H Kajikawa's research while affiliated with Osaka Medical College and other places

... Dural arteriovenous fistulas (dAVFs) comprise approximately 10% -15% of all intracranial arteriovenous malformations [1] [2]. Most of them are located in the posterior fossa or in the region of the cavernous sinus [3]- [5]. ...

... Lin et al. demonstrated that Hb and HMGB1 acted synergistically to promote the release of proinflammatory cytokines from macrophages [20]. Hb was also reported to cause strong vasospasm [37]. Our previous data showed that the expressions of vasoconstriction-related receptors AT-1 PAR-1, V1 and TxA2 were up-regulated at 24 h after ICH and the up-regulation was suppressed by anti-HMGB1 mAb treatment [11]. ...

... This is especially true for recurrent tumors (which occur with nearly all patients with high-grade gliomas), where imaging distinctions for remnant tumor, regrowth, or postradiation necrosis are difficult, 31 and "pseudoprogression" (radiographic indications -usually, gadolinium enhancement -that appear as progressively growing tumor following radiation but later resolve or devolve into radiation necrosis) is another common problem. 32,33 Tumor diagnostic/biomarker capabilities from an accessible compartment (blood/sera, urine, or saliva) would be a major advance for neuro-oncology, especially since there seem to be no circulating exfoliated brain tumor cells 34 (cerebral spinal fluid offers mixed results 35,36 ). Thus, most biomarker efforts for GBM are geared towards the determination of recurrent disease, either in the context of standard of care treatment or in a clinical trial setting, with an emphasis on clinical-level assessments. ...

... In dogs, 10 mg/kg of ACTZ produces a significant decrease in the production and absorption of CSF within three hours of ingestion. 10 Our report is unique in that we know of no other study that evaluated changes in CSF volume over time with the extended use of ACTZ in human infants. Bucholz and Pittman 11 briefly discuss the use of ACTZ to decrease CSF output in a 29 month old hydrocephalic infant with ventriculoperitoneal shunt and ascites. ...

... Colloid-like cysts situated outside the third ventricle are extremely rare. They have been found in the lateral [22,23,30,31] and fourth ventricle [18,27], as well as in the septum pellucidum [5], frontal [35] and parietal lobes [3,9], optic nerve [17], cerebellum [4,13,17,24,25,33], brainstem [1,8,10,14,16,20,24,26,29], and at the craniovertebral junction [2,28]. Instances of multiple colloid cysts have also been reported [23,32]. ...

... в клиническом исследовании с участием 39 пациентов показали эффективность комбинированного лечения лучевой терапией, нимустином гидрохлоридом и β-ин тер феро ном человека при злокачественных супратенториальных глиомах мозга у людей [10]. На пользу от применения β-ин тер фе ро на при злокачественных опухолях мозга указывают результаты еще нескольких клинических исследований [63,85,141]. ...

... Thus both morphological abnormalities and reduced growth rates have been noted in tissue cultures of biopsied human central nervous system tumours at steroid concentrations of greater than 100 micrograms/ml. However, complete lysis was seldom seen even with concentrations as high as 5000 micrograms/ml (Burton et al., 1967; Mealy et al., 1971; Wilson et al., 1972; Kajikama et al., 1974 ). Additional evidence for steroid induced tumour inhibition or oncolysis or both comes from in vivo studies where, in mice, steroids have been shown to have an inhibitory effect on transplanted melanomas (Kotsilimbas et al., 1967), transplanted lymphoid tumours (Baserga and Shubik, 1954), and a naturally occurring intracerebral ependymoblastoma (Shapiro and Posner, 1974). ...