Ghulam Nabi Dahiri’s scientific contributions

... ZFAS1 is a gene that is found in several cancers including hepatocellular carcinoma, colorectal cancer, gastric cancer, ovarian cancer, glioma, osteosarcoma, esophageal squamous cell carcinoma, acute myeloid leukemia, non-small cell lung cancer, breast cancer etc. There are abnormally expressed lncRNAs (Zhou et al. 2016) and up-regulation of ZFAS1 expression is positively connected with lymph node metastasis of colorectal cancer, gastric cancer, ovarian cancer and non-small cell lung cancer (He et al. 2019); ZFAS1 can regulate miR-588 and regulate the body's inflammatory response through the miR-588/ROCK1 axis (Geng et al. 2022) and miR-588 has been reported to be involved in the pathogenesis of lung cancer, human breast cancer, colorectal cancer and other tumors (Yu et al. 2017;Fattahi et al. 2019;Dahiri et al. 2022); therefore, ZFAS1 can regulate inflammatory responses and is abnormally expressed in many tumors, further exploring its mechanism of action will help discover the role of lncRNA in tumor occurrence and development. ...

Reference:

Potential Interaction between Inflammation and Tumor Microenvironment