Grant M Jones's research while affiliated with Harvard University and other places

Publications (6)

Article
Full-text available
Tobacco use is the single largest cause of preventable death worldwide, but none of the established treatments aimed at smoking cessation work for a majority of smokers. As such, there is an urgent need for interventions capable of reliably treating nicotine addiction. The use of classic psychedelics has been associated with lower odds of many form...
Article
Full-text available
Opioid use disorder (OUD) is a major source of morbidity and mortality in the U.S. and there is a pressing need to identify additional treatments for the disorder. Classic psychedelics (psilocybin, peyote, mescaline, LSD) have been linked to the alleviation of various substance use disorders and may hold promise as potential treatments for OUD. The...
Article
Full-text available
Cocaine Use Disorder (CUD) is a significant public health problem associated with elevated morbidity and mortality within the United States. Current behavioral treatments have limited efficacy and there are currently no FDA approved pharmacological treatments for CUD. Classic psychedelics might be associated with lowered odds of substance misuse an...
Article
Background Depression is a major mental health issue worldwide, with high rates of chronicity and non-recovery associated with the condition. Existing treatments such as antidepressant medication and psychological treatments have modest effectiveness, suggesting the need for alternative interventions. Aim The aim of this study was to examine the r...
Article
Background Suicide is one of the leading causes of death worldwide and rates within the United States have risen over the past two decades. Hence, there is a critical need for novel tools to treat suicidal ideation and related mental health conditions. 3,4-Methylenedioxymethamphetamine (MDMA)/ecstasy and classic psychedelics may be two such tools....
Article
Background The United States boasts the largest prison population in the world, conferring significant direct and indirect costs (e.g. lost wages for the incarcerated, increased morbidity/mortality, etc.) to society. Recidivism rates are high for the imprisoned and most interventions to reduce criminality are minimally effective. Thus, in addition...

Citations

... One recent meta-analysis even found decreased suicidality following psychedelics administered in a therapeutic setting, which again emphasizes the importance of set and setting variables (Zeifman et al., 2022). Moreover, also large population-based studies found use of psychedelics associated with reduced psychological distress and suicidality (Hendricks et al., 2015;Jones and Nock, 2022b), depression (Jones and Nock, 2022a), lowered odds of crime arrests (Jones and Nock, 2022c;Hendricks et al., 2018), lowered odds of opiate use disorder (only psilocybin) (Jones et al., 2022), lower odds of heart disease and diabetes (Simonsson et al., 2021a), and lower odds of overweight (Simonsson et al., 2021b). However, it should be further noticed that psychedelics have an outstanding suggestive potency. ...
... These findings also are consistent with other population-based survey research on classic psychedelics suggesting that naturalistic use of LSD in particular is associated with increased odds of adverse outcomes 21,22 , despite evidence for LSD's therapeutic efficacy under clinical administration 23 . Negative outcomes have been associated with the use of some psychedelics, such as paranoia, stress, anxiety, and increased odds of psychosis 24 , and might underlie the association between LSD use and increased odds of nicotine dependence. ...
... One recent meta-analysis even found decreased suicidality following psychedelics administered in a therapeutic setting, which again emphasizes the importance of set and setting variables (Zeifman et al., 2022). Moreover, also large population-based studies found use of psychedelics associated with reduced psychological distress and suicidality (Hendricks et al., 2015;Jones and Nock, 2022b), depression (Jones and Nock, 2022a), lowered odds of crime arrests (Jones and Nock, 2022c;Hendricks et al., 2018), lowered odds of opiate use disorder (only psilocybin) (Jones et al., 2022), lower odds of heart disease and diabetes (Simonsson et al., 2021a), and lower odds of overweight (Simonsson et al., 2021b). However, it should be further noticed that psychedelics have an outstanding suggestive potency. ...
... One recent meta-analysis even found decreased suicidality following psychedelics administered in a therapeutic setting, which again emphasizes the importance of set and setting variables (Zeifman et al., 2022). Moreover, also large population-based studies found use of psychedelics associated with reduced psychological distress and suicidality (Hendricks et al., 2015;Jones and Nock, 2022b), depression (Jones and Nock, 2022a), lowered odds of crime arrests (Jones and Nock, 2022c;Hendricks et al., 2018), lowered odds of opiate use disorder (only psilocybin) (Jones et al., 2022), lower odds of heart disease and diabetes (Simonsson et al., 2021a), and lower odds of overweight (Simonsson et al., 2021b). However, it should be further noticed that psychedelics have an outstanding suggestive potency. ...
... Ketamine in particular has strong psychedelic features (20). All have induction of mystical experience as a shared feature, including MDMA (21,22) and ketamine (23,24). ...