Hafsa Abbas's research while affiliated with The University of Warwick and other places

Publications (4)

Article
Full-text available
Background Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. We investigated the role of MG and Glo1 in cancer chemotherapy related in multidrug resistance (MDR). Methods Human Glo1 was...
Article
Full-text available
The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produced an urgent requirement and search for improved treatments while effective vaccines are developed. A strategy for improved drug therapy is to increase levels of endogenous reactive metabolites for selective toxicity to SARS-CoV-2 by preferential...
Preprint
There is an urgent requirement for improved treatments of COVID-19 disease. A strategy for chemotherapy is to increase levels of endogenous reactive metabolites — such as reactive oxygen species and arginine-directed glycating agent, methylglyoxal — for selective toxicity to SARS-CoV-2. Sequence analysis of functional domains in the SARS-CoV-2 prot...

Citations

... Interesting in this regard the study of Tamori et al., conducted on a breast cancer model, also confirmed that GLO1 expression is dependent on the histopathological grade of tumor malignancy (c 2 test, p = 0.002) and was significantly higher in basal cell breast cancer (43). Additionally, our study observed higher GLO1 expression among patients with drug resistance, which is consistent with the observations of Alhujaly et al. who found that overexpression of this gene and protein reduces the antitumor properties of cisplatin, among others (44). ...
... 23,33 Also, coronavirus spike proteins are rich in tryptophan, which, like cysteine, is highly vulnerable to oxidation. 34 Also, an interesting conclusion about D-dimer expands the discussion of the role of oxygen-ozone therapy in thromboembolism or vascular and thrombotic disorders related to COVID-19, because D-dimer typically increases during COVID-19 and is greatly reduced in the existence of ozone. Oxygen-ozone also affects nitric oxide (NO) and inducible nitric oxide synthase signaling pathways. ...
... It is difficult to state if this finding is due to a drug anti-viral effect or to a selection bias. Recent studies have identified a possible activity of doxorubicin against SARS-CoV-2 [24][25][26]. A potential therapeutic effect of cyclophosphamide for respiratory failure caused by COVID-19 has been hypothesized [27], but in animal models this drug has been used to exacerbate COVID-19 infection [28]. ...
... The U.S. Food and Drug Administration (FDA) recently revoked its Emergency Use Authorization (EUA) to treat COVID-19 [187]. Other drugs include the anti-HIV drugs Lopinavir-Ritonavir in combination with Ribavirin [188][189][190], tumor chemotherapy drugs, doxorubicin and paclitaxel [191], traditional herbal medicines [192], broad spectrum antiviral drug Niclosamide [193], Janus-associated kinase (JAK) 1 and 2 inhibitor, Ruxolitinib [194], anti-influenza drug Favipiravir [195], antiviral drug Remdesivir [196][197][198], and most recently, a commonly used steroid, dexamethasone [199]. Many of these drugs primarily target the RdRp (NSP12) or the main protease, M pro . ...