Harib H. Ezaldein's research while affiliated with Case Western Reserve University and other places

Publications (64)

Article
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Little is known regarding the characteristics of newborns with congenital cutaneous hemangioma (CH) and the burden of CH on newborn care. The objective of this study is to describe the burden of CH on newborn inpatient stays in the United States. Specific aims include characterizing newborns with CH, assessing factors predictive of CH and procedure...
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Little is known regarding the burden of sunburns leading to emergency department (ED) visits in the United States (US). The objectives of this research were to characterize the burden of sunburn ED visits, investigate predictors of severe sunburns, and evaluate risk factors for increased cost of care in patients presenting to the ED for sunburn. In...
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Background: Pure and mixed desmoplastic melanomas (DMs) may have different natural histories and behaviors. Methods: We conducted a retrospective review of patients diagnosed with DM at our institution between January 1997 and April 2019. A total of 33 unique DMs were identified and subsequently analyzed based on the histologic type (pure vs. mi...
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BACKGROUND: Microneedling is a relatively safe therapeutic procedure used to treat many dermatological conditions, including acne vulgaris, alopecia, melasma and other pigmentary disorders, as well as to promote skin rejuvenation, rhytide reduction, and scar remodeling. Given its popularity among patients and increasing use in the clinic and at hom...
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BACKGROUND: There appears to be limited research on whether the ultraviolet radiation used in nail lamps for gel manicures is increasing the incidence of skin cancer on the hands and nails of young adults. OBJECTIVE: We sought to assess evidence in the literature regarding the incidence of skin cancer on the hands and nails of young adults who rece...
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Background: The Food and Drug Administration (FDA) has approved several new dermatologic drugs in the last decade. The public response to their approval has not yet been evaluated. Objective: To analyze the United States stock market response surrounding FDA approval of new dermatologic drugs between 2008 and 2018. Methods: A list of 34 FDA approve...
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Erosive pustular dermatosis of the scalp (EPDS) occurs in elderly individuals with significant actinic damage. EPDS also occurs in association with surgery; however, significant studies determining an association of EPDS with type of surgical closure is absent. This review examines whether the closure method following cutaneous surgery performed on...
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Background and Objectives Device innovation in dermatology is increasing. Medical devices identified as “substantially equivalent” to predicate ones by the United States Food and Drug Administration (FDA) may be exempt from premarket approval through the 510(k) pathway. The 510(k) pathway has been criticized for having less stringent clinical data...
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Keratinocyte carcinomas, including basal and squamous cell carcinomas, are the most common human cancers worldwide. While 75% of all keratinocyte carcinoma (4 million annual cases in the United States) are treated with conventional excision, this surgical modality has much lower cure rates than Mohs micrographic surgery, likely due to the bread-loa...
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Background: Although there is a large body of evidence demonstrating the safety and efficacy of Mohs micrographic surgery (MMS) in adults, little is known regarding the safety and efficacy of MMS in children and adolescents. Methods: The authors searched all publications from 1993 to 2018 reporting on the use of MMS for the treatment of cutaneou...
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Background: Knowledge regarding the inpatient burden of cutaneous squamous cell carcinoma (cSCC) is limited. Objective: To provide nationally representative estimates for hospitalization characteristics due to cSCC and determine predictors for increased length of stay (LOS) and cost of care. Methods/materials: A retrospective cohort study of t...
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Objectives: Although adolescents and young adults (AYA) suffer disproportionately from cutaneous melanoma (CM), little is known regarding the burden of CM leading to hospitalization in AYA. The objective of this study was to elucidate sociodemographic/hospitalization characteristics of AYA CM inpatients, determine which factors lead to the greater...
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It is estimated that 75% of dermatologists will face malpractice litigation by age 65.1 Furthermore, 28.7% of medical malpractice cases against dermatologists between 2006 and 2015 were decided in favor of plaintiffs with an average indemnity payment of $238,135 United States dollars (USD).2 Although psoriasis affects more than 7 million adults in...
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Introduction: Cryolipolysis is a noninvasive technique that involves the application of cooling for localized fat reduction. In recent years, cryolipolysis has been increasingly favored for its limited side effects compared to more invasive methods. Methods: Records from a public United States Food and Drug Administration (FDA) database for premark...
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Gottron papules, a heliotrope rash, scalp and extremity erythema, pruritus, and fatigue are the characteristic signs and symptoms of amyopathic dermatomyositis (ADM). Amyopathic dermatomyositis is considered a distinct entity from dermatomyositis (DM) because the characteristic muscle weakness and muscle enzyme elevations of DM are absent in ADM. W...
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Night shift workers may have a disrupted circadian rhythm, which may contribute to the development of skin disease. The purpose of this study was to determine whether there is a significant difference in the prevalence and severity of self-reported skin disease between “regular” day shift workers compared to “graveyard” night shift workers. We cond...
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Importance The prevalence of keratinocyte carcinoma (KC) exceeds that of all other malignant neoplasms combined. Despite the steady rise of payments for medical malpractice liability claims over time, data regarding the characteristics of malpractice litigation for KC are scarce. Objective To identify state and federal appellate medical malpractic...
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Knowledge surrounding inpatient dermatologic procedure costs is limited; therefore to learn more, we performed a cross-sectional analysis of dermatologic procedures contained in a publicly available Washington State Comprehensive Hospital Abstract Reporting System database from 2014. Dermatologic procedure utilization and cost were evaluated based...
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Importance Despite the increasing incidence of chronic cutaneous ulcers (CCUs), limited information exists regarding their incremental economic burden. Objective To provide nationally representative estimates regarding the incremental health care cost of CCUs, controlling for comorbidities and sociodemographic characteristics. Design, Setting, an...
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Background Limited information exists regarding the burden of emergency department (ED) visits due to scabies in the United States. The goal of this study was to provide population-level estimates regarding scabies visits to American EDs. Methods This study was a retrospective analysis of the nationally representative National Emergency Department...
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Introduction Innovations in cancer treatment coupled with an increasing number of cancer patients have led to the growth of brachytherapy devices. The objective of this study is to characterize the development and safety of brachytherapy devices marketed in the United States (US) over the last 15 years. Methods We reviewed records from a public US...
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Introduction: Powered muscle stimulators have been popularized in recent years due to their muscle toning effects. This study aims to describe marketing trends and reporting of adverse effects of powered muscle stimulators. Methods: We performed a cross-sectional retrospective analysis of records from the United States FDA database for 510(k) prema...
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Acne vulgaris affects a large portion of the population and drives many patients to seek over-the-counter (OTC) treatments. Light-emitting diode (LED) therapy has recently emerged as a potential therapeutic option for inflammatory acne. We used the U.S. Food and Drug Administration (FDA) 510(k) premarket submission database to assess the growth in...
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Introduction: Greater demand for noninvasive techniques to reduce cellulite and contour the body have led to the growth of electromagnetic and radiofrequency devices. In this study, we aimed to characterize the evolution and safety of electromagnetic devices marketed in the U.S. over the last two decades. Methods: We examined records from a U.S. FD...
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Importance Medicare represents the second largest component of national health expenditures, and dermatologists receive a disproportionate percentage of Medicare payments. Analyzing trends in Medicare utilization by dermatologists informs optimal Medicare usage for both patients and physicians. Objective To characterize Medicare charges and paymen...
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Importance Knowledge regarding differences in dermatologic care for patients with a broad range of dermatologic conditions is limited. Objective To elucidate nationwide differences in use of outpatient dermatologic care. Design, Setting, and Participants Retrospective analysis of nationally representative data from the 2007 to 2015 Medical Expend...
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Introduction: Low-level laser therapy has demonstrated superior efficacy relative to other nonsurgical treatment options for the treatment of androgenetic alopecia. Methods: Records from a public U.S. FDA database for premarket approval of low-level laser therapy devices approved between January 1 2000 and July 15 2018 were reviewed. Results:...
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The role of biologic therapies in the field of dermatology continues to evolve as newer drugs and biosimilars are introduced to the U.S. market. Prescribing patterns and expenditures regarding biologic drugs are not well described. To address this knowledge gap, a retrospective review was conducted using the Medicare Provider Utilization and Paymen...
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Scholarly consensus is lacking for the risk stratification of patients who present with acute or subacute dermatologic conditions of the lower extremity, particularly cellulitis and its mimickers. This lack of consensus leads to overconsumption of hospital resources and may result in delayed recognition and treatment, adversely affecting patient ou...
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Extracorporeal photochemotherapy (ECP) is a cancer immunotherapy for cutaneous T cell lymphoma (CTCL) operative in more than 350 centers worldwide. While its efficacy and favorable safety profile have driven its widespread use, elucidation of its underlying mechanism has been difficult. In this study, we identify the principal contributors to the a...
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Importance: Surveying identical twins allows us to qualitatively separate genetic and environmental factors that may contribute to acne severity. Objective: To study a cohort of identical and fraternal twins to identify environmental factors that may influence acne severity. Design, setting, participants: A survey was administered to 139 ident...
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Importance The US Food and Drug Administration approves Class III medical devices via the premarket approval pathway, often requiring clinical data on safety and efficacy. Manufacturers can submit incremental device changes via supplemental applications, which are not subjected to such vetting measures and can cause understudied changes that lead t...
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Objective To identify trends in patient presentation and outcomes data that may guide the development of clinical algorithms on Merkel Cell Carcinoma (MCC). Methods We performed a retrospective cohort study searching in the National Cancer Institute's SEER registry for documented MCC cases from 1986-2013. No exclusion criteria were applied. We her...
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Extracorporeal Photochemotherapy (ECP) is a widely applied anti-cancer immunotherapy for patients with cutaneous T cell lymphoma (CTCL). By using apoptotic malignant cells as a source of patient-specific tumor antigen, it enables clinically relevant and curative anti-CTCL immunity, with potential efficacy in other tumors. Currentmethods to track pa...
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Background: Stevens Johnson Syndrome (SJS) is a life threatening skin condition with an overall mortality rate of 5%. Although the causes and pathology of the disease have been well studied, the factors that significantly contribute to mortality remain unclear. Objective: To determine relevant risk factors that increase the likelihood of inpatie...
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This case report describes the occurrence of inverse psoriasiform eruption during pembrolizumab therapy for metastatic melanoma.Research in immunotherapy has led to tremendous advancements in the treatment of patients with advanced or metastatic melanoma. The immune checkpoint inhibitors are highly selective agents that exploit key molecular pathwa...
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The Surveillance, Epidemiology, and End Results (SEER 18) database is the largest national registry for cancer-related patient data in the United States. Despite these advances, Black populations consistently have shown poorer survival statistics, possibly due to later stages of presentation, increased tumor aggressiveness, treatment noncompliance,...
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p16 immunostaining has been used to aid and improve the histopathologic evaluation of equivocal cervical lesions with associated low-grade or high-grade dysplasia. However, the utility of p16 immunostaining in the diagnosis of atypical genital skin lesions remains debatable. We conducted a cross-sectional study of genital skin lesions with varying...
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Background Trigonocephalic treatment entails frontoorbital reshaping of the forehead, increasing bitemporal dimensions, and advancing lateral orbits. Various techniques can achieve this, but no consensus exists regarding effects on long-term skull growth. Overcorrecting forehead dimensions is one strategy though preserving a vascularized fronto-orb...
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Background: Secondary enophthalmos correction, especially in severe cases, represents a surgical challenge. The complex injury pattern involving the hard and soft tissue warrants individualized multimodality treatment strategies. Even with seemingly successfully surgical execution, relapse or incomplete correction of globe position can occur. In a...
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Background Metopic synostosis is characterized by trigonocephaly, lateral supraorbital retrusion, and hypotelorism. Most phenotypic evaluations have focused on the forehead without much emphasis on the orbits. The study seeks to explore differences in orbital dysmorphology for metopic and control patients, along with different degrees of metopic sy...

Citations

... Our findings indicate that HS imposes major financial and emotional burdens upon patients and that online crowdfunding campaigns for covering HS-related costs achieve on average less than a quarter of their goal. The predominant patient demographics identified, namely adult women in the southern USA, reflect the known overall epidemiology of HS. 4 Thematic analysis revealed that financial insecurity among patients with HS is compounded by the significant impact on QoL, 5 lending support to the notion that HS disease burden is both extensive and underestimated. 1,2 The limitations of the current study include the exclusion of campaigns for which donation outcomes were not visible, reliance on self-reported diagnoses of HS, and inability to analyse race/ethnicity data. ...
... A biocompatible MN eliminates the risk of biohazard waste and possible contaminations if needle breakage occurs. Previous studies have also shown that the microneedle technology for drug delivery is safe, has minimal adverse effects and minimizes the risk of infection compared to the conventional needle system [15][16][17]. Besides, maltose has also been shown to be biocompatible and acceptable polymers for use in humans, making it an ideal candidate for microneedle constituents [18]. ...
... It joins with the plate of the nail to form a protective coating over the matrix, which, if weakened, can cause permanent nail scarring. This protection also includes UV protection to complement the natural UV protection provided by the nail plate 14 . The matrix is the only subungual location where functional melanocytes can be found, and UV protection can help to minimize the risk of cancer. ...
... 1 First described in 1977, 2 it is commonly associated with actinic damage and baldness, although it has been linked to drug reactions, surgical closures, and trauma. 3,4 Patients with EPDS present with recurrent pustules and nonhealing crusted ulcerations, producing scarring alopecia with skin atrophy. The diagnosis is often delayed because it is a diagnosis of exclusion. ...
... In addition to being a risk factor for development of cutaneous melanoma and KC, inflammation from sunburn is itself a negative health outcome of exposure to UV radiation (primarily UV-B wavelengths). A recent cross-sectional study of the United States National Emergency Department Sample evaluated the burden of sunburns presenting to emergency departments (ED) in 950 hospitals [214]. Of 82,048 visits for sunburn, 21% were classified as severe sunburn. ...
... In addition, fluorescent SBPs can be rendered optically silent by the addition of a quenching moiety that is lost upon reaction with the protease target of interest, ensuring that the probes only produce a signal in tumor tissue when acted upon by an enzyme activity associated with a tumor or its surrounding margins [47]. In our more recent work, we have developed a method for topical application of imaging probes to tissues using topical application of both quenched activity-based probes [28,29,48] and a third generation quenched SBP [31,49]. Topical application into the surgical cavity to identify remaining or "missed" cancer following lumpectomy has the potential to reduce positive surgical margins and integrates well into the surgical workflow. ...
... need multiple hospitalizations for further disease assessment and follow-up treatment. In consideration of this, researchers have analyzed the relevant factors on the length of stay (LOS) and hospitalization costs in US adolescent and young adult patients with melanoma (10). Although hospitalization cost is one of the main burdens for patients with melanoma (11), few studies describe and analyze the economic features of melanoma hospitalization in China. ...
... There are limited options for effective treatment of distant metastasis or unresectable disease. Those patients who do develop metastases will incur a significant impact on their quality of life [7,8] and consume significant healthcare system resources [9]. ...
... Our search identified eight studies from 2005 to 2019: four case reports/series, [14][15][16][17] one open-label pilot study, 18 and one randomized controlled trial, 19 in which overall cutaneous DM was the primary focus as well as one case report 20 and one retrospective review 6 in which scalp DM was the primary focus. The studies included 150 patients with cutaneous DM diagnosed based on skin biopsy, laboratory findings, and/or Bohan and Peter's diagnostic criteria. ...
... 76 Although paradoxical because PD-1 inhibitors can be used to treat metastatic SCC, secondary eruptive squamoproliferative lesions, including invasive cutaneous SCC, have been reported (Fig. 17). 77,78 CONCLUSION Dermatologic adverse events are among the most common toxicities of systemic anticancer therapeutics and can range from bothersome to life threatening. Thus, dermatologists play an essential role on the care teams of patients with cancer through early recognition and management of mucocutaneous toxicities. ...