Geoffrey T Manley’s research while affiliated with Chan Zuckerberg Biohub San Francisco and other places

... Modifiers, Knowledge to Practice, and Retrospective Classification-and provided direction and collaboration throughout the initiative. [5][6][7][8] Working groups had opportunities to give feedback on each other's evolving work. Additionally, the general public was invited to participate in the Initiative through participation in the January 2024 in-person workshop and through a Request for Information distributed by NINDS. ...

Reference:

Toward More Holistic Early Traumatic Brain Injury Evaluation and Care: Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Psychosocial and Environmental Modifiers Working Group

... Modifiers, Knowledge to Practice, and Retrospective Classification-and provided direction and collaboration throughout the initiative. [5][6][7][8] Working groups had opportunities to give feedback on each other's evolving work. Additionally, the general public was invited to participate in the Initiative through participation in the January 2024 in-person workshop and through a Request for Information distributed by NINDS. ...

Reference:

Toward More Holistic Early Traumatic Brain Injury Evaluation and Care: Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Psychosocial and Environmental Modifiers Working Group

... Modifiers, Knowledge to Practice, and Retrospective Classification-and provided direction and collaboration throughout the initiative. [5][6][7][8] Working groups had opportunities to give feedback on each other's evolving work. Additionally, the general public was invited to participate in the Initiative through participation in the January 2024 in-person workshop and through a Request for Information distributed by NINDS. ...

Reference:

Toward More Holistic Early Traumatic Brain Injury Evaluation and Care: Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Psychosocial and Environmental Modifiers Working Group

... Modifiers, Knowledge to Practice, and Retrospective Classification-and provided direction and collaboration throughout the initiative. [5][6][7][8] Working groups had opportunities to give feedback on each other's evolving work. Additionally, the general public was invited to participate in the Initiative through participation in the January 2024 in-person workshop and through a Request for Information distributed by NINDS. ...

Reference:

Toward More Holistic Early Traumatic Brain Injury Evaluation and Care: Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Psychosocial and Environmental Modifiers Working Group

... Given the potential for Ang2 to serve as a biomarker of microvascular injury, an abstract presented at the AAN 2025 Annual Meeting aimed to assess the relationship between Ang2 plasma levels, TBI severity, CT findings, and the temporal evolution of Ang2 levels in the weeks following TBI. 4 Ang2 is an important biomarker for TBI, particularly for identifying microvascular injury Mapping the Genetics of the Hypothalamus: Implications for Neuropsychiatric Disease ...

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Review of the American Academy of Neurology (AAN) 2025 Annual Meeting

... Although NLR, albumin, and BMI have individually been linked to stroke mortality 5,19,20 ; their isolated use fails to capture the synergistic effects of inflammation and malnutrition-a gap addressed by our composite ALI index in NCH. This approach aligns with emerging trends in critical care prognostication, where integrated biomarkers (e.g., the Controlling Nutritional Status score in sepsis) outperform single parameters, yet contrasts with stroke models still reliant on neurological scales alone 21 .While traditional prognostic tools (e.g., GCS, SOFA, LODS) mainly capture the severity of neurological injury [22][23][24] , our data suggest that ALI provides additional prognostic value by incorporating systemic factors. This observation supports recent evidence that emphasizes the interplay between neuroinflammation and catabolic processes in secondary brain injury 23,[25][26][27] . ...

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Advanced lung cancer inflammation index is associated with mortality in critically ill patients with non-traumatic cerebral hemorrhage

... In a study of mild TBI (mTBI) subjects [8], the authors quantified the prevalence of psychiatric and medical comorbidities at five years post-injury and as a function of the biological sex and age of the subjects. Mild TBI survivors are prone to developing highly diverse comorbidities ranging from cardiovascular, neurologic, and respiratory to psychiatric [8,[11][12][13][14]. Similar results have also been reported after severe and moderate impacts to the brain [10]. ...

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Exploring comorbidity networks in mild traumatic brain injury subjects through graph theory: a traumatic brain injury model systems study

... In light of these challenges, there is an urgent need to explore alternative sources of support, including enhanced investment from state agencies, private foundations, and public-private partnerships. Strategic collaborations such as TRACK-SCI 21,22 , which has fostered multicenter data harmonization and accelerated clinical insights, demonstrate how coordinated efforts can generate impactful outcomes even within constrained funding environments (https://cdmrp.health.mil/scirp/research_highlights/21track-sci_highlight). ...

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Systematic analysis of federal funding for spinal cord injury research

... Age-related differences likely involve individual differences to pre-injury cognitive reserve and extent of presymptomatic neural degenerative disease as well as baseline changes or progressive defects in regulating neural inflammation, signaling or repair mechanisms. Targeted human genome-wide association (GWAS) based studies have provided useful insight, despite the difficulties working with the complexity of head trauma and the relatively limited number of individuals for a given study [17][18][19]. Research has initially focused on known neurological factors including allelic variants of the Apolipoprotien-E (APOE) gene, which has also been associated as a risk factor for the development of Alzheimer's disease (AD) [20,21]. GWAS based studies have consistently indicated that carriers with the APOEe4 allele have relatively poor outcomes following different types of TBI exposures [4,22,23]. ...

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Genetic Modifiers Influencing the Acute and Long-Term Responses to Traumatic Brain Injury in Drosophila

... This score ranges between 3 (worst response) to 15 (best response). This score is a useful tool for assessing severity of injury, need of intensive monitoring and outcome [27]. ...

Reference:

Brain microdialysis to assess trace elements dynamics in traumatic brain injury: An exploratory study