Galina Shenkerman's research while affiliated with Tel Aviv Sourasky Medical Center and other places
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Publications (22)
Objectives:
We aimed to examine the relationships between body mass index (BMI) and metabolic syndrome (MS) components as a function of age and gender across weight categories.
Methods:
This cross-sectional study included 19,328 subjects who participated in a health-screening program. We analyzed 14,093 apparently healthy subjects with a BMI ≥ 1...
Background:
In the treatment of obesity/metabolic syndrome, dietary measures traditionally focus on reducing carbohydrate/fat-related caloric intake. The possibility that changes in potassium consumption may be related to the achieved weight loss has not been previously explored.
Methods:
Sixty-eight participants, with a mean age of 51.6 ± 11.0...
ORAL SESSION 8B: OBESITY AND METABOLIC SYNDROME
Background: Lifestyle modification targeting physical exercise, better nutrition and weight loss and are the hallmark of current therapy of the metabolic syndrome, but treatment failure and progression to diabetes and/or other complications of the metabolic syndrome are rather common.
Aim: To evaluate how baseline features affect weight loss. Prese...
It is still uncertain whether mild primary hyperparathyroidism (PHPT) carries the same risk for increased cardiovascular (CV) morbidity as the more severe symptomatic form. In recent years, the even more subtle normocalcemic (NC) variant is being increasingly recognized. We sought to compare the prevalence of CV risk factors in patients with NC- an...
To characterize the obesity phenotype(s) in patients with idiopathic intracranial hypertension (IIH).
Database study.
We studied 44 consecutive patients with IIH, in addition to 184 women attending the obesity clinic of the same medical center and 199 obese women participating in the first Israeli national survey on health and nutrition conducted i...
To assess arterial stiffness in a cohort of hypogonadal males and to investigate the effect of testosterone replacement therapy on arterial properties in this specific group.
Eighteen male patients with untreated acquired hypogonadism due to either adult-onset idiopathic hypogonadotropic hypogonadism (n=9) or pituitary tumor (n=9) and 12 age-, sex,...
In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals.
A total of 6319 individuals participated in the study. Complete blood counts, high sensitivity C-reactive protein (hs-CRP) serum levels, and body mass index (BMI) were measured during r...
The authors assessed the practicality and results of forced titrating of blood pressure to <130/85 mm Hg based on guidelines of the sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure in the setting of a clinical practice in 257 diabetic, hypertensive patients. Goal diastolic press...
Salivary cortisol is unaffected by cortisol binding globulin (CBG) and hence allows CBG-related variations in serum total cortisol to be bypassed. We assessed whether or not salivary cortisol can be used for the low-dose (1 microg) ACTH test in subjects with presumed normal and elevated levels of CBG.
We measured serum and salivary cortisol respons...
There is no consensus as to the optimal postoperative treatment of patients with clinically nonfunctioning pituitary adenomas (NFPA) in whom total tumour removal has not been achieved. In this study we assessed whether dopamine agonist (DA) treatment can prevent postoperative remnant enlargement in NFPA.
Thirty-three patients (25 men/8 women; mean...
Objective
: To examine the relationship between blood pressure and three measures of obesity – weight (W), body mass index (BMI) and waist to hip ratio (WHR) in morbidly obese patients.
Design
: Cross-sectional survey of 219 consecutive obese patients (F/M – 169/45), aged 17–78 y at the Tel Aviv- Sourasky Medical Center Obesity Clinic.
Results
Fo...
Enhanced red blood cell (RBC) aggregation has an adverse effect on microcirculatory blood flow and tissue oxygenation. It has been previously shown that obesity is associated with increased RBC aggregation. The objectives of the present study were to further characterize obesity-related RBC aggregation and to examine whether the enhanced aggregatio...
Insulin resistance is associated with low-grade inflammatory response. The probability that the acute-phase response is associated with enhanced erythrocyte adhesiveness/aggregation was not explored.
The degree of erythrocyte adhesiveness/aggregation was evaluated by using a simple slide test. The insulin resistance was evaluated by insulin and glu...
Previous studies have suggested that obesity enhances the inflammatory response, producing macromolecules involved in the induction and/or maintenance of increased erythrocyte aggregation. The objectives of this study were to evaluate the correlation between inflammation markers, erythrocyte adhesiveness/aggregation, and the degree of obesity and t...
The practicality of attaining currently recommended target levels of less than 130/85 mm Hg in hypertensive type 2 diabetic patients remains to be shown, particularly in middle aged and older individuals. We systematically implemented JNC-VI guidelines (target < 130/85 mm Hg) in 257 type 2 diabetic hypertensive patients treated for hypertension at...
Citations
... Furthermore, the weighted prevalence of MHO when 4 definitions were combined was only 5.7% [22]. The most recent large-scale study on the prevalence of MHO was done in Israel and involved more than 19,000 apparently healthy adults as part of a routine check-up and found that the over-all prevalence of MHO (defined as obesity + absence of any MetS components and no drug treatment) was 7.5% [30]. This prevalence substantially declined to 1% once BMI reached ≥36 kg/m 2 [30]. ...
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... As mentioned above, the present research did not evaluate dietary micronutrients' intake, thus the association refers to serum potassium levels. These findings are in agreement with previous studies concerning dietary potassium intake, which demonstrated an association between higher potassium consumption and reduced BMI in obese patients [50,51]. ...
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... Although it is considered that nHPT has a milder clinical course than asymptomatic pHPT, recent studies have shown that it may be associated with insulin resistance, metabolic syndrome (MetS), osteoporosis, and cardiovascular risk factors [8][9][10][11][12]. Several recommendations Abstract Introduction: Normocalcaemic hyperparathyroidism is a condition first defined in 2008, characterized by normal serum calcium and high parathormone levels. ...
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... A previous single-centre study of waistto-hip ratios demonstrated a preference for lower body fat distribution when compared with central adiposity in controls living with obesity. 68 However, this notion was refuted using dual-energy X-ray absorptiometry scanning as patients with IIH portrayed typical centripetal fat distribution, similar to BMI and gender-matched controls. Truncal fat mas also significantly correlated with LP opening pressure, not BMI. ...
... Men are believed to have greater testosterone exertion during exercise than women [66]. Testosterone is known to lower PWV in the short and long terms [67][68][69]. In their review article, Moreau et al. argued that these effects are due to structural changes in the endothelium, as well as acute changes in nitric oxide signaling [70,71]. ...
... cells can also result in platelet aggregation and coagulation which impair blood flow [52][53][54]. RBC aggregation directly decreases plasma flow and can decrease oxygen transfer to tissues and thus exacerbate ischemia, creating a cycle of injury [55,56]. We also found erythrocyte aggregates in the peripheral circulation following renal ischemia. ...
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... 29 Researchers have also observed an increase in peripheral blood erythrocyte aggregation in patients with obesity and insulin resistance. 30 Imbalances in the MAFLD population between energy intakes and consumption may lead to insulin resistance in numerous tissues. 31 Several researches have discovered that RBC is an unknown risk factor for NAFLD. ...
... From this, we postulate that L-shape might serve as a template that can undergo extension by coupling with the nearby RBCs to give rise to a Y-shape rouleaux (Fig. 3d). As a final stage of aggregation phenomena, these Y shapes form large clump shape rouleaux in higher concentration of dextran that might contribute to flow-resistant irreversible aggregate as similar earlier study reports in which flow-resistant RBC aggregates contribute to various disease complications [62,63]. Our SEM micrographs result not only distinguished individual RBC in rouleaux formation but also demonstrated prevalence of echinocyte RBC. ...
... Mild pHPT has been discovered to have multi-gland involvement in up to a staggering 50% of cases [8]. A separate study conducted by Tordjman et al. discovered that 18% of patients diagnosed and treated with mild pHPT were found to have hyperplasia and up to 82% to have a single adenoma [58]. Moreover, when comparing pathology, patients with the mild form of pHPT have been found to have lower-weight adenomas and overall smaller amounts of parathyroid tissue than their classical pHPT counterparts [33]. ...
... DAs, especially cabergoline, are the first-choice treatment for patients with prolactin (PRL)-secreting PitNETs, since they are effective in inducing prolactin normalization and in reducing tumor size, but about 10% of patients are resistant to the treatment [1]. In non-functioning (NF)-PitNETs, DAs can reduce tumor mass in a subset of patients, but their use is not recommended, since published data are insufficient and controversial in demonstrating their efficacy [2][3][4][5][6]. ...
