Gyu Park's research while affiliated with Virginia Commonwealth University and other places

Publications (4)

Article
Full-text available
We previously reported that co-expression of the Gi-coupled metabotropic glutamate receptor 2 (mGlu2R) and the Gq-coupled serotonin (5-HT) 2A receptor (2AR) in Xenopus oocytes (Fribourg et al. Cell 147:1011–1023, 2011) results in inverse cross-signaling, where for either receptor, strong agonists suppress and inverse agonists potentiate the signali...
Article
We recently reported that a heteromeric complex formed between the Gi-coupled metabotropic glutamate 2 receptor (mGluR2) and the Gq-coupled serotonin 5-HT2A receptor (2AR) integrates the actions of serotonergic and glutamatergic drugs, modulating the balance between Gi and Gq signaling in a way that can be used to predict the psychoactive propertie...
Article
Full-text available
Atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the serotonin 5-HT(2A) G protein-coupled receptor (GPCR), the 2AR, which signals via a G(q) heterotrimeric G protein. The closely related non-antipsychotic drugs, such as ritanserin and methysergide, also block 2AR function, but they lack comparable neuropsych...

Citations

... Immunoprecipitation studies were performed to evaluate whether the 5-HT 2A and the mGlu2/3 receptor proteins physically associate in PFc synaptosomes. We focused on the mGlu2 subunit protein since previous studies showed that this is the subunit which preferentially interacts with 5-HT 2A receptor proteins by means of specific aminoacid(s) [12,[30][31][32]. The lysates of PFc synaptosomes were immunoprecipitated with an antibody recognizing the mGlu2 receptor protein (Figure 3a), or with an antibody recognizing the 5-HT 2A receptor protein (Figure 3b). ...
... Pharmacology, Biochemistry and Behavior 175 (2018) [89][90][91][92][93][94][95][96][97][98][99][100] studies showing that extended access to self-administered meth and 7 days of withdrawal alters synaptic plasticity and mGlu expression in the PRh Scofield et al., 2015), produces PRh/ dHPC-dependent memory deficits , dysregulates 5-HT levels (Brennan et al., 2010) and glutamate neurophysiology in the PFC (Mishra et al., 2016). As the functional (and behavioral) outcome of the 5-HT2A and mGlu2 interaction depends on the relative amount of each receptor (Baki et al., 2013), the 5-HT2A/mGlu2 protein expression ratio was also calculated. Extended access to meth upregulated 5-HT2A protein levels in the mPFC [t(9) = 2.96, p < 0.05] and the PRh [t (9) = 2.61, p < 0.05] compared to yoked-saline rats. ...
... In addition to presynaptically controlling glutamate exocytosis, mGlu2/3 receptors were also reported to colocalize and functionally crosstalk with 5-HT 2A receptors, contributing to an integrated "metamodulation" of synaptic transmission [8][9][10]. This interaction was first described in the mammal cortex, where the 5-HT 2A receptors and mGlu2 receptors were shown to physically associate in a heterodimeric complex at the postsynaptic level [11][12][13][14]. The two receptors were proposed to crosstalk in an antagonist fashion, based on the finding that the pharmacological antagonism of mGlu2/3 receptors potentiated the spontaneous excitatory postsynaptic currents elicited by 5-HT 2A receptors, whereas mGlu2/3 agonists reduced their expression and functions [15][16][17][18]. ...