Geoffrey A Modest's research while affiliated with Boston University and other places
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Publications (7)
To the Editor: The Clinical Crossroads article by Drs Carrozza and Sellke¹ addresses the therapeutic options for a 69-year-old woman with disease of the left main coronary artery. Their discussion reflects state-of-the-art approaches² ; promoting these surgical interventions rests on the assumption of the therapeutic inferiority of medical manageme...
To the Editor: A healthy 20-year-old woman presented with breast pain and bilateral purulent nipple discharge three weeks after having her nipples pierced. She received a course of antibiotics (cephalexin), and her infection resolved. Two weeks later, she returned because of bilateral spontaneous galactorrhea. Evaluation at that time showed a prola...
To the Editor: In their Rational Clinical Examination
article, Dr Bent and colleagues1 evaluated
the accuracy and precision of the clinical history and examination for the
diagnosis of urinary tract infection (UTI). Clinicians often rely on a single
symptom or sign to establish the diagnosis,2
so it is important that they be aware of the pretest pr...
We report the case of a 36 year old man who was hospitalized with pneumonia and pancytopenia with refractory anemia with excess blasts confirmed by bone marrow biopsy. He was subsequently found to have advanced HIV infection. Both the HIV infection and the myelodysplastic syndrome responded to highly active anti-retroviral therapy (HAART) with sust...
Citations
... 56,82 Promising results were obtained in several reports of NADCs treatment in HIV-infected people with HAART-drugs alone or in combination with chemotherapy, which resulted in a good clinical response. [83][84][85][86][87] Combination of HAART and chemotherapy HIV-infected people are generally excluded from clinical trials; therefore, data on toxicity, outcomes and possible drug interactions during cancer treatment are limited. Despite the increased toxicity and drug-drug interactions, HAART withdrawal during chemotherapy is unfavorable in HIV-patients with cancer and can lead to a poorer outcome 88 ; therefore, in general, any HAART interruption is not advisable during cancer treatment. ...
... UTIs cause an estimated 11 million doctor visits in the USA annually, and over 150 million doctor visits globally, with an annual cost upwards of $6 billion (Bower et al., 2005;Foxman, 2003;Nielubowicz & Mobley, 2010;Stamm & Hooton, 1993;Stamm & Norrby, 2001). Categories of disease include complicated and uncomplicated infections, which are further classified according to symptoms and diagnostic markers as urethritis, acute and chronic cystitis, prostatitis and pyelonephritis (Hay & Fahey, 2002;Kaufmann & Modest, 2002;Neild, 2003;Nicolle, 2008). Complicated UTIs are defined by their association with structural or functional abnormalities of the urinary tract that leads to enhanced susceptibility to infection (Johansen et al., 2011). ...
... All patients must meet the diagnostic criteria for adult CHD established by the American College of Cardiology/American Heart Association, [15] and all patients must have undergone PCI. There will be no limits placed on basic patient characteristics (including region, race, and sex). ...
... This negative feedback mechanism explains hyperprolactinemia observed when using dopamine inhibitors (33)(34)(35)(36) or when D2 receptors genes are knocked out (37)(38)(39)(40). During late pregnancy and lactation, dopamine synthesis is blocked, meaning that PRL secretion is disinhibited, and PRL level remains high after birth (41,42). Noteworthy, the cycle of PRL and dopamine is dependent on the nonselective, Ca2þ-permeable, and receptor-operated cation channel, denoted as transient receptor potential channel (Trpc5), expressed in dopaminergic neurons. ...
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... However, regardless of how well cholesterol is controlled, at least 20% of patients experience recurrent myocardial infarction within 3 years after the first clinical manifestation. 5 Other treatments are urgently needed to reduce the morbidity and mortality associated with atherosclerosis. ...
