Hao Chen's research while affiliated with Sun Yat-Sen University and other places

Publications (805)

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Background Microglia-mediated neuroinflammatory response following traumatic brain injury (TBI) is considered as a vital secondary injury factor, which drives trauma-induced neurodegeneration and is lack of efficient treatment. ACT001, a sesquiterpene lactone derivative, is reportedly involved in alleviation of inflammatory response. However, littl...
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Background The forkhead box O3a protein (FoxO3a) has been reported to be involved in the migration and invasion of trophoblast, but its underlying mechanisms unknown. In this study, we aim to explore the transcriptional and metabolic regulations of FoxO3a on the migration and invasion of early placental development. Methods Lentiviral vectors were...
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Chemotherapeutic drugs play an important role in the treatment of cancer, but the individual differences of patients' sensitivity to chemotherapeutic drugs and the drug resistance of chemotherapeutic drugs have always been a thorny problem in clinical treatment. In recent years, with the progress in research on human microbiota, gut microbiome play...
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The utilization of bamboo resources can significantly alleviate the wood shortage and facilitate CO2 neutralization. However, the adhesive bonding performance of bamboo is not ideal, which greatly limits its application. Therefore, the biggest challenge is to explore a simple and effective method to enhance the bonding between bamboo and adhesive....
Preprint
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Background Pancreatic cancer, of which pancreatic ductal adenocarcinoma (PDAC) is one of the most prevalent type, is one of the most malignant tumors, with a 5-year survival rate of about 10%. Pancreatic cancer stem cells play pivotal roles in chemoresistance and recurrence. Long non-coding RNAs (lncRNAs) have been identified as key regulators of t...
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For (Na0.5Bi0.5)0.7Sr0.3TiO3-based (BNST) energy storage materials, a critical bottleneck is the early polarization saturation and low breakdown electric field (Eb), which severely limits further development in the field of advancing pulsed power capacitors. Herein, a strategy, via multiscale regulation, including synergistically manipulation of th...
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Objective This study aims to investigate the clinical outcome of single and double incision for double-level percutaneous interlaminar lumbar discectomy Methods A retrospective analysis was performed involving patients with L4/5 and L5/S1 double-level lumbar disc herniation who received percutaneous interlaminar lumbar discectomy (PEID) in our hos...
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Background: Neoadjuvant chemoradiotherapy (neo-CRT) in combination with surgery increases survival compared to surgery alone, as indicated by the esophageal squamous cell carcinoma (ESCC) treatment recommendations. However, the benefits of neo-CRT are diverse among patients. Consequently, the development of new biomarkers that correlate with neo-C...
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Background Although a substantial increase in the survival of patients with other cancers has been observed in recent decades, pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest diseases. No effective screening approach exists. Methods Differential exosomal long noncoding RNAs (lncRNAs) isolated from the serum of patients with PD...
Preprint
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The cyclin-dependent kinases, CDK4 and CDK6 are upregulated in various cancers, including pancreatic ductal adenocarcinoma. However, monotherapy with CDK4/6 inhibitors has been unsatisfactory and several oncogenic pathways might be activated. We demonstrated that PD-0332991, an FDA-approved CDK4/6 inhibitor, moderately suppressed tumor growth and i...
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计算机检索MEDLINE、The Cochrane Library、EMBASE、中国生物医学文献数据库、中国学术期刊网络出版总库、万方数据库,检索时间均为建库至2018年9月。筛选食管胃结合部癌切除术后各种消化道重建方式,采用Stata SE 15软件进行频率学网状Meta分析。本研究共纳入19篇随机对照试验,共计1 542例患者。结果显示,与食管胃直接吻合相比,功能性空肠间置吻合、双通道吻合、空肠间置双S吻合和单腔空肠段间置吻合均有更低的反流症状发生率(均P<0.05),功能性空肠间置吻合和改良襻式代胃吻合具有更低的反流性食管炎发生率(P<0.05),功能性空肠间置吻合和空肠间置双S吻合具有更低的钡餐X线检查反流发生率(P<0.05)。根据累积排序概率曲线下面积排序结果,功能性空肠间置吻...
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All‐solid‐state batteries (ASSBs) show great potential as high‐energy and high‐power energy storage devices but their attainable energy/power density at room temperature is severely reduced because of the sluggish kinetics of lithium‐ion transport. Here we first reported a thermally modulated current collector (TMCC), which can rapidly cold‐start A...
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Effective staff scheduling is a critical activity of successful software development management. Due to its difficulty and broad applications in many service delivery scenarios, staff scheduling has been studied for several decades. However, most existing work focus on constructing the working schedules based on a given workforce size. This paper t...
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Background Difficult tumors can be treated with a combination of radical surgery and photodynamic therapy to reduce recurrences. The aim of this study is to present a combined application of radical surgery combined with intraoperative PDT approach in patients with various cancers suspected of post-operative recurrence from a single center. Method...
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Nickel–zinc (Ni–Zn) batteries hold a lot of promise for energy storage thanks to their high output voltage, plentiful Zn supply, and low toxicity. Achieving the facile preparation of high-performance cathodes at ambient temperature remains a challenge, it is however essential for practical applications. Here, in the present study, an efficient ultr...
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The natural product diphyllin has demonstrated great potential in the treatment of various human cancers, especially pancreatic cancer. However, its relative weak potency, low aqueous solubility, and poor metabolic stability limits its development ability. In this study, we designed and synthesized two series of novel nitrogen-containing diphyllin...
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Background: Gastric cancer (GC) is the most common malignant tumor. Due to the lack of practical molecular markers, the prognosis of patients with advanced gastric cancer is still poor. A number of studies have confirmed that the coagulation system is closely related to tumor progression. Therefore, the purpose of this study was to construct a coag...
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Ammonium vanadate holds promise for the high-performance cathode in aqueous zinc ion batteries (ZIBs) due to its stable layered structure and superior theoretical capacity. However, excessive ammonium cations occupying the interlayer and too strong electrostatic interaction between Zn²⁺ and defect-free V-O bonds largely hinder the capacity and rate...
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All‐solid‐state lithium metal batteries are prominent candidates for next‐generation batteries with high energy density and low safety risks. However, the traditional planar contact between Li metal and solid‐state electrolytes (SSEs) exhibits substantive void formation and large interfacial morphological fluctuation, causing poor interfacial stabi...
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The development of efficient carbon dioxide reduction reaction (CO2RR) catalysts is one of the practical solutions to the current environmental problems. Usually, metal-doped catalysts are used for the CO2RR, but the metal elements can easily aggregate, resulting in a reduction in the catalytic performance. In this study, NiFe-LDH was exfoliated to...
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Purpose To investigate the safety and efficacy of a reverse puncture device (RPD) and specimen eversion of the rectum for resection in total laparoscopic proctectomy. Methods In a prospective study from August 2019 to March 2021, 40 patients underwent a procedure with an RPD and specimen eversion of the rectum for total laparoscopic low rectal can...
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Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant metastasis is a critical factor in the prognosis of patients with GC. Understanding the mechanism of GC metastasis will help improve patient prognosis. Studies have confirmed that urokinase-type plasminogen activator receptor (PLAUR) promotes GC metastasis; however...
Preprint
Objective: To assess the clinical effectiveness and radiographic results of unilateral and bilateral percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fractures (OVCF) associated with scoliosis. Methods : 52 patients who had OVCF with scoliosis and underwent PKP were retrospectively analyzed. Among the patients,...
Preprint
Purpose Leaf resorption is an important mechanism for plant nutrient conservation, but not all elements are resorbed by plants. It is believed that aluminum (Al) and iron (Fe) are accumulated in old leaves rather than be resorbed due to their toxic effects, but this view never be systematically evaluated. Methods Here, a data synthesis was conducte...
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Tissue factor (TF), an initiator of extrinsic coagulation pathway, is positively correlated with venous thromboembolism (VTE) of tumor patients. Beyond thrombosis, TF plays a vital role in tumor progression. TF is highly expressed in cancer tissues and circulating tumor cell (CTC), and activates factor VIIa (FVIIa), which increases tumor cells prol...
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Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc. The interactions between these components, which are divided into anti-tumor and pro-tumor, determine the trend of anti-tumor immunity. Although the immune system can eliminate tumor through the cancer-immune cycle, tumors appear to eventually evade from immune...
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This work investigates the substitution of Ce donor for Bi at A-site, which effectively improves the piezoelectricity and electrical resistivity of Aurivillius-phase CaBi4Ti4O15 (CBT) ceramic. Crystal structures of CaBi4-xCexTi4O15 ceramics are studied systematically, revealing the reason of unit cell contraction and the decreased ferro-distortion...
Preprint
Purpose Biological nitrogen fixation of deep-rooted legumes is a major pathway of nitrogen (N) inputs to drylands ecosystems. Water sources including groundwater and streamflow are vital to the growth of deep-rooted legumes in drylands, but it is unclear how their different availability and biochemical properties may influence plant N fixation. Met...
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Objective: In recent years, there are several systematic reviews published on animal experiments of Traditional Chinese medicine (TCM). PRISMA (preferred reporting items for systematic reviews and meta-analysis) guidelines provide a guarantee for significantly improving the reporting quality of systematic reviews (SRs) and meta-analysis (MAs) to a...
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Ultrasonic transducers may need to operate in direct contact with the human body, especially with the skin or closer to blood vessels. Eco-friendly lead-free materials and devices are therefore being vigorously developed for biosafety considerations. This work presents high-performance potassium sodium niobate [(K,Na)NbO3, KNN]-based lead-free cera...
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Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by high degree of innervation and desmoplasia in its tumor microenvironment (TME). Nerves and cancer associated fibroblast (CAFs) represent two key components of TME. Schwann cells (SCs), the most prevalent cell type in peripheral nerves, have been reported to support neurons and...
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Background Prognosis for patients recurred rapidly after resection of pancreatic ductal adenocarcinoma (PDAC) was extremely poor. We proposed the concept of postoperative hyper-progression disease (PO-HPD) to define recurrence within 2 months after surgery, explored the role of surgery for postoperative HPD patients and determined the predictive pr...
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Objective: Innate immunity plays important roles in pancreatic ductal adenocarcinoma (PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune system. Here, we aimed to explore the heterogeneity and pro-tumour mechanisms of neutrophils in PDAC. Design: We analysed single-cell transcriptomes of peripheral blood polymor...
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The prodrug mycophenolate mofetil (MMF), which is presystemically hydrolyzed into the pharmacologically active compound mycophenolic acid (MPA), has been widely used for the prophylaxis of acute allograft rejection in solid organ transplantation. However, the huge variability in the plasma concentration level makes the development of MMF drug produ...
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The paper presents results of simulation tests of a hybrid excited permanent magnet machine operating in various states. The common feature of this machine is the presence of magnetic barriers in the rotor structure. Structurally, this machine combines the advantages of the PMa-SynRM machine (Permanent Magnet assisted Synchronous Machine) and a wou...
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Immune cell invasion after the transplantation of solid organs is directed by chemokines binding to glycosaminoglycans (GAGs), creating gradients that guide immune cell infiltration. Renal transplant is the preferred treatment for end stage renal failure, but organ supply is limited and allografts are often injured during transport, surgery or by c...
Preprint
Background Checkpoint-based immunotherapy has failed to elicit responses in the majority of patients with pancreatic cancer. In our study, we aimed to identify the role of a novel immune checkpoint molecule V-set Ig domain-containing 4 (VSIG4) in pancreatic ductal adenocarcinoma (PDAC). Methods Online datasets and tissue microarray (TMA) were utili...
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Background: This study aimed to explore the effect and mechanism of iguratimod (IGT) on M1 macrophage polarization and antibody-mediated rejection (ABMR) after renal transplant. Methods: Bioinformatics analysis was performed using three public databases derived from the GEO database. Sprague–Dawley (SD) rats were pre-sensitized with donors of Wista...
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Objective: To evaluate the safety and efficacy of cervical pedicle screw (CPS) placement with O-arm navigation in the treatment of lower cervical fracture-dislocation. Methods: A retrospective clinical study was performed involving 42 consecutive patients with lower cervical spine fracture-dislocation who underwent CPS fixation surgery with O-ar...
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Reconstruction of damaged nerves remains a significant unmet challenge in clinical medicine. Topographical and mechanical stimulations play important roles to repair peripheral nerve injury. The synergistic effects of topography and mechanical rigidity may significantly accelerate nerve regeneration. In this work, we developed a nerve‐guiding colla...
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Objective: To explore the efficacy of photodynamic therapy combined with chemotherapy, targeted therapy, and immunotherapy in poorly differentiated gastric adenocarcinoma (GAC). Background: Advanced GAC has high malignancy and mortality rate. To date, no study has applied photodynamic treatment (PDT) combined with chemo-, targeted, and immunotherap...
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In this paper, a control strategy to minimize the root-mean-square (rms) current and eliminate the backflow power over a wide operation range is proposed to enhance the conversion efficiency of a semi dual-bridge resonant converter (SDBRC). Steady-state analysis of the converter is performed using the fundamental harmonic approximation approach. Op...
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CaBi2Nb2O9 (CBN), one of the bismuth layered structural ferroelectrics (BLSFs), with high Curie temperature (TC), has great potentiality in high temperature applications. In this work, high curie temperature and piezoelectric constant (d33) are realized in modified CaBi2Nb2O9 ceramics with Ce‐substitution. Ce‐substitution changes the crystal struct...
Preprint
Purpose: To investigate the safety and efficacy of a reverse puncture device and specimen eversion of the rectum for resection in total laparoscopic proctectomy. Methods: In a prospective study from August 2019 to March 2021, 40 patients underwent a procedure with a reverse puncture device and specimen eversion of the rectum for resection in total...
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The imbalance between acetylation and deacetylation of histone proteins, important for epigenetic modifications, is closely associated with various diseases, including cancer. However, knowledge regarding the modification of histones across the different types of digestive cancers is still lacking. The purpose of this research was to analyze the ro...
Preprint
Pancreatic cancer, which most commonly refers to pancreatic ductal adenocarcinoma (PDAC), is one of the most malignant tumors, with a 5-year survival rate of about 4%. Pancreatic cancer stem cells play pivotal roles in chemoresistance and recurrence. Long non-coding RNAs (lncRNAs) have been identified as key regulators of the biological progression...
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An appropriate amount of (Li,Ce) ions are incorporated into bismuth layer-structured piezoelectric ceramics to reduce the oxygen vacancy concentration, limit the grain growth, and enhance the electrical properties and hardness of the ceramics. The existence of a pseudo-tetragonal phase region, the change in the domain structure, and the increase in...
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The lithium–sulfur (Li–S) battery is one of the most promising battery systems due to its high theoretical energy density and low cost. Despite impressive progress in its development, there has been a lack of comprehensive analyses of key performance parameters affecting the energy density of Li–S batteries. Here, we analyse the potential causes of...
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Background: Percutaneous endoscopic lumbar discectomy (PELD) has become a favorable surgical approach for lumbar radiculopathy caused by intervertebral disc herniation. Studies have revealed patients with type II Modic change may suffer from unrelieved low back pain and higher LDH recurrence after herniated nucleus pulposus removal. Therefore, in...
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Charcot arthropathy of the shoulder joint is usually referred to as shoulder joint involvement of Charcot arthropathy, which is a chronic, degenerative, destructive condition resulting from decreasing or loss of sensorial innervation. To date, several reports have described the shoulder Charcot arthropathy, caused by malformations of the occipital...
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A phase-shifted dual-bridge series resonant DC-DC converter (DBSRC) is a competitive candidate for applications of an energy storage system. At the request of a step-load-change command such as the start-up and power-level change, the converter may suffer from large-amplitude transient oscillations due to improper transient modulation. Furthermore,...
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High piezoelectric properties (d33 = 936 pC/N, d33* = 1015 pm/V, and kp = 0.701) are obtained from 960 °C sintered PNN–PZT piezoceramics by adding Li2CO3. The introduction of Li+ ions into PNN–PZT ceramics causes the phase shifts to the morphotropic phase boundary (MPB) region, which has not been reported for lead-based ferroelectrics. The Li+ ion...
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Aim This study aimed at a comprehensive analysis of Ribosomal Protein S6 Kinase A4 (RPS6KA4) and seeked the prognostic value for hepatocellular carcinoma (HCC). Background Liver cancer is a common type of tumor worldwide, and HCC accounts for about 75 to 85% of all primary liver cancer cases. The Ribosomal S6 protein kinases (RSK) family plays an...
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Purpose To evaluate the effects of the association between first trimester vitamin D (VitD) concentrations and increased prepregnancy body mass index (BMI) on early fetal growth restriction (FGR). Methods This retrospective cohort study included 15,651 women with singleton pregnancy who delivered at the International Peace Maternity and Child Heal...
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CaBi2Nb2O9 (CBN) with Aurivillius phase has an enormous potential in high-temperature piezoelectric devices due to their high Curie temperature and excellent free-fatigue characteristics. Nevertheless, simultaneous enhancement of electrical and mechanical properties in CBN-based ceramics are still a great challenge because of the trade-off between...
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Bi4Ti3O12 (BIT), a typical layered-structure ferroelectric with a high Curie temperature (TC), is a promising material for high-temperature sensors. Herein, W/Cr co-substitution at the B-site of BIT ceramics (BITWC100x) is carried out to investigate the phase structure, domain structure, and electrical properties. The W/Cr addition apparently reduc...
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Background: Accurate assessment of the tumour immune microenvironment promotes individualised immunotherapy regimens and screens dominant populations suitable for immunotherapy. Therefore, potential molecular markers were investigated to make an overall assessment of the immune microenvironment status of liver hepatocellular carcinoma (LIHC). Res...
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Objectives: Early diagnosis and detection of acute rejection following kidney transplantation are of great significance for guiding the treatment and improving the prognosis of renal transplant recipients. In this study, we are aimed to explore the biological characteristics of biopsy-proven acute rejection (BPAR) and establish a predictive model....
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Purpose: To investigate the role of LAMC1 in gastric cancer (GC), if it is of great importance to identify tumour driver genes with prognostic value. Patients and methods: GC-related gene expression profile data were downloaded from TCGA. R-limma package and univariate Cox regression were used to identify the differentially expressed genes (DEGs...
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Objective: To identify the potential pharmacological targets of Jisuikang (JSK) for the treatment of spinal cord injury (SCI) using network pharmacology. Methods: The bioactive compounds of JSK herbs and their corresponding potential SCI targets were obtained from three traditional Chinese medicine (TCM) databases. SCI-related therapeutic target...