituitary-adrenal axis and inducing stress proteins, many adaptogens also possess immunomodulatory and / or anabolic activities.
January 1993
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19 Reads
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49 Citations
Planta Medica
Citations (4)
... Nowadays, R. carthamoides is classified as an adaptogenic herb. According to the definition first introduced by Dr. Nikolai Lazarev in 1947, adaptogens are substances with the ability to enhance nonspecific resistance and adapt to exceptional stress factors in humans (Wagner et al. 1994). Adaptogens increase the ability of the organism to adjust to and prevent damage from environmental factors (Panossian et al. 1999). ...
- Citing Article
June 1994
Phytomedicine
... The primary class of bioactive compounds are flavonoids, which include methoxy flavonoids and their glycosides (luteolin, isothymusin, and cirsimartin), as well as C-glycoside flavonoids (orientin, isoorientin, isovitexin, and vicenin) from oysters (Norr, H., Wagner, H., 1992). Using atmospheric pressure chemical ionisation mass spectrometry (APCI-MS), Grayer et al., 2001 investigated the distribution of 8-oxygenated flavones on Os leaf surface and identified apigenin, cirsimaritin, salvigenin, crisilineol, eupatorin, isothymusin, and gardenin. ...
- Citing Article
January 1993
Planta Medica
... 1983;Sharma et. al, 1998;Kumar et.al, 2000;Padhya, 1986;Khan et.al, 1989 Glycosides Cordioside, Cordifolioside A, Cordifolioside-B, Palmatoside-F, Cordiofoliside-B 2 , Cordifoliside-D 2 , Cordifoliside, Tinocordiside, Tinocordifolioside, Palmatoside-C Bhatt and Sabata, 1989;Swaminathan et. al, 1989, Maurya et. al, 1995Ghosal and Vishwakarma, 1997;Sipahimalani et. al, 1994;Kapil and Sharma, 1997 Sesqui-terpenoid Tinocordifolin Pathak et. al, 1995 Root Alkaloid Palmatine Maurya and Handa, 1998 Aerial Parts ...
- Citing Article
January 1995
Planta Medica
... Codonopsis pilosula (CP), a well-known Chinese herbal medicine, has long time been prescribed in traditional folk medicine in China, Japan and Korea. CP has complex component, including polysaccharides, sesquiterpenes, saponins, polyphenolic glycosides, polyacetylenes, alkaloids, essential oils, and phytosteroids (Mizutani et al., 1988;Norr and Wagner, 1994;Wang et al., 1995;Wang and Wang, 1996). As the main bioactive components of CP extracts, the CP polysaccharide (CPP) is identified as a major constituent responsible for the therapeutic function of CP, such as antitumor, antimicrobial, immunoenhancing and antioxidant functions (Liu et al., 1988;Luo et al., 2007;Zong et al., 2012). ...
- Citing Article
November 1994
Planta Medica