Gustavo Martínez-Coronilla’s research while affiliated with Autonomous University of Baja California and other places

What is this page?


This page lists works of an author who doesn't have a ResearchGate profile or hasn't added the works to their profile yet. It is automatically generated from public (personal) data to further our legitimate goal of comprehensive and accurate scientific recordkeeping. If you are this author and want this page removed, please let us know.

Publications (10)


Capítulo 8. Lípidos
  • Chapter

March 2023

·

31 Reads

·

·

·

[...]

·

damiana jesus mandujano

El Capítulo 9. Lípidos, presenta la definición de los lípidos y sus diversas clasificaciones. Cada tipo de lípido se aborda describiendo sus componentes e indicando sus diferentes funciones ya sea como reserva de energía o como moléculas estructurales. Así mismo, se menciona la importancia clínica de cada tipo de lípido, señalando las principales alteraciones relacionadas con su deficiencia o su incremento en el organismo. Además, se describen las lipoproteínas sanguíneas enfatizando sus características, funciones y niveles óptimos para el buen funcionamiento del organismo. Finalmente, se aborda el metabolismo de los principales tipos de lípidos para la obtención de moléculas energéticas y la síntesis de componentes estructurales.


Energy saving on green pepper dehydration process
  • Article
  • Full-text available

December 2022

·

117 Reads

Se modificó el proceso de liofilizado en el pimiento morrón verde para preservar su sabor, color, textura y propiedades naturales y reducir el gasto energético. En este proceso se compararon 6 pre tratamientos alcalinos diferentes utilizando aceites de oliva, aguacate, coco, uva, sésamo y cártamo para reducir el tiempo requerido para los pasos de deshidratación. Además, se modificó el paso de congelado utilizando hielo seco (CO2). Nuestros resultados muestran que el uso de una solución alcalina con aceite de coco puede resultar en un ahorro de energía del 45%. El producto final tenía alta calidad y humedad dentro de un rango de 3% a 7%, sin daño a los atributos organolépticos, y recuperaba todas las características de un producto fresco al rehidratarse. Debido a la propiedad higroscópica de los productos liofilizados, el producto debe empaquetarse y sellarse cuidadosamente después de la liofilización. Finalmente, sugerimos que todas las empresas en este campo tengan en cuenta estos hallazgos y mejoren sus protocolos de procesamiento de alimentos para evitar la emisión de varios kg de CO2 a la atmósfera.

Download

Figure 1. The possible role of chronic intake of fructose on lung injury through regulation of the RAS, UA, and AGEs production: (A) The lung damage is induced by the disbalance of the ACE/Ang II/ATR1 and ACE2/Ang-(1-7)/MasR axes [77,78]. Chronic intake of fructose induces the activation of the RAS in several tissues, including the lung. Fructose increases protein ACE and PRR [85], promoting the elevation of Ang II, while a decrease in ACE2 and Ang-(1-7) levels may induce the development of, or exacerbation of, lung injury [91,93]; (B) High UA levels are associated with exacerbating lung damage, promoting immune cell infiltration and inflammation [43-46]. UA is a byproduct of fructose metabolism, which is produced by purine degradation. Chronic intake of fructose increases UA levels by its metabolism in the liver [40,42], which may be a source of UA that plays an important role in the worsening of lung damage; (C) AGEs activate the RAGE
Figure 2. The possible role of chronic intake of fructose on lung injury through regulation of AR and mTORC1: (A) AR is an enzyme of the polyol pathway, that is involved in lung damage by promoting immune cell infiltration, inflammation, and fibrosis [124-126]. Fructose induces AR expression in several tissues [127-129]. Chronic intake of fructose may regulate the activity of AR in the lung, inducing lung damage through the activation of the inflammation; (B) mTORC1 is involved in the development of lung damage; mTORC1 induces extracellular matrix deposition and inflammation in lung epithelial cells [136-138]; moreover, in PBMCs, mTORC1 induces corticoid resistance, which is a barrier to lung disease treatment [139]. Chronic intake of fructose activates mTORC1 in various tissues; thus, fructose may play a role in the development or exacerbation of lung damage. AR: aldose reductase; mTORC1: mammalian target of rapamycin complex 1. The Figure has gotten the copyright permission. Created with BioRender.com (accessed on 25 August 2022).
Negative Effects of Chronic High Intake of Fructose on Lung Diseases

October 2022

·

115 Reads

·

8 Citations

In the modern diet, excessive fructose intake (>50 g/day) had been driven by the increase, in recent decades, of the consumption of sugar-sweetened beverages. This phenomenon has dramatically increased within the Caribbean and Latin American regions. Epidemiological studies show that chronic high intake of fructose related to sugar-sweetened beverages increases the risk of developing several non-communicable diseases, such as chronic obstructive pulmonary disease and asthma, and may also contribute to the exacerbation of lung diseases, such as COVID-19. Evidence supports several mechanisms—such as dysregulation of the renin–angiotensin system, increased uric acid production, induction of aldose reductase activity, production of advanced glycation end-products, and activation of the mTORC1 pathway—that can be implicated in lung damage. This review addresses how these pathophysiologic and molecular mechanisms may explain the lung damage resulting from high intake of fructose.


Figure 1. Helminths may promote tumorigenesis through different processes such as chronic inflammation; the polarization of immune cells such as macrophages and T cells; or by inducing persistent
Figure 3. S. japonicum worms can release extracellular vesicles that transport miRNA cargo, such as Sja-mir-125b and Sja-bantam. These miRNAs are internalized by host macrophages, bind molecular targets, and induce a proinflammatory phenotype. Moreover, these miRNAs secreted by the worms promote the proliferation of macrophages. Created using BioRender.com.
miRNAs encoded by S. japonicum with antitumoral activity.
Parasitic miRNAs possibly involved in cancer promotion.
Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

July 2022

·

174 Reads

·

7 Citations

International Journal of Molecular Sciences

Infectious agents such as viruses, bacteria, and parasites can lead to cancer development. Infection with the helminthic parasite Schistosoma haematobium can cause cancer of the urinary bladder in humans, and infection with the parasites Clonorchis sinensis and Opisthorchis viverrini can promote cholangiocarcinoma. These three pathogens have been categorized as “group 1: carcinogenic to humans” by the International Agency for Research on Cancer (IARC). Additionally, the parasite Schistosoma japonicum has been associated with liver and colorectal cancer and classified as “group 2B: possibly carcinogenic to humans”. These parasites express regulatory non-coding RNAs as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which modulate genic expression in different biological processes. In this review, we discuss the potential roles of miRNAS and lncRNAs encoded by helminthic parasites that are classified by the IARC as carcinogenic and possibly carcinogenic to humans. The miRNAs of these parasites may be involved in carcinogenesis by modulating the biological functions of the pathogen and the host and by altering microenvironments prone to tumor growth. miRNAs were identified in different host fluids. Additionally, some miRNAs showed direct antitumoral effects. Together, these miRNAs show potential for use in future therapeutic and diagnostic applications. LncRNAs have been less studied in these parasites, and their biological effects in the parasite–host interaction are largely unknown.


Isthmin 2 is Decreased in Preeclampsia and Highly Expressed in Choriocarcinoma: A Prospective Cross-sectional Study

June 2022

·

16 Reads

Isthmin 2 (ISM2) is a protein that is almost exclusively expressed in the human placenta. There has been no previous study that looked into this protein in preeclampsia or choriocarcinoma. A prospective, cross-sectional study of women with preeclampsia, gestational hypertension, and normotensive pregnancy was carried out. We measured serum concentrations of ISM2 protein and performed immunohistochemistry in placenta tissues. In addition, we compared ISM2 immunohistochemistry in choriocarcinoma samples to lung, prostate, colon, stomach, and breast cancer tissues. A total of 81 individuals were enrolled in the study, 30 of whom had preeclampsia, 21 of whom had gestational hypertension, and 30 of whom were healthy controls. When compared to the control group, the ISM2 protein was shown to be lower in preeclampsia patients (P ¼ 0.036). Immunohistochemistry validated these findings. The ISM2 protein was also shown to be overexpressed in choriocarcinoma. Our findings imply that ISM2 has an angiogenic function. Its lower serum level in our preeclampsia patients could imply that it is implicated in the disease's aetiology; on the other hand, its high expression in choriocarcinoma suggests that ISM2 may be involved in the angiogenesis of this and other malignancies.


Figure 3. The microbial component of atherogenesis. The bacteria invade the endothelial cells (E layer causing apoptosis. The endothelium releases chemokines as monocyte chemoattractant p tein 1 (MCP-1) in the lumen, inducing the activation of blood monocytes and macrophages a promoting their adhesion and diapedesis. Moreover, the transmigrating leucocytes can harbor v ble bacteria, which allow systemic bacterial dissemination to distant sites. Atheroma can grow d to the proliferation of smooth muscle cells (SMC), which is mediated by macrophages-secre growth factors [88].
Acute Myocardial Infarction and Periodontitis: Importance of Awareness and Prevention in Latin America

March 2022

·

133 Reads

·

3 Citations

Applied Sciences

By 2030, non-communicable diseases will have accounted for more than three-quarters of deaths worldwide. Cardiovascular diseases (CVDs) have been the leading cause of death worldwide for several years. Acute myocardial infarction (AMI) is a CVD characterized by necrosis of the heart at the myocardial level due to prolonged ischemia caused by the reduction or sudden absence of coronary blood supply. The prevalence of AMI is higher in men at all ages. The incidence of AMI has decreased in industrialized nations; however, it has been on the rise in Latin America (LATAM) due to lifestyle changes. These changes have caused the combined incidence of CVDs and unresolved health concerns in LATAM, such as infections and malnutrition. It is well known that periodontitis, a highly prevalent chronic infectious inflammatory disease, has been associated with systemic diseases, such as diabetes, kidney diseases, and AMI. This review addresses proposed aspects of the correlation between periodontitis and AMI, explains the importance of preventing periodontitis and CVDs, and analyzes the preventative measures being implemented in LATAM, particularly in Mexico.


MicroRNAs Encoded by Virus and Small RNAs Encoded by Bacteria Associated with Oncogenic Processes

December 2021

·

138 Reads

·

3 Citations

Processes

Cancer is a deadly disease and, globally, represents the second leading cause of death in the world. Although it is a disease where several factors can help its development, virus induced infections have been associated with different types of neoplasms. However, in bacterial infections, their participation is not known for certain. Among the proposed approaches to oncogenesis risks in different infections are microRNAs (miRNAs). These are small molecules composed of RNA with a length of 22 nucleotides capable of regulating gene expression by directing protein complexes that suppress the untranslated region of mRNA. These miRNAs and other recently described, such as small RNAs (sRNAs), are deregulated in the development of cancer, becoming promising biomarkers. Thus, resulting in a study possibility, searching for new tools with diagnostic and therapeutic approaches to multiple oncological diseases, as miRNAs and sRNAs are main players of gene expression and host–infectious agent interaction. Moreover, sRNAs with limited complementarity are similar to eukaryotic miRNAs in their ability to modulate the activity and stability of multiple mRNAs. Here, we will describe the regulatory RNAs from viruses that have been associated with cancer and how sRNAs in bacteria can be related to this disease.


Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma

October 2020

·

95 Reads

·

10 Citations

Heliyon

Introduction: Isthmin 2 (ISM2) is a protein which expression in humans is almost specific to the placenta. There is no previous report in the literature that investigated this protein in preeclampsia or choriocarcinoma. Methods: We conducted a prospective, cross-sectional study that included women with preeclampsia, gestational hypertension and normotensive pregnancy. We measured serum concentrations of ISM2 protein and performed immunohistochemistry in placenta tissues. We also performed immunohistochemistry of ISM2 in samples from choriocarcinoma and compare with lung, prostate, colon, gastric and breast cancers. Results: A total of 81 patients were included, 30 with preeclampsia, 21 with gestational hypertension and 30 controls. The ISM2 protein was found to be decreased in patients with preeclampsia compared to the control group (P = 0.036). These results were confirmed by immunohistochemistry. We also found that ISM2 protein was overexpressed in choriocarcinoma. Discussion: Taken together, our results suggest an angiogenic function for ISM2. Its serum level decreased in our patients with preeclampsia could be reflecting that it is involved in the pathogenesis of the disease; on the other hand its high expression in choriocarcinoma, indicates that ISM2 may play an active role in the angiogenesis of this and other cancers.



Myeloid derived suppressor cell: A new player in periodontal disease?

August 2016

·

99 Reads

·

8 Citations

Medical Hypotheses

Periodontal disease can be initiated by a shift from a symbiotic to a dysbiotic microbial community. An increase in the recruitment of leukocytes and production of inflammatory cytokines, chemokines and oxidative stress are generated by this shift. In periodontitis, an exacerbated, poorly specific and effective inflammatory response is mounted. Moreover, failure in the inflammation resolving mechanism leads to establishment of a chronic inflammatory process, resulting in the progressive destruction of bone and soft tissue. In different diseases presenting chronic inflammation some important players of immune response are defectives. Thus, an immunosuppressive environment could be induced during chronic inflammation. Myeloid derived suppressor cells (MDSC), a heterogenic group of immature myeloid cells with potent immune suppressive activity, are increased in several acute and chronic inflammatory diseases. Dysbiosis-mediated inflammation can induce increased frequency of MDSC. In addition, mediators generated in diverse inflammatory diseases have demonstrated to promote expansion, activation and recruitment of MDSC, similar mediators have been described in periodontal disease. MDSC promote generation of nitric oxide (NO) and reactive oxygen species (ROS). Furthermore, MDSC can differentiate in functional osteoclasts. We hypothesize that MDSC are generated during periodontal disease. Review of literature evaluating this hypothesis and possible implications are assed in this work. It encourages the study of MDSC in this common disease.

Citations (7)


... There have been reported ultrastructural changes in mitochondria in the lungs of mice fed with a high-fructose diet (HFrD), even without allergen exposure [12]. The high fructose/glucose ratio in sweetened beverages, fructose malabsorption and the formation of asthma-triggering immunogens in the gastrointestinal tract lumen have also been linked to asthma [13][14][15]. ...

Reference:

Rosuvastatin Attenuates Vascular Dysfunction Induced by High-Fructose Diets and Allergic Asthma in Rats
Negative Effects of Chronic High Intake of Fructose on Lung Diseases

... Unlike short RNAs [60][61][62][63][64][65][66], the mechanisms of regulation of lncRNAs are largely unknown in parasites. In addition, while short RNAs (especially microRNAs) have been more explored in various helminths [67][68][69][70], lncRNAs have received little attention, being identified by transcriptomic approaches only in a few helminths other than S. mansoni and in protozoans [19,[71][72][73] or studied in a limited number of free-living nematodes [74,75]. ...

Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

International Journal of Molecular Sciences

... Periodontal disease encompasses disorders occurring in periodontal tissue being the main periodontal diseases: gingivitis and periodontitis (Faulkner et al., 2022;Li et al., 2022;Tsuchida and Nakayama, 2022). Recent studies have estimated that periodontitis affects 45%-50% of the world's population and the prevalence of periodontal disease is projected to increase due to the aging population, which constitutes an important public health concern (González- Ramírez et al., 2022). Gingivitis is the mildest form of periodontal disease, which involves inflammation of the gingival tissue. ...

Acute Myocardial Infarction and Periodontitis: Importance of Awareness and Prevention in Latin America

Applied Sciences

... Small noncoding RNAs (sncRNAs) are key mediators of post-transcriptional regulators in bacteria and eukaryotes that control gene expression through a variety of mechanisms (Wang and Fu, 2019). These include micro-RNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs) (Orendain-Jaime et al., 2021), and tRNA-derived small RNAs (tsRNAs) (Li et al., 2018). Apart from these, which mostly act as silencers, in 2006 Long-Cheng Li and colleagues identified small RNAs that target gene promoter sequences to activate expression in a process called RNA activation (RNAa) (Li et al., 2006). ...

MicroRNAs Encoded by Virus and Small RNAs Encoded by Bacteria Associated with Oncogenic Processes

Processes

... Although ISM1 was first discovered in the brain (Pera et al., 2002), it was later found to be expressed in many tissues. ISM2 is highly expressed in placenta, however this protein was also detected in other tissues like prostate, lung, etc. (Martinez et al., 2020). ...

Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma

Heliyon

... However, since this strand is in the sense orientation, it is unlikely to harm mRNA or protein production. Notably, this lncRNA has also been reported in another inflammatory condition, periodontitis, although the specific molecular mechanisms underlying its involvement in periodontitis have yet to be described [22]. SENP3-EIF4A1 is an lncRNA located on chromosome 17's p-arm at position 13.1 [20]. ...

Periodontitis may modulate long-non coding RNA expression
  • Citing Article
  • August 2018

Archives of Oral Biology

... Previously, it was suggested that MDSCs could be involved in periodontal diseases (23) and since then different studies have analyzed MDSC in the context of this disease. For instance, bioinformatic analyses using the single-cell RNA-sequencing data of gingival tissues from healthy individuals and periodontitis patients suggested increased presence of M-MDSCs in periodontitis (24). ...

Myeloid derived suppressor cell: A new player in periodontal disease?
  • Citing Article
  • August 2016

Medical Hypotheses