Hector L. Lopez's research while affiliated with Center for Applied Health Sciences (CAHS) and other places

Publications (19)

Article
Objective: We sought to determine how one bout of resistance training to failure with either higher repetitions (30FAIL) or lower repetitions (80FAIL) affected the promoter methylation statuses of genes that drive skeletal muscle hypertrophy. Hypotheses: We hypothesized that a bout of 80FAIL training would lead to a more robust hypomethylation o...
Article
Objective: Our objective was to determine how global DNA methylation status of skeletal muscle differs with resistance training (RT) to failure in trained participants using either 80% of their estimated one-repetition maximum (Est. 1-RM) (80FAIL) or 30% of their Est. 1-RM (30FAIL). Hypotheses: We hypothesize there will be a significant decrease...
Article
Limited pre-clinical and clinical data suggest theacrine or theacrine-based supplements modulate biological processes associated with lipid metabolism and aging. Herein, we sought to examine if 12 weeks of daily supplementation with a theacrine-based supplement (termed NAD3®; 312 mg of combined Wasabia japonica freeze-dried rhizome standardized for...
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Based on a comprehensive review and critical analysis of the literature regarding the effects of sodium bicarbonate supplementation on exercise performance, conducted by experts in the field and selected members of the International Society of Sports Nutrition (ISSN), the following conclusions represent the official Position of the Society: 1. Sup...
Article
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We determined the effects of a commercially available, GRAS (Generally Recognized As Safe) by independent conclusion, CBD-containing hemp oil extract on stress resilience, perceived recovery, mood, affect, body composition, and clinical safety markers in healthy human subjects. Methods: Using a randomized, placebo-controlled, double-blind design, 6...
Article
The market for products featuring hemp extracts is large and growing larger. However, safety concerns have been raised by medical and regulatory agencies. Post marketing surveillance of full spectrum hemp extract (FSHE) products manufactured and distributed by CV Sciences (CVSI) and traded under the brand PlusCBD™ was conducted over a 2-year period...
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We examined if resistance training affected muscle NAD+ and NADH concentrations as well as nicotinamide phosphoribosyltransferase (NAMPT) protein levels and sirtuin (SIRT) activity markers in middle-aged, untrained (MA) individuals. MA participants (59±4 years old; n=16) completed 10 weeks of full-body resistance training (2 d/wk). Body composition...
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Milk and dairy products are known to contain various bioactives with potential anti-inflammatory and immune modulating effects. Previous research has indicated that milk produced from hyperimmunized cows provided meaningful health benefits to individuals suffering from varying degrees of osteoarthritis and rheumatoid arthritis. PURPOSE: To examine...
Article
Dietary supplement marketers assure the safety of their products by complying with current good manufacturing practices and a host of federal regulations, including those enforced by the Food and Drug Administration (FDA). Post-market surveillance is a key part of identifying safety problems associated with dietary supplement products. FDA requires...
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Background Previous research has demonstrated the permissive effect of insulin on muscle protein kinetics, and the enhanced insulin sensitizing effect of chromium. In the presence of adequate whole protein and/or essential amino acids (EAA), insulin has a stimulatory effect on muscle protein synthesis, whereas in conditions of lower blood EAA conce...
Article
Background: Very few weight and fat loss supplements undergo finished-product research to examine efficacy. The purpose of this study was to determine the effects of an 8-week diet and exercise program on body composition, hip and waist girth, and adipokines and evaluate whether a dietary supplement containing raspberry ketone, capsaicin, caffeine,...
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Background Joint and connective tissue integrity, comfort and function are paramount to optimal performance in exercise, recreational and occupational activities. The fruit of Terminalia chebula has been used extensively in various traditional health systems for different ailments, with additional preclinical and clinical data demonstrating antioxi...
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Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations which may help explain the observed improvements in high intensity exercise performance leading to greater training adaptations. In addition to athletic and exerci...
Article
Using a prospective, randomized, double-blind, crossover study design, fifteen healthy male (n = 8) and female (n = 7) participants (mean ± standard deviation (SD): 28.3 ± 6.1 yr, 176.3 ± 11.4 cm, 89.8 ± 21.7 kg, 28.5 ± 4.8 kg/m(2)) completed this study. Two testing sessions occurred after an overnight fast and refraining from physical exercise. Pr...
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Background The primary purpose of this investigation was to examine the effects of arachidonic acid (ARA) supplementation on functional performance and body composition in trained males. In addition, we performed a secondary study looking at molecular responses of ARA supplementation following an acute exercise bout in rodents. Methods Thirty stre...
Article
Theacrine (1,3,7,9-tetramethyluric acid) is a naturally occurring purine alkaloid, present in Camellia assamica variety kucha tea. Using a two-part approach in humans, the impact of theacrine (TeaCrine®, TC) was used to examine subjective dose-response, daily changes in cognitive and psychometric parameters, and changes in gas exchange and vital si...
Article
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Context: Little is known about the effect of nutritional supplementation on metabolic optimization for enhancing adaptation and recovery of the connective tissue elements that support musculoskeletal function. Objective: The study aimed to determine the potential effect of supplementation with a novel, hydrolyzed chicken sternal cartilage extrac...
Article
Full-text available
Background The extracellular matrix (ECM) of muscle, tendon, and ligament is sensitive to exercise-induced mechanical stimuli. Exercise-induced muscle damage is associated with not only myofibrillar injury, but also the involvement of connective tissue elements such as collagen, proteoglycans (PG), tendon and ligament. However, little is known abou...

Citations

... The latest supplement analyzed in the study is caffeine. This supplement is one of the most studied, and it has shown improvements in performance not only in various sports modalities but also in different aspects of sports performance [39][40][41][42] such as endurance, speed, muscle strength and cognitive function. ...
... One of such insects is honey bees. positive effects of hemp extracts have been described many times in relation to diseases such as depression, epilepsy, Alzheimer's, appetite disorders, as an aid in the treatment of cancer and in multiple sclerosis [27][28][29][30][31]. There are also interesting studies in which the hemp extract helped to regenerate damaged brain tissues in rats, damaged as a result of the action of chemical agents [32]. ...
... The literature regarding adverse effects of CBD was considerably expanded since the writing of our article, so that besides the anecdotal reports and paediatric studies already mentioned, several case reports 8-10 , a survey 9 , a meta-analysis of clinical trials 11 and a post marketing safety assessment of a full spectrum hemp extract 12 became available. Specifically the survey 9 reports observations of adverse effects including "feeling high", an effect likely to be explained by Δ 9 -THC contamination rather than by CBD. ...
... Additionally, although direct increases in expression of components of NAD + metabolism did not occur after RET, other proteins within the NAD + pathway did show increased abundance after RET in ageing muscle. A general pattern of enhanced mitochondrial capacity therefore characterises ageing RET adaptations, which does not feature strongly in younger muscle, supporting previous observations [41,42]. The untrained ageing muscle proteome and phosphoproteome also associated with upregulation of focal adhesion-related and cytoskeletal protein networks. ...
... First, the causal relationship between exercise and progression of symptoms was unclear because the KNHANES only records crosssectional data. The American Physical Therapy Association recommends strengthening exercises and progressive walking in older patients with LBP [35] because regular exercise may help to relieve LBP and prevent further damage. Second, we did not have data on the history of pharmacological or surgical treatment of LBP in the study participants. ...
... The high prevalence of DS intake may be explained by the widespread belief that these products could improve consumer health [1,10]. However, dietary supplements can also be harmful due to adverse effects and excessive intake of nutrients that can be toxic [1,11]. Thus, because of their potentially beneficial and adverse effects and increasing use, interest in supplement use has increased in recent years. ...
... Elevated plasma leptin concentrations have been found in obese individuals. This leads to decreased sensitivity of leptin receptors located in the hypothalamus, resulting in an increased sensation of hunger when attempting to lose weight and re-gain weight [47]. Dietary EPA supply decreases the decrease in leptin in blood, which reduces the hunger experienced by the patient and decreases the risk of re-gaining weight [48]. ...
... Together with these, T. chebula was found to mitigate the arthritic condition by suppressing inflammatory markers TNF-R1, IL-1b, TNF-α, IL-6, MMP-3, and COX-2 granuloma formation [52,57,58]. AyuFlex ® , a standardised formulation of T. chebula fruit, improved arthritis index in a human trial [59]. The global prevalence of diabetes mellitus (DM) seems to be increasing critically. ...
... The human body is able to synthesize it starting from three amino acids called glycine, methionine, and arginine. Creatine is produced in the liver, pancreas, and kidneys and then it is sent primarily to the muscles, brain, and heart [8,9]. ...
... Many studies suggest that insulin can play an important role in enhancing net protein balance by reducing protein degradation [10,15]. In the presence of adequate whole protein and/ or essential amino acids (EAAs), insulin stimulates MPS, while at lower blood EAA levels, insulin inhibits protein breakdown [16,17]. At the molecular level, the phosphoinositide-3-kinase (PI3K/Akt/mammalian mechanistic) target of the rapamycin (mTOR) pathway has a critical role in regulating skeletal muscle protein metabolism and mass [18]. ...