Geert Frederix's research while affiliated with Utrecht University and other places

Publications (4)

Article
Precision diagnostics is one of the two pillars of precision medicine. Sequencing efforts in the past decade have firmly established cancer as a primarily genetically driven disease. This concept is supported by therapeutic successes aimed at particular pathways that are perturbed by specific driver mutations in protein-coding domains and reflected...
Article
Full-text available
Introduction Personalized medicine-based treatments in advanced cancer hold the promise to offer substantial health benefits to genetic subgroups but require efficient biomarker-based patient stratification to match patients to the right treatment and may be expensive. Standard molecular diagnostics is currently very heterogeneous, and tests are of...
Article
Full-text available
Purpose: Predictive diagnostics play an increasingly important role in personalized medicine for cancer treatment. Whole genome sequencing (WGS) based treatment selection is expected to rapidly increase worldwide. This study aimed to calculate and compare the total cost of currently used diagnostic techniques and of WGS in treatment of non-small ce...
Article
Full-text available
Background: Under a constrained health care budget, cost-increasing technologies may displace funds from existing health services. However, it is unknown what services are displaced and how such displacement takes place in practice. The aim of our study was to investigate how the Dutch hospital sector has dealt with the introduction of cost-increa...

Citations

... The successful clinical implementation of WGS for the diagnostics of germline conditions has paved the way for the introduction of WGS in the diagnostic setting of malignancies (39,40). In pioneering studies, WGS, often combined with WTS, has been evaluated as a diagnostic tool in acute leukemia with promising results. ...
... It is important to be aware of this aspect, to prevent unneeded rebiopsies for repeat-analysis. A third consideration is the costeffectiveness of WGS as a single pre-screening tool, which is currently being investigated [28]. WGS inherently requires substantially more sequencing capacity compared to panelbased NGS and thus it is more expensive. ...
... Costs were based on a published Dutch microcosting analysis [13]. Costs for machinery, material, personnel, and small equipment for each diagnostic test in standard diagnostics for lung cancer were incorporated in the cost analysis. ...