Hai-Ying Yu’s research while affiliated with Mental Health Center of Denver and other places

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Publications (2)


Figure 1. Effects of CUMS exposure and ketamine administration on immobility time during FST and latency to feed during NSFT of rats. Data are presented as the mean ± SEM of 8 rats per group. *P < 0.05, ***P < 0.001, versus control, # P < 0.05, ## P < 0.01, ### P < 0.001, versus CUMS (saline). Ket = ketamine.  
The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus
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July 2015

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155 Reads

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88 Citations

Upsala Journal of Medical Sciences

Nan Wang

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Hai-Ying Yu

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Xiao-Feng Shen

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Guang-Fen Zhang

Active inflammatory responses play an important role in the pathogenesis of depression. We hypothesized that the rapid antidepressant effect of ketamine is associated with the down-regulation of pro-inflammatory mediators. Forty-eight rats were equally randomized into six groups (a control and five chronic unpredictable mild stress (CUMS) groups) and given either saline or 10 mg/kg ketamine, respectively. The forced swimming test was performed, and the hippocampus was subsequently harvested for the determination of levels of interleukin (IL)-1β, IL-6, tumour necrosis factor-α (TNF-α), indoleamine 2,3-dioxygenase (IDO), kynurenine (KYN), and tryptophan (TRP). CUMS induced depression-like behaviours and up-regulated the hippocampal levels of IL-1β, IL-6, TNF-α, IDO, and the KYN/TRP ratio, which were attenuated by a sub-anaesthetic dose of ketamine. CUMS-induced depression-like behaviours are associated with a reduction in hippocampal inflammatory mediators, whereas ketamine's antidepressant effect is associated with a down-regulation of pro-inflammatory cytokines in the rat hippocampus.

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Citations (2)


... A meta-analysis examining cytokine levels in individuals with major depression found that depressed subjects had significantly elevated serum levels of TNF-α and IL-6 compared to non-depressed controls [10]. Furthermore, studies have demonstrated that chronic stress exposure leads to elevated levels of TNF-α, IL-1β, and IL-6 in the hippocampus of rats [11]. Similarly, cytokine administration induces increased neuroinflammation and behavior deficits in rodents [12]. ...

Reference:

Systemic Administration of a Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits and Neuroinflammation in Mice
The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus

Upsala Journal of Medical Sciences

... Proinflammatory cytokines such as TNF-α and IL-6 activate IDO which then reduces tryptophan, resulting in the downregulation of serotonin production [67]. Similarly in humans, ketamine reduced serum IL-6 concentration in patients with treatment resistant depression through a single intravenous infusion [79]. Therefore, ketamine may exert some of its antidepressant effects by having potent anti-inflammatory properties. ...

Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major Depression

Biological Psychiatry