Hannah E. Reses's research while affiliated with Centers for Disease Control and Prevention and other places

Publications (13)

Article
Background Carbapenem-resistant Enterobacterales (CRE) are usually healthcare-associated but are also emerging in the community. Methods Active, population-based surveillance was conducted to identify case-patients with cultures positive for Enterobacterales not susceptible to a carbapenem (excluding ertapenem) and resistant to all third-generatio...
Article
Nursing home residents have experienced disproportionally high levels of COVID-19-associated morbidity and mortality and were prioritized for early COVID-19 vaccination (1). Following reported declines in vaccine-induced immunity after primary series vaccination, defined as receipt of 2 primary doses of an mRNA vaccine (BNT162b2 [Pfizer-BioNTech] o...
Article
Objective The incidence of infections from extended-spectrum β-lactamase (ESBL)–producing Enterobacterales (ESBL-E) is increasing in the United States. We describe the epidemiology of ESBL-E at 5 Emerging Infections Program (EIP) sites. Methods During October–December 2017, we piloted active laboratory- and population-based (New York, New Mexico,...
Article
Full-text available
Background Optimized symptom-based COVID-19 case definitions that guide public health surveillance and individual patient management in the community may assist pandemic control. Methods We assessed diagnostic performance of existing cases definitions (e.g. influenza-like illness, COVID-like illness) using symptoms reported from 185 household cont...
Article
Background In the USA, COVID-19 vaccines became available in mid-December, 2020, with adults aged 65 years and older among the first groups prioritised for vaccination. We estimated the national-level impact of the initial phases of the US COVID-19 vaccination programme on COVID-19 cases, emergency department visits, hospital admissions, and deaths...
Article
Full-text available
To protect both patients and staff, healthcare personnel (HCP) were among the first groups in the United States recommended to receive the COVID-19 vaccine. We analyzed data reported to the U.S. Department of Health and Human Services (HHS) Unified Hospital Data Surveillance System on COVID-19 vaccination coverage among hospital-based HCP. After va...
Article
Although COVID-19 generally results in milder disease in children and adolescents than in adults, severe illness from COVID-19 can occur in children and adolescents and might require hospitalization and intensive care unit (ICU) support (1-3). It is not known whether the B.1.617.2 (Delta) variant,* which has been the predominant variant of SARS-CoV...
Article
Full-text available
Throughout the COVID-19 pandemic, older U.S. adults have been at increased risk for severe COVID-19-associated illness and death (1). On December 14, 2020, the United States began a nationwide vaccination campaign after the Food and Drug Administration's Emergency Use Authorization of Pfizer-BioNTech COVID-19 vaccine. The Advisory Committee on Immu...
Article
Full-text available
Background and objectives: Limited data exist on severe acute respiratory syndrome coronavirus 2 in children. We described infection rates and symptom profiles among pediatric household contacts of individuals with coronavirus disease 2019. Methods: We enrolled individuals with coronavirus disease 2019 and their household contacts, assessed dail...
Preprint
Full-text available
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), presents with a broad range of symptoms. Existing COVID-19 case definitions were developed from early reports of severely ill, primarily hospitalized, patients. Symptom-based case definitions that guide public health s...
Article
Background: Detection of SARS-CoV-2 infection has principally been performed through the use of real-time reverse-transcription PCR (rRT-PCR) testing. Results of such tests can be reported as cycle threshold (Ct) values, which may provide semi-quantitative or indirect measurements of viral load. Previous reports have examined temporal trends in Ct...
Article
Background Although many viral respiratory illnesses are transmitted within households, the evidence base for SARS-CoV-2 is nascent. We sought to characterize SARS-CoV-2 transmission within US households and estimate the household secondary infection rate (SIR) to inform strategies to reduce transmission. Methods We recruited laboratory-confirmed...
Article
Full-text available
Background: Improved understanding of SARS-CoV-2 spectrum of disease is essential for clinical and public health interventions. There are limited data on mild or asymptomatic infections, but recognition of these individuals is key as they contribute to viral transmission. We describe the symptom profiles from individuals with mild or asymptomatic...

Citations

... The ABRicate Galaxy version 1.0.1 tool [32,[89][90][91][92] was applied with the ResFinder 4.1 database [93] for the identification of acquired ARGs harbored by the metagenomic contigs, with the settings of a ≥95% threshold for sequence identity [90,92,94,95] and a minimum coverage of ≥60% [26,91,93]. ResFinder is aimed at detecting ARGs that are involved in acquired antibiotic resistance [93]. ...
... However, the phenomenon of breakthrough infections has been frequently reported in persons who have completed a primary vaccination series [6], likely because of the waning immunity caused by loss of vaccine-induced immunological protection or lower vaccine effectiveness against new variants [7]. Newly implemented booster and additional vaccinations among adults were highly effective at preventing severe acute respiratory syndrome coronavirus 2 (SAR-S-CoV-2) infection or death during the Delta and Omicron variant predominant period [4,8]. ...
... However, although the data speak positively on a macro-level scale, individuals are nevertheless confronted with challenges at the micro level. For instance, in some countries, HCPs were assigned as one of the priority healthcare groups for vaccination (2,3). A recent Centers for Disease Control and Prevention study published in 2021 (4) reported that vaccination has a greater protection rate than those previously infected with COVID-19. ...
... Rare adverse events, including arrhythmia, may not become apparent in phase 3 clinical trials due to limited sample sizes, whereas postmarketing studies after the launch of a vaccine significantly augment the vaccination paradigm with more comprehensive understanding. Similar to the previous finding that younger males are more susceptible to myocarditis after COVID-19 vaccination, 62 people with known risk factors for arrhythmia, including older age, male sex, white race, and cardiovascular comorbidities, 56 should be appropriately addressed; these individuals may need to be monitored when receiving COVID-19vaccinations. Nonetheless, the risk for such rare adverse events should be outweighed by the benefits of vaccination, including lower chance of infection, hospitalization, complications, and even death.63,64 These ideas would be crucial when drafting vaccination policies and should be dynamically updated as the pandemic evolves. ...
... To serve as a point of comparison for the combinations, we evaluated the predictive performance of three previously established case definitions: the interim CSTE COVID-19 case definition (17), and two compound symptom combinations found to work well in a published development study (16). We redefine these last two as follows: ...
... Continued occurrence of COVID-19 cases throughout 2022 in the U.S. and worldwide indicate that the pandemic is not ending. This collaborative modeling effort underscored the moderate direct and overall benefits of expanding the vaccination program to [5][6][7][8][9][10][11] year-olds across a range of different scenarios, including ones where the Delta variant remains dominant until mid-March 2022 and incidences gradually decline. Most importantly, increasing vaccination in children also builds resilience to potential increases in the upcoming pandemic trajectory, which may be fueled by new variants, waning immunity, increased contacts, or other unpredictable factors. ...
... Sputnik V, Janssen, AstraZeneca) and RNA based vaccine (e.g. Pfizer/BioNTech, Moderna) [5].Vaccination programs have known successful progress amongst the world despite scientific debate of the variable efficacy reported with different vaccines [6][7][8][9][10][11].However, breakthrough infection (post-vaccination infection)still happens after vaccination among fully vaccinated people with changing patterns according to the predominant virus of concern (VOC) [7,12].In addition, several studies found that not fully vaccinated persons were more likely tobe affected by critical COVID-19 illness leading to hospitalizations and deaths compared with fully vaccinated people [13][14][15].Tunisia knew its first epidemic phase of COVID-19 in March 2020 making it mandatory to implement special emergency measures, which help slow down the epidemic spread. However, this epidemic has known four waves resulted in a substantial rise in deaths in the country. ...
... The incidence of COVID-19 disease in children is not truly understood because of the lack of generalized reports and the prioritization of testing for adults with COVID-19 disease. Latest data indicate that compared to adults, children most probably have a very much alike viral disease, [15] and can transmit the virus to other people [16,17]. Preliminary statistics show that children have not been affected seriously by SARS-CoV-2 and less spread the virus because most of the countries were closed school early and parents struggle to protect their children therefore researchers still investigate to not affected children during the pandemic period. ...
... Thus, the primary aim of this study was to determine the role of children in the transmission of SARS-CoV-2 in households. Household transmission clusters allow the evaluation of viral transmission and susceptibility to infection [8,11], as the household is a stable setting, with close contact between cohabitants and without restrictive measures. ...
... ,25,26 If one correlates Ct values with clinical progression, Ct values are lowest in the immediate presymptomatic and first week of the symptomatic phases of COVID-19.27 Therefore, Ct values correlate closely with a clinical history and examination. ...