Harald Gündel’s research while affiliated with Ulm University and other places

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Publications (367)


Acute Effects of Slow-Paced Breathing on Measures of HRV in Hospitalized Patients With Bilateral COVID-19 Pneumonia: A Secondary Analysis of a Randomized Clinical Trial
  • Article

January 2025

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47 Reads

Psychosomatic Medicine

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Harald Gündel

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Objective Slow-paced breathing (SPB) with prolonged exhalation is assumed to stimulate vagal reflexes, which is represented by increased heart rate variability (HRV) values. However, most trials were conducted in healthy participants. We sought to evaluate the feasibility of SPB in hospitalized patients with confirmed bilateral COVID-19 pneumonia with major respiratory impairment and to investigate if SPB shows acute increasing effects on HRV measures in these severely ill patients with distinctly reduced vagal tone. Methods This single-center randomized controlled clinical trial enrolled 23 patients in the intervention (4-second inhalation, 6-second exhalation for 20 minutes 3× daily) and 23 patients in the control group (IG/CG). The effects of SPB on HRV were calculated using post-hoc likelihood ratio tests. Baseline HRV measures between the groups over time were compared using multilevel mixed-effect linear regression models with random slope including the covariates relevant comorbidities, COVID-19 medication, and age. Results HRV values at baseline were significantly decreased in all patients. During SPB, HRV parameters increased significantly (ln(SDNN), ln(LF), ln(TP); all p < .001). Higher breathing rate at baseline correlated with lower LF during SPB ( p < .045). IL-6 morning levels were associated with lower HRV measures ( p < .001). Resting HRV measures as well as subjective health increased over hospitalization time with no differences between IG and CG (comparing random slope with random slope interaction models: all LR χ ² (5) < 4.5; p > .48). Conclusion SPB is feasible and safe in patients with bilateral COVID-19 pneumonia and appears to be an effective self-performed intervention to acutely increase HRV measures. This observation was independent of comorbidities and comedication. Further trials should corroborate these findings and extend it to other severely ill populations. Registration German Clinical Trials Register under ID DRKS00023971 (https://drks.de/search/en/trial/DRKS00023971), with a Universal Trial Number (UTN) U1111-1263-8658


PRISMA Flowchart demonstrating the study selection process
A Traffic Light Plot demonstrating the domain level judgements of risk of bias analysis for each study. B Visualized contribution of risk of bias judgements within each domain
Forestplot for SMD pre-post. Effect sizes and their 95% CIs per sample for the main training effects comparing pre-to-post scores of emotional competencies are illustrated. The diamond-shaped figure shows the metanalytical computed average effect
Forestplot for SMD pre-post. Post-intervention means, standard deviations, sample sizes as well as effect sizes and their 95% CIs for the main training effects comparing mean changes between intervention- and control-groups are illustrated. The diamond-shaped figure shows the metaanalytical computed average effect
Funnel plot for the training effect of comparative effect-size metaanalysis
Training emotional competencies at the workplace: a systematic review and metaanalysis
  • Literature Review
  • Full-text available

December 2024

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66 Reads

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1 Citation

BMC Psychology

Recent systematic reviews have shown that emotional competencies can be improved through training. In the workplace, such training has become increasingly popular over the last decade. These programs aim to enhance emotional intelligence, empathy or emotion regulation. This study wants to assess the training effects and potential moderators of these workplace interventions. To our knowledge, this is the first systematic review that focuses on the workplace context and integrates emotional intelligence, empathy, and emotion regulation training interventions. This study has been preregistered with PROSPERO and a protocol has been published before the review was conducted (CRD42021267073). We conducted a systematic literature search using Embase, PsycInfo, PSYNDEX, Web of Science and the Cochrane Central Register of Controlled Trials. The included studies were analyzed in two metaanalyses. In the primary analysis, we analyzed standardized mean changes in emotional competencies before and after the training for 50 included studies, depending on (a) training construct and (b) participants’ profession (teachers, health professionals, managers, and others). To determine the efficacy of the trainings, we conducted a separate metaanalysis of controlled trials only (k = 27). Both metaanalyses yielded moderate overall effect sizes that also persisted more than three months after the training end: (1) SMDpre-post = 0.44 (95% CI [0.29, 0.59]), (2) SMDEG-CG = 0.46 (95% CI [0.30, 0.63]). All professions benefited equally from the interventions and we observed no significant differences in the effectiveness of emotional intelligence, empathy, and emotion regulation trainings. Overall, our results suggest that workplace interventions effectively train emotional competencies, regardless of profession or specific training focus. Limitations are the high heterogeneity and the low methodological quality of the studies analyzed. Our study shows the need for more high-quality studies, like randomized controlled trials. Additionally, companies may consider incorporating emotional competence training into their employee and leadership development programs routinely. This study was preregistered on PROSPERO (CRD42021267073). Supplementary Information The online version contains supplementary material available at 10.1186/s40359-024-02198-3.

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Illustration of the underlying conceptual model of the study exploring the relationship between SME leaders’ personality functioning on the dimensions of self-perception and self-regulation and perceived stress reactivity and symptoms of anxiety and depression
Illustration of the aggregated results model showing significant associations between SME leaders’ personality functioning (on the core facets of affect differentiation, affect tolerance, regulation of self-esteem and impulse control) and mental distress (perceived stress reactivity and symptoms of anxiety and depression)
Note. semi-partial correlation coefficients rsp indicating the unique relation of each independent variable with the corresponding dependant variable.
Table of means of the study variables for the total sample (N = 174)
Percentages for symptoms of anxiety and depression on the HADS categorized by symptom severity
Results of the three regression analyses for PSR (Model 1), anxiety (Model 2) and depression (Model 3)
Personality functioning and mental distress in leaders of small- and medium sized enterprises

November 2024

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67 Reads

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1 Citation

Objective For leaders of small and medium-sized enterprises (SMEs) grappling with diverse tasks and stressors, personality functioning can play a key role on stress perception and building and managing professional relationships. We investigated the relationship between SME leaders’ personality functioning on the dimensions of self-perception and self-regulation on perceived stress reactivity (PSR), and symptoms of anxiety and depression. Methods A cross-sectional sub analysis of a multi-centre RCT project was performed. A sample of N = 174 SME leaders from various sectors in southern Germany were examined on their self-rated levels of personality functioning (OPD-SQ), involving self-perception (facets: self-reflection, affect differentiation, sense of identity) and self-reflection (facets: impulse control, affect tolerance, regulation of self-esteem), with higher scores indicating lower levels of personality functioning. The outcome variables were perceived stress reactivity (PSRS) and symptoms of depression and anxiety (HADS). Results The mean score for symptoms of anxiety was M = 6.13 (SD = 3.34), depression M = 4.40 (SD = 3.35), and for PSRS M = 21.39 (SD = 8.04). The mean sum score for self-perception was M = 7.71 (SD = 7.19) and for self-regulation M = 10.50 (SD = 7.09). The results of three regression models showed that higher scores for affect differentiation (rsp = .13), impulse control (rsp = .14) and regulation of self-esteem (rsp = .29) were associated with higher scores for PSR. Higher scores for affect differentiation (rsp = .17) and affect tolerance (rsp = .20) were significantly associated with higher scores for anxiety. A higher score for regulation of self-esteem (rsp = .17) was associated with higher depression scores. Conclusion This study highlights the association between core dimensions of SME leaders’ personality functioning and mental distress. The findings can be applied on interventions and health promotion and the establishment of high-quality professional relationships and leadership skills.


Study flow for participants in the 3for1-project
Effectiveness of a three-component intervention supporting unemployed individuals with mental health issues in their job search and mental health recovery (3for1): study protocol of a non-randomized controlled study

November 2024

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34 Reads

BMC Public Health

Background There is a vicious cycle between unemployment and mental health issues. Unemployed individuals with mental health issues require individualized support at multiple levels in order to promote their mental health, and obtain and retain employment. The 3for1-intervention program aims to provide such support with three components (short-term psychotherapy, job coaching based on the Individual Placement and Support approach, and peer support). This study protocol outlines how the effectiveness of this three-component intervention program in terms of re-employment, mental health, and psychosocial outcomes will be evaluated. Methods The 3for1-intervention program will be evaluated with a non-randomized controlled trial design in a multi-center study. 500 eligible participants aged between 18 and 60 years from six job centers in Southern Germany will be allocated to a control group or an intervention group. Allocation is time-based, with the control group being recruited first, followed by recruitment of the intervention group. The control group will receive treatment as usual, whereas the intervention group will receive treatment as usual as well as access to the three intervention components over a period of 12 months. Assessment will be conducted at baseline (t0), and 12 (t1) and 18 (t3) months later. The primary outcome will be the proportion of participants who are in employment subject to social insurance contributions at t1. Differences between control and intervention group will be tested with logistic regression analysis, controlling for relevant covariates. Analyses of secondary outcomes will relate to group differences regarding re-employment, health and well-being, social integration, help-seeking, and self-stigma at t1 and t2, applying logistic regression analysis or analysis of covariance. Additionally, usage of health services will be measured to evaluate the intervention program’s cost effectiveness. Discussion The 3for1-intervention aims to improve employability and mental health outcomes of a vulnerable population with high need for assistance. Improvements for this population would benefit the German welfare state as well. This study could provide valuable insights into the feasibility, implementation, and sustainability of this individualized, multi-level support program within German job centers. Trial registration This trial is registered with the German Clinical Trials Register: DRKS00029002 (registered on 11 May 2022).


Joint responses to crying: How mothers and their children comfort crying babies

October 2024

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80 Reads

Research on Children and Social Interaction

One of the fascinating challenges in adult-child interaction is found in the fine-grained coordination of joint activities in the real time of play-interactions. In this contribution we take a closer look at caregiving activities that are jointly carried out by mothers and their five-year-old children. At this age, changing diapers, feeding, and comforting a crying baby (doll) is a challenging activity. The focus of our empirical study is on responses to crying. The investigation is innovative in so far as in prior research it was always the reaction by the mother (or the father or, not so often, by the sibling) that was under scrutiny. Here, we analyse sequentially how children comfort a lifelike doll together with their mother.


Examine the effect of slow-paced breathing intervention in hospitalized COVID-19-pneumonia patients -secondary results from a clinical randomized controlled trial Background

October 2024

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37 Reads

Symposia IV-2: MEASURE FOR MEASURE: COMPARATIVE UTILITY OF HEART RATE VARIABILITY INDICES OF CARDIAC VAGAL CONTROL Slow-paced breathing (SPB) is a long-known, noninvasive, and inexpensive method to stimulate vagal fibers known to directly decrease heart rate (HR) and increase indicators of HR variability (HRV). The aim of the present analysis is to investigate the direct effects of SPB in C19-pneumonia patients on commonly used HRV. Patients from the BeatCOVID RCT intervention group (DRKS00023971) wore bidaily holter monitors (Faros 180) during 5min-Rest, 4x5min SPB, and 5min recovery, processed in Kubios for HRV calculation. SPB effect on HRV-parameters were analyzed using multilevel fixed-effect linear regression models.


The Balancing Act of Fitting In: A Grounded Theory Study on How Patients With Posttraumatic Stress Disorder Following Childhood Maltreatment Experience Participating in a Randomized Controlled Psychotherapy Study

October 2024

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140 Reads

Qualitative Psychology

Randomized controlled trials are routinely used to assess the efficacy of psychotherapy. To date, our knowledge about how patients experience participation in such a trial is scant. Therefore, the present analysis aims at an in-depth exploration of patients’ perspectives on how a trial environment affects them. This study was conducted within the framework of the ENHANCE study, a large randomized controlled trial comparing two trauma-focused treatments, that is, psychodynamic and cognitive behavioral therapy, for patients diagnosed with posttraumatic stress disorder resulting from childhood maltreatment. We analyzed 17 posttherapy interviews with trial participants, employing an extended version of the Client Change Interview and grounded theory methodology for analysis. Analysis yielded one core category, revolving around the extent to which participants needed to conform to the external research framework to obtain personal benefits. This ambivalence was intertwined with trauma-related characteristics specific to this patient group. Three clusters fed into the core category: (1) positive and negative fantasies aroused by the research framework, (2) basic needs of patients colliding with the study conditions, and (3) inner and outer confrontations prompted by participation in the study. Study participation affects patients at various intrapsychic levels, resulting in specific dilemmas. Participation primarily serves as a means to obtain a therapy spot. Patients willingly accept the challenges associated with the study setting, viewing them as the trade-off for treatment access. Due to a positive therapy experience, participants maintain a favorable attitude toward study participation at large. Implications for integrating our findings in future studies are discussed.



Paralleles Mediationsmodell (Modell 3) mit standardisierten Regressionskoeffizienten. Anmerkungen:N = 103, *** p < 0,0001, ** p < 0,001, c′ = signifikanter indirekter Effekt gesundheitsbezogener organisationaler Normen unter Berücksichtigung der Moderatoren M1 und M2 auf „gesundes“ Führungsverhalten, c = direkter Effekt organisationaler Normen auf „gesundes“ Führungsverhalten unter Kontrolle der Mediatoren M1 und M2. Die im Modell berücksichtigen Kontrollvariablen Alter, Geschlecht, Berufsgruppe (Pflege/Mediziner) und Krankenhaus-Dauer sind aufgrund von nicht vorhandener Signifikanz nicht mit abgebildet (vgl. Tab. 2)
Handlungsleitende Bedingungen gesunder Führung: Eine längsschnittliche Untersuchung aus der Perspektive der Theory of Planned Behavior

Gruppe. Interaktion. Organisation. Zeitschrift für Angewandte Organisationspsychologie (GIO)

Zusammenfassung Unter Rückgriff auf die Theory of Planned Behavior (TPB) trägt unsere Studie zu einem besseren Verständnis der Mechanismen handlungsleitender Bedingungen „gesunder Führung“ bei. Die Unterstützung durch Führungskräfte ist für die erfolgreiche Umsetzung von gesundheitsförderlichen Arbeitsgestaltungsmaßnahmen in Organisationen von entscheidender Bedeutung. Es gibt bislang nur wenige Erkenntnisse darüber, welche Bedingungen Führungskräfte dazu veranlassen, sich für die Gestaltung gesünderer Arbeitsbedingungen für die Beschäftigten einzusetzen. Die übergeordnete Rolle von Organisationsnormen und deren Wechselwirkungen mit anderen TPB-Prädiktoren konnte mithilfe von Regressionsanalysen mit paralleler Mediation empirisch bestätigt werden. Basierend auf längsschnittlich herhobenen Daten konnte gezeigt werden, dass gesundheitsbezogene Organisationsnormen von Bedeutung sind, um Führungskräfte für die Gestaltung gesundheitsförderlicher Arbeitsbedingungen zu gewinnen. Zudem liefern die Ergebnisse Hinweise darauf, warum sich diese Normen auf ein gesundheitsförderliches Führungsverhalten auswirken. Die Ergebnisse der Studie lassen sich zur theoretischen Weiterentwicklung des Prozessmodells „gesunder Führung“ nutzen, indem sie wesentliche handlungsleitende Bedingungen aufzeigen, die Führungskräfte dazu veranlassen gesundheitsförderlich zu führen.


Citations (60)


... As previously stated in relation to potential core dimensions of personality functions, the influence of mental stress on managerial behavior is not only significant at the individual level, but also in terms of the broader leader-member dynamic. Conversely, positive professional relationships serve as an influential protective factor for mental and physical health [53,54]. ...

Reference:

Personality functioning and mental distress in leaders of small- and medium sized enterprises
Unveiling social relationships: exploring the importance of relationships as a moderator of the link between effort-reward imbalance and leader-member exchange among healthcare professionals

BMC Public Health

... Furthermore, findings by Diebig et al. [56] indicate that leaders who exhibit high levels of stress reactivity tend to experience challenges in fostering positive and high-quality relationships with their followers. More specifically, it was also found that the individual Leader-Member-Exchange (LMX) relationship quality formed between a leader and each follower within the team (LMX differentiation) is associated with followers' psychological strain on the individual, yet also on the level of the whole team [10]. ...

Leaders' mental health and leader-member exchange: Exploring relations on different levels of analysis
  • Citing Article
  • July 2024

Scandinavian Journal of Psychology

... B. durch eine explizite Entscheidung zwischen den Optionen) (Born et al. 2020). Damit einhergehend sinkt die berufliche psychische Beanspruchung über den Trainingsverlauf hinweg (Born et al. 2022). Auch die kollegiale Umwelt der teilnehmenden Führungskräfte scheint von einem veränderten Verhalten der Führungskräfte profitiert zu haben (Born et al. 2020). ...

The effects of a dilemma management training program on mental health: a prospective study with mid-level executives in hospitals
  • Citing Article
  • July 2022

Leadership in Health Services

... For instance, increased sympathetic activity (as seen in lower HRV) can stimulate the release of cortisol via the HPA axis. Additionally, while the ANS (measured by HRV) provides rapid adjustments in physiological functions, the HPA axis directs longerterm adaptations to stressors through the release of cortisol (Balint et al., 2023). Therefore, as hypnotherapy improves the autonomic balance, hot flashes would be expected to improve, as demonstrated in the case study. ...

Heart rate variability predicts outcome of short‐term psychotherapy at the workplace

Psychophysiology

... In this study, maternal CM experiences had no significant effect on maternal attachment representation, in contrast to previous studies [12][13][14]45]. However, unlike previous studies [12][13][14], our study only distinguished between secure and insecure attachment representations. ...

Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology

... In our study, the presence of albumin extravasation served as an indication of the destruction of the blood-brain barrier, which is consistent with findings from a previous study conducted on gerbils, wherein immunohistochemical analysis demonstrated increased permeability of the blood-brain barrier to serum albumin after infarction in the hippocampus [13]. In comparison to our prior investigations in swine, the following disparities were observed: following HS alone without simultaneous ASDH or any other direct acute brain injury, no alterations in the levels of extravascular albumin had been noted [14], whereas following ASDH alone, i.e., direct acute brain injury, but without concomitant circulatory depression, a significant increase in extravascular albumin was detected in the ipsilateral, i.e., blood-injected brain hemisphere [6]. In the present study, the concurrent occurrence of ASDH and HS induced an extravasation of albumin. ...

Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na2S2O3) Treatment

... In our own randomized-controlled trial (RCT) on day patient treatment, approximately 30% of patients required a second admission to the hospital during a 2½-year follow-up [19]. In addition, inpatient treatment is associated with the highest treatment costs compared to other treatment modalities [20]. Given the very high readmission rates after IP [21,22] and increased hospital admissions of children and adolescents with AN-especially during the COVID-19 pandemic [23,24]-innovative ideas are desperately needed. ...

First onset of treatment of patients with eating disorders and treatment course: Results of data from a German health insurance company
  • Citing Article
  • May 2022

European Eating Disorders Review

... [21,22]). Research has shown that patients and their partners may experience different stressors and adopt distinct coping and communication patterns [23,24]. Therefore, interventions tailored to the individual needs of patients and partners may be more effective and allow for more flexible consultations [25]. ...

Couples Coping With Hematological Cancer: Support Within and Outside the Couple – Findings From a Qualitative Analysis of Dyadic Interviews

... Vielversprechende Ergebnisse liefert auch ein weiteres Versorgungsmodell dieser Art, das eine psychosomatische Sprechstunde im Betrieb und die Möglichkeit einer anschließenden Kurzintervention beinhaltet: Der Vergleich zwischen den Messzeitpunkten vor und nach der Intervention zeigte eine signifikant verbesserte Arbeitsfähigkeit und verringerte psychische Symptomatik in der Selbsteinschätzung (Balint et al., 2021). Eine korrelative Analyse verdeutlichte den möglichen Effekt dieser Intervention auf reduzierte Fehltage (Gantner et al., 2022). Zudem gibt es zahlreiche internationale Studien, die mehrheitlich stärkere arbeitsbezogene Effekte im Vergleich zu nichtarbeitsbezogenen Interventionen berichten (Dalgaard et al., 2017;Joyce et al., 2016;Lagerveld et al., 2012;Nieuwenhuijsen et al., 2020;Øverland et al., 2018;Reme et al., 2015;Slater et al., 2023). ...

Psychotherapeutic Consultation Services in the Workplace: A Longitudinal Analysis of Treatments and Sick Leave Using Health Insurance Data

... Supporting this notion, it has been reported that having a longitudinal higher well-being, evaluated through different psychosocial factors, is related to a higher abundance of mitochondrial OxPhos in postmortem individuals' brain 40 . Furthermore, mitochondrial respiration and content in PBMCs have been found to be altered in women that have experienced early life stress, reflecting allostatic load 41 . Thus, living with chronic social stress could chronically impair mitochondrial functioning. ...

Investigating mitochondrial bioenergetics in peripheral blood mononuclear cells of women with childhood maltreatment from post-parturition period to one-year follow-up

Psychological Medicine