Gerard Godoy-Tena's research while affiliated with IJC Josep Carreras Leukemia Research Institute and other places

Publications (7)

Preprint
Dendritic cells (DCs) are central in the immune system, bridging the adaptive and innate immune responses. Research on in vitro differentiation of DCs from monocytes provides both in-depth understanding of the analogous in vivo process and potential sources for cancer cell therapy. Active DNA demethylation is crucial in DC differentiation. Vitamin...
Article
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Dendritic cells (DCs) are professional antigen-presenting cells with the distinctive property of inducing the priming and differentiation of naïve CD4+ and CD8+ T cells into helper and cytotoxic effector T cells to develop efficient tumor-immune responses. DCs display pathogenic and tumorigenic antigens on their surface through major histocompatibi...
Article
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An immunochemical strategy to detect and quantify AIP-IV, the quorum sensing (QS) signaling molecule produced by Staphylococcus aureus agr type IV, is reported here for the first time. Theoretical calculations and molecular modeling studies have assisted on the design and synthesis of a suitable peptide hapten (AIPIVS), allowing to obtain high avid...
Article
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The active form of vitamin D, 1,25-dihydroxyvitamin D3, induces a stable tolerogenic phenotype in dendritic cells (DCs). This process involves the vitamin D receptor (VDR), which translocates to the nucleus, binds its cognate genomic sites, and promotes epigenetic and transcriptional remodeling. In this study, we report the occurrence of vitamin D-...
Article
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: Staphylococcus aureus is a commensal and frequent colonizer of the upper respiratory tract. When mechanical ventilation disrupts natural defenses, S. aureus is frequently isolated from the lower airways, but distinguishing between colonization and infection is difficult. The objectives of this study were (1) to investigate the bacterial genome se...
Article
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Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. Here, we identify widespread DN...

Citations

... In consequence, vitamin D3 inhibits NLRP3 inflammasome activation and IL-1β secretion and thus might be useful in the treatment of inflammatory conditions [49]. At the crossroads between innate and adaptive immunity, vitamin D3 induces a tolerogenic phenotype in dendritic cells (DCs) [50], which has recently been linked to JAK2-mediated STAT3 phosphorylation [51]. The induction of tolerogenic DCs might help control autoreactive T cells in autoimmune diseases. ...
... 37 Through the interaction with MM cells, BMSCs show abnormal epigenetic aberrancies, thus impairing their ability to differentiate into osteoblasts, and targeting therapy has proved to be efficient in reversing MBD. 38 ...