Glenys Dore's research while affiliated with Royal North Shore Hospital and other places

... 4,5 A number of evidence-based strategies had been used for the treatment of addiction as psychosocial interventions and primary care with or without drugs. [6][7][8] Key to successful treatment of substance use disorder was long-term prevention of relapse by pharmacological and behavioral means, 9 however, outcomes can only be measured in months and years, and efficacy varies a lot. 10 It was reported that many factors, such as the treating phase, 11,12 the age of patients, 13 the comorbidity, 14 and doses of medication 15 would impact the efficacy of therapy. Moreover, studies on the treatment of substance use disorder pointed out the potential of various neuromodulation techniques in improving substance treatment outcomes, but well-controlled clinical trials were lacked to support their efficacy. ...

... Current neurocognitive batteries are limited by their focus on functions that are not core to addiction. These functions were typically selected from neuropsychological tests intended for use in brain injury and neurological disorders, such as processing speed, attention span, episodic memory, and nonverbal reasoning, among others [10,11]. Despite some being associated with risk for certain substance use disorders (eg, working memory and alcohol addiction) [12], they are not broadly thought to be mechanistically and causally linked to the perpetuation of substance and behavioral addictions and, as such, cannot inform risk detection. ...

... Além disso, a dosagem dos níveis plasmáticos de lactato e piruvato é importante, pois a tiamina atua como cofator da piruvato desidrogenase e sua inibição causa aumento de seus níveis. (Latt & Dore, 2014). ...

... [6][7][8][9] Several other studies reported adverse impacts of drug abuse and addiction on human health and the socio-economy, ranging from chronic diseases, infection, and psychiatric ailment to increased crime and law default. [10][11][12][13][14][15] Given the overwhelming prevalence of drug abuse and robust reports on its adverse effects on human health and socio-economy, [6][7][8][9][10][11][12][13][14][15] providing solutions became the focal point for health professionals and other scientists. Through effective awareness and counselling programs and management centres, behavioural therapies were reported to be potent interventions for different forms of drug abuse and dependence as they help improve individuals' knowledge, awareness and perception of drug abuse. ...

... Referrals are made to IDAT based on health needs [45] and treatment is offered based on a holistic approach. This differs from a crime prevention focus, as of the former Alcohol Mandatory Treatment Program in the Northern Territory [24]. ...

... Additionally, nicotine administration should result in optimum therapeutic effects without imparting abuse potential or toxicity (Majdi et al., 2017). However, high-dose nicotine treatment has been reported to induce phenotypes of spatial memory impairment (Sirasanagandla et al., 2014), anxiety, depression, and cognitive impairment (Jasinska et al., 2014;Hermens et al., 2013) in animals and chronic nicotine (10 mg/kg, s.c) treatment impairs spatial memory (Motaghinejad et al., 2020). In addition, chronic nicotine treatment was found to be anxietylike in females but not in male mice (Caldarone et al., 2008). ...

... Twenty-one references were selected, and twenty-four articles from the reference sections were identified and added. After examining the full text of 45 articles, 17 articles [1,15,19,[22][23][24][31][32][33][34][35][36][37][38][39][40][41] fulfilled the search criteria. These studies included 11 cases [15,[22][23][24]32,33,[36][37][38][39][40] reports and six case series [1,19,31,34,35,41] (Table 2). ...

... [1][2][3][4] Many individuals with opioid use disorder (OUD) have co-occurring disorders such as post-traumatic stress disorder (PTSD) and/or major depressive disorder (MDD). [5][6][7] Most individuals with OUD have experienced trauma and close to two-thirds go on to experience co-occurring PTSD. [6][7][8] Approximately half of those with OUD also have lifetime major depression 9 and 20% have a 12-month diagnosis of a mood disorder. ...