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September 1977
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13 Reads
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11 Citations
Annals of Ophthalmology
A 70-year-old man had a rapid growth of a pigmented eyelid lesion, previously stationary for at least 50 years. Because of the suspicion of malignant melanoma, the lesion which resembled a cutaneous horn was excised. Histologic examination demonstrated a benign epithelial tumor, inverted follicular keratosis.
November 1975
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25 Reads
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73 Citations
Archives of Ophthalmology
Fourteen patients (ten women, four men) with iris nevus (Cogan-Reese) syndrome, all having unilateral glaucoma, were studied clinically. Many had corneal edema, and all had changes in the iris consisting of one or more of the following: iris whorls or nodules or both, atrophy of iris stroma, heterochromia (the darker iris usually involved), or ectropion uveae. All had peripheral anterior synechias. Material for histological study was available from ten patients and showed a nonmalignant diffuse nevus of the anterior surface of the iris. An overgrowth of endothelium and Descemet membrane extending onto the iris surface may be a characteristic part of the process. Patients tended to be women in middle age. Conservative treatment avoiding enucleation is advised. Whenever a patient with suspected iris nevus syndrome or essential iris atrophy is subjected to glaucoma surgery, a biopsy specimen of the iris should be obtained for histological study.
February 1975
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16 Reads
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5 Citations
Annals of Ophthalmology
The water drinking test was performed on 122 glaucoma suspect patients using the standardized Schiotz tonometer and Goldmann applanation tonometer. Additionally, the tonography was performed on 12 glaucoma suspect patients before the water test and on 69 glaucoma suspect patients after the water test. Our results showed that the most accurate test is the applanation water test. However, the accuracy of tonography was also increased if the tonography was performed after the water drinking test. The evaluation of the water drinking test only by Schiotz tonometer was not satisfactory. By using the applanation tonometry the sensitivity of the water test could be improved by 70%.
January 1974
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12 Reads
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55 Citations
Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology
Two eyes were obtained post mortem from a patient who had all the clinical features of 'pigmentary glaucoma' except for glaucoma. The characteristic features of the syndrome are bilateral presence of positive peripheral iris transillumination and widespread pigment dispersion within the anterior compartment of the eye. The iris pigment epithelium undergoes variable degrees of atrophy, dysplasia, and hyperplasia. Histologically, atrophic areas and hyprplastic areas containing multilayers of dilator muscle cells are seen. Macrophages filled with melanin granules are present in the adjacent iris stroma. Melanin granules released from the iris pigment epithelium are present within the corneal and trabecular endothelial cells as well as within the cells of the juxtacanalicular connective tissue. The findings suggest that the defect may be congenital in nature.
February 1972
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5 Reads
Modern Problems in Ophthalmology
September 1971
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4 Reads
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26 Citations
Annals of Ophthalmology
August 1971
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6 Reads
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8 Citations
Annals of Ophthalmology
November 1970
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5 Reads
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61 Citations
Archives of Ophthalmology
February 1969
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3 Reads
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1 Citation
Surgical Forum
February 1969
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5 Reads
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18 Citations
Bibliotheca Ophthalmologica: Supplementa Ad Ophthalmologica
... Earlier reports concluded that the WDT is a reliable tool to detect IOP peaks of 24-hour IOP profile. [26,[43][44][45][46][47] Additionally, healthy subjects without glaucoma and treated POAG patients do not manifest a repeatable diurnal IOP pattern from day to day. [48,49] This observation limits the clinical value of 1-day diurnal IOP testing in clinical practice. ...
February 1975
Annals of Ophthalmology
... ICE syndrome occurs sporadically, is usually unilateral, and typically affects women 30-40 years of age. 5 Although its etiology is not fully known, it is thought to be of viral origin. 6 In the differential diagnosis, consideration should be given to conditions such as posterior polymorphous corneal dystrophy, Fuchs endothelial dystrophy, and Axenfeld-Rieger syndrome. ...
November 1975
Archives of Ophthalmology
... Pregnant women who got infection may bring devastating effects to their children, ranging from abortions to infants with congenital rubella syndrome (CRS), including visual or hearing impairment, heart disease and so on [1]. Especially in the first trimester [2], the virus could pass through the placental barrier whether it is dominant infected or not. Rubella occurs throughout all the year, exhibiting a fluctuating curve with high incidences in low-temperature weather. ...
June 1967
JAMA The Journal of the American Medical Association
... The cause of PDS is the release of pigment and accumulation in structures in the AC, which can give rise to increases in IOP and lead to PG. It was originally thought that PDS and PG had a congenital etiology, due to pigment loss from the iris from congenital mesodermal dysgenesis [15] or atrophy or degeneration of the iris pigment epithelium (IPE) [16,17]. Possible genetic factors have been hypothesized to explain the familial presence of Krukenberg spindle [18]. ...
January 1974
Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology
... There have been multiple proposed hypotheses over the years regarding the etiology of amyloidomas. Glass et al [5] proposed that amyloidomas may derive from a plasmacytoma transformation. Cohen et al [6] proposed that genetically predisposed microglia were responsible for the production of amyloid precursor proteins. ...
September 1971
Annals of Ophthalmology
... Cyclodestructive procedures have evolved since the 1920s, progressing from cyclectomy, cyclodiathermy, cyclocryotherapy, and eventually to cyclophotocoagulation [1][2][3]. Cyclophotocoagulation was initially performed in 1961 by using light from xenon arc photocoagulation [4] and subsequently using a ruby laser in 1969 [5]. Cyclophotocoagulation established a more widespread application once Nd:YAG (neodymium-yttrium-aluminum garnet) and eventually semiconductor diode lasers were developed. ...
February 1969
Bibliotheca Ophthalmologica: Supplementa Ad Ophthalmologica
... İlk kez 1970 yılında Yanoff tarafından, siliyer cisim melanomu olan bir hastada tanımlanan melanomalitik glokom tek taraflı artmış GİB, iris heterokromisi ile birlikte kornea endoteline, iris ön yüzeyine, açıya ve vitreusa pigment dispersiyonu ile karakterizedir. 6 Melanomalitik glokom tüm uveal melanomlarda görülebilirken gonyoskopik muayenede açı genellikle açıktır ve trabeküler ağda pigment hücresi birikimi vardır. Kantitatif aköz perfüzyon çalışmaları, melanomalitik glokomlarda dışa akımda meydana gelen belirgin azalmayı göstermiştir. ...
Reference:
Intraocular Tumors and Glaucoma
November 1970
Archives of Ophthalmology
... Sm binds primarily to the peptidyl (P) site and, because of the stabilization of the P-site/tRNA, the drug blocks the critical movement of tRNAs between the aminoacyl site and P-site, resulting in the inhibition of peptide bond formation and the inability of aminoacyl-tRNA to access the P-site [9][10][11]. Despite acute toxicity of Sm in mice [6] and Sm-related retinopathy in the phase I clinical study [12], an active testing program of the drug related to the protein biosynthesis machinery has continued [10,13,14]. Considering the effects of Sm on protein translation, the in vitro inhibitory activity of Sm against the most common and deadliest human malaria parasite, P. falciparum (3D7 and K1) [15], was evaluated. ...
November 1966
Archives of Ophthalmology
