Haruhiro Inoue’s research while affiliated with Showa University Koto Toyosu Hospital and other places

... 28 Additionally, intragastric pressure (IGP) was evalu-ated using the Endoscopic Pressure Study Integrated System (EPSIS), which continuously measures IGP during gastric insufflation through esophagogastroduodenoscopy (EGD). [29][30][31][32] EPSIS parameters, previously validated as reliable for assessing EARTh outcomes, 32 were compared before and after treatment. ...

Reference:

A pilot study on anti‐reflux mucoplasty with valve as novel endoscopic therapy for gastroesophageal reflux disease

... Endoscopy, the gold standard for ESCC diagnosis, relies heavily on the skill and experience of the endoscopist. Subtle lesions may be missed, particularly in resource-limited settings where access to highquality equipment and trained personnel is restricted (Hassan et al., 2024). Biopsy, while essential for histopathological confirmation, is an invasive procedure that carries risks such as bleeding and perforation. ...

Reference:

AI-Driven Transformation of Esophageal Squamous Cell Carcinoma Diagnosis, Treatment, and Research

... Achalasia cardia is a rare disease with a reported incidence of one per 1,00,000 population. Peroral endoscopic myotomy is a novel procedure for the management of achalasia cardia, which was first performed in Japan in 2008 [3]. A randomized controlled trial (RCT) has shown that laparoscopic hellers myotomy, compared to balloon dilation, is not associated with superior rates of therapeutic success in these patients [4]. ...

Reference:

Peroral Endoscopic Myotomy (POEM) for Achalasia Cardia: A Report of Two Cases

... Inoue et al. proposed the "phase concept" regarding the antireflux mechanism. 9 According to this concept, the antireflux mechanism of the esophagus and stomach consists of three phases: Phase I (gastric phase), Phase II (lower esophageal sphincter phase), and Phase III (esophageal clearance phase). Sling fibers and clasp fibers are included in Phase I. Generally, endoscopic antireflux procedures aim to restore Phase I. ...

Reference:

Antireflux myoplasty: Endoscopic myoplasty with bilateral sling fiber plication for refractory gastroesophageal reflux disease

... Under general anesthesia with endotracheal intubation, all procedures were performed by a single operator (Haruhiro Inoue) using a therapeutic endoscope (H290T; Olympus) 24 with a super-soft hood (Space Adjuster; TOP) 42 attached, an endoscopic snare (Smart Snare Hex25; TOP Corporation or Snare Master 25 mm; Olympus), and silk thread (NA11SW; NescoSuture) for angulation control. 43 For endoscopic submucosal dissection, an electrosurgical unit (VIO3; ERBE Elektromedizin GmbH) was employed with Endocut I current settings of 1-3-3. Mucosal incisions were made along approximately one-third of the lesser curvature circumference using a Triangle Tip Knife J (TTJ; Olympus) after saline with indigo carmine was injected. ...

Reference:

A pilot study on anti‐reflux mucoplasty with valve as novel endoscopic therapy for gastroesophageal reflux disease

... Various endoscopic treatments for refractory gastroesophageal reflux disease (GERD) have been reported by Inoue et al., including antireflux mucosectomy, 1 antireflux mucosal ablation, 2 antireflux mucoplasty (ARM-P), 3 and ARM-P with a valve. 4 Specifically, ARM-P 3 involves resecting 1/3-2/3 of the mucosa at the gastric lesser curvature using endoscopic mucosal resection or endoscopic submucosal dissection (ESD), followed by suturing of the mucosal defect to reconstruct the gastroesophageal junction, leading to immediate treatment effects. ...

Reference:

Antireflux myoplasty: Endoscopic myoplasty with bilateral sling fiber plication for refractory gastroesophageal reflux disease

... The differences were mainly in the time of submucosal tunnelling and myotomy, and without significant differences between the two groups in terms of the time taken to perform mucosal incisions and closure. Moreover, there was no significant difference in median submucosal tunnel and myotomy length between the two groups (12 [10][11][12][13]cm vs 12 [11][12][13] cm, P = 0.730, and 7 [7][8][9] cm vs 7 [7][8][9][10] cm, P = 0.501, in the FTM and CMM groups, respectively). Additionally, both groups underwent gastric and esophageal myotomies were similar in length. ...

Reference:

Effectiveness and safety of full-thickness versus circular muscle myotomy in peroral endoscopic myotomy: a retrospective single-center analysis of 152 patients

... However, these are invasive procedures with high complication rates [30][31][32]. In addition to progress in surgical management with minimally invasive techniques and robotics, new endoscopic approaches, such as D-POEM with septotomy have been shown to be as effective as surgery with shorter hospital stays and reduced anesthesia times [33,34]. ...

Reference:

High‐Resolution Manometry With Solid Provocative Test in Patients With Mid‐Thoracic and Epiphrenic Esophageal Diverticula

... It was reported as safe and sufficient in closing defects after gastric subepithelial lesion removal under laparoscopic observation, rectal EFTR, thoracoscopy-assisted esophageal EFTR, POEM, gastric POEM, antireflux mucoplasty, postoperative anastomotic leak, and mucosal closure for gastric ulcer bleeding [21][22][23][24][25][26]. Moreover, it was successful in closing rare fistulas after the removal of the lumen-apposing metal stent (LAMS) [27] and preventing self-expandable metal stents (SEMS) from migrating in the digestive tract [28]. In addition, Okamura et al. [29] recently described the case of EHS following ESD at the anastomosis after right hemicolectomy. ...

Reference:

Endoscopic hand suturing after advanced endoscopic procedures - early outcomes of 31 cases in upper and lower GI tract (with video)

... Two to three reopenable endoclips (SureClip; Microtech) secured the mucosal edge to the muscle layer to maintain flap elevation ( Figure 2). Mucosal defects were closed using established techniques, including loop clips (Loop-9), 44 anchor pronged clips (MANTIS; Boston Scientific; Figure 3), 45 and endoscopic hand suturing with a needle holder (FG-260Q; Olympus), and 3-0 V-Loc sutures (VLOCN0804; Medtronic). 46 The choice of closure method was solely at the operator's discretion. ...

Reference:

A pilot study on anti‐reflux mucoplasty with valve as novel endoscopic therapy for gastroesophageal reflux disease