George Detre's scientific contributions

Publication (1)

Article
A method for obtaining 1H NMR spectra of org. mols. covalently attached to solid - phase synthesis beads using magic angle spinning in a conventional spectrometer is described. The new method offers substantial qual. and quant. advantages and makes 1H NMR truly available as an anal. tool to the solid - phase synthesis practitioner

Citations

... The fundamental requirement is that the spinning rate must exceed the linewidth, which may be many kilohertz. In some instances, typically with soft solids or gels, a relatively slow spinning rate ($3000-5000 Hz) is applied under high-resolution MAS (HR-MAS) conditions, requiring a specialized probe to achieve liquid-state-like resolution (Fitch et al. 1994). In samples with broader lines and (or) slower motion that are not amenable to HR-MAS, the required spinning rates tend to be higher and distinct solid-oriented classes of experiment are applied. ...