Gabriel Lima de Barros Araujo’s scientific contributions

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Publications (1)

Figure 1 Technical drawing for the assembly of the pin camera
Figure 2 Technical drawing for the assembly of the inlet cone and inlet tube
Figure 3 Technical drawing for the assembly of the chamber and physical aerosol testing area
Figure 5 (1) -Capture chamber; (2) -Impactor design of a proposed stage; (3) -Overview of the 3D drawing of the IMPACTOR of a stage; (4) -Flow meter, capacity 50 l/min.; (5) -Vacuum pump, capacity of 60 l/min. and 6 -Nozzle
Figure 6 (1) -3D drawing of the L-tube (trachea), schematic based on USP Pharmacopeia; (2) -3D drawing of the entry cone (trachea), schematic based on USP Pharmacopeia; (3) -General control equipment; 4 -SIMPATEC-USP equipment The performance of the SIMPATEC-USP impactor was assessed by measuring the percentage recovery of four types of inhalation-grade lactose (InhaLac® 500, InhaLac® 400, InhaLac® 251, and InhaLac® 70) across three different inhalation devices (Aerocaps, CDM Haler, and Seebri Neohaler). Recovery and losses of lactose through the recovery plate, walls, and filter were analyzed. We quantified the mass recovered on the plate to evaluate the behavior and repeatability of the impactor. Losses on the walls and filter were included in the calculation, along with the material recovered on the collection plate, to determine the mass differential and the delivery efficiency of the devices. The total

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Development of SIMPATEC-USP: An abbreviated impactor for rapid testing of inhalation devices
  • Article
  • Full-text available

July 2024

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187 Reads

International Journal of Science and Research Archive

Cleudeucio Manoel Ferreira dos Santos Nascimento

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Mariana Yasue Saito Miyagi

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Ana Paula dos Santos Cardoso

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Gabriel Lima de Barros Araujo

Cascade impactors like the Andersen Cascade Impactor (ACI) and Next Generation Impactor (NGI) are complex and costly due to multiple stages. This study introduces SIMPATEC-USP (Simplified Impactor Developed at the University of São Paulo), a low-cost, single-stage alternative meeting US Pharmacopeia standards for testing dry powder inhalers (DPIs). SIMPATEC-USP simplifies particle retention into a single Petri dish stage, eliminating multi-stage complexity. Its design includes a straightforward closure system for easy assembly/disassembly. A collection chamber holds a glass Petri dish with filter paper for final filtration, ensuring efficient aerosol product collection. SIMPATEC-USP also offers potential use with culture media for applications like antibacterial screening. Operating at 30 L/min, SIMPATEC-USP consists of three parts: a single-stage chamber, an L-shaped tube mimicking the trachea, and a vacuum pump. Aerosol particles are deposited onto the Petri dish via a nozzle, and the collected sample is weighed to determine drug concentration. Tested with inhalation-grade lactose, SIMPATEC-USP effectively collects and analyzes particles, allowing for rapid aerodynamic comparison of formulations, capsule retention assessment, and sample collection for drug release studies. The results demonstrate that it is possible to evaluate the performance of three inhalation devices regarding the mass migrating to the collection plate and that retained within the device itself. In conclusion, SIMPATEC-USP is highly suitable for exploratory studies and educational activities in pharmaceutical technology and pulmonary drug delivery systems.

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