Hafida Merzouk's research while affiliated with Abou Bakr Belkaid University of Tlemcen and other places

Publications (36)

Article
The aim of this study is to show the relationship between the adherence score to the Midetaraneen diet and the effects of metformin and insulin on metabolic disorders and oxydatif stress markers in Algerian men with T2D, in order to recommend the best treatment, which can minimize diabetes complications and demonstrate the value of adapting a Medit...
Article
This article opens a new field on the therapeutic virtues of the phytochemical constituents of plant by-products at the level of their antioxidant and antibacterial activities which greatly contribute to the reduction of the risk of developing diseases related to oxidative stress as well as to the treatment of bacterial infections. This work gives...
Article
Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has spread rapidly, infecting more than 194 million and killing more than 4 million people worldwide. Algeria has not escaped this scourge; according to World Health Organisation (WHO), 162,155 confirmed cases and 4,063 deaths have been recorded from 3rd January 2020 to 26th July 2021....
Article
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Background The Algerian COVID-19 vaccination campaign, which started by the end of January 2021, is marked by a slowly ascending curve despite the deployed resources. To tackle the issue, we assessed the levels and explored determinants of engagement towards the COVID-19 vaccine among the Algerian population. Methods A nationwide, online-based cro...
Article
Chlorpyrifos-ethyl (CE) is one of the most widely used organophosphorus insecticides for industrial, agricultural and public health purposes. The aim of the study was to evaluate the effect of CE exposure via gavage on metabolic and redox status in pregnant, lactating rats and their pups at weaning. The oral administration of this pesticide at dose...
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an infectious disease that causes severe coronavirus disease 2019 (COVID-19) and its complications, this appears to be related to an increase in the release of pro-inflammatory cytokines, described as "the cytokine storm." SARS-CoV-2 by binding to its receptor angiotensin convertin...
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The present study aimed at determining the effectiveness of Bunium incrassatum acetonic and ethanolic tuber extracts as antioxidant (DPPH assay) and anti-hemolytic agents (hypotonic solution, H2O2 and triton X100 assays) and tubers’ powder as dietary supplement on body weight, on histological (liver, thyroid, testes, and kidney) and biochemical par...
Article
The aim of the present study was to evaluate the protective effects of linseed oil on lipid peroxidation, antioxidative capacity, as well as serum glucose, total cholesterol (TC), LDL-C and TG levels, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food and energy intakes were also evaluated....
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Our work focuses on the study of a medicinal plant Crocus sativus. L known as saffron, which is very popular and widely used as a spice and in traditional medicine. The purpose of this work was to compare saffron genotypes derived from three different regions, namely Tlemcen, Khenchela (Algeria) and Taliouine (Morocco).Phenotypic diversity was dete...
Article
Dietary fiber is a group of food components which is the subject of many studies on several aspects of human health. Recent research demonstrate that dietary fiber intake is associated with reduced diabetes risk. The aim of the present work was to test the effect of dietary fiber such as cellulose and mucilage on disorders of lipid metabolism induc...
Preprint
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Background The Algerian COVID-19 vaccination campaign, which started by the end of January 2021,is marked by a slowly ascending curvedespite thedeployed resources.To tackle the issue, we assessed the levels and explored determinants of engagement towards the COVID-19 vaccine among the Algerian population. Methods A nationwide, online-based cross-se...
Article
Sucrose drink induced obesity and metabolic syndrome in human and animal models. However, age-specific metabolic effects of sucrose beverages are not clear yet. The purpose of this study was then to investigate changes in plasma biochemical parameters, oxidative stress markers, as well as lipid and redox contents and lipolytic activities in insulin...
Chapter
The production of free radicals in the body is inevitable, but sometimes they become toxic responsible for significant cell damage and are implicated in the etiology of several human diseases as well as aging. Coffee is the most popular and common worldwide drink. It contains large amounts of bioactive compounds including polyphenols. Coffee polyph...
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Diabetes mellitus is a heterogeneous group of metabolic dysregulation that shares phenotype of hyperglycemia and for which genetic and environmental risk factors act synergistically. Dietary acid load and low pH of interstitial fluid are the most important , factors reducing insulin sensitivity and making the body condition worse in Type 2 diabetes...
Article
Irritable bowel syndrome (IBS) is known to be a heterogeneous disease, characterized by abdominal pain and disorders of intestinal motility. This study aims at investigating if serum calcium levels correlate with lipid values in IBS and the oxidant / antioxidant system as one of the factors proposed in the etiology of IBS. A total of 70 patient’s w...
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Background Recurrent pregnancy loss (RPL) is a common disorder that affects around 3 to 5% of pregnant women. It has different causes, and in about 50%, it is of unknown etiology. Thrombophilia might increase the risk of RPL by adversely affecting the normal placental vascular function. Our study aimed to determine the frequency of factor V Leiden...
Article
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We investigated factors implicated in the development of pregnant high blood pressure risks and fetal-maternal repercussions. Were evaluated (Age, Gestity, Childbirth type, Eclampsia, Gestational diabetes, Overweight, TA/S, TA/D, Baby’s weight). The logistic model retained, age of mother (OR = 1.17, 95% CI = 1.08-1.27, P < 0.001). The gestity (OR =...
Article
PurposeThis study aims to evaluate the anti-inflammatory and antioxidant effects of N. gaditana on streptozotocin (STZ)-induced diabetes mellitus in Wistar rats.Methods Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (45 mg/kg). Male rats were fed on control diet supplemented or not with N. gaditana (10%) for a p...
Article
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Glycosyltransferases (GTs) are widely present in several organisms. These enzymes specifically transfer sugar moieties to a range of substrates. The processes of bacterial glycosylation of the cell wall and their relations with host–pathogen interactions have been studied extensively, yet the majority of mycobacterial GTs involved in the cell wall...
Article
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Introduction: Algeria has more than 1.7 million diabetic patients on to whom a descriptive assessment particularly on the insulin usage behaviors has not yet been initiated, although is needed. This study aims to provide a descriptive analysis of how Algerian diabetic patients perceive and apply insulin injection techniques. Methods: using the "...
Article
Potatoes have been a dietary staple in the world for centuries, and one of the most input-intensive crops and is the heaviest user of chemical pesticides of all major food crops. Mancozeb is a manganese/zinc ethylene bis-dithiocarbamate fungicide that is widely used in agriculture to control a broad variety of fungal infections of both vegetables a...
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Background Even though β thalassemia major is a genetic blood disorder, the damages endured by erythrocytes are mediated in part by oxidative stress. Antioxidants such as anthocyanins are capable to prevent the pro-oxidant effects induced by reactive oxygen species (ROS). Objective This study aims to evaluate the in Vitro preventive effects of one...
Article
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Introduction: Changes in leptin signaling during obesity are emerging as a potential risk factor leading to pregnancy complications. Increased oxidative stress may also contribute to the adverse outcomes associated with pregnancy in obese women. Although hyperleptinemia and oxidative stress are risk factors of pregnancy complications during obesity...
Article
Objective Numerous epidemiological studies show an increased prevalence of metabolic diseases related to oxidation stress causing cell damage. Antioxidant supplementation is then useful to protect against the oxidative stress mediated disease development, and has become an increasingly popular practice. In this review, a selection of clinical and i...
Article
Aging is an inevitable biological event that is associated with immune alterations. These alterations are related to increased cellular oxidative stress and micronutrient deficiency. Antioxidant supplementation could improve these age-related abnormalities. The aim of this study was to determine in vitro effects of vitamin A, vitamin C, vitamin E,...
Article
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The aim of this work was to study the in vitro effects of new pyrido[2,3-d] pyrimidines, especially 4-(N-phenylethylamino)-5,7-diphenylpyrido[2,3-d] pyrimidine (3a) and 4-(N-benzylamino)-5-(4-chlorophenyl)-7-(3-methoxyphenyl) pyrido[2,3-d]-pyrimidine (3b), on the proliferative responses of human peripheral blood mononuclear cells, cytokine secretio...
Article
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Background According to many studies, dietary fiber has highly beneficial effects in nutrition and public health. A diet rich in fiber lower the incidence of gastrointestinal disorders, diabetes mellitus and cardiovascular diseases. Purpose The aim of this study was to evaluate the effect of a dietary fiber-enriched diet (cellulose/mucilage: CM) o...
Article
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Introduction Oxidative stress has been shown to play an important role during diabetes. Micro algae constitute a major field for the research of new bioactive molecules of interest for the health and care of the disease such as polyunsaturated fatty acids and carotenoids. Nannochloropsis gaditana is a genusmicroalgae that has anti-inflammatory, ant...
Article
In Algeria, more than one million people have cardiovascular diseases including coronary syndrome, with 20,000 to 25,000 deaths each year. The aim of our study was to determine the oxidative stress markers and antioxidant defence system during acute coronary syndrome. This work was carried on 50 men with acute coronary syndrome admitted in cardiolo...
Article
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Background The polycystic ovary syndrome (PCOS) is multifactorial, consisting in hyper androgenic, ovulatory disorders and polycystic appearance of the ovaries. PCOS is a metabolic disorder associated with an increased risk of insulin resistance, hyper insulin blood level, central obesity, high blood pressure, type 2 diabetes, dyslipidemia and card...
Article
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Background and aims: Interaction between oxidative stress and inflammation has not been comprehensively investigated in the association obesity – diabetes - hypertension. Our aim was to investigate interrelations between inflammatory and oxidative stress biomarkers in obese women with two complications (hypertension, type 2 diabetes). Material and...
Article
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Background and aims: Quercetin, is a polyphenolic antioxidant compound. It is able to form complex with metal ions such as iron and exerts a broad range of biological activities like improving metabolic disorders. This research aims at investigating the effect of oral supplementation of iron (2.5mg Fe/Kg/day) and its complex form (molar ratio 1:5;...
Article
Natural products can be very effective in the prevention of obesity-related metabolic disorders. The aim of the present study was to investigate the anti-obesity effects of Aloe vera (Aloe barbadensis Miller) gel administration at 100 and 200 mg/kg/day, in a diet-induced obesity rat model. The whole gel was used. Plasma and tissue parameters and ad...
Article
The aim of this study was designed to determine whether maternal supplementation with olive oil influence plasma lipid profile and oxidant/antioxidant status later in life of rats with cafeteria-diet-fed during gestation and in their offspring throughout adulthood. Altering the fatty acid profile of rat diets during the gestation has long-term cons...

Citations

... Wali et al. [75] demonstrated the well-expressed in vitro antioxidant, antimicrobial, and anticancer activity of microalgae Nannochloropsis oculata extracts, delivering terpenoids along with carotenoids, polyphenols, and fatty acids. The antioxidant and anti-inflammatory effects of the microalgae Nannochloropsis gaditana on streptozotocin-induced diabetes mellitus in Wistar rats were demonstrated by Nacher et al. [76]. Gϋrlec et al. [77] found that crude extracts of several microalgae, i.e., Galdieria sulphuraria, Ettlia carotinosa, Neochloris texensis, Chlorella minutissima, Stichococcus bacillaris, Schizochytrium limacinum, Crypthecodinium cohnii, and Chlorella vulgaris, showed high radical scavenging and good cytotoxic activity, both indicating the microalgae's potential for use in novel therapeutic approaches. ...
... 12 Such a low level of COVID-19 vaccine uptake can be attributed to low rates of vaccine engagement in the country as evidenced by recent publications which reported generally high levels of COVID-19 vaccine hesitancy in different study groups. [13][14][15][16] Subsequently, several waves of COVID-19epidemics were observed in the country, with drastic consequences which in turn can result in lower levels of complacency towards the disease and a higher chance of vaccine acceptance. 17,18 In the present study, we aimed to investigate the overall rate of COVID-19 vaccine acceptance among the general public in Algeria. ...
... It plays an important role in bacterial drug resistance and host-pathogen interaction, and also in phage resistance of Mycobacteria. 28 Glycosyltransferases are widely found in mycobacterial cells. These enzymes transfer glycosyl onto a range of substrates and participate in the synthesis of GPLs. ...
... Ayyagari et al. (2015), reached the same conclusion in terms of medication, but they outbid the medical factor by stating that good insulin pen adhesion greatly decreases hospitalizations and their high cost to the healthcare system [8]. In a previous publication, we recommended that Algerian insurance providers pay for insulin pen needles [27], and we reinforce the same recommendations in order to find a solution for uninsured diabetics on insulin. ...
... sporadic and RPL, late fetal loss), pre-eclampsia, and HELLP syndrome, are associated with thrombotic mechanisms and thrombophilia (10) . Thrombotic disorders are detectable in 40-50% of RPL cases (11) . It has been presumed that the etiology of RPL is associated with factors involved in fibrinolysis and coagulation (3,12) . ...
... Studies in obese individuals have shown a correlation between leptin levels and oxidative stress parameters such as nitric oxide (NO), superoxide anion (O₂ − .), peroxynitrite, MDA , hydroperoxides, protein carbonyl (PC) contents, GSH, and SOD [106][107][108]. Studies in which hyperleptinemia was induced by the administration of exogenous leptin in nonobese animals suggest that leptin increases the level of systemic oxidative stress [109,110]. ...
... Natural antioxidants, vitamins A, D, E, carotenoids, and certain elements, which are consumed in the diet, play a vital role in the maintenance of antioxidant status in biological systems. Recently, much interest has been shown in herbal antioxidants as preventatives in opposition to oxidative damage in the pathophysiology of various health issues [11]. Among a range of antioxidants, vitamins, zinc and N-acetylcysteine (NAC) were found to play an important role in the regulation of the antioxidant system [7,10]. ...
... Pyrido [2,3-d]pyrimidine is one of the most privileged heterocyclic frameworks in several efficacious pharmacological compounds. Pyrido [2,3-d]pyrimidine ring systems have assorted biological and pharmacological activities such as being analgesic, anti-inflammatory [1-3], antitubercular [4], antimicrobial [5][6][7], a threonine tyrosine kinase (TTK) inhibitor [8], an adenosine kinase inhibitor [9], antiviral [10], antioxidant [11][12][13][14], a dihydrofolate reductase inhibitor [15,16], and an efficient glucosidase inhibitor [17,18]. Moreover, the 1,3-benzothiazole nucleus is a kinase (TTK) inhibitor [8], an adenosine kinase inhibitor [9], antiviral [10], antioxidant [11][12][13][14], a dihydrofolate reductase inhibitor [15,16], and an efficient glucosidase inhibitor [17,18]. ...
... There was direct relationship between inflammatory, oxidative stress and procoagulant markers and inverse relationship with eNOS which catalyzes formation of the vasodilator, nitric oxide (NO). According to Karaouzeneet al, inflammatory and pro- (Expressed as mean ± SD); p value *significant, **highly significant, ***very highly significant Ind J Clin Biochem 123 oxidant markers are elevated with decrease in antioxidant markers in obese women with hypertension [12]. In this study, percentage of EMPs in group III with a value of 13.51 ± 4.38 and Median Fluorescence Intensity (MFI) of 3.0 ± 0.19 was the highest in hypertensive patients with end organ damage ( Fig. 1) (Table 2). ...
... Dyslipidemia is one of the factors that can be modified to prevent the development of cardiovascular diseases, atherosclerosis, stroke, and type 2 diabetes [1,[3][4][5][6][7][8]. e 3, 3′, 4′, 5, 7-pentahydroxyflavone, known as quercetin, is a flavonoid that could be found widely in a large variety of fruits and vegetables [9][10][11]. ...