Ghader Molavi's research while affiliated with Tabriz University of Medical Sciences and other places

Publications (9)

Article
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Background: The coronavirus disease (COVID-19) pandemic has made a great impact on health-care services. The prognosis of the severity of the disease help reduces mortality by prioritizing the allocation of hospital resources. Early mortality prediction of this disease through paramount biomarkers is the main aim of this study. Materials and meth...
Article
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Breast cancer is the most common malignancy among females worldwide. Recent studies have shown extra-ribosomal roles of the moonlight ribosomal proteins in the development of human cancers. Accurate quantification of the gene expression level is based on the selection of the reference genes whose expression is independent of cancer properties and p...
Article
It is generally accepted that L‐asparagine is an important amino acid required for the fast growth of cells. Cancerous cells receive this amino acid from extracellular sources. The depletion of L‐asparagine from its surrounding environments by asparaginase enzyme can be used as a therapeutic strategy in cancer patients. This therapeutic enzyme is p...
Article
Acinetobacter baumannii is known as a Gram-negative bacterium that has become one of the most important health problems due to antibiotic resistance. Today, numerous efforts are being made to find new antibiotics against this nosocomial pathogen. As an alternative solution, finding bacterial target(s), necessary for survival and spread of most resi...
Article
The most frequent kind of malignancy in the universe is skin cancer, which has been categorized into non-melanoma and melanoma skin cancer. There are no complete information of the skin carcinogenesis process. A variety of external and internal agents contribute to the non-melanoma and melanoma skin cancer pathogenesis. These factors are epigenetic...
Article
Leukemia is a cancer, which is derived from leukocytes and precursors of leukocytes in the bone marrow. A large number of pivotal biological processes are linked to leukemia pathogenesis. More insights into these mechanisms can provide a better developing pharmacological platform for patients with leukemia. Among the different players in leukemia p...
Article
“Moonlighting protein” is a term used to define a single protein with multiple functions and different activities that are not derived from gene fusions, multiple RNA splicing, or the proteolytic activity of promiscuous enzymes. Different proteinous constituents of ribosomes have been shown to have important moonlighting extra‐ribosomal functions....
Article
Full-text available
Malva sylvestris L. (Malvaceae), an annual plant, has been already commonly used as a medicinal plant in Iran. In the present work, we evaluate some bioactivities of the plant extracts. The aired-dried plant flowers and leaves were extracted by soxhlet apparatus with n-hexane, dichloromethane and methanol. The antimicrobial, cytotoxic, and phytotox...

Citations

... Correspondingly, HLA-A Ã 02:01 allele was selected, as it is so abundant among patients with ALL in Iran (Gorodezky et al., 2014;Hadadianpour et al., 2018). The IC 50 values of 50 nM for allele HLA-A Ã 02:01 in the MHC class I binding epitopes were further selected as a strong binder epitope (Zadeh Hosseingholi et al., 2020). The MHC class II binding regions were additionally predicted by the ProPred server. ...
... The aforementioned results underscored the importance of the pilus assembly system in the pathogenesis and immunogenicity of A. baumannii. Furthermore, the aforementioned data suggest that in silico approaches might be helpful in discovering likely drug and immunogenic candidates that have been ignored up to now (33). ...
... Therefore, circRNAs can be considered biomarkers for the evaluation of reproductive diseases [16]. Recent research has shown that circRNAs act as potential molecular markers for the diagnosis and treatment of diseases and plays important roles in the onset and progression of human diseases [39][40][41][42]. Some circRNAs appear to be involved in the regulation of apoptosis in cells. ...
... Chemoresistant AML cells were able to induce increased expression of MRP-1 in chemosensitive AML cells through EVs to enable them to be resistant to chemotherapy drugs (193). EVs contain higher levels of known clinical risk factors, such as TGF-b1, miR-21, miR-155, miR-10b (194,195). Similarly, exosomes carry Fas ligand (FAS-L), NPM1, FLT3, matrix metallopeptidase 9 (MMP9), insulin-like growth factor type 1 receptor (IGF1-R), CXCR4, and chaperones to alter the BM microenvironment and to improve the survival of leukemia cells, especially LSCs (196,197). Overall, EVs can directly or indirectly alter the signaling pathways, or increase the mitochondrial content, leading to the proliferation, survival, and drug resistance of AML. ...
... The interaction between RP and MDM2 causes p53 stabilization and subsequent cell cycle blocking [28][29][30]. Overall, the extra-ribosomal function of RPs regulates affects p53 pathway by regulating several cell processes, including cell cycle, DNA repair, maintaining genome integrity, cell proliferation, apoptosis, cell migration, and invasion [28,31,32]. ...
... Mint leaves has a wide range of culinary usage and uses in food preparation to enhance taste and appearance (Hutchings and Van Staden 1994). Moreover, the extract and essential oil of wild mint possesses a number of pharmacological activities such as antimicrobial (Al-Bayati 2009), antispasmodic (Razavi et al. 2012), anticancer properties (Tabassum et al. 2016) and can be used as a natural source of antioxidants in food preservatives (D zami c et al. 2010;Al-Okbi et al. 2015;Hintz et al. 2015) due to their potential in promoting health and lowering the risk for cancer, hypertension and heart diseases (Valko et al. 2007). ...
... Malva sylvestris L. come from North Africa, Southwest Asia, and South Europe, although it is found worldwide as a weed. It prefers to grow in moist areas near oceans, swamps, canals, waterways, and meadows, among other spots (Razavi et al. 2011). ...