Gregor R. Szycik's research while affiliated with Hannover Medical School and other places

Publications (45)

Article
Synaesthesia is a phenomenon in which the stimulation of one sensory modality automatically and consistently over time evokes a sensation in the same or a different modality in an idiosyncratic manner. In addition to pure sensory coupling, synaesthetes are characterized by cognitive peculiarities, such as abnormalities in perception, creativity, ad...
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Deficits in audiovisual speech perception have consistently been detected in patients with Autism Spectrum Disorder (ASD). Especially for patients with a highly functional subtype of ASD, it remains uncertain whether these deficits and underlying neural mechanisms persist into adulthood. Research indicates differences in audiovisual speech processi...
Article
Background A widened temporal window of integration (TWI) in audiovisual processing has been detected for children with autism spectrum disorder. However, research indicates a narrowing of this TWI and an associated change in audiovisual integration in the course of development. Methods To further elucidate audiovisual integration processes in adu...
Article
Synaesthesia is a multimodal phenomenon in which the activation of one sensory modality leads to an involuntary additional experience in another sensory modality. To date, normal multisensory processing has hardly been investigated in synaesthetes. In the present study we examine processes of audiovisual separation in synaesthesia by using a simult...
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Reporting of new or unexpected adverse drug reactions of medicines that are subject to additional monitoring ("black triangle" label), such as the antipsychotic drug cariprazine, is of paramount importance to improve pharmacotherapy safety.
Article
Background Due to the hygiene measures during the coronavirus pandemic at the beginning of 2020, psychotherapy by personal attendance was no longer possible or only possible to a limited extent in many places in Germany. In its place, psychotherapy via video conference was used as an alternative option for treatment.Objective The present study was...
Article
Central pontine myelinolysis is a rare but severe disease that often occurs in alcohol-dependent and malnourished patients. One pathological mechanism is the rapid correction of chronic hyponatremia, even though the disease can occur independently of decreased serum sodium levels. Here, we present a patient suffering from malnutrition, alcohol depe...
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Background and aims: In addition to craving responses to salient food cues, the anticipation of short-term rewarding consumption of palatable food may overrun the anticipation of long-term negative consequences of obesity. The present investigation addressed the potential interplay of food cravings and decision-making abilities in individuals with...
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Social stress contributes to major societal health burdens, such as anxiety disorders and nervousness. Nx4 has been found to modulate stress responses. We investigated whether dampening of such responses is associated with neuronal correlates in brain regions involved in stress and anxiety. In a randomized, placebo-controlled, double-blind, cross-o...
Article
Excessive video gaming has a number of psychological and social consequences. In this study, we looked at possible changes in gray and white matter and asked whether these changes are correlated to psychological measures. Twentynine players of violent videogames (mean daily playing time 4.7 h) and age matched controls were subjected to a battery of...
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Our ability to integrate multiple sensory-based representations of our surrounding supplies us with a more holistic view of our world. There are many complex algorithms our nervous system uses to construct a coherent perception. An indicator to solve this ‘binding problem’ are the temporal characteristics with the specificity that environmental inf...
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Audiovisual (AV) integration deficits have been proposed to underlie difficulties in speech perception in Asperger’s syndrome (AS). It is not known, if the AV deficits are related to alterations in sensory processing at the level of unisensory processing or at levels of conjoint multisensory processing. Functional Magnetic-resonance images (MRI) wa...
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Developmental dyslexia is a specific deficit in reading and spelling that often persists into adulthood. In the present study, we used slow event-related fMRI and independent component analysis to identify brain networks involved in perception of audio-visual speech in a group of adult readers with dyslexia (RD) and a group of fluent readers (FR)....
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Objectives There is good scientific evidence that attention deficit hyperactivity disorder (ADHD) is both a predictor and a comorbidity of addictive disorders in adulthood. These associations not only focus on substance-related addictions but also on behavioral addictions like gambling disorder and Internet use disorder (IUD). For IUD, systematic r...
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Objectives: To investigate whether the typically reported deficient sensorimotor gating in patients with schizophrenia using unimodal paradigms can also be detected by a cross-modal paradigm which made use of an electrocutaneous-acoustic coupling of stimuli. Methods: Twenty-one male schizophrenia patients took part in a prepulse inhibition (PPI)...
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Playing violent video games have been linked to long-term emotional desensitization. We hypothesized that desensitization effects in excessive users of violent video games should lead to decreased brain activations to highly salient emotional pictures in emotional sensitivity brain regions. Twenty-eight male adult subjects showing excessive long-te...
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The use of violent video games has been often linked to increase of aggressive behavior. According to the General Aggression Model, one of the central mechanisms for this aggressiveness inducing impact is an emotional desensitization process resulting from long lasting repeated violent game playing. This desensitization should evidence itself in a...
Article
Introduction: In the present study we were interested in the processing of audio-visual integration in schizophrenia compared to healthy controls. The amount of sound-induced double-flash illusions served as an indicator of audio-visual integration. We expected an altered integration as well as a different window of temporal integration for patien...
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Die Frage inwieweit das Spielen von First-Person-Shootern (FPS) eine Wirkung auf reale aggressive Verhaltensweisen hat, ist noch nicht abschließend geklärt und weiter heftig umstritten. Inwiefern hierbei quantitative Aspekte einer exzessiven bzw. abhängigen FPS-Nutzung von Bedeutung sind, wurde bislang kaum untersucht. Die vorliegende Studie beschä...
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Recent research suggests synesthesia as a result of a hypersensitive multimodal binding mechanism. To address the question whether multimodal integration is altered in synesthetes in general, grapheme-colour and auditory-visual synesthetes were investigated using speech-related stimulation in two behavioural experiments. First, we used the McGurk i...
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Synesthesia entails a special kind of sensory perception, where stimulation in one sensory modality leads to an internally generated perceptual experience of another, not stimulated sensory modality. This phenomenon can be viewed as an abnormal multisensory integration process as here the synesthetic percept is aberrantly fused with the stimulated...
Article
The auditory system continuously monitors the environment for irregularities in an automatic, preattentive fashion. This is presumably accomplished by two mechanisms: a sensory mechanism detects a deviant sound on the basis of differential refractoriness of neural populations sensitive to the standard and deviant sounds, whereas the cognitive mecha...
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Speech comprehension relies on auditory as well as visual information, and is enhanced in healthy subjects, when audiovisual information is present. Patients with schizophrenia have been reported to have problems regarding this audiovisual integration process, but little is known about which underlying neural processes are altered. Functional magne...
Article
Grapheme-color synesthesia is a condition in which letters are perceived with an additional color dimension. To identify brain regions involved in this type of synesthesia and to analyze functional connectivity of these areas, 18 grapheme-color synesthetes and 18 matched controls were stimulated with letters and pseudo-letters presented in black an...
Article
It has been suggested that synaesthesia is the result of a hyper-sensitive multimodal binding-mechanism. To address the question whether multi-modal integration is altered in synaesthetes in general, grapheme-colour and auditory-visual synaesthetes were studied using the double-flash illusion. This illusion is induced by a single light flash presen...
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In natural communication speech perception is profoundly influenced by observable mouth movements. The additional visual information can greatly facilitate intelligibility but incongruent visual information may also lead to novel percepts that neither match the auditory nor the visual information as evidenced by the McGurk effect. Recent models of...
Article
In synesthesia, certain stimuli to one sensory modality lead to sensory perception in another unstimulated modality. In addition to other models, a two-stage model is discussed to explain this phenomenon, which combines two previously formulated hypotheses regarding synesthesia: direct cross-activation and hyperbinding. The direct cross-activation...
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In synaesthesia certain external stimuli (e.g., music) trigger automatically internally generated sensations (e.g., colour). Results of behavioural investigations indicate that multisensory processing works differently in synaesthetes. However, the reasons for these differences and the underlying neural correlates remain unclear. The aim of the cur...
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Synesthesia is a condition in which stimulation in one processing stream (e.g., letters or music) leads to perception in an unstimulated processing stream (e.g., colors). Behavioral differences in mutisensory processing have been shown for multimodal illusions, but the differences in neural processing are still unclear. In the present study, we exa...
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Introduction Natural speech perception relies on both, auditory and visual information. Both sensory channels provide redundant and complementary information, such that speech perception is enhanced in healthy subjects, when both information channels are present. Objectives Patients with schizophrenia have been reported to have problems regarding...
Article
In auditory-visual synaesthesia, all kinds of sound can induce additional visual experiences. To identify the brain regions mainly involved in this form of synaesthesia, functional magnetic resonance imaging (fMRI) has been used during non-linguistic sound perception (chords and pure tones) in synaesthetes and non-synaesthetes. Synaesthetes showed...
Article
Color percept induction in synaesthetes by hearing words was previously shown to involve activation of visual and specifically color processing cortex areas. While this provides a rationale for the origin of the anomalous color percept the question of mechanism of this crossmodal activation remains unclear. We pursued this question with fMRI in col...
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Response inhibition impairment is one of the most characteristic symptoms of attention-deficit/hyperactivity disorder (ADHD). Thus functional magnetic resonance imaging (fMRI) during a Go/No-Go task seems to be an ideal tool for examining neuronal correlates of inhibitory control deficits in ADHD. Prior studies have shown frontostriatal abnormaliti...
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The selection of one of two concurrent speech messages for comprehension was investigated in healthy young adults in two event-related potential experiments. The stories were presented from virtual locations located 30 degrees to the left and right azimuth by convolving the speech message by the appropriate head-related transfer function determined...
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Visual information (lip movements) significantly contributes to speech comprehension raising the question for the neural implementation of audiovisual (AV) integration during speech processing. To replicate and extend earlier neuroimaging findings, we compared two different analysis approaches in a slow event-related fMRI study of healthy native sp...
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Speech perception is an essential part of social interaction. Visual information (lip movements, facial expression) may supplement auditory information in particular under inadvertent listening situations. Schizophrenia patients have been shown to have a deficit in integrating articulatory motions with the auditory speech input. The goal of this st...
Article
Speech comprehension in noisy environments is greatly improved by the availability of visual information, i.e. lip and facial movements. This suggests that the brain is in possession of an audiovisual integration mechanism supplementing speech comprehension. To reveal the respective brain areas, we used a step-wise functional neuroimaging approach...

Citations

... Overall, the child seemed to have severe difficulties with social intelligence and was highly unresponsive to environmental cues at that time [14]. Due to tactile defensiveness, it was extremely difficult to touch the patient [15]. This is why some therapeutic interventions at this point of development could not be implemented. ...
... Importantly, there were five patients (cases 5, 6, 7, 17, 18) (36,37,44,45) with comorbid substance use disorder, who had several antipsychotic failures previously either due to ineffectiveness in reducing symptoms of schizophrenia and addiction, or due to severe side-effects. The patients had severely impaired psychosocial functioning and quality of life. ...
... Many clients noted the convenience of online therapy for not having to travel; however, reports of this time being useful for preparation before each session and integration afterwards were also prevalent. Technical problems (see Ghaneirad et al., 2021) and potential organisational issues were also important: many reported problems with online connection, camera positioning, and a lack of body language (Abbass and Elliott, 2020); however, participants also noted the convenience of the online setting in terms of flexibility (e.g., booking appointments and extending sessions). ...
... [1][2][3][4][5][6][7][8] The ODS neuropathologic syndrome is caused by a hastily adjustment of a temporary or chronic deficiency of the homeostatic sodium gradient as it can be pertinent to diverse homeostatic hormonal sodic perturbations such as those afflicted by exaggerated body fluid losses and emergently treated for alcoholism, diabetes as well as to defective dialysis. [1][2][3][9][10][11][12][13][14] A large reference list of ODS literature was recently cited [15][16][17][18][19] and it appeared that EPM lesions can appear before any CPM ones [19][20][21][22][23][24][25] and ODS in human EPM cases would be more frequent than CPM ones. 23 There, ODS can frequently appear clinically in the elderly, hospitalized population. ...
... In terms of food addiction, several studies have addressed addiction-like responses to palatable, highly processed foods in individuals with obesity in general (Fernandez-Aranda et al., 2018;Sinha, 2018;Volkow et al., 2013) and in bariatric surgery patients in particular (Ben-Porat et al., 2021;Brunault et al., 2016;Chiappetta et al., 2020;Guerrero Perez et al., 2018;Ivezaj et al., 2017;Lescher et al., 2020;Müller et al., 2018). Most studies made use of the Yale Food Addiction Scale (YFAS; Gearhardt et al., 2016) that measures food addiction based on substance dependence criteria (APA, 2000(APA, , 2013 adopted for palatable, processed food (e.g., persistent desire or unsuccessful efforts to cut down or control eating, continued eating despite physical or psychological problems) and impairment or distress resulting from those symptoms. ...
... Nx4 has been previously reported to alter cortical electroencephalographic (EEG) spectral windows in rats and humans (Dimpfel, 2019;Dimpfel, Roeska, & Seilheimer, 2012), reduce stress-induced increased amygdala activity as assessed by functional magnetic resonance imaging (fMRI; Herrmann et al., 2020), decrease human stress biomarkers following social performance stressors (Doering et al., 2016) and is implicated in calming restlessness/nervousness, and other symptoms associated with stress (Hübner, van Haselen, & Klein, 2009). Nx4 also improved self-reported sleep latency and sleep disturbances in individuals with onset insomnia (Waldschütz & Klein, 2008). ...
... Using video games is one of the most popular leisure activities for children and adolescents, and while many of them are able to regulate their interaction with games, a significant proportion do not (Brunborg et al., 2013;Mohammadi et al., 2020). As a result, some European studies report that adolescents (secondary-school pupils of 13-14 years on average) with excessive use of video games may present various signs of addiction, such as constant preoccupation with the act of playing, multiple problems both in family and social relations, and a considerable fluctuation in mood (Bonnaire & Phan, 2017;Griffiths, Király, Pontes, & Demetrovics, 2015;Vadlin, Åslund, Hellström, & Nilsson, 2016;Wartberg, Kriston, Kramer, Schwedler, Lincoln, & Kammerl, 2017). ...
... The substantial evidence for altered audiovisual temporal binding in autistic youth, as well as observed relations between TBWs for audiovisual speech and other domains of functioning in autistic youth, has engendered increasing interest in the possibility of training audiovisual integration in autistic youth (e.g., Bahrick & Todd 2012;Cascio et al., 2016;Feldman et al., 2018;Zhou et al., 2020). A number of training studies targeting audiovisual temporal binding have been conducted in non-autistic adults, and have been shown to narrow TBWs in a relatively short period of time (i.e., 3-5 sessions;De Niear et al., 2016McGovern et al., 2016;Powers et al., 2009;Setti et al., 2014;Sürig et al., 2018;Zerr et al., 2019). These training paradigms provide automated feedback after each trial of a computerized task wherein participants must make judgements about the synchrony or temporal order of audiovisual stimuli, such as flashes and beeps (e.g., Powers et al., 2009;Setti et al., 2014;Sürig et al., 2018) and audiovisual speech, such as a speaker saying the syllable "ba" (De Niear et al., 2018). ...
... BOLD signal in the amygdala is increased specifically during olfactory-visual integration, and the BOLD signal in a superior temporal is increased during auditory-visual integration in both groups. The left auditory cortex (BA41) shows stronger activation in TD controls than in subjects with Asperger's syndrome (Tietze et al., 2019). ...
... The increased priority given to Internet activities leads to neglect of daily activities and life interests, and IUD is associated with social, physical and mental burden (9,10). In addition, high comorbidity with psychiatric disorder has been reported, especially depressive disorders, anxiety disorders, attention deficit hyperactive disorder, substance use disorders and impulse control disorders (11)(12)(13)(14)(15)(16). Although representative studies often report a balanced gender distribution (5,6,17,18), it is predominantly male IUD patients who come to clinics for therapy (19,20). ...